PD Dr. sc. agr. habil. Siriluck Wimmers
Forschungsinstitut für Nutztierbiologie (FBN)
Leiterin der Arbeitsgruppe Integrative Genomik
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Leiterin der Arbeitsgruppe Integrative Genomik
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Forschungsinteressen
- Molekulargenetik und Expression der Fleischqualität und weiterer Leistungseigenschaften landwirtschaftlicher Nutztiere
- miRNA regulatorische Netzwerke des Energiemetabolismus und der Fleischqualität in Muskelzellen
- Eigenschaftsabhängige Variation der Genotyp-Phänotyp Beziehung auf molekularer Ebene
Lebenslauf
- seit 2014: Abteilungsleitung Funktionale Genomanalyse im Institut Genombiologie am FBN
- 2004-2013: Oberassistentin Funktionale Genomanalyse , FBN
- 2003: Habilitation, venia legendi an der Agrarwissenschaftlichen Fakultät der Universität Bonn
- 1997-2003: Wissenschaftliche Mitarbeiterin an der Agrarwissenschaftlichen Fakultät der Universität Bonn
- 01/1997: Assistenzprofessor im Institut für Tierwissenschaften an der Agrarwissenschaftlichen Fakultät der Universität Chiang Mai, Thailand
- 1990-1995: DAAD-Stipendiatin, Promotion am Institut für Tierwissenschaften der TU Berlin
- 1987-1997: Dozentin am Institut für Tierwissenschaften der Agrarwissenschaftlichen Fakultät an der Universität Chiang Mai, Thailand
Lehre
Vorlesungen und Seminare an der Agrarwissenschaftlichen Fakultät der Universität Bonn
Publikationen
Du, Y.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2012):
Flexible and efficient genome tiling design with penalized uniqueness score. BMC Bioinformatics 13: 323-334
https://dx.doi.org/10.1186/1471-2105-13-323
Diesing, A.-K.; Nossol, C.; Ponsuksili, S.; Wimmers, K.; Kluess, J.; Walk, N.; Post, A.; Rothkötter, H.-J.; Kahlert, S. (2012):
Gene regulation of intestinal porcine epithelial cells IPEC-J2 is dependent on the site of deoxynivalenol toxicological action. Plos One 7 (4): 1-10
https://dx.doi.org/10.1371/journal.pone.0034136
Cinar, M. U.; Kayan, A.; Uddin, M. J.; Jonas, E; Tesfaye, D.; Phatsara, C.; Ponsuksili, S.; Wimmers, K.; Tholen, E.; Looft, C.; Jüngst, H.; Schellander, K. (2012):
Association and expression quantitative trait loci (eQTL) analysis of porcine AMBP, GC and PPP1R3B genes with meat quality traits. Mol Biol Rep 39 (4): 4809-4821
https://dx.doi.org/10.1007/s11033-011-1274-4
Chomwisarutkun, K.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2012):
Gene expression analysis of mammary tissue during fetal bud formation and growth in two pig breeds - indications of prenatal initiation of postnatal phenotypic differences. BMC Dev Biol 12: 13-29
https://dx.doi.org/10.1186/1471-213x-12-13
Altmann, S.; Muràni, E.; Schwerin, M.; Metges, C. C.; Wimmers, K.; Ponsuksili, S. (2012):
Maternal dietary protein restriction and excess affects offspring gene expression and methylation of non-SMC subunits of condensin I in liver and skeletal muscle. Epigenetics-US 7 (3): 239-252
https://dx.doi.org/10.4161/epi.7.3.19183
Altmann, S.; Muràni, E.; Schwerin, M.; Metges, C. C.; Wimmers, K.; Ponsuksili, S. (2012):
Somatic cytochrome c (CYCS) gene expression and promoter-specific DNA methylation in a porcine model of prenatal exposure to maternal dietary protein excess and restriction. Brit J Nutr 107 (6): 791-799
https://dx.doi.org/10.1017/S0007114511003667
Altmann, S.; Muràni, E.; Metges, C. C.; Schwerin, M.; Wimmers, K.; Ponsuksili, S. (2012):
Effect of gestational protein deficiency and excess on hepatic expression of genes related to cell cycle and proliferation in offspring from late gestation to finishing phase in pig. Mol Biol Rep 39 (6): 7095-7104
https://dx.doi.org/10.1007/s11033-012-1541-z
Muràni, E.; Reyer, H.; Ponsuksili, S.; Fritschka, S.; Wimmers, K. (2012):
A substitution in the ligand binding domain of the porcine glucocorticoid receptor affects activity of the adrenal gland. Plos One 7 (9): 1-10
https://dx.doi.org/10.1371/journal.pone.0045518
Brunner, R. M.; Srikanchai, T.; Muràni, E.; Wimmers, K.; Ponsuksili, S. (2012):
Genes with expression levels correlating to drip loss prove association of their polymorphism with water holding capacity of pork. Mol Biol Rep 39 (1): 97-107
https://dx.doi.org/10.1007/s11033-011-0714-5
Chomwisarutkun, K.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2012):
Microarray analysis reveals genes and functional networks relevant to the predisposition to inverted teats in pigs. J Anim Sci 90 (1): 1-15
https://dx.doi.org/10.2527/jas.2011-4269
Wimmers, K.; Do, V. A. K.; Schütze, S.; Muràni, E.; Ponsuksili, S. (2011):
The three-way relationship of polymorphisms of porcine genes encoding terminal complement components, their differential expression, and health-related phenotypes. BMC Proceedings 5 (Suppl.4): S19, 1-4
https://dx.doi.org/10.1186/1753-6561-5-S4-S19
Do, V. A. K.; Ponsuksili, S.; Muràni, E.; Wimmers, K. (2011):
Polymorphic sites in the 5'-region of the porcine C8A gene. Arch Tierzucht 54 (4): 430-438
Ponsuksili, S.; Muràni, E.; Brand, B.; Schwerin, M.; Wimmers, K. (2011):
Integrating expression profiling and whole-genome association for dissection of fat traits in a porcine model. J Lipid Res 52 (4): 668-678
https://dx.doi.org/10.1194/Jlr.M013342
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2011):
A high protein diet during pregnancy affects hepatic gene expression of energy sensing pathways along ontogenesis in a porcine model. Plos One 6 (7): 1-12
https://dx.doi.org/10.1371/journal.pone.0021691
Gandolfi, G.; Cinar, M. U.; Ponsuksili, S.; Wimmers, K.; Tesfaye, D.; Looft, C.; Jüngst, H.; Tholen, E.; Phatsara, C.; Schellander, K.; Davoli, R. (2011):
Association of PPARGC1A and CAPNS1 gene polymorphisms and expression with meat quality traits in pigs. Meat Sci 89 (4): 478-485
https://dx.doi.org/10.1016/j.meatsci.2011.05.015
Kayan, A.; Cinar, M. U.; Uddin, M. J.; Phatsara, C.; Wimmers, K.; Ponsuksili, S.; Tesfaye, D.; Looft, C.; Jüngst, H.; Tholen, E.; Schellander, K. (2011):
Polymorphism and expression of the porcine Tenascin C gene associated with meat and carcass quality. Meat Sci 89 (1): 76-83
https://dx.doi.org/10.1016/j.meatsci.2011.04.001
Kayan, A.; Uddin, M. J.; Cinar, M. U.; Grosse-Brinkhaus, C.; Phatsara, C.; Wimmers, K.; Ponsuksili, S.; Tesfaye, D.; Looft, C.; Jüngst, H.; Tholen, E.; Schellander, K. (2011):
Investigation on interferon alpha-inducible protein 6 (IFI6) gene as a candidate for meat and carcass quality in pig. Meat Sci 89 (4): 755-760
https://dx.doi.org/10.1016/j.meatsci.2011.03.009
Brand, B.; Hartmann, S.; Repsilber, D.; Griesbeck-Zilch, B.; Wellnitz, O.; Kühn, C.; Ponsuksili, S.; Meyer, H. H. D.; Schwerin, M. (2011):
Comparative expression profiling of E. coli and S. aureus inoculated primary mammary gland cells sampled from cows with different genetic predispositions for somatic cell score. Genet Sel Evol 43: 24-41
https://dx.doi.org/10.1186/1297-9686-43-24
Muràni, E.; Ponsuksili, S.; D´Eath, R. B.; Turner, S.P.; Evans, G.; Thölking, L.; Kurt, E.; Klont, R.; Foury, A.; Mormède, P.; Wimmers, K. (2011):
Differential mRNA expression of genes in the porcine adrenal gland associated with psychosocial stress. J Mol Endocrinol 46 (3): 165-174
https://dx.doi.org/10.1530/Jme-10-0147
Wimmers, K.; Dolle, K.; Leeb, T.; Schellander, K.; Brunner, R. M.; Muràni, E.; Ponsuksili, S. (2010):
Identification of porcine candidate genes for water-holding capacity using QTL-region-specific BAC-arrays. In: Proceedings of the 9th World Congress on Genetics Applied to Livestock Production (Gesellschaft für Tierzuchtwissenschaften e.V., Hrsg.) (978-00-031608) (2010): 455