Dr. rer. nat. Juliane Günther

+49 38208 68-752
Forschungsinstitut für Nutztierbiologie (FBN)
Institut für Fortpflanzungsbiologie
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Forschungsinteressen

  • Molekularbiologie
  • Infektionsbiologie
  • Zellbiologie
  • Immunologie
  • Epigenetik
  • Cell-signalling

Lebenslauf

  • Seit 2013: Nachwuchsgruppenleiterin in der Genomphysiologie am Leibniz-Institut für Nutztierbiologie (FBN)
  • 2006-2013: Postdoc in der Arbeitsgruppe Genanalyse am Leibniz-Institut für Nutztierbiologie (FBN)
  • 2005: Promotion zum PhD an der Friedrich Schiller Universität Jena
  • 2002-2005: Doktorandin am Leibniz-Insititut für Naturstoff-Forschung und Infektionsbiologie (Hans-Knöll Institut) in Jena
  • 2001: Diplom in Biologie an der Friedrich Schiller Universität Jena
  • 1995-2001: Studium der Biologie an der Friedrich Schiller Universität Jena

Lehre

  • Seit 2011: "Diversität und Evolution" im Masterstudiengang an der Mathematisch Naturwissenschaftlichen Fakultät der universität Rostock

Publikationen

Revskij, D.; Haubold, S. S.; Plinski, C.; Viergutz, T.; Tuchscherer, A.; Kröger-Koch, C.; Albrecht, E.; Günther, J.; Tröscher, A.; Hammon, H. M.; Schuberth, H.-J.; Mielenz, M. (2022):
Cellular detection of the chemokine receptor CXCR4 in bovine mammary glands and its distribution and regulation on bovine leukocytes. J Dairy Sci 105 (1): 866-876
https://doi.org/10.3168/jds.2021-20799
Hachem, N. E.; Humpfle, L.; Simon, P.; Kaese, M.; Weinhold, B.; Günther, J.; Galuska, S. P.; Middendorff, R. (2021):
The Loss of Polysialic Acid Impairs the Contractile Phenotype of Peritubular Smooth Muscle Cells in the Postnatal Testis. Cells-Basel 10 (6): 1347, 1-12
https://doi.org/10.3390/cells10061347
Magray, A. R.; Martorell Ribera, J.; Isernhagen, L.; Galuska, S. P.; Günther, J.; Verleih, M.; Viergutz, T.; Brunner, R. M.; Ganai, B.; Ahmad, F.; Zlatina, K.; Rebl, A. (2021):
Evaluation of blood cell viability rate, gene expression, and O-GlcNAcylation profiles as indicative signatures for fungal stimulation of salmonid cell models. MOL IMMUNOL 142: 120-129
https://doi.org/10.1016/j.molimm.2021.12.019
Polei, M.; Günther, J.; Koczan, D.; Fürbaß, R. (2020):
Trophoblast cell differentiation in the bovine placenta: Differentially expressed genes between uninucleate trophoblast cells and trophoblast giant cells are involved in the composition and remodeling of the extracellular matrix and O-glycan biosynthesis. BMC Mol Cell Biol 21: 1, 1-12
https://doi.org/10.1186/s12860-020-0246-8
Polei, M.; Günther, J.; Koczan, D.; Fürbaß, R. (2020):
Gene expression profiles of bovine uninucleate trophoblast cells and trophoblast giant cells: a data note. BMC Res Notes 13: 115, 1-3
https://doi.org//10.1186/s13104-020-04964-z
Knaust, J.; Weikard, R.; Albrecht, E.; Brunner, R. M.; Günther, J.; Kühn, Ch. (2020):
Indication of premelanosome protein (PMEL) expression outside of pigmented bovine skin suggests functions beyond eumelanogenesis. Genes-Basel 11 (7): 788,1-13
https://doi.org/10.3390/genes11070788
Günther, J.; Fallarino, F.; Fuchs, D.; Wirthgen, E. (2020):
Editorial: Immunomodulatory roles of tryptophan metabolites in inflammation and cancer. Front Immunol 11: 1497,1-3
https://doi.org/10.3389/fimmu.2020.01497
Brodhagen, J.; Weikard, R.; Thom, U.; Heimes, A.; Günther, J.; Hadlich, F.; Zerbe, H.; Petzl, W.; Meyerholz, M. M.; Hoedemaker, M.; Schubert, H-J; Engelmann, S.; Kühn, Ch. (2019):
Development and evaluation of a milk protein transcript depletion method for differential transcriptome analysis in mammary gland tissue. BMC Genomics 20 (1): 400, 1-19
https://doi.org/10.1186/s12864-019-5781-3
Günther, J.; Däbritz, J.; Wirthgen, Elisa (2019):
Limitations and off-target effects of tryptophan-related IDO inhibitors in cancer treatment. Front Immunol 10: 1801, 1-8
https://doi.org/10.3389/fimmu.2019.01801
Petzl, W.; Zerbe, H.; Günther, J.; Seyfert, H.-M.; Hussen, J.; Schuberth, H.-J. (2018):
Pathogen-specific responses in the bovine udder: Models and immunoprophylactic concepts. Res Vet Sci 116: 55-61
https://doi.org/10.1016/j.rvsc.2017.12.012
Wirthgen, E.; Otten, W.; Tuchscherer, M.; Tuchscherer, A.; Domanska, G.; Brenmoehl, J.; Günther, J.; Ohde, D.; Weitschies, W.; Seidlitz, A.; Scheuch, E.; Kanitz, E. (2018):
Effects of 1-Methyltryptophan on immune responses and the kynurenine pathway after lipopolysaccharide challenge in pigs. Int J Mol Sci 19 (10): 3009, 1-23
https://doi.org/10.3390/ijms19103009
Günther, J.; Seyfert, H.M. (2018):
The first line of defence: insights into mechanisms and relevance of phagocytosis in epithelial cells. Semin Immunopathol 40 (6): 555-565
https://doi.org/10.1007/s00281-018-0701-1
Günther, J.; Petzl, W.; Zerbe, H.; Schuberth, H.-J.; Seyfert, H.-M. (2017):
TLR ligands, but not modulators of histone modifiers, can induce the complex immune response pattern of endotoxin tolerance in mammary epithelial cells. Innate Immun-London 23 (2): 155-164
https://dx.doi.org/10.1177/1753425916681076
Günther, J.; Petzl, W.; Bauer, I.; Ponsuksili, S.; Zerbe, H.; Schuberth, H.-J.; Brunner, R. M.; Seyfert, H.-M. (2017):
Differentiating Staphylococcus aureus from Escherichia coli mastitis: S. aureus triggers unbalanced immune-dampening and host cell invasion immediately after udder infection. Sci Rep-UK 7: 4811,1-14
https://dx.doi.org/10.1038/s41598-017-05107-4
Wirthgen, E.; Hoeflich, A.; Rebl, A.; Günther, J. (2017):
Kynurenic acid: The Janus-faced role of an immunomodulatory tryptophan metabolite and its link to pathological conditions. Front Immunol 8: 1957, 1-13
https://dx.doi.org/10.3389/fimmu.2017.01957
Günther, J.; Czabanska, A.; Bauer, I.; Leigh, J.; Holst, Otto; Seyfert, H.-M. (2016):
Streptococcus uberis strains isolated from the bovine mammary gland evade immune recognition by mammary epithelial cells, but not of macrophages. Vet Res 47: 13, 1-14
https://dx.doi.org/10.1186/s13567-015-0287-8
Günther, J.; Koy, M.; Berthold, A.; Schuberth, H.-J.; Seyfert, H.-M. (2016):
Comparison of the pathogen species-specific immune response in udder derived cell types and their models. Vet Res 47: 22, 1-11
https://dx.doi.org/10.1186/s13567-016-0307-3
Petzl, W.; Günther, J.; Mühlbauer, I.C.; Seyfert, H.-M.; Schuberth, H.-J.; Hussen, J.; Sauter-Louis, C.; Hafner-Marx, A.; Zerbe, H. (2016):
Early transcriptional events in the udder and teat after intramammary Escherichia coli and Staphylococcus aureus challenge. Innate Immun-London 22 (4): 294-304
https://dx.doi.org/10.1177/1753425916640057
Chang, G.; Petzl, W.; Vanselow, J.; Günther, J.; Shen, Z.; Seyfert, H.-M. (2015):
Epigenetic mechanisms contribute to enhanced expression of immune response genes in the liver of cows after experimentally induced Escherichia coli mastitis. Vet J 203 (3): 339-341
https://dx.doi.org/10.1016/j.tvjl.2014.12.023 10.1016/j.tvjl.2014.12.023
Bauer, I.; Günther, J.; Wheeler, T.T.; Engelmann, S.; Seyfert, H.-M. (2015):
Extracellular milieu grossly alters pathogen-specific immune response of mammary epithelial cells. BMC Vet Res 11: 172-186
https://dx.doi.org/10.1186/s12917-015-0489-3