PD Dr. rer. nat. habil. Manfred Mielenz

+49 38208 68-652
Forschungsinstitut für Nutztierbiologie (FBN)
Institut für Ernährungsphysiologie "Oskar Kellner"
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Forschungsinteressen

  • Insekten als Nutztiere zur Verwertung von Rest- und Nebenstoffen
  • Nährstoff-Sensing
  • Energieverwertung
  • Metabolismus
  • Adipokine
  • Fettsäuren
  • metabolische Signalwege
  • bioaktive Futterinhaltsstoffe

Lebenslauf

  • 2013–heute: Wissenschaftlicher Mitarbeiter am Forschungsinstitut für Nutztierbiologie (FBN) Dummerstorf, Institut für Ernährungsphysiologie "Oskar Kellner"
  • 2013–heute: Privatdozent an der Rheinischen Friedrich-Wilhelms-Universität Bonn
  • 2013: Habilitation im Fach Physiologie an der Rheinischen Friedrich-Wilhelms-Universität Bonn
  • 2002–2012: Arbeitsgruppenleiter an der Rheinischen Friedrich-Wilhelms-Universität Bonn im Institut für Tierwissenschaften, Abteilung Physiologie und Hygiene
  • Promotion an der Gottfried Wilhelm Leibniz Universität Hannover; Anfertigung der Dissertation am Friedrich-Loeffler Institut, Institut Nutztiergenetik, Abteilung Funktionelle Genetik und Bioregulation, ehemals Bundesforschungsanstalt für Landwirtschaft (FAL) in Mariensee
  • Studium der Biologie an der Gottfried Wilhelm Leibniz Universität Hannover; Diplomarbeit an der Bundesforschungsanstalt für Landwirtschaft (FAL) in Mariensee

Lehre

  • Physiologie und Anatomie

Publikationen

Revskij, D.; Haubold, S. S.; Plinski, C.; Viergutz, T.; Tuchscherer, A.; Kröger-Koch, C.; Albrecht, E.; Günther, J.; Tröscher, A.; Hammon, H. M.; Schuberth, H.-J.; Mielenz, M. (2022):
Cellular detection of the chemokine receptor CXCR4 in bovine mammary glands and its distribution and regulation on bovine leukocytes. J Dairy Sci 105 (1): 866-876
https://doi.org/10.3168/jds.2021-20799
Koch, F.; Derno, M.; Langhammer, M.; Tuchscherer, A.; Hammon, H. M.; Mielenz, M.; Metges, C. C.; Kuhla, B. (2021):
A high-protein diet containing inulin/oligofructose supports body weight gain associated with lower energy expenditure and carbohydrate oxidation, and alters faecal microbiota in C57BL/6 mice. J NUTR SCI 10: e50, 1-10
https://doi.org/10.1017/jns.2021.42
Gnott, M.; Vogel, L.; Kröger-Koch, C.; Dannenberger, D.; Tuchscherer, A.; Tröscher, A.; Trevisi, E.; Stefaniak, T.; Jawor, P.; Starke, S.; Mielenz, M.; Bachmann, L.; Hammon, H. M. (2020):
Changes in fatty acids in plasma and association with the inflammatory response in dairy cows abomasally infused with essential fatty acids and conjugated linoleic acid during late and early lactation. J Dairy Sci 103 (12): 11889-11910
https://doi.org/10.3168/jds.2020-18735
Revskij, D.; Haubold, S. S.; Viergutz, T.; Kröger-Koch, C.; Tuchscherer, A.; Kirchberger, H.S.; Rychlik, M.; Tröscher, A.; Hammon, H. M.; Schuberth, H.-J.; Mielenz, M. (2019):
Dietary fatty acids affect red blood cell membrane composition and red blood cell ATP release in dairy cows. Int J Mol Sci 20: 2769, 1-19
https://doi.org/10.3390/ijms20112769
Sadri, H.; Saremi, B.; Dänicke, S.; Rehage, J.; Mielenz, M.; Sauerwein, H. (2018):
Lactation-related changes in tissue expression of PEDF in dairy cows. DOMEST ANIM ENDOCRIN 64: 93-101
https://doi.org/10.1016/j.domaniend.2018.04.004
Mielenz, M.; Pfaffl, M.W.; Schlumbohm, C.; Harmeyer, J.; Parvizi, N. (2018):
Growth hormone secretion patterns in German Landrace (DL) fetuses and piglets compared to DL piglets with inherited 1,25-dihydroxyvitamin D3 deficiency. Nutrients 10: 617, 1-7
Mansouryar, M.; Mirzaei-Alamouti, H.; Dehghan-banadaky, M.; Sauerwein, H.; Mielenz, M.; Nielsen, M. O. (2018):
Short communication: relationship between body condition score and plasma adipokines in early-lactating Holstein dairy cows. J Dairy Sci 101 (9): 8552-8558
https://doi.org/10.3168/jds.2017-14122
Mielenz, M. (2017):
Invited review: nutrient-sensing receptors for free fatty acids and hydroxycarboxylic acids in farm animals. Animal 11 (6): 1008-1016
https://dx.doi.org/10.1017/S175173111600238X
Aguinaga Casañas, M.; Schäff, C. T.; Albrecht, E.; Hammon, H. M.; Kuhla, B.; Röntgen, M.; Nürnberg, G.; Mielenz, M. (2017):
Short communication: Free fatty acid receptors FFAR1 and FFAR2 during the peripartal period in liver of dairy cows grouped by their postpartum plasma beta-hydroxybutyrate concentrations. J Dairy Sci 100 (4): 3287-3292
https://dx.doi.org/10.3168/jds.2016-11021
Pfundt, B.; Mielenz, B.; Sanver, F.; Pfeffer, E.; Sauerwein, H.; Mielenz, M. (2016):
Effects of largely different feeding intensities on serum insulin-like growth factor-1 concentrations, quantified by enzyme immunoassay, leptin and growth hormone receptor 1 mRNA in rainbow trout (Oncorhynchus mykiss). Aquacult Nutr 22 (3): 586-596
https://dx.doi.org/10.1111/anu.12282
Weber, M.; Locher, L.; Huber, K.; Kenéz, Á.; Rehage, J.; Tienken, R.; Meyer, U.; Dänicke, S.; Sauerwein, H.; Mielenz, M. (2016):
Longitudinal changes in adipose tissue of dairy cows from late pregnancy to lactation, Part 1: The adipokines apelin and resistin and their relationship to receptors linked with lipolysis. J Dairy Sci 99 (2): 1549-1559
https://dx.doi.org/10.3168/jds.2015-10131
Weber, M.; Locher, L.; Rehage, J.; Tienken, R.; Meyer, U.; Dänicke, S.; Webb, L.; Sauerwein, H.; Mielenz, M. (2016):
Longitudinal changes in adipose tissue of dairy cows from late pregnancy to lactation, Part 2: The SIRT-PPARGC1A axis and its relationship with the adiponectin system. J Dairy Sci 99 (2): 1560-1570
https://dx.doi.org/10.3168/jds.2015-10132
Friedrichs, P.; Sauerwein, H.; Huber, K.; Locher, L. F.; Rehage, J.; Meyer, U.; Dänicke, S.; Kuhla, B.; Mielenz, M. (2016):
Expression of metabolic sensing receptors in adipose tissues of periparturient dairy cows with differing extent of negative energy balance. Animal 10 (4): 623-632
https://dx.doi.org/10.1017/s175173111500227x
Stoldt, A.-K.; Mielenz, M.; Nürnberg, G.; Sauerwein, H.; Esatbeyoglu, T.; Wagner, A. E.; Rimbach, G.; Starke, S.; Wolffram, S.; Metges, C. C. (2016):
Effects of a six-week intraduodenal supplementation with quercetin on liver lipid metabolism and oxidative stress in peripartal dairy cows. J Anim Sci 94 (5): 1913-1923
https://dx.doi.org/10.2527/jas.2016-0338
van den Borne, J.J.G.C.; Labussière, E.; Mielenz, M.; Sauerwein, H.; Gerrits, W. J. J. (2016):
Exchanging fat for lactose in milk replacer stimulates de novo lipogenesis in calves. In: Energy and protein metabolism and nutrition : 5th EAAP International Symposium, Krakow, Poland, 12-15 September 2016 (EAAP Publication , 137) (Jacek Skomial, Hélène Lapierre, Hrsg.) Wageninen Academic Publishers, Wageningen (978-90-8686-286-3): 145-146
Schäff, C. T.; Gruse, J.; Maciej, J.; Mielenz, M.; Wirthgen, E.; Hoeflich, A.; Schmicke, M.; Pfuhl, R.; Jawor, P.; Stefaniak, T.; Hammon, H. M. (2016):
Effects of feeding milk replacer ad libitum or in restricted amounts for the first five weeks of life on the growth, metabolic adaptation, and immune status of newborn calves. Plos One 11 (12): e0168974, 1-24
https://dx.doi.org/10.1371/journal.pone.0168974
Kuhla, B.; Mielenz, M.; Metges, C. C. (2015):
Die Kuh produziert kein Methan. Leibniz Nordost 20: 6-7
Lamp, O.; Derno, M.; Otten, W.; Mielenz, M.; Nürnberg, G.; Kuhla, B. (2015):
Metabolic heat stress adaption in transition cows: differences in macronutrient oxidation between late-gestating and early-lactating German Holstein dairy cows. Plos One 10 (5): e0125264, 1-24
https://dx.doi.org/10.1371/journal.pone.0125264
Rahman, M.M.; Lecchi, C.; Sauerwein, H.; Mielenz, M.; Häussler, S.; Restelli, L.; Giudice, C.; Ceciliani, F. (2015):
Expression of α1-acid glycoprotein and lipopolysaccharide binding protein in visceral and subcutaneous adipose tissue of dairy cattle. Vet J 203 (2): 223-227
https://dx.doi.org/10.1016/j.tvjl.2014.12.001
Tienken, R.; Kersten, S.; Frahm, J.; Meyer, U.; Locher, L.; Rehage, J.; Huber, K.; Kenéz, Á.; Sauerwein, H.; Mielenz, M.; Dänicke, S. (2015):
Effects of an energy-dense diet and nicotinic acid supplementation on production and metabolic variables of primiparous or multiparous cows in periparturient period. Arch Anim Nutr 69 (5): 319-339
https://dx.doi.org/10.1080/1745039x.2015.1073002