Dr. rer. nat. Julia Brenmoehl
+49 38208 68-929
Forschungsinstitut für Nutztierbiologie (FBN)
Institut für Genombiologie
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Institut für Genombiologie
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Forschungsinteressen
- Fett- und Ernergiemetabolismus, Zellsignalanalyse
Lebenslauf
- seit 2009: Forschungsinstitut für Nutztierbiologie (FBN)
- 2007–2009: Universitätsklinikum Jena, Innere Medizin IV, Abteilung für Gastroenterologie, Hepatologie und Infektiologie
- 2005–2007: Promotion zum Dr. rer. nat.
- 2003–2004: wissenschaftliche Tätigkeit im Fach Biologie, Universität Regensburg
- 2002–2006: Universitätsklinikum Regensburg, Abteilung für Gastroenterologie, Endokrinologie, Rheumatologie, Infectiologie und Notfallmedizin
- 2002: Universitätsklinikum Rostock, Innere Medizin, Abteilung Gastroenterologie
- 2001–2001: Creatogen AG Augsburg, Abteilung für Impfstoffe
- 1997–2002: Studium der Biotechnologie, Fachhochschule Jena
- 1997: Hochschulreife
Publikationen
Meier, J. K.-H.; Scharl, M.; Miller, S. N.; Brenmoehl, J.; Hausmann, M.; Kellermeier, S.; Schölmerich, J.; Rogler, G. (2011):
Specific differences in migratory function of myofibroblasts isolated from Crohn's disease fistulae and strictures. Inflamm Bowel Dis 17 (1): 202-212
https://dx.doi.org/10.1002/ibd.21344
Rieder, F.; Georgieva, M.; Schirbel, A.; Artinger, M.; Zügner, A.; Blank, M.; Brenmoehl, J.; Schölmerich, J.; Rogler, G. (2010):
Prostaglandin E2 Inhibits Migration of Colonic Lamina Propria Fibroblasts. Inflamm Bowel Dis 16 (9): 1505-1513
https://dx.doi.org/10.1002/ibd.21255
Kosovac, K.; Brenmoehl, J.; Holler, E.; Falk, W.; Schoelmerich, J.; Hausmann, M.; Rogler, G. (2010):
Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients. Inflamm Bowel Dis 16 (8): 1311-1321
https://dx.doi.org/10.1002/ibd.21223
Landfried, K.; Bataille, F.; Rogler, G.; Brenmoehl, J.; Kosovac, K.; Wolff, D.; Hilgendorf, I.; Hahn, J.; Edinger, M.; Hoffmann, P.; Obermeier, J.; Schoelmerich, J.; Andreesen, R.; Holler, E. (2009):
Recipient NOD2/CARD15 status affects cellular infiltrates in human intestinal graft-versus-host disease. Clin Exp Immunol 159 (1): 87-92
https://dx.doi.org/10.1111/j.1365-2249.2009.04049.x
Pohlers, D.; Brenmoehl, J.; Löffler, I.; Müller, M.; Leipner, C.; Schultze-Mosgau, S.; Stallmach, A.; Kinne, R.; Wolf, I (2009):
TGF-β and fibrosis in different organs — molecular pathway imprints. BBA-Mol Basis Dis 1792 (8): 746-756
https://dx.doi.org/10.1016/j.bbadis.2009.06.004
Lang, M.; Schlechtweg, M.; Kellermeier, S.; Brenmoehl, J.; Falk, W.; Schölmerich, J.; Herfarth, H.; Rogler, G.; Hausmann, M. (2009):
Gene expression profiles of mucosal fibroblasts from strictured and nonstrictured areas of patients with Crohn's disease. Inflamm Bowel Dis 15 (2): 212-223
https://dx.doi.org/10.1002/ibd.20735
Brenmoehl, J.; Miller, S. N.; Hofmann, C.; Vogl, D.; Falk, W.; Schölmerich, J.; Rogler, G. (2009):
Transforming growth factor-β1 induces intestinal myofibroblast differentiation and modulates their migration. World J Gastroentero 15 (12): 1431-1442
https://dx.doi.org/10.3748/wjg.15.1431
Brenmoehl, J.; Falk, W.; Goke, M.; Scholmerich, J.; Rogler, G. (2008):
Inflammation modulates fibronectin isoform expression in colonic lamina propria fibroblasts (CLPF). Int J Colorectal Dis 23: 947-955
Bataille, F.; Rohrmeier, C.; Bates, R.; Weber, A.; Rieder, F.; Brenmoehl, J.; Strauch, U.; Farkas, S.; Furst, A.; Hofstadter, F.; Scholmerich, J.; Herfarth, H.; Rogler, G. (2008):
Evidence for a role of epithelial mesenchymal transition during pathogenesis of fistulae in Crohn's disease. Inflamm Bowel Dis 14: 1514-1527
Lippert, E.; Gunckel, M.; Brenmoehl, J.; Bataille, F.; Falk, W.; Scholmerich, J.; Obermeier, F.; Rogler, G. (2008):
Regulation of galectin-3 function in mucosal fibroblasts: potential role in mucosal inflammation. Clin. Exp. Immunol. 152: 285-297
Holler, E.; Rogler, G.; Brenmoehl, J.; Hahn, J.; Greinix, H.; Dickinson, A. M.; Socie, G.; Wolff, D.; Finke, J.; Fischer, G.; Jackson, G.; Rocha, V.; Hilgendorf, I.; Eissner, G.; Marienhagen, J.; Andreesen, R. (2008):
The role of genetic variants of NOD2/CARD15, a receptor of the innate immune system, in GvHD and complications following related and unrelated donor haematopoietic stem cell transplantation. Int. J. Immunogenet. 35: 381-384
Holler, E.; Hahn, J.; Andreesen, R.; Rogler, G.; Brenmoehl, J.; Greinix, H.; Dickinson, A. M.; Socie, G.; Wolff, D.; Finke, J. (2008):
NOD2/CARD15 polymorphisms in allogeneic stem-cell transplantation from unrelated donors: T depletion matters. J Clin Oncol 26: 338-339
Hildebrandt, G. C.; Granell, M.; Urbano-Ispizua, A.; Wolff, D.; Hertenstein, B.; Greinix, H. T.; Brenmoehl, J.; Schulz, C.; Dickinson, A. M.; Hahn, J.; Rogler, G.; Andreesen, R.; Holler, E. (2008):
Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation. Biol Blood Marrow Transplant 14: 67-74
Brenmoehl, J.; Lang, M.; Hausmann, M.; Leeb, S. N.; Falk, W.; Scholmerich, J.; Goke, M.; Rogler, G. (2007):
Evidence for a differential expression of fibronectin splice forms ED-A and ED-B in Crohn's disease (CD) mucosa. Int J Colorectal Dis 22: 611-623
Brenmoehl, J.; Holler, E.; Rogler, G. (2007):
Polymorphisms within epithelial receptors: NOD2/CARD15. Methods Mol Med 134: 115-122
Brenmoehl, J.; Herfarth, H.; Gluck, T.; Audebert, F.; Barlage, S.; Schmitz, G.; Froehlich, D.; Schreiber, S.; Hampe, J.; Scholmerich, J.; Holler, E.; Rogler, G. (2007):
Genetic variants in the NOD2/CARD15 gene are associated with early mortality in sepsis patients. Intensive Care Med 33: 1541-1548
Rieder, F.; Brenmoehl, J.; Leeb, S.; Scholmerich, J.; Rogler, G. (2007):
Wound healing and fibrosis in intestinal disease. Gut 56: 130-139
Holler, E.; Rogler, G.; Brenmoehl, J.; Hahn, J.; Herfarth, H.; Greinix, H.; Dickinson, A. M.; Socie, G.; Wolff, D.; Fischer, G.; Jackson, G.; Rocha, V.; Steiner, B.; Eissner, G.; Marienhagen, J.; Schoelmerich, J.; Andreesen, R. (2006):
Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination. Blood 107: 4189-4193
Wolff, D.; Roessler, V.; Steiner, B.; Wilhelm, S.; Weirich, V.; Brenmoehl, J.; Leithaeuser, M.; Hofmeister, N.; Junghanss, C.; Casper, J.; Hartung, G.; Holler, E.; Freund, M. (2005):
Treatment of steroid-resistant acute graft-versus-host disease with daclizumab and etanercept. Bone Marrow Transplant. 35: 1003-1010