PD Dr. sc. agr. habil. Siriluck Wimmers
Forschungsinteressen
- Molekulargenetik und Expression der Fleischqualität und weiterer Leistungseigenschaften landwirtschaftlicher Nutztiere
- miRNA regulatorische Netzwerke des Energiemetabolismus und der Fleischqualität in Muskelzellen
- Eigenschaftsabhängige Variation der Genotyp-Phänotyp Beziehung auf molekularer Ebene
Lebenslauf
- seit 2014: Abteilungsleitung Funktionale Genomanalyse im Institut Genombiologie am FBN
- 2004-2013: Oberassistentin Funktionale Genomanalyse , FBN
- 2003: Habilitation, venia legendi an der Agrarwissenschaftlichen Fakultät der Universität Bonn
- 1997-2003: Wissenschaftliche Mitarbeiterin an der Agrarwissenschaftlichen Fakultät der Universität Bonn
- 01/1997: Assistenzprofessor im Institut für Tierwissenschaften an der Agrarwissenschaftlichen Fakultät der Universität Chiang Mai, Thailand
- 1990-1995: DAAD-Stipendiatin, Promotion am Institut für Tierwissenschaften der TU Berlin
- 1987-1997: Dozentin am Institut für Tierwissenschaften der Agrarwissenschaftlichen Fakultät an der Universität Chiang Mai, Thailand
Lehre
Vorlesungen und Seminare an der Agrarwissenschaftlichen Fakultät der Universität Bonn
Publikationen
Oster, M.; Muràni, E.; Ponsuksili, S.; D´Eath, R. B.; Turner, S.P.; Evans, G.; Thölking, L.; Kurt, E.; Klont, R.; Foury, A.; Mormède, P.; Wimmers, K. (2014):
Transcriptional responses of PBMC in psychosocially stressed animals indicate an alerting of the immune system in female but not in castrated male pigs. BMC Genomics 15: 967-978
https://dx.doi.org/10.1186/1471-2164-15-967
Ponsuksili, S.; Tesfaye, D.; Schellander, K.; Hoelker, M; Hadlich, F.; Schwerin, M.; Wimmers, K. (2014):
Differential expression of miRNAs and their target mRNAs in endometria prior to maternal recognition of pregnancy associates with endometrial receptivity for in vivo- and in vitro-produced bovine embryos. Biol Reprod 91 (6): 135-147
https://dx.doi.org/10.1095/biolreprod.114.121392
Oster, M.; Muràni, E.; Ponsuksili, S.; D´Eath, R. B.; Turner, S.P.; Evans, G.; Thölking, L.; Kurt, E.; Klont, R.; Foury, A.; Mormède, P.; Wimmers, K. (2014):
Hepatic expression patterns in psychosocially high-stressed pigs suggest mechanisms following allostatic principles. Physiol Behav 128: 159-165
https://dx.doi.org/10.1016/j.physbeh.2014.02.014
Ponsuksili, S.; Muràni, E.; Trakooljul, N.; Schwerin, M.; Wimmers, K. (2014):
Discovery of candidate genes for muscle traits based on GWAS supported by eQTL-analysis. Int J Biol Sci 10 (3): 327-337
https://dx.doi.org/10.7150/ijbs.8134
Loan, H. T. P.; Muràni, E.; Maak, S.; Ponsuksili, S.; Wimmers, K. (2014):
UBXN1 polymorphism and its expression in porcine M. longissimus dorsi are associated with water holding capacity. Mol Biol Rep 41 (3): 1411-1418
https://dx.doi.org/10.1007/s11033-013-2985-5
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2014):
High- and low-protein gestation diets do not provoke common transcriptional responses representing universal target-pathways in muscle and liver of porcine progeny. Acta Physiol 210 (1): 202-214
https://dx.doi.org/10.1111/Apha.12192
Reyer, H.; Ponsuksili, S.; Wimmers, K.; Muràni, E. (2014):
Association of N-terminal domain polymorphisms of the porcine glucocorticoid receptor with carcass composition and meat quality traits. Anim Genet 45 (1): 125-129
https://dx.doi.org/10.1111/age.12083.
Komolka, K.; Ponsuksili, S.; Schwerin, M. (2013):
Healthy sheep that differ in scrapie associated PRNP genotypes exhibit significant differences of expression pattern associated with immune response and cell-to-cell signalling in retropharyngeal lymph nodes. VET IMMUNOL IMMUNOP 152 (3-4): 370-380
https://dx.doi.org/10.1016/j.vetimm.2013.01.014
Du, Y.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2013):
BiomvRCNS: copy number variation study and segmentation for multivariate biological data. Schriftenreihe / Leibniz-Institut für Nutztierbiol 21: 11-14
Huynh, L. T. P.; Muràni, E.; Maak, S.; Ponsuksili, S.; Wimmers, K. (2013):
UBE3B and TRIP12 polymorphisms and transcript abundance are associated with water holding capacity of porcine m. longissimus dorsi . Schriftenreihe / Leibniz-Institut für Nutztierbiol 21: 27-30
Pareek, C. S.; Michno, J.; Smoczynski, R.; Tyburski, J.; Golebiewski, M.; Piechocki, K.; Sredzinska, M.; Pierzchala, M.; Czarnik, U.; Ponsuksili, S.; Wimmers, K. (2013):
Identification of predicted genes expressed differentially in pituitary gland tissue of young growing bulls revealed by cDNA-AFLP technique. Czech J Anim Sci 58 (4): 147-158
https://dx.doi.org/10.1371/journal.pone.0018135
Loan, H. T. P.; Muràni, E.; Maak, S.; Ponsuksili, S.; Wimmers, K. (2013):
Novel SNPs of the porcine TRIP12 are associated with water holding capacity of meat. Czech J Anim Sci 58 (11): 525-533
Siengdee, P.; Trakooljul, N.; Muràni, E.; Schwerin, M.; Wimmers, K.; Ponsuksili, S. (2013):
Transcriptional profiling and miRNA-dependent regulatory network analysis of longissimus dorsi muscle during prenatal and adult stages in two distinct pig breeds. Anim Genet 44 (4): 398-407
https://dx.doi.org/10.1111/Age.12032
Adler, M.; Muràni, E.; Brunner, R. M.; Ponsuksili, S.; Wimmers, K. (2013):
Transcriptomic response of porcine PBMCs to vaccination with tetanus toxoid as a model antigen. Plos One 8 (3): 1-8
https://dx.doi.org/10.1371/journal.pone.0058306
Rangkasenee, N.; Muràni, E.; Brunner, R. M.; Schellander, K.; Cinar, M. U.; Luther, H.; Hofer, A.; Stoll, M.; Witten, A.; Ponsuksili, S.; Wimmers, K. (2013):
Genome-wide association identifies TBX5 as candidate gene for osteochondrosis providing a functional link to cartilage perfusion as initial factor. Front Genet 4: 78
https://dx.doi.org/10.3389/fgene.2013.00078
Ponsuksili, S.; Du, Y.; Hadlich, F.; Siengdee, P.; Muràni, E.; Schwerin, M.; Wimmers, K. (2013):
Correlated mRNAs and miRNAs from co-expression and regulatory networks affect porcine muscle and finally meat properties. BMC Genomics 14: 533-550
https://dx.doi.org/10.1186/1471-2164-14-533
Rangkasenee, N.; Muràni, E.; Schellander, K.; Cinar, M. U.; Ponsuksili, S.; Wimmers, K. (2013):
Gene expression profiling of articular cartilage reveals functional pathways and networks of candidate genes for osteochondrosis in pigs. Physiol Genomics 45 (18): 856-865
https://dx.doi.org/10.1152/physiolgenomics.00055.2013
Nossol, C.; Diesing, A.-K.; Kahlert, S.; Kersten, S.; Kluess, J.; Ponsuksili, S.; Hartig, R.; Wimmers, K.; Dänicke, S.; Rothkötter, H.-J. (2013):
Deoxynivalenol affects the composition of the basement membrane proteins and influences en route the migration of CD16+ cells into the intestinal epithelium. Mycotoxin Res 29 (4): 245-254
https://dx.doi.org/10.1007/s12550-013-0177-8
Heidt, H.; Cinar, M. U.; Uddin, M. J.; Looft, C.; Jüngst, H.; Tesfaye, D.; Becker, A.; Zimmer, A.; Ponsuksili, S.; Wimmers, K.; Tholen, E.; Schellander, K.; Grosse-Brinkhaus, C. (2013):
A genetical genomics approach reveals new candidates and confirms known candidate genes for drip loss in a porcine resource population. Mamm Genome 24 (9-10): 416-426
https://dx.doi.org/10.1007/s00335-013-9473-z