PD Dr. rer. nat. habil. Manfred Mielenz
Forschungsinteressen
- Insekten als Nutztiere zur Verwertung von Rest- und Nebenstoffen
- Nährstoff-Sensing
- Energieverwertung
- Metabolismus
- Adipokine
- Fettsäuren
- metabolische Signalwege
- bioaktive Futterinhaltsstoffe
Lebenslauf
- 2013–heute: Wissenschaftlicher Mitarbeiter am Forschungsinstitut für Nutztierbiologie (FBN) Dummerstorf, Institut für Ernährungsphysiologie "Oskar Kellner"
- 2013–heute: Privatdozent an der Rheinischen Friedrich-Wilhelms-Universität Bonn
- 2013: Habilitation im Fach Physiologie an der Rheinischen Friedrich-Wilhelms-Universität Bonn
- 2002–2012: Arbeitsgruppenleiter an der Rheinischen Friedrich-Wilhelms-Universität Bonn im Institut für Tierwissenschaften, Abteilung Physiologie und Hygiene
- Promotion an der Gottfried Wilhelm Leibniz Universität Hannover; Anfertigung der Dissertation am Friedrich-Loeffler Institut, Institut Nutztiergenetik, Abteilung Funktionelle Genetik und Bioregulation, ehemals Bundesforschungsanstalt für Landwirtschaft (FAL) in Mariensee
- Studium der Biologie an der Gottfried Wilhelm Leibniz Universität Hannover; Diplomarbeit an der Bundesforschungsanstalt für Landwirtschaft (FAL) in Mariensee
Lehre
Publikationen
Friedrichs, P.; Sauerwein, H.; Huber, K.; Locher, L. F.; Rehage, J.; Meyer, U.; Dänicke, S.; Kuhla, B.; Mielenz, M. (2016):
Expression of metabolic sensing receptors in adipose tissues of periparturient dairy cows with differing extent of negative energy balance. Animal 10 (4): 623-632
https://dx.doi.org/10.1017/s175173111500227x
Weber, M.; Locher, L.; Rehage, J.; Tienken, R.; Meyer, U.; Dänicke, S.; Webb, L.; Sauerwein, H.; Mielenz, M. (2016):
Longitudinal changes in adipose tissue of dairy cows from late pregnancy to lactation, Part 2: The SIRT-PPARGC1A axis and its relationship with the adiponectin system. J Dairy Sci 99 (2): 1560-1570
https://dx.doi.org/10.3168/jds.2015-10132
Weber, M.; Locher, L.; Huber, K.; Kenéz, Á.; Rehage, J.; Tienken, R.; Meyer, U.; Dänicke, S.; Sauerwein, H.; Mielenz, M. (2016):
Longitudinal changes in adipose tissue of dairy cows from late pregnancy to lactation, Part 1: The adipokines apelin and resistin and their relationship to receptors linked with lipolysis. J Dairy Sci 99 (2): 1549-1559
https://dx.doi.org/10.3168/jds.2015-10131
Pfundt, B.; Mielenz, B.; Sanver, F.; Pfeffer, E.; Sauerwein, H.; Mielenz, M. (2016):
Effects of largely different feeding intensities on serum insulin-like growth factor-1 concentrations, quantified by enzyme immunoassay, leptin and growth hormone receptor 1 mRNA in rainbow trout (Oncorhynchus mykiss). Aquacult Nutr 22 (3): 586-596
https://dx.doi.org/10.1111/anu.12282
Tienken, R.; Kersten, S.; Frahm, J.; Meyer, U.; Locher, L.; Rehage, J.; Huber, K.; Kenéz, Á.; Sauerwein, H.; Mielenz, M.; Dänicke, S. (2015):
Effects of an energy-dense diet and nicotinic acid supplementation on production and metabolic variables of primiparous or multiparous cows in periparturient period. Arch Anim Nutr 69 (5): 319-339
https://dx.doi.org/10.1080/1745039x.2015.1073002
Rahman, M.M.; Lecchi, C.; Sauerwein, H.; Mielenz, M.; Häussler, S.; Restelli, L.; Giudice, C.; Ceciliani, F. (2015):
Expression of α1-acid glycoprotein and lipopolysaccharide binding protein in visceral and subcutaneous adipose tissue of dairy cattle. Vet J 203 (2): 223-227
https://dx.doi.org/10.1016/j.tvjl.2014.12.001
Lamp, O.; Derno, M.; Otten, W.; Mielenz, M.; Nürnberg, G.; Kuhla, B. (2015):
Metabolic heat stress adaption in transition cows: differences in macronutrient oxidation between late-gestating and early-lactating German Holstein dairy cows. Plos One 10 (5): e0125264, 1-24
https://dx.doi.org/10.1371/journal.pone.0125264
Kuhla, B.; Mielenz, M.; Metges, C. C. (2015):
Die Kuh produziert kein Methan. Leibniz Nordost 20: 6-7
Kopp, C.; Hosseini, A.; Singh, S. P.; Regenhard, P.; Khalilvandi-Behroozyar, H.; Sauerwein, H.; Mielenz, M. (2014):
Nicotinic acid increases adiponectin secretion from differentiated bovine preadipocytes through G-protein coupled receptor signaling. Int J Mol Sci 15: 21401-21418
https://dx.doi.org/10.3390/ijms151121401
Singh, S. P.; Häussler, S.; Heinz, J. F. L.; Akter, H.S.; Saremi, B.; Müller, U.; Rehage, J.; Dänicke, S.; Mielenz, M.; Sauerwein, H. (2014):
Lactation driven dynamics of adiponectin supply from different fat depots to circulation in cows. DOMEST ANIM ENDOCRIN 47: 35-46
https://dx.doi.org/10.1016/j.domaniend.2013.12.001
Singh, S. P.; Häussler, S.; Heinz, J. F. L.; Saremi, B.; Mielenz, B.; Rehage, J.; Dänicke, S.; Mielenz, M.; Sauerwein, H. (2014):
Supplementation with conjugated linoleic acids extends the adiponectin deficit during early lactation in dairy cows. Gen Comp Endocr 198: 13-21
https://dx.doi.org/10.1016/j.ygcen.2013.12.008
Friedrichs, P.; Saremi, B.; Winand, S.; Rehage, J.; Dänicke, S.; Sauerwein, H.; Mielenz, M. (2014):
Energy and metabolic sensing G protein-coupled receptors during lactation-induced changes in energy balance. DOMEST ANIM ENDOCRIN 48: 33-41
https://dx.doi.org/10.1016/j.domaniend.2014.01.005
Kopp, C.; Singh, S. P.; Regenhard, P.; Müller, U.; Sauerwein, H.; Mielenz, M. (2014):
Trans-cinnamic acid increases adiponectin and the phosphorylation of AMP-activated protein kinase through G-protein-coupled receptor signaling in 3T3-L1 adipocytes. Int J Mol Sci 15 (2): 2906-2915
https://dx.doi.org/10.3390/ijms15022906
Saremi, B.; Winand, S.; Friedrichs, P.; Kinoshita, A.; Rehage, J.; Dänicke, S.; Häussler, S.; Breves, G.; Mielenz, M.; Sauerwein, H. (2014):
Longitudinal profiling of the tissue-specific expression of genes related with insulin sensitivity in dairy cows during lactation focusing on different fat depots. Plos One 9 (1): 1-15
https://dx.doi.org/10.1371/journal.pone.0086211
Mielenz, M. (2013):
Role of adipose tissue in metabolic regulation of farmed animals. Habilitationsschrift, Rheinische Friedrich-Wilhelms-Universität Bonn: 1-161
Saremi, B.; Mielenz, M.; Rahmann, M. M.; Hosseini, A.; Kopp, C.; Dänicke, S.; Ceciliani, F.; Sauerwein, H. (2013):
Hepatic and extrahepatic expression of serum amyloid A3 during lactation in dairy cows. J Dairy Sci 96 (11): 6944-6954
https://dx.doi.org/10.3168/jds.2012-6495
Sauerwein, H.; Saremi, B.; Pappritz, J.; von Soosten, D.; Meyer, U.; Dänicke, S.; Mielenz, M. (2013):
Aquaporin-7 mRNA in adipose depots of primiparous and pluriparous dairy cows: long-term physiological and conjugated linoleic acid-induced changes. J Dairy Sci 96 (7): 4508-4513
https://dx.doi.org/10.3168/jds.2012-6363
Mielenz, M.; Mielenz, B.; Singh, S. P.; Kopp, C.; Heinz, J.; Häussler, S.; Sauerwein, H. (2013):
Development, validation, and pilot application of a semiquantitative Western blot analysis and an ELISA for bovine adiponectin. DOMEST ANIM ENDOCRIN 44 (3): 121-130
https://dx.doi.org/10.1016/j.domaniend.2012.10.004
Mielenz, M.; Kuhla, B.; Hammon, H. M. (2013):
Abundance of adiponectin system and G-protein coupled receptor GPR109A mRNA in adipose tissue and liver of F2 offspring cows of Charolais x German Holstein crosses that differ in body fat accumulation. J Dairy Sci 96 (1): 278-289
https://dx.doi.org/10.3168/jds.2012-5816