PD Dr. rer. nat. habil. Jens Vanselow

Forschungsinstitut für Nutztierbiologie (FBN)
Leiter des Kompetenzfeldes Reproduktion und Ernährung
Leiter der Arbeitsgruppe Zellphysiologie und Reproduktion
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Forschungsinteressen

  • Reproduktionsbiologie
  • Follikulogenese, Luteinisierung
  • Genregulation
  • Epigenetik

Lebenslauf

  • 2013-heute: Leiter des Instituts für Fortpflanzungsbiologie am Leibniz Institut für Nutztierbiologie (FBN) Dummerstorf
  • 2002: Habilitation und Dozent an der Mathematisch-Naturwissenschaftlichen Fakultät und Agrar- und Umweltwissenschaftlichen Fakultät der Universität Rostock
  • 1992-2012: Leiter der Abteilung Genregulation am Leibniz Institut für Nutztierbiologie (FBN) Dummerstorf, Forschungsbereich Molekularbiologie
  • 1990-1992: Postdoc-Stipendiat des Boehringer Ingelheim Fonds
  • 1990-1992: Harvard Research Fellow am Massachusetts General Hospital, Institut für Entwicklungsbiologie, Boston, USA
  • 1988-1990: Mitglied des DFG Graduierten Kollegs "Neurobiologie" an der Eberhard Karls Universität Tübingen
  • 1990: Promotion zum Dr. rer. nat. an der Eberhard Karls Universität Tübingen und am Max-Planck-Institut für Entwicklungsbiologie Tübingen
  • 1987: Diplom in Biologie an der Eberhard Karls Universität Tübingen
  • 1983: Vordiplom in Biologie an der Johannes Gutenberg University Mainz

Lehre

  • 2013-heute: "Populationsgenetik, molekulare Tierzucht und Reproduktionstechniken" (MSc) an der Agrar- und Umweltwissenschaftlichen Fakultät der Universität Rostock
  • 2014-heute: "Zuchtprogramme und Reproduktionsmanagement" (B.Sc.) an der Agrar- und Umweltwissenschaftlichen Fakultät der Universität Rostock
  • 2011-heute: "Molekulare Tierzucht" (MSc) an der Mathematisch-naturwissenschaftliche Fakultät der Universität Rostock
  • 1997-2010: "Molekulare Mechanismen der Entwicklung und and Differenzierung" (Dipl.-Biol.), Mathematisch-naturwissenschaftliche Fakultät der Universität Rostock

Publikationen

Baddela, V. S.; Sharma, A.; Viergutz, T.; Koczan, D.; Vanselow, J. (2018):
Low oxygen levels induce early luteinization associated changes in bovine granulosa cells. Front Physiol 9: 1066, 1-15
https://doi.org/10.3389/fphys.2018.01066
Baufeld, A.; Vanselow, J. (2018):
Lactate promotes specific differentiation in bovine granulosa cells depending on lactate uptake thus mimicking an early post-LH stage. Reprod Biol Endocrin 16: 15, 1-11
https://doi.org/10.1186/s12958-018-0332-3
Baddela, V. S.; Koczan, D.; Viergutz, T.; Vernunft, A.; Vanselow, J. (2018):
Global gene expression analysis indicates that small luteal cells are involved in extracellular matrix modulation and immune cell recruitment in the bovine corpus luteum. Mol Cell Endocrinol 474: 201-213
https://doi.org/10.1016/j.mce.2018.03.011
Yenuganti, V.; Vanselow, J. (2017):
Oleic acid induces down-regulation of the granulosa cell identity marker FOXL2, and up-regulation of the Sertoli cell marker SOX9 in bovine granulosa cells. Reprod Biol Endocrin 15: 57, 1-5
https://doi.org/10.1186/s12958-017-0276-z
Yenuganti, V.; Vanselow, J. (2017):
Cultured bovine granulosa cells rapidly lose important features of their identity and functionality but partially recover under long-term culture conditions. Cell Tissue Res 368 (2): 397-403
https://dx.doi.org/10.1007/s00441-017-2571-6
Baufeld, A.; Koczan, D.; Vanselow, J. (2017):
Induction of altered gene expression profiles in cultured bovine granulosa cells at high cell density. Reprod Biol Endocrin 15: 3, 1-14
https://dx.doi.org/10.1186/s12958-016-0221-6
Vanselow, J.; Vernunft, A.; Koczan, D.; Spitschak, M.; Kuhla, B. (2016):
Exposure of lactating dairy cows to acute pre-ovulatory heat stress affects granulosa cell-specific gene expression profiles in dominant follicles. Plos One 11 (8): e0160600, 1-19
https://dx.doi.org/10.1371/journal.pone.0160600
Yenuganti, V.; Viergutz, T.; Vanselow, J. (2016):
Oleic acid induces specific alterations in the morphology, gene expression and steroid hormone production of cultured bovine granulosa cells. Gen Comp Endocr 232: 134-144
https://dx.doi.org/10.1016/j.ygcen.2016.04.020
Vanselow, J.; Kucia, M.; Langhammer, M.; Koczan, D.; Metges, C. C. (2016):
Maternal high-protein diet during pregnancy, but not during suckling, induced altered expression of an increasing number of hepatic genes in adult mouse offspring. Eur J Nutr 55 (3): 917-930
https://dx.doi.org/10.1007/s00394-015-0906-1
Rudolf, H.; Nuernberg, G.; Koczan, D.; Vanselow, J.; Gempe, T.; Beye, M.; Leboulle, G.; Bienefeld, K.; Reinsch, N. (2015):
On the relevance of technical variation due to building pools in microarray experiments. BMC Genomics 16: 1027, 1-12
https://dx.doi.org/10.1186/s12864-015-2055-6
Kunze, M.; Wirthgen, E.; Walz, C.; Spitschak, M.; Brenmoehl, J.; Vanselow, J.; Schwerin, M.; Wimmers, K.; Hoeflich, A. (2015):
Bioanalytical validation for simultaneous quantification of non-aromatic steroids in follicular fluid from cattle via ESI-LC-MS/MS. J Chromatogr B 1007: 132-139
https://dx.doi.org/10.1016/j.jchromb.2015.10.010
Yenuganti, V.; Baddela, V.S.; Baufeld, A.; Singh, D.; Vanselow, J. (2015):
The gene expression pattern induced by high plating density in cultured bovine and buffalo granulosa cells might be regulated by specific miRNA species. J Reprod Develop 61 (2): 154-160
https://dx.doi.org/10.1262/jrd.2014-119
Chang, G.; Petzl, W.; Vanselow, J.; Günther, J.; Shen, Z.; Seyfert, H.-M. (2015):
Epigenetic mechanisms contribute to enhanced expression of immune response genes in the liver of cows after experimentally induced Escherichia coli mastitis. Vet J 203 (3): 339-341
https://dx.doi.org/10.1016/j.tvjl.2014.12.023 10.1016/j.tvjl.2014.12.023
Shrestha, K.; Lukasik, K.; Baufeld, A.; Vanselow, J.; Moallem, U.; Meidan, R. (2015):
Regulation of ovulatory genes in bovine granulosa cells: lessons from siRNA silencing of PTGS2. Reproduction 149 (1): 21-29
https://dx.doi.org/10.1530/REP-14-0337
Baddela, V.; Baufeld, A.; Yenuganti, V.; Vanselow, J.; Singh, D. (2014):
Suitable housekeeping genes for normalization of transcript abundance analysis by real-time RT-PCR in cultured bovine granulosa cells during hypoxia and differential cell plating density. Reprod Biol Endocrin 12: 118-125
https://dx.doi.org/10.1186/1477-7827-12-118
Vanselow, J. (2014):
ISSRF Newsletter: Epigenetic Modulation and Reproduction: A Link Between Environment and Genetics. ISSRF Newsletter (15): 8-11
Vanselow, J. (2014):
Modified maternal protein supply imprints persistent alterations on offspring growth, hepatic gene expression and epigenetic profiles. In: Invited Lectures: Climate Resilient Livestock Feeding Systems for Global Food Security (Samanta,A.K., Bhatta,V., Sejian,V., Kolte,P.K., Malik,P.K., Sirohi,S.K., Prasad,C., Hrsg.) Global Animal Nutrition Conference, April 20-22, 2014, Bengalore, Indien: 88-91
Sahmi, F.; Nicola, E.S.; Zamberlam, G. O.; Goncalves, P. D. B.; Vanselow, J.; Price, C.A. (2014):
Factors regulating the bovine, caprine, rat and human ovarian aromatase promoters in a bovine granulosa cell model. Gen Comp Endocr 200: 10-17
https://dx.doi.org/10.1016/j.ygcen.2014.02.008
Baufeld, A.; Vanselow, J. (2013):
Increasing cell plating density mimics an early post-LH stage in cultured bovine granulosa cells. Cell Tissue Res 354 (3): 869-880
https://dx.doi.org/10.1007/s00441-013-1712-9
Christenson, L. K.; Gunewardena, S.; Hong, X.; Spitschak, M.; Baufeld, A.; Vanselow, J. (2013):
Preovulatory LH surge effects on follicular theca and granulosa transcriptomes. Mol Endocrinol 27 (7): 1153-1171
https://dx.doi.org/10.1210/Me.2013-1093