PD Dr. rer. nat. habil. Joachim Weitzel
Forschungsinstitut für Nutztierbiologie (FBN)
Leiter der Arbeitsgruppe Reproduktionsbiochemie
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Leiter der Arbeitsgruppe Reproduktionsbiochemie
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Forschungsinteressen
- Reproduktionsbiologie
- Endokrinologie
- Biochemie
Lebenslauf
- 2007–heute: Abteilungsleiter Reproduktionsbiochemie am Leibniz Institut für Nutztierbiologie (FBN) Dummerstorf im Institut für Fortpflanzungsbiologie
- 2006-2007: Universitätsklinikum Charité, Berlin, Institut für Experimentelle Endokrinologie
- 1997-2006: Universität Hamburg, Universitätsklinikum Hamburg-Eppendorf, Zentrum für Experimentalmedizin, Abteilung Biochemie und Molekulare Zellbiologie
Lehre
Universität Rostock: Bachelor "Agrarwissenschaften", Master "Nutztierwissenschaften"
Publikationen
Weitzel, J. M.; Vernunft, A.; Krüger, B.; Plinski, C.; Viergutz, T. (2014):
LOX-1 regulates estrogenesis via intracellular calcium release from bovine granulosa cells. Cytom Part A 85 (1): 88-93
https://dx.doi.org/10.1002/cyto.a.22353
Gohlke, A.; Ingelmann, C. -J.; Nürnberg, G.; Weitzel, J. M.; Hammon, H. M.; Görs, S.; Starke, A.; Wolffram, S.; Metges, C. C. (2013):
Influence of 4-week intraduodenal supplementation of quercetin on performance, glucose metabolism, and mRNA abundance of genes related to glucose metabolism and antioxidative status in dairy cows. J Dairy Sci 96 (11): 6986-7000
https://dx.doi.org/10.3168/jds.2013-6852
Michaelis, M.; Langhammer, M.; Hoeflich, A.; Reinsch, N.; Schön, J.; Weitzel, J. M. (2013):
Initial characterization of an outbreed mouse model for male factor (in)fertility. Andrology 1 (5): 772-778
https://dx.doi.org/10.1111/j.2047-2927.2013.00108.x
Vernunft, A.; Weitzel, J. M.; Viergutz, T. (2013):
Corpus luteum development and its morphology after aspiration of a preovulatory follicle is related to size and steroid content of the follicle in dairy cows. Vet Med-Czech 58 (4): 221-229
Vernunft, A.; Löhrke, B.; Tuchscherer, A.; Weitzel, J. M.; Viergutz, T. (2013):
Anti-Müller-Hormonkonzentrationen in der Follikelflüssigkeit von antralen Follikeln und ihre Beziehungen zu funktionalen Merkmalen der Follikelentwicklung bei Stuten. Berl Munch Tierarztl 126 (1/2): 77-82
https://dx.doi.org/10.2376/0005-9366-126-77
Metges, C. C.; Lang, I. S.; Hennig, U.; Brüssow, K.-P.; Kanitz, E.; Tuchscherer, M.; Schneider, F.; Weitzel, J. M.; Steinhoff-Ooster, A.; Sauerwein, H.; Bellmann, O.; Nürnberg, G.; Rehfeldt, C.; Otten, W. (2012):
Intrauterine growth retarded progeny of pregnant sows fed high protein:low carbohydrate diet is related to metabolic energy deficit. Plos One 7 (2): 1-10
https://dx.doi.org/10.1371/journal.pone.0031390
Ebeling, S.; Töpfer, D.; Weitzel, J. M.; Meinecke, B. (2011):
Bone morphogenetic protein-6 (BMP-6): mRNA expression and effect on steroidogenesis during in vitro maturation of porcine cumulus oocyte complexes. Reprod Fert Develop 23: 1034-1042
https://dx.doi.org/10.1071/Rd11027
Löhrke, B.; Weitzel, J. M.; Krüger, B.; Xu, T.; Vernunft, A.; Viergutz, T. (2011):
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) activity decreases estrogenesis in ovarian granulosa cells. Cytom Part A 79 (9): 669-671
https://dx.doi.org/10.1002/Cyto.A.21082
Weitzel, J. M.; Iwen, K. A. (2011):
Coordination of mitochondrial biogenesis by thyroid hormone. Mol Cell Endocrinol 342 (1-2): 1-7
https://dx.doi.org/10.1016/j.mce.2011.05.009
Chang, L.; Schwarzenbach, H.; Meyer-Staeckling, S.; Brandt, B.; Mayr, G. W.; Weitzel, J. M.; Windhorst, S. (2011):
Expression regulation of the metastasis-promoting protein InsP3-kinase-A in tumor cells. Mol Cancer Res 9 (4): 497-506
https://dx.doi.org/10.1158/1541-7786.Mcr-10-0556
Kota, V.; Rai, P.; Weitzel, J. M.; Middendorff, R.; Bhande, S.; Shivaji, S. (2010):
Role of glycerol-3-phosphate dehydrogenase 2 in mouse sperm capacitation. Mol Reprod Dev 77 (9): 773-783
https://dx.doi.org/10.1002/mrd.21218
Löhrke, B.; Xu, T.; Weitzel, J. M.; Krüger, B.; Goldammer, T.; Viergutz, T. (2010):
N-acetylcysteine impairs survival of luteal cells through mitochondrial dysfunction. Cytom Part A 77 A (4): 310-320
https://dx.doi.org/10.1002/cyto.a.20873
Rajkovic, M.; Iwen, K. A.; Hofmann, P. J.; Harneit, A.; Weitzel, J. M. (2010):
Functional cooperation between CREM and GCNF directs gene expression in haploid male germ cells. Nucleic Acids Res 38 (7): 2268-2278
https://dx.doi.org/10.1093/nar/gkp1220
Taleux, N.; Guigas, B.; Dubouchaud, H.; Moreno, M.; Weitzel, J. M.; Goglia, F.; Favier, R.; Leverve, X. (2009):
High expression of thyroid hormone receptors and mitochondrial glycerol-3-phosphate dehydrogenase in the liver is linked to enhanced fatty acid oxidation in Lou/C, a rat strain resistant to obesity. J Biol Chem 284 (7): 4308-4316
https://dx.doi.org/10.1074/jbc.M806187200
Weitzel, J. M. (2008):
To bind or not to bind - how to down-regulate target genes by liganded thyroid hormone receptor?. Thyroid Res 1 (1): 4-4
https://dx.doi.org/10.1186/1756-6614-1-4
Wulf, A.; Wetzel, M.; Kebenko, M.; Kröger, M.; Harneit, A.; Merz, J.; Weitzel, J. M. (2008):
The role of thyroid hormone receptor DNA binding in negative thyroid hormone-mediated gene transcription. J Mol Endocrinol 41 (1): 25-34
https://dx.doi.org/10.1677/JME-08-0023
Schweizer, U.; Weitzel, J. M.; Schomburg, L. (2008):
Think globally: act locally. New insights into the local regulation of thyroid hormone availability challenge long accepted dogmas. Mol Cell Endocrinol 289 (1-2): 1-9
https://dx.doi.org/10.1016/j.mce.2008.04.007
Wulf, A.; Harneit, A.; Kröger, M.; Kebenko, M.; Wetzel, M.; Weitzel, J. M. (2008):
T3-mediated expression of PGC-1alpha via a far upstream located thyroid hormone response element. Mol Cell Endocrinol 287 (1-2): 90-95
https://dx.doi.org/10.1016/j.mce.2008.01.017
Wulf, A.; Harneit, A.; Weitzel, J. M. (2008):
T3-mediated gene expression is independent of PGC-1alpha. Mol Cell Endocrinol 270 (1-2): 57-63
https://dx.doi.org/10.1016/j.mce.2007.02.008