PD Dr. rer. nat. habil. Manfred Mielenz

Institut für Ernährungsphysiologie "Oskar Kellner"

+49 38208 68-652
Leibniz-Institut für Nutztierbiologie (FBN)
Institut für Ernährungsphysiologie "Oskar Kellner"
Arbeitsgruppe Zelluläre Nährstoffsignale
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Forschungsinteressen

  • Nährstoff-Sensing
  • Energieverwertung
  • Metabolismus
  • Adipokine
  • Fettsäuren
  • metabolische Signalwege
  • bioaktive Futterinhaltsstoffe

Lebenslauf

  • 2013-heute: Wissenschaftlicher Mitarbeiter am Leibniz Institut für Nutztierbiologie (FBN) Dummerstorf, Institut für Ernährungsphysiologie "Oskar Kellner"
  • 2013-heute: Privatdozent an der Rheinischen Friedrich-Wilhelms-Universität Bonn
  • 2013: Habilitation im Fach Physiologie an der Rheinischen Friedrich-Wilhelms-Universität Bonn
  • 2002-2012: Arbeitsgruppenleiter an der Rheinischen Friedrich-Wilhelms-Universität Bonn im Institut für Tierwissenschaften, Abteilung Physiologie und Hygiene
  • Promotion an der Gottfried Wilhelm Leibniz Universität Hannover; Anfertigung der Dissertation am Friedrich-Loeffler Institut, Institut Nutztiergenetik, Abteilung Funktionelle Genetik und Bioregulation, ehemals Bundesforschungsanstalt für Landwirtschaft (FAL) in Mariensee
  • Studium der Biologie an der Gottfried Wilhelm Leibniz Universität Hannover; Diplomarbeit an der Bundesforschungsanstalt für Landwirtschaft (FAL) in Mariensee

Lehre

  • Physiologie und Anatomie

Publikationen

Revskij, D; Haubold, S.S; Viergutz, T.; Kröger-Koch, C.; Tuchscherer, A.; Kirchberger, H.S.; Rychlik, M.; Tröscher, A.; Hammon, H. M.; Schuberth, H.-J.; Mielenz, M. (2019):
Dietary Fatty Acids Affect Red Blood Cell Membrane Composition and Red Blood Cell ATP Release in Dairy Cows. Int J Mol Sci 20: 2769
Sadri, H.; Saremi, B.; Dänicke, S.; Rehage, J.; Mielenz, M.; Sauerwein, H. (2018):
Lactation-related changes in tissue expression of PEDF in dairy cows. DOMEST ANIM ENDOCRIN 64: 93-101
Mielenz, M.; Pfaffl, M.W.; Schlumbohm, C.; Harmeyer, J.; Parvizi, N. (2018):
Growth hormone secretion patterns in German Landrace (DL) fetuses and piglets compared to DL piglets with inherited 1,25-dihydroxyvitamin D3 deficiency. Nutrients 10: 617, 1-7
Mansouryar, M.; Mirzaei-Alamouti, H.; Dehghan-banadaky, M.; Sauerwein, H.; Mielenz, M.; Nielsen, M. O. (2018):
Short communication: relationship between body condition score and plasma adipokines in early-lactating Holstein dairy cows. J Dairy Sci 101 (9): 8552-8558
Mielenz, M. (2017):
Invited review: nutrient-sensing receptors for free fatty acids and hydroxycarboxylic acids in farm animals. Animal 11 (6): 1008-1016
Aguinaga Casañas, M.; Schäff, C.; Albrecht, E.; Hammon, H. M.; Kuhla, B.; Röntgen, M.; Nürnberg, G.; Mielenz, M. (2017):
Short communication: Free fatty acid receptors FFAR1 and FFAR2 during the peripartal period in liver of dairy cows grouped by their postpartum plasma beta-hydroxybutyrate concentrations. J Dairy Sci 100 (4): 3287-3292
Pfundt, B.; Mielenz, B.; Sanver, F.; Pfeffer, E.; Sauerwein, H.; Mielenz, M. (2016):
Effects of largely different feeding intensities on serum insulin-like growth factor-1 concentrations, quantified by enzyme immunoassay, leptin and growth hormone receptor 1 mRNA in rainbow trout (Oncorhynchus mykiss). Aquacult Nutr 22 (3): 586-596
Weber, M.; Locher, L.; Huber, K.; Kenéz, Á.; Rehage, J.; Tienken, R.; Meyer, U.; Dänicke, S.; Sauerwein, H.; Mielenz, M. (2016):
Longitudinal changes in adipose tissue of dairy cows from late pregnancy to lactation, Part 1: The adipokines apelin and resistin and their relationship to receptors linked with lipolysis. J Dairy Sci 99 (2): 1549-1559
Weber, M.; Locher, L.; Rehage, J.; Tienken, R.; Meyer, U.; Dänicke, S.; Webb, L.; Sauerwein, H.; Mielenz, M. (2016):
Longitudinal changes in adipose tissue of dairy cows from late pregnancy to lactation, Part 2: The SIRT-PPARGC1A axis and its relationship with the adiponectin system. J Dairy Sci 99 (2): 1560-1570
Friedrichs, P.; Sauerwein, H.; Huber, K.; Locher, L. F.; Rehage, J.; Meyer, U.; Dänicke, S.; Kuhla, B.; Mielenz, M. (2016):
Expression of metabolic sensing receptors in adipose tissues of periparturient dairy cows with differing extent of negative energy balance. Animal 10 (4): 623-632
Stoldt, A.-K.; Mielenz, M.; Nürnberg, G.; Sauerwein, H.; Esatbeyoglu, T.; Wagner, A. E.; Rimbach, G.; Starke, A.; Wolffram, S.; Metges, C. C. (2016):
Effects of a six-week intraduodenal supplementation with quercetin on liver lipid metabolism and oxidative stress in peripartal dairy cows. J Anim Sci 94 (5): 1913-1923
van den Borne, J.J.G.C.; Labussière, E.; Mielenz, M.; Sauerwein, H.; Gerrits, W. J. J. (2016):
Exchanging fat for lactose in milk replacer stimulates de novo lipogenesis in calves. In: Energy and protein metabolism and nutrition : 5th EAAP International Symposium, Krakow, Poland, 12-15 September 2016 (EAAP Publication , 137) (Jacek Skomial, Hélène
Schäff, C.; Gruse, J.; Maciej, J.; Mielenz, M.; Wirthgen, E.; Hoeflich, A.; Schmicke, M.; Pfuhl, R.; Jawor, P.; Stefaniak, T.; Hammon, H. M. (2016):
Effects of feeding milk replacer ad libitum or in restricted amounts for the first five weeks of life on the growth, metabolic adaptation, and immune status of newborn calves. Plos One 11 (12): e0168974, 1-24
Kuhla, B.; Mielenz, M.; Metges, C. C. (2015):
Die Kuh produziert kein Methan. Leibniz Nordost 20: 6-7
Lamp, O.; Derno, M.; Otten, W.; Mielenz, M.; Nürnberg, G.; Kuhla, B. (2015):
Metabolic heat stress adaption in transition cows: differences in macronutrient oxidation between late-gestating and early-lactating German Holstein dairy cows. Plos One 10 (5): e0125264, 1-24
Rahman, M.M.; Lecchi, C.; Sauerwein, H.; Mielenz, M.; Häussler, S.; Restelli, L.; Giudice, C.; Ceciliani, F. (2015):
Expression of α1-acid glycoprotein and lipopolysaccharide binding protein in visceral and subcutaneous adipose tissue of dairy cattle. Vet J 203 (2): 223-227
Tienken, R.; Kersten, S.; Frahm, J.; Meyer, U.; Locher, L.; Rehage, J.; Huber, K.; Kenéz, Á.; Sauerwein, H.; Mielenz, M.; Dänicke, S. (2015):
Effects of an energy-dense diet and nicotinic acid supplementation on production and metabolic variables of primiparous or multiparous cows in periparturient period. Arch Anim Nutr 69 (5): 319-339
Saremi, B.; Winand, S.; Friedrichs, P.; Kinoshita, A.; Rehage, J.; Dänicke, S.; Häussler, S.; Breves, G.; Mielenz, M.; Sauerwein, H. (2014):
Longitudinal profiling of the tissue-specific expression of genes related with insulin sensitivity in dairy cows during lactation focusing on different fat depots. Plos One 9 (1): 1-15
Kopp, C.; Singh, S. P.; Regenhard, P.; Müller, U.; Sauerwein, H.; Mielenz, M. (2014):
Trans-cinnamic acid increases adiponectin and the phosphorylation of AMP-activated protein kinase through G-protein-coupled receptor signaling in 3T3-L1 adipocytes. Int J Mol Sci 15 (2): 2906-2915
Friedrichs, P.; Saremi, B.; Winand, S.; Rehage, J.; Dänicke, S.; Sauerwein, H.; Mielenz, M. (2014):
Energy and metabolic sensing G protein-coupled receptors during lactation-induced changes in energy balance. DOMEST ANIM ENDOCRIN 48: 33-41