Immunomodulatory Roles of Tryptophan Metabolites in Inflammation and Cancer

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Renowned journal invites FBN scientist to curate a special issue (Research Topic).

Renowned journal invites FBN scientist to curate a special issue (Research Topic).
Research Topics in the journals of Frontiers Publishers (cf. Fig. 2) are peer-reviewed collections of articles on cutting-edge and innovative topics compiled independently by renowned researchers. The molecular biologist Juliane Günther from Dummerstorf has been invited together with experts from the Medical University Innsbruck, the University Medicine Rostock and the Italian Università degli Studi di Perugia to compile such a research topic on "Immunomodulatory Roles of Tryptophan Metabolites in Inflammation and Cancer" for the journal "Frontiers in Immunology".

The Research Topic focuses on the immunomodulatory aspects of tryptophan (TRP) metabolites. TRP is one of the essential amino acids of the mammalian organism. In addition to its basic function in protein synthesis, TRP is degraded in various ways. This leads to the formation of a number of more or less stable metabolites. In addition, intestinal microbiota degrade TRP into bacteria-specific metabolites. Both endogenous and bacterial TRP metabolites have profound effects on the host physiology.

Due to their influence on various significant diseases, TRP metabolites are regarded as promising disease-related novel biomarkers and their synthesis routes as attractive targets for therapeutic interventions. The aim of the planned special issue is not only to illustrate the current state of research, but also to provide new impulses for ongoing research in order to strengthen the understanding of the relationship between TRP metabolism and the immune system.


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