Dr. rer. nat. Julia Brenmoehl

+49 38208 68-929
Leibniz-Institut für Nutztierbiologie (FBN)
Institut für Genombiologie
Abteilung Signaltransduktion
Wilhelm-Stahl-Allee 2
18196 Dummerstorf


  • Fett- und Ernergiemetabolismus, Zellsignalanalyse


  • seit 2009: Leibniz-Institut für Nutztierbiologie (FBN)
  • 2007–2009: Universitätsklinikum Jena, Innere Medizin IV, Abteilung für Gastroenterologie, Hepatologie und Infektiologie
  • 2005–2007: Promotion zum Dr. rer. nat.
  • 2003–2004: wissenschaftliche Tätigkeit im Fach Biologie, Universität Regensburg
  • 2002–2006: Universitätsklinikum Regensburg, Abteilung für Gastroenterologie, Endokrinologie, Rheumatologie, Infectiologie und Notfallmedizin
  • 2002: Universitätsklinikum Rostock, Innere Medizin, Abteilung Gastroenterologie
  • 2001–2001: Creatogen AG Augsburg, Abteilung für Impfstoffe
  • 1997–2002: Studium der Biotechnologie, Fachhochschule Jena
  • 1997: Hochschulreife


Hoeflich, A.; Fitzner, B.; Walz, C.; Hecker, M.; Tuchscherer, A; Brenmoehl, J.; Zettl, U. K. (2021):
Reduced fragmentation of IGFBP-2 and IGFBP-3 as a potential mechanism for decreased ratios of IGF-II to IGFBPs in cerebrospinal fluid in response to repeated intrathecal administration of triamcinolone acetonide in patients with multiple sclerosis. Front
Ohde, D.; Walz, M.; Walz, C.; Noce, A.; Brenmoehl, J.; Langhammer, M.; Hoeflich, A. (2020):
Sex-specific control of muscle mass: elevated IGFBP proteolysis and reductions of IGF-1 levels are associated with substantial loss of carcass weight in male DU6PxIGFBP-2 transgenic mice. Cells-Basel 9 (10): 2174, 1-17
Hoeflich, A.; Fitzner, B.; Walz, C.; Hecker, M.; Tuchscherer, A; Bastian, M.; Brenmoehl, J.; Schröder, S.; Willenberg, H.S.; Reincke, M. (2020):
Systemic effects by intrathecal administration of triamcinolone acetonide in patients with multiple sclerosis. Front Endocrinol 11: 574, 1-8
Walz, M.; Chau, L.; Sawitzky, M.; Ohde, D.; Brenmoehl, J.; Tuchscherer, A; Langhammer, M.; Metzger, F.; Höflich, C.; Hoeflich, A. (2020):
Overlap of peak growth activity and peak IGF-1 to IGFBP ratio: delayed increase of IGFBPs versus IGF-1 in serum as a mechanism to speed up and down postnatal weight gain in mice. Cells-Basel 9 (6): 1516, 1-12
Braude, S.; Holtze, S.; Begall, S.; Brenmoehl, J.; Burda, H.; Dammann, P.; de Marmol, D.; Gorshkova, E.; Henning, Y.; Hoeflich, A.; Höhn, A.; Jung, T.; Hamo, D.; Sahm, A.; Shebzukhov, Y.; Šumbera, R.; Miwa, S.; Vyssokikh, M.; von Zglinicki, T.; Averina, O.; Hildebrandt, T. B. (2020):
Surprisingly long survival of premature conclusions about naked mole-rat biology. Biol Rev (https://doi.org/10.1111/brv.12660)
Brenmoehl, J.; Ohde, D.; Walz, C.; Langhammer, M.; Schultz, J.; Hoeflich, A. (2020):
Analysis of activity-dependent energy metabolism in mice reveals regulation of mitochondrial fission and fusion mRNA by voluntary physical exercise in subcutaneous fat from male marathon mice (DUhTP). Cells-Basel 9: 2697, 1-20
Verleih, M.; Borchel, A.; Rebl, A.; Brenmoehl, J.; Kühn, C.; Goldammer, T. (2019):
A molecular survey of programmed cell death in rainbow trout: Structural and functional specifications of apoptotic key molecules. Comp Biochem Phys B 230: 57-69
Brenmoehl, J.; Ohde, D.; Wirthgen, E.; Hoeflich, A. (2018):
Cytokines in milk and the role of TGF-beta. Best Pract Res Cl En 32 (1): 47-56
Brenmoehl, J.; Walz, C.; Spitschak, M.; Wirthgen, E.; Walz, M.; Langhammer, M.; Tuchscherer, A; Naumann, R.; Höflich, A. (2018):
Partial phenotype conversion and differential trait response to conditions of husbandry in mice. J Comp Physiol B 188 (3): 527-539
Wirthgen, E.; Otten, W.; Tuchscherer, M.; Tuchscherer, A; Domanska, G.; Brenmoehl, J.; Günther, J.; Ohde, D.; Weitschies, W.; Seidlitz, A.; Scheuch, E.; Kanitz, E. (2018):
Effects of 1-Methyltryptophan on immune responses and the kynurenine pathway after lipopolysaccharide challenge in pigs. Int J Mol Sci 19 (10): 3009, 1-23
Brenmoehl, J.; Ohde, D.; Albrecht, E.; Walz, C.; Tuchscherer, A; Hoeflich, A. (2017):
Browning of subcutaneous fat and higher surface temperature in response to phenotype selection for advanced endurance exercise performance in male DUhTP mice. J Comp Physiol B 187 (2): 361-373
Wirthgen, E.; Kunze, M.; Goumon, S.; Walz, C.; Höflich, C.; Spitschak, M.; Brenmoehl, J.; Kanitz, E.; Tuchscherer, M.; Otten, W.; Gimsa, U.; Schön, P.- C.; Manteuffel, C.; Tuchscherer, A; Pfuhl, R.; Metges, C. C.; Stabenow, B.; Erdmann, S.; Schluricke, K.; Faucitano, L.; Hoeflich, A. (2017):
Interference of stress with the somatotropic axis in pigs - lights on new biomarkers. Sci Rep-UK 7: 12055, 1-13
Swiderski, K.; Martins, K. J. B.; Chee, A.; Trieu, J.; Naim, T.; Gehrig, S. M.; Baum, D. M.; Brenmoehl, J.; Chau, L.; Koopman, R.; Metzger, F.; Hoeflich, A.; Lynch, G. S. (2016):
Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology. Growth Horm IGF Res 30-31: 1-10
Ohde, D.; Brenmoehl, J.; Walz, C.; Tuchscherer, A; Wirthgen, E.; Hoeflich, A. (2016):
Comparative analysis of hepatic miRNA levels in male marathon mice reveals a link between obesity and endurance exercise capacities. J Comp Physiol B 186 (8): 1067-1078
Hoeflich, A.; Reyer, A.; Ohde, D.; Brenmoehl, J.; Spitschak, M.; Langhammer, M.; Tuchscherer, A; Wirthgen, E.; Renner-Müller, Ingrid; Wanke, R.; Metzger, F.; Bielohuby, M.; Wolf, E. (2016):
Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice. Aging Cell 15 (1): 111-117
Ohde, D.; Moeller, M.; Brenmoehl, J.; Walz, C.; Ponsuksili, S.; Schwerin, M.; Fuellen, G.; Hoeflich, A. (2016):
Advanced running performance by genetic predisposition in male Dummerstorf marathon mice (DUhTP) reveals higher sterol regulatory element-binding protein (SREBP) related mRNA expression in the liver and higher serum levels of progesterone. Plos One 11 (1)
Albrecht, E.; Norheim, F.; Thiede, B.; Holen, T.; Ohashi, T.; Schering, L.; Lee, S.; Brenmoehl, J.; Thomas, S.; Drevon, C. A.; Erickson, H. P.; Maak, S. (2015):
Irisin - a myth rather than an exercise-inducible myokine. Sci Rep-UK 5: 1-10
Reyer, A.; Schindler, N.; Ohde, D.; Walz, C.; Kunze, M.; Tuchscherer, A; Wirthgen, E.; Brenmoehl, J.; Hoeflich, A. (2015):
The RGD sequence present in IGFBP-2 is required for reduced glucose clearance after oral glucose administration in female transgenic mice. Am J Physiol-Endoc M 309 (4): 409-417
Ohde, D.; Brenmoehl, J.; Walz, C.; Höflich, A. (2015):
Identification and characterization of microRNAs relevant for energy metabolism in Dummerstorf "marathon mice" DUhTP. Schriftenreihe / Leibniz-Institut für Nutztierbiol 24: 33-36"
Grube, M.; Brenmoehl, J.; Rogler, G.; Hahn, J.; Herr, W.; Holler, E. (2015):
Donor nucleotide-binding oligomerization-containing protein 2 (NOD2) single nucleotide polymorphism 13 is associated with septic shock after allogeneic stem cell transplantation. Biol Blood Marrow Tr 21 (8): 1399-1404