Dr. rer. nat. Juliane Günther

Institut für Genombiologie

+49 38208 68-702
Leibniz-Institut für Nutztierbiologie (FBN)
Institut für Genombiologie
Abteilung Genomphysiologie
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Forschungsinteressen

  • Molekularbiologie
  • Infektionsbiologie
  • Zellbiologie
  • Immunologie
  • Epigenetik
  • Cell-signalling

Lebenslauf

  • Seit 2013: Nachwuchsgruppenleiterin in der Genomphysiologie am Leibniz-Institut für Nutztierbiologie (FBN)
  • 2006-2013: Postdoc in der Arbeitsgruppe Genanalyse am Leibniz-Institut für Nutztierbiologie (FBN)
  • 2005: Promotion zum PhD an der Friedrich Schiller Universität Jena
  • 2002-2005: Doktorandin am Leibniz-Insititut für Naturstoff-Forschung und Infektionsbiologie (Hans-Knöll Institut) in Jena
  • 2001: Diplom in Biologie an der Friedrich Schiller Universität Jena
  • 1995-2001: Studium der Biologie an der Friedrich Schiller Universität Jena

Lehre

  • Seit 2011: "Diversität und Evolution" im Masterstudiengang an der Mathematisch Naturwissenschaftlichen Fakultät der universität Rostock

Publikationen

Brodhagen, J.; Weikard, R.; Thom, U.; Heimes, A.; Günther, J.; Hadlich, F.; Zerbe, H.; Petzl, W.; Meyerholz, M. M.; Hoedemaker, M.; Schubert, H-J; Engelmann, S.; Kühn, Ch. (2019):
Development and evaluation of a milk protein transcript depletion method for differential transcriptome analysis in mammary gland tissue. BMC Genomics 20 (1): 400
Petzl, W.; Zerbe, H.; Günther, J.; Seyfert, H.-M.; Hussen, J.; Schuberth, H.-J. (2018):
Pathogen-specific responses in the bovine udder: Models and immunoprophylactic concepts. Res Vet Sci 116: 55-61
Wirthgen, E.; Otten, W.; Tuchscherer, M.; Tuchscherer, A.; Domanska, G.; Brenmoehl, J.; Günther, J.; Ohde, D.; Weitschies, W.; Seidlitz, A.; Scheuch, W.; Kanitz, E. (2018):
Effects of 1-Methyltryptophan on immune responses and the kynurenine pathway after lipopolysaccharide challenge in pigs. Int J Mol Sci 19 (10): 3009, 1-23
Günther, J.; Seyfert, H.M. (2018):
The first line of defence: insights into mechanisms and relevance of phagocytosis in epithelial cells. Semin Immunopathol 40 (6): 555-565
Günther, J.; Petzl, W.; Zerbe, H.; Schuberth, H.-J.; Seyfert, H.-M. (2017):
TLR ligands, but not modulators of histone modifiers, can induce the complex immune response pattern of endotoxin tolerance in mammary epithelial cells. Innate Immun-London 23 (2): 155-164
Günther, J.; Petzl, W.; Bauer, I.; Ponsuksili, S.; Zerbe, H.; Schuberth, H.-J.; Brunner, R. M.; Seyfert, H.-M. (2017):
Differentiating Staphylococcus aureus from Escherichia coli mastitis: S. aureus triggers unbalanced immune-dampening and host cell invasion immediately after udder infection. Sci Rep-UK 7: 4811,1-14
Wirthgen, E.; Hoeflich, A.; Rebl, A.; Günther, J. (2017):
Kynurenic acid: The Janus-faced role of an immunomodulatory tryptophan metabolite and its link to pathological conditions. Front Immunol 8: 1957, 1-13
Günther, J.; Czabanska, A.; Bauer, I.; Leigh, J.; Holst, Otto; Seyfert, H.-M. (2016):
Streptococcus uberis strains isolated from the bovine mammary gland evade immune recognition by mammary epithelial cells, but not of macrophages. Vet Res 47: 13, 1-14
Günther, J.; Koy, M.; Berthold, A.; Schuberth, H.-J.; Seyfert, H.-M. (2016):
Comparison of the pathogen species-specific immune response in udder derived cell types and their models. Vet Res 47: 22, 1-11
Petzl, W.; Günther, J.; Mühlbauer, I.C.; Seyfert, H.-M.; Schuberth, H.-J.; Hussen, J.; Sauter-Louis, C.; Hafner-Marx, A.; Zerbe, H. (2016):
Early transcriptional events in the udder and teat after intramammary Escherichia coli and Staphylococcus aureus challenge. Innate Immun-London 22 (4): 294-304
Chang, G.; Petzl, W.; Vanselow, J.; Günther, J.; Shen, Z.; Seyfert, H.-M. (2015):
Epigenetic mechanisms contribute to enhanced expression of immune response genes in the liver of cows after experimentally induced Escherichia coli mastitis. Vet J 203 (3): 339-341
Bauer, I.; Günther, J.; Wheeler, T.T.; Engelmann, S.; Seyfert, H.-M. (2015):
Extracellular milieu grossly alters pathogen-specific immune response of mammary epithelial cells. BMC Vet Res 11: 172-186
Jaeger, A.; Bardehle, D.; Oster, M.; Günther, J.; Muràni, E.; Ponsuksili, S.; Wimmers, K.; Kemper, N. (2015):
Gene expression profiling of porcine mammary epithelial cells after challenge with Escherichia coli and Staphylococcus aureus in vitro. Vet Res 46: 1-18
Patterson, N.; Günther, J.; Gibson, A.; Offord, V.; Coffey, T. J.; Splitter, G.; Monk, I.; Seyfert, H.-M.; Werling, Dirk (2014):
TwoTIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response. Front microbiol 5: 662-676
Jensen, K.; Günther, J.; Talbot, R.; Petzl, W.; Zerbe, H.; Schuberth, H.-J.; Seyfert, H.-M.; Glass, E. (2013):
Escherichia coli- and Staphylococcus aureus-induced mastitis differentially modulate transcriptional response in neighbouring uninfected bovine mammary gland quarters. BMC Genomics 14: 36-55
Petzl, W.; Günther, J.; Pfister, T.; Sauter-Louis, C.; Goetze, L.; von Aulock, S.; Hafner-Marx, A.; Schuberth, H.-J.; Seyfert, H.-M.; Zerbe, H. (2012):
Lipopolysaccharide pretreatment of the udder protects against experimental Escherichia coli mastitis. Innate Immun-London 18 (3): 467-477
Günther, J.; Petzl, W.; Zerbe, H.; Schuberth, H.-J.; Koczan, D.; Goetze, L.; Seyfert, H.-M. (2012):
Lipopolysaccharide priming enhances expression of effectors of immune defence while decreasing expression of pro-inflammatory cytokines in mammary epithelia cells from cows. BMC Genomics 13: 17-30
Lewandowska-Sabat, A. M.; Günther, J.; Seyfert, H.-M.; Olsaker, I. (2012):
Combining quantitative trait loci and heterogeneous microarray data analyses reveals putative candidate pathways affecting mastitis in cattle. Anim Genet 43 (6): 793-796
Günther, J.; Esch, K.; Poschadel, N.; Petzl, W.; Zerbe, H.; Mitterhuemer, S.; Blum, H.; Seyfert, H.-M. (2011):
Comparative kinetics of Escherichia coli- and Staphylococcus aureus-specific activation of key immune pathways in mammary epithelial cells demonstrates that S. aureus elicits a delayed response dominated by interleukin-6 (IL-6) but not by IL-1A or tumor n
Lui, S.; Shi, X.; Bauer, I.; Günther, J.; Seyfert, H.-M. (2011):
Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-kappaB p65 and C/EBPbeta in mammary epithelial cells. MOL IMMUNOL 48 (6-7): 895-908