Dr. rer. nat. Marten Michaelis
Forschungsinstitut für Nutztierbiologie (FBN)
Arbeitsgruppe Reproduktionsbiochemie
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Arbeitsgruppe Reproduktionsbiochemie
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Forschungsinteressen
- Männliche Fertilität
- Endokrinologie
- Selenoproteine
Lebenslauf
- aktuell: Post Doc am Leibniz-Institute für Nutztierbiologie (FBN) Dummerstorf, Institute für Reproduktionsbiologie
- Promotion in Molekularbiologie an der Humboldt Universität, Berlin
- M.Sc. Medizinalchemie, University of Sussex, UK
- Dipl.Ing. (FH) in Chemie an der Fachhochschule für Technik und Wirtschaft, Berlin
Publikationen
Tao, X.; Brenmoehl, J.; Marten, M.; Vanselow, J.; Baddela, V. (2025):
CD36 regulates glucose metabolism but not fatty acid uptake in bovine granulosa cells
Molecular and Cellular Endocrinology 613: 112717, 1-11
https://doi.org/10.1016/j.mce.2025.112717
Calanni-Pileri, M.; Weitzel, J. M.; Höflich, A.; Langhammer, M.; Michaelis, M. (2025):
The special phenotypic characteristics of Dummerstorf superfertile mouse lines could depend on the expression levels of IGF-axis genes
Reproductive Biology 25 (2): 101012, 1-9
https://doi.org/10.1016/j.repbio.2025.101012
Baddela, V. S.; Michaelis, M.; Tao, X.; Koczan, D.; Brenmoehl, J.; Vanselow, J. (2025):
Comparative analysis of PI3K-AKT and MEK-ERK1/2 signaling-driven molecular changes in granulosa cells
Reproduction 169 (2): e240317, 1-13
https://doi.org/10.1530/REP-24-0317
Tao, X.; Rahimi, M.; Michaelis, M.; Görs, S.; Brenmoehl, J.; Vanselow, J.; Baddela, V. S. (2024):
Saturated fatty acids inhibit unsaturated fatty acid induced glucose uptake involving GLUT10 and aerobic glycolysis in bovine granulosa cells
Scientific Reports 14: 9888, 1-15
https://doi.org/10.1038/s41598-024-59883-x
Fürbaß, R.; Michaelis, M.; Schuler, G. (2023):
Unhatched bovine blastocysts express all transcripts of the estrogen biosynthetic pathway, but steroid hormone synthesis could not yet be demonstrated
Domestic Animal Endocrinology 82: 106770, 1-9
https://doi.org/10.1016/j.domaniend.2022.106770
Baddela, V. S.; Michaelis, M.; Tao, X.; Koczan, D.; Vanselow, J. (2023):
ERK1/2-SOX9/FOXL2 axis regulates ovarian steroidogenesis and favors the follicular–luteal transition
Life Science Alliance 6 (10): e202302100, 1-13
https://doi.org/10.26508/lsa.202302100
Calanni Pileri, M.; Michaelis, M.; Langhammer, M.; Rosellini Tognetti, P.; Weitzel, J. M. (2023):
The Imitation of the Ovarian Fatty Acid Profile of Superfertile Dummerstorf Mouse Lines during IVM of Control Line Oocytes Could Influence Their Maturation Rates
Biomedicines 11 (5): 1439, 1-13
https://doi.org/10.3390/biomedicines11051439
Ludwig, C.; Bohleber, S.; Lapp, R.; Rebl, A.; Wirth, C.; Langhammer, M.; Schweizer, U.; Weitzel, J. M.; Michaelis, M. (2023):
Alterations in gonadotropin, apoptotic and metabolic pathways in granulosa cells warrant superior fertility of the Dummerstorf high fertility mouse line 1
Journal of Ovarian Research 16: 32, 1-16
https://doi.org/10.1186/s13048-023-01113-5
Baddela, V. S.; Michaelis, M.; Sharma, A.; Plinski, C.; Viergutz, T.; Vanselow, J. (2022):
Estradiol production of granulosa cells is unaffected by the physiological mix of nonesterified fatty acids in follicular fluid
Journal of Biological Chemistry 298 (10): 102477, 1-11
https://doi.org/10.1016/j.jbc.2022.102477
Calanni Pileri, M.; Weitzel, J. M.; Dannenberger, D.; Langhammer, M.; Michaelis, M. (2022):
Lower Plasmatic Levels of Saturated Fatty Acids and a Characteristic Fatty Acid Composition in the Ovary Could Contribute to the High-Fertility Phenotype in Dummerstorf Superfertile Mice
International Journal of Molecular Sciences 23 (18): 10245, 1-23
https://doi.org/10.3390/ijms231810245
Calanni Pileri, M.; Weitzel, J. M.; Langhammer, M.; Michaelis, M. (2022):
Higher quality rather than superior quantity of oocytes determine the amount of fertilizable oocytes in two outbred Dummerstorf high-fertility mouse lines
Reproduction in Domestic Animals 57 (10): 1198-1207
https://doi.org/10.1111/rda.14194
Ludwig, C.; Bohleber, S.; Rebl, A.; Wirth, E.; Venuto, M. T.; Langhammer, M.; Schweizer, U.; Weitzel, J. M.; Michaelis, M. (2022):
Endocrine and molecular factors of increased female reproductive performance in the Dummerstorf high-fertility mouse line FL1
Journal Molecular Endocrinology 69 (1): 285-298
https://doi.org/10.1530/JME-22-0012
Calanni Pileri, M.; Weitzel, J. M.; Langhammer, M.; Wytrwat, E.; Michaelis, M. (2022):
Altered insulin, leptin and ghrelin hormone levels and atypical estrous cycle lengths in two highly fertile mouse lines
Reproduction in Domestic Animals 57 (6): 577-586
https://onlinelibrary.wiley.com/doi/10.1111/rda.14097
Langhammer, M.; Wytrwat, E.; Michaelis, M.; Schön, J.; Tuchscherer, A.; Reinsch, N.; Weitzel, J. M. (2021):
Two mouse lines selected for large litter size display different lifetime fecundities. Reproduction 161: 721-730
https://doi.org/10.1530/REP-20-0563
Michaelis, M.; Sobczak, A.; Ludwig, C.; Marvanova, H.; Langhammer, M.; Schön, J.; Weitzel, J. M. (2020):
Altered testicular cell type composition in males of two outbred mouse lines selected for high fertility. Andrology 8 (5): 1419-1427
https://doi.org/10.1111/andr.12802
Baddela, V. S.; Sharma, A.; Michaelis, M.; Vanselow, J. (2020):
HIF1 driven transcriptional activity regulates steroidogenesis and proliferation of bovine granulosa cells. Sci Rep-UK 10: 3906
https://doi.org/10.1038/s41598-020-60935-1
Michaelis, M.; Sobczak, A.; Koczan, D.; Langhammer, M.; Reinsch, N.; Schön, J.; Weitzel, J. M. (2018):
Testicular transcriptional signatures associated with high fertility. Reproduction 155 (2): 219-231
https://doi.org/10.1530/REP-17-0392
Michaelis, M.; Sobczak, A.; Koczan, D.; Langhammer, M.; Reinsch, N.; Schön, J.; Weitzel, J. M. (2017):
Selection for female traits of high fertility affects male reproductive performance and alters the testicular transcriptional profile. BMC Genomics 18 (1): 889, 1-19
https://doi.org/10.1186/s12864-017-4288-z
Langhammer, M.; Michaelis, M.; Hartmann, F.; Wudy, A.; Sobczak, A.; Nürnberg, G.; Reinsch, N.; Schön, J.; Weitzel, J. M. (2017):
Reproductive performance primarily depends on the female genotype in a two-factorial breeding experiment using high-fertility mouse lines. Reproduction 153 (3): 361-368
https://dx.doi.org/10.1530/REP-16-0434
Michaelis, M.; Sobczak, A.; Weitzel, J. M. (2014):
In vivo microinjection and electroporation of mouse testis. J Visualized Experiments 23 (90): 1-8
https://dx.doi.org/10.3791/51802