PD Dr. sc. agr. habil. Siriluck Wimmers
Forschungsinstitut für Nutztierbiologie (FBN)
Leiterin der Arbeitsgruppe Integrative Genomik
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Leiterin der Arbeitsgruppe Integrative Genomik
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Forschungsinteressen
- Molekulargenetik und Expression der Fleischqualität und weiterer Leistungseigenschaften landwirtschaftlicher Nutztiere
- miRNA regulatorische Netzwerke des Energiemetabolismus und der Fleischqualität in Muskelzellen
- Eigenschaftsabhängige Variation der Genotyp-Phänotyp Beziehung auf molekularer Ebene
Lebenslauf
- seit 2014: Abteilungsleitung Funktionale Genomanalyse im Institut Genombiologie am FBN
- 2004-2013: Oberassistentin Funktionale Genomanalyse , FBN
- 2003: Habilitation, venia legendi an der Agrarwissenschaftlichen Fakultät der Universität Bonn
- 1997-2003: Wissenschaftliche Mitarbeiterin an der Agrarwissenschaftlichen Fakultät der Universität Bonn
- 01/1997: Assistenzprofessor im Institut für Tierwissenschaften an der Agrarwissenschaftlichen Fakultät der Universität Chiang Mai, Thailand
- 1990-1995: DAAD-Stipendiatin, Promotion am Institut für Tierwissenschaften der TU Berlin
- 1987-1997: Dozentin am Institut für Tierwissenschaften der Agrarwissenschaftlichen Fakultät an der Universität Chiang Mai, Thailand
Lehre
Vorlesungen und Seminare an der Agrarwissenschaftlichen Fakultät der Universität Bonn
Publikationen
Liu, X; Du, Y.; Trakooljul, N.; Brand, B.; Muràni, E.; Krischek, C.; Wicke, M.; Schwerin, M.; Wimmers, K.; Ponsuksili, S. (2015):
Muscle transcriptional profile based on muscle fiber, mitochondrial respiratory activity, and metabolic enzymes. Int J Biol Sci 11 (12): 1348-1362
https://dx.doi.org/10.7150/ijbs.13132
Ponsuksili, S.; Zebunke, M.; Muràni, E.; Trakooljul, N.; Krieter, J.; Puppe, B.; Schwerin, M.; Wimmers, K. (2015):
Integrated Genome-wide association and hypothalamus eQTL studies indicate a link between the circadian rhythm-related gene PER1 and coping behavior. Sci Rep-UK 5: 16264, 1-14
https://dx.doi.org/10.1038/srep16264
Reyer, H.; Hawken, R.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2015):
The genetics of feed conversion efficiency traits in a commercial broiler line. Sci Rep-UK 5: 16387, 1-11
https://dx.doi.org/10.1038/srep16387
Jaeger, A.; Fritschka, S.; Ponsuksili, S.; Wimmers, K.; Muràni, E. (2015):
Identification and functional characterization of cis-regulatory elements controlling expression of the porcine ADRB2 gene. Int J Biol Sci 11 (9): 1006-1015
https://dx.doi.org/10.7150/ijbs.12456
Jaeger, A.; Bardehle, D.; Oster, M.; Günther, J.; Muràni, E.; Ponsuksili, S.; Wimmers, K.; Kemper, N. (2015):
Gene expression profiling of porcine mammary epithelial cells after challenge with Escherichia coli and Staphylococcus aureus in vitro. Vet Res 46: 50, 1-18
https://dx.doi.org/10.1186/s13567-015-0178-z
Oster, M.; Scheel, M.; Muràni, E.; Ponsuksili, S.; Zebunke, M.; Puppe, B.; Wimmers, K. (2015):
The fight-or-flight response is associated with PBMC expression profiles related to immune defence and recovery in swine. Plos One 10 (3): e0120153, 1-15
https://dx.doi.org/10.1371/journal.pone.0120153
Görres, A.; Ponsuksili, S.; Wimmers, K.; Muràni, E. (2015):
Analysis of non-synonymous SNPs of the porcine SERPINA6 gene as potential causal variants for a QTL affecting plasma cortisol levels on SSC7. Anim Genet 46 (3): 239-246
https://dx.doi.org/10.1111/age.12276
Muràni, E.; Reyer, H.; Görres, A.; Tuchscherer, A.; Kanitz, E.; Ponsuksili, S.; Wimmers, K. (2014):
From phenotype to QTN and back: Identification and characterization of a genetic variant of the porcine glucocorticoid receptor with a major effect on HPA axis activity. In: Proceedings / 10th World Congress of Genetics Applied to Livestock Production (https://asas.org/wcgalp-proceedings) (https://asas.org/wcgalp-proceedings/species-breeding-swine): 371
Oster, M.; Muràni, E.; Ponsuksili, S.; D´Eath, R. B.; Turner, S.P.; Evans, G.; Thölking, L.; Kurt, E.; Klont, R.; Foury, A.; Mormède, P.; Wimmers, K. (2014):
Transcriptional responses of PBMC in psychosocially stressed animals indicate an alerting of the immune system in female but not in castrated male pigs. BMC Genomics 15: 967-978
https://dx.doi.org/10.1186/1471-2164-15-967
Ponsuksili, S.; Tesfaye, D.; Schellander, K.; Hoelker, M; Hadlich, F.; Schwerin, M.; Wimmers, K. (2014):
Differential expression of miRNAs and their target mRNAs in endometria prior to maternal recognition of pregnancy associates with endometrial receptivity for in vivo- and in vitro-produced bovine embryos. Biol Reprod 91 (6): 135-147
https://dx.doi.org/10.1095/biolreprod.114.121392
Oster, M.; Muràni, E.; Ponsuksili, S.; D´Eath, R. B.; Turner, S.P.; Evans, G.; Thölking, L.; Kurt, E.; Klont, R.; Foury, A.; Mormède, P.; Wimmers, K. (2014):
Hepatic expression patterns in psychosocially high-stressed pigs suggest mechanisms following allostatic principles. Physiol Behav 128: 159-165
https://dx.doi.org/10.1016/j.physbeh.2014.02.014
Ponsuksili, S.; Muràni, E.; Trakooljul, N.; Schwerin, M.; Wimmers, K. (2014):
Discovery of candidate genes for muscle traits based on GWAS supported by eQTL-analysis. Int J Biol Sci 10 (3): 327-337
https://dx.doi.org/10.7150/ijbs.8134
Du, Y.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2014):
biomvRhsmm: genomic segmentation with hidden semi-Markov model. BioMed Res Int 2014: 1-11
https://dx.doi.org/10.1155/2014/910390
Loan, H. T. P.; Muràni, E.; Maak, S.; Ponsuksili, S.; Wimmers, K. (2014):
UBXN1 polymorphism and its expression in porcine M. longissimus dorsi are associated with water holding capacity. Mol Biol Rep 41 (3): 1411-1418
https://dx.doi.org/10.1007/s11033-013-2985-5
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2014):
High- and low-protein gestation diets do not provoke common transcriptional responses representing universal target-pathways in muscle and liver of porcine progeny. Acta Physiol 210 (1): 202-214
https://dx.doi.org/10.1111/Apha.12192
Reyer, H.; Ponsuksili, S.; Wimmers, K.; Muràni, E. (2014):
Association of N-terminal domain polymorphisms of the porcine glucocorticoid receptor with carcass composition and meat quality traits. Anim Genet 45 (1): 125-129
https://dx.doi.org/10.1111/age.12083.
Komolka, K.; Ponsuksili, S.; Schwerin, M. (2013):
Healthy sheep that differ in scrapie associated PRNP genotypes exhibit significant differences of expression pattern associated with immune response and cell-to-cell signalling in retropharyngeal lymph nodes. VET IMMUNOL IMMUNOP 152 (3-4): 370-380
https://dx.doi.org/10.1016/j.vetimm.2013.01.014
Du, Y.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2013):
BiomvRCNS: copy number variation study and segmentation for multivariate biological data. Schriftenreihe / Leibniz-Institut für Nutztierbiol 21: 11-14
Huynh, L. T. P.; Muràni, E.; Maak, S.; Ponsuksili, S.; Wimmers, K. (2013):
UBE3B and TRIP12 polymorphisms and transcript abundance are associated with water holding capacity of porcine m. longissimus dorsi . Schriftenreihe / Leibniz-Institut für Nutztierbiol 21: 27-30
Pareek, C. S.; Michno, J.; Smoczynski, R.; Tyburski, J.; Golebiewski, M.; Piechocki, K.; Sredzinska, M.; Pierzchala, M.; Czarnik, U.; Ponsuksili, S.; Wimmers, K. (2013):
Identification of predicted genes expressed differentially in pituitary gland tissue of young growing bulls revealed by cDNA-AFLP technique. Czech J Anim Sci 58 (4): 147-158
https://dx.doi.org/10.1371/journal.pone.0018135