Dr. rer. tech. Pål Westermark
Forschungsinstitut für Nutztierbiologie (FBN)
Leiter der Arbeitsgruppe Chronobiologie und Bioinformatik
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Leiter der Arbeitsgruppe Chronobiologie und Bioinformatik
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Forschungsinteressen
- Circadiane Rhythmen in Tieren
- Regulierung der Genexpression und Stoffwechsel- bzw. Singaltransduktionswege
- Mechanismen der Gewebehomeostase
- Biogerontologie
- Zeitreihenanalyse
- Regelungstheorie
- Biostatistik
- mehr unter: orcid.org/0000-0002-6637-2566
Lebenslauf
- 2016 – jetzt: Abteilungsleiter, Bioinformatik und Biomathematik, FBN Dummerstorf
- 2011 – 2016: Gruppenleiter, Institut für theoretische Biologie, Charité – Universitätsmedizin Berlin
- 2005 – 2011: Wissenschaftlicher Mitarbeiter, AG Prof. Herzel, Institut für theoretische Biologie, Charité – Universitätsmedizin Berlin
- 2005: Promotion "Models of the Metabolism of the Pancreatic β-Cell", KTH Stockholm, Schweden
- 1999: Master, Dipl.-Ing. Molekulare Biotechnologie, Uppsala Universität, Schweden
Publikationen
Mansingh, S.; Maier, G.; Delezie, J.; Westermark, P. O.; Ritz, D.; Duchemin, W.; Santos, G.; Karrer-Cardel, B.; Steurer, A.; Albrecht, U.; Handschin, C. (2024):
More than the clock: distinct regulation of muscle function and metabolism by PER2 and RORα
The Journal of Physiology
https://doi.org/10.1113/JP285585
Maier, G.; Delezie, J.; Westermark, P. O.; Santos, G.; Ritz, D.; Handschin, C. (2022):
Transcriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and zeitgeber activity of training in mouse muscle. J Physiol-London 600 (4): 769-796
https://doi.org/10.1113/JP281535
Casanova-Vallve, N.; Duglan, D.; Vaughan, M.; Pariollaud, M.; Handzlik, M.; Fan, W.; Yu, R; Liddle, C.; Downes, M.; Delezie, J.; Mello, R.; Chan, A.; Westermark, P. O.; Metallo, C.; Evans, R.; Lamia, K. (2022):
Daily running enhances molecular and physiological circadian rhythms in skeletal muscle. Mol Metab 61: 101504, 1-15
Pett, P.J.; Westermark, P. O.; Herzel, H. (2021):
Simple kinetic models in molecular chronobiology. In: Circadian Clocks: Methods and Protocols (Steven A. Brown, Hrsg.) Springer, New York, NY (978-1-07-160381-9): 87-100
https://doi.org/10.1007/978-1-0716-0381-9_7
Pett, J. P.; Westermark, P. O.; Herzel, H. (2020):
Simple kinetic models in molecular chronobiology. In: Circadian clocks : methods and protocols (Methods in molecular biology , 2130) (Steven A. Brown, Hrsg.) Humana Press, New York (978-1-07-160380-2): 87-100
https://doi.org/10.1007/978-1-0716-0381-9_7
Klosa, J.; Simon, N.; Westermark, P. O.; Liebscher, V.; Wittenburg, D. (2020):
Seagull: lasso, group lasso and sparse-group lasso regularisation for linear regression models via proximal gradient descent. BMC Bioinformatics 21: 407, 1-8
https://doi.org/10.1186/s12859-020-03725-w
Daş, G.; Westermark, P. O.; Gauly, M. (2019):
Diurnal variation in egg excretion by Heterakis gallinarum. Parasitology 146 (2): 206-212
https://doi.org/ doi:10.1017/S0031182018001075
Wang, J.; Symul, L.; Yeung, J.; Gobet, C.; Sobel, J.; Lück, S.; Westermark, P. O.; Molina, N.; Naef, F. (2018):
Circadian clock-dependent and -independent posttranscriptional regulation underlies temporal mRNA accumulation in mouse liver. P Natl Acad Sci USA 115 (8): E1916-E1925
https://doi.org/10.1073/pnas.1715225115
Thurley, K.; Herbst, C.; Wesener, F.; Koller, B.; Wallach, T.; Maier, B.; Kramer, A.; Westermark, P. O. (2017):
Principles for circadian orchestration of metabolic pathways. Proceedings of the National Academy of Sciences 114: 1572-1577
Hughes, M.; Abruzzi, K.; Allada, A.; Anafi, R.; Arpat, A. B.; Asher, G.; Baldi, P.; de Bekker, C.; Bell-Pedersen, D.; Blau, J.; Brown, S.; Ceriani, F.; ..., ; Westermark, P. O.; et al., . (2017):
Guidelines for genome-scale analysis of biological rhythms. J Biol Rhythm 32 (5): 380-393
https://dx.doi.org/10.1177/0748730417728663
van der Linden, N.; Cornelis, T.; Kimenai, D. M.; Klinkenberg, L. J. J.; Hilderink, J. M.; Lück, S.; Litjens, E. J. R.; Peeters, F. E. C. M.; Streng, A. S.; Breidthardt, T.; van Loon, L. J. C.; Bekers, O.; Kooman, J. P.; Westermark, P.; Mueller, C.; Meex, S. J. R. (2017):
Origin of cardiac troponin T elevations in chronic kidney disease. Circulation 136 (11): 1073-1075
https://dx.doi.org/10.1161/CIRCULATIONAHA.117.029986
Westermark, P. O. (2016):
Linking core promoter classes to circadian transcription. PLoS Genet. 12: e1006231
Thaben, P. F.; Westermark, P. O. (2016):
Differential rhythmicity: detecting altered rhythmicity in biological data. Bioinformatics 32: 2800-2808
Lück, S.; Westermark, P. O. (2016):
Circadian mRNA expression: insights from modeling and transcriptomics. Cell. Mol. Life Sci. 73: 497-521
Thaben, P. F.; Westermark, P. O. (2014):
Detecting rhythms in time series with RAIN. J. Biol. Rhythms 29: 391-400
Lück, S.; Thurley, K.; Thaben, Paul F.; Westermark, Pål O. (2014):
Rhythmic degradation explains and unifies circadian transcriptome and proteome data. Cell Reports 9: 741-751
Westermark, Pål O.; Herzel, H. (2013):
Mechanism for 12 hr rhythm generation by the circadian clock. Cell Reports 3: 1228-1238
Relógio, A.; Westermark, P. O.; Wallach, T.; Schellenberg, K.; Kramer, A.; Herzel, H. (2011):
Tuning the mammalian circadian clock: robust synergy of two loops. PLoS Comp. Biol. 7: e1002309
Arner, E.; Westermark, P. O.; Spalding, K. L.; Britton, T.; Rydén, M.; Frisén, J.; Bernard, S.; Arner, P. (2010):
Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 59: 105-109