PD Dr. sc. agr. habil. Siriluck Wimmers
Forschungsinstitut für Nutztierbiologie (FBN)
Leiterin der Arbeitsgruppe Integrative Genomik
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Leiterin der Arbeitsgruppe Integrative Genomik
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Forschungsinteressen
- Molekulargenetik und Expression der Fleischqualität und weiterer Leistungseigenschaften landwirtschaftlicher Nutztiere
- miRNA regulatorische Netzwerke des Energiemetabolismus und der Fleischqualität in Muskelzellen
- Eigenschaftsabhängige Variation der Genotyp-Phänotyp Beziehung auf molekularer Ebene
Lebenslauf
- seit 2014: Abteilungsleitung Funktionale Genomanalyse im Institut Genombiologie am FBN
- 2004-2013: Oberassistentin Funktionale Genomanalyse , FBN
- 2003: Habilitation, venia legendi an der Agrarwissenschaftlichen Fakultät der Universität Bonn
- 1997-2003: Wissenschaftliche Mitarbeiterin an der Agrarwissenschaftlichen Fakultät der Universität Bonn
- 01/1997: Assistenzprofessor im Institut für Tierwissenschaften an der Agrarwissenschaftlichen Fakultät der Universität Chiang Mai, Thailand
- 1990-1995: DAAD-Stipendiatin, Promotion am Institut für Tierwissenschaften der TU Berlin
- 1987-1997: Dozentin am Institut für Tierwissenschaften der Agrarwissenschaftlichen Fakultät an der Universität Chiang Mai, Thailand
Lehre
Vorlesungen und Seminare an der Agrarwissenschaftlichen Fakultät der Universität Bonn
Publikationen
Ponsuksili, S.; Muràni, E.; Schwerin, M.; Schellander, K.; Tesfaye, D.; Wimmers, K. (2012):
Gene expression and DNA-methylation of bovine pretransfer endometrium depending on its receptivity after in vitro-produced embryo transfer. Plos One 7 (8): 1-13
https://dx.doi.org/10.1371/journal.pone.0042402
Ponsuksili, S.; Du, Y.; Muràni, E.; Schwerin, M.; Wimmers, K. (2012):
Elucidating molecular networks that either affect or respond to plasma cortisol concentration in target tissues of liver and muscle. Genetics 192 (3): 1109-1122
https://dx.doi.org/10.1534/genetics.112.143081
Pareek, C. S.; Pierzchala, M.; Michno, J.; Szymanska, S.; Smoczynski, R.; Jasik, N.; Golebiewski, M.; Tyburski, J.; Urbanski, P.; Goluch, D.; Oprzadek, J.; Zwierzchowski, L.; Ponsuksili, S.; Wimmers, K. (2012):
Gene expression profiling by cDNA-AFLP and identification of differentially expressed transcripts of bovine pituitary gland in growing bulls of dairy breeds. Anim Sci Pap Rep 30 (2): 103-119
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2012):
Transcriptional response of skeletal muscle to a low-protein gestation diet in porcine offspring accumulates in growth- and cell cycle-regulating pathways. Physiol Genomics 44 (16): 811-818
https://dx.doi.org/10.1152/physiolgenomics.00050.2012
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2012):
A low protein diet during pregnancy provokes a lasting shift of hepatic expression of genes related to cell cycle throughout ontogenesis in a porcine model. BMC Genomics 13 (1): 93-107
https://dx.doi.org/10.1186/1471-2164-13-93
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2012):
A gestational high protein diet affects the abundance of muscle transcripts related to cell cycle regulation throughout development in porcine progeny. Plos One 7 (3): 1-9
https://dx.doi.org/10.1371/journal.pone.0034519
Du, Y.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2012):
Flexible and efficient genome tiling design with penalized uniqueness score. BMC Bioinformatics 13: 323-334
https://dx.doi.org/10.1186/1471-2105-13-323
Diesing, A.-K.; Nossol, C.; Ponsuksili, S.; Wimmers, K.; Kluess, J.; Walk, N.; Post, A.; Rothkötter, H.-J.; Kahlert, S. (2012):
Gene regulation of intestinal porcine epithelial cells IPEC-J2 is dependent on the site of deoxynivalenol toxicological action. Plos One 7 (4): 1-10
https://dx.doi.org/10.1371/journal.pone.0034136
Cinar, M. U.; Kayan, A.; Uddin, M. J.; Jonas, E; Tesfaye, D.; Phatsara, C.; Ponsuksili, S.; Wimmers, K.; Tholen, E.; Looft, C.; Jüngst, H.; Schellander, K. (2012):
Association and expression quantitative trait loci (eQTL) analysis of porcine AMBP, GC and PPP1R3B genes with meat quality traits. Mol Biol Rep 39 (4): 4809-4821
https://dx.doi.org/10.1007/s11033-011-1274-4
Chomwisarutkun, K.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2012):
Gene expression analysis of mammary tissue during fetal bud formation and growth in two pig breeds - indications of prenatal initiation of postnatal phenotypic differences. BMC Dev Biol 12: 13-29
https://dx.doi.org/10.1186/1471-213x-12-13
Altmann, S.; Muràni, E.; Schwerin, M.; Metges, C. C.; Wimmers, K.; Ponsuksili, S. (2012):
Maternal dietary protein restriction and excess affects offspring gene expression and methylation of non-SMC subunits of condensin I in liver and skeletal muscle. Epigenetics-US 7 (3): 239-252
https://dx.doi.org/10.4161/epi.7.3.19183
Altmann, S.; Muràni, E.; Schwerin, M.; Metges, C. C.; Wimmers, K.; Ponsuksili, S. (2012):
Somatic cytochrome c (CYCS) gene expression and promoter-specific DNA methylation in a porcine model of prenatal exposure to maternal dietary protein excess and restriction. Brit J Nutr 107 (6): 791-799
https://dx.doi.org/10.1017/S0007114511003667
Altmann, S.; Muràni, E.; Metges, C. C.; Schwerin, M.; Wimmers, K.; Ponsuksili, S. (2012):
Effect of gestational protein deficiency and excess on hepatic expression of genes related to cell cycle and proliferation in offspring from late gestation to finishing phase in pig. Mol Biol Rep 39 (6): 7095-7104
https://dx.doi.org/10.1007/s11033-012-1541-z
Muràni, E.; Reyer, H.; Ponsuksili, S.; Fritschka, S.; Wimmers, K. (2012):
A substitution in the ligand binding domain of the porcine glucocorticoid receptor affects activity of the adrenal gland. Plos One 7 (9): 1-10
https://dx.doi.org/10.1371/journal.pone.0045518
Brunner, R. M.; Srikanchai, T.; Muràni, E.; Wimmers, K.; Ponsuksili, S. (2012):
Genes with expression levels correlating to drip loss prove association of their polymorphism with water holding capacity of pork. Mol Biol Rep 39 (1): 97-107
https://dx.doi.org/10.1007/s11033-011-0714-5
Chomwisarutkun, K.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2012):
Microarray analysis reveals genes and functional networks relevant to the predisposition to inverted teats in pigs. J Anim Sci 90 (1): 1-15
https://dx.doi.org/10.2527/jas.2011-4269
Wimmers, K.; Do, V. A. K.; Schütze, S.; Muràni, E.; Ponsuksili, S. (2011):
The three-way relationship of polymorphisms of porcine genes encoding terminal complement components, their differential expression, and health-related phenotypes. BMC Proceedings 5 (Suppl.4): S19, 1-4
https://dx.doi.org/10.1186/1753-6561-5-S4-S19
Do, V. A. K.; Ponsuksili, S.; Muràni, E.; Wimmers, K. (2011):
Polymorphic sites in the 5'-region of the porcine C8A gene. Arch Tierzucht 54 (4): 430-438
Ponsuksili, S.; Muràni, E.; Brand, B.; Schwerin, M.; Wimmers, K. (2011):
Integrating expression profiling and whole-genome association for dissection of fat traits in a porcine model. J Lipid Res 52 (4): 668-678
https://dx.doi.org/10.1194/Jlr.M013342
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2011):
A high protein diet during pregnancy affects hepatic gene expression of energy sensing pathways along ontogenesis in a porcine model. Plos One 6 (7): 1-12
https://dx.doi.org/10.1371/journal.pone.0021691