PD Dr. rer. nat. habil. Jens Vanselow

Forschungsinstitut für Nutztierbiologie (FBN)
Leiter des Kompetenzfeldes Reproduktion und Ernährung
Leiter der Arbeitsgruppe Zellphysiologie und Reproduktion
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Forschungsinteressen

Reproduktionsbiologie
Follikulogenese, Luteinisierung
Genregulation
Epigenetik

Lebenslauf

2013-heute: Leiter des Instituts für Fortpflanzungsbiologie am Leibniz Institut für Nutztierbiologie (FBN) Dummerstorf
2002: Habilitation und Dozent an der Mathematisch-Naturwissenschaftlichen Fakultät und Agrar- und Umweltwissenschaftlichen Fakultät der Universität Rostock
1992-2012: Leiter der Abteilung Genregulation am Leibniz Institut für Nutztierbiologie (FBN) Dummerstorf, Forschungsbereich Molekularbiologie
1990-1992: Postdoc-Stipendiat des Boehringer Ingelheim Fonds
1990-1992: Harvard Research Fellow am Massachusetts General Hospital, Institut für Entwicklungsbiologie, Boston, USA
1988-1990: Mitglied des DFG Graduierten Kollegs "Neurobiologie" an der Eberhard Karls Universität Tübingen
1990: Promotion zum Dr. rer. nat. an der Eberhard Karls Universität Tübingen und am Max-Planck-Institut für Entwicklungsbiologie Tübingen
1987: Diplom in Biologie an der Eberhard Karls Universität Tübingen
1983: Vordiplom in Biologie an der Johannes Gutenberg University Mainz

Lehre

2013-heute: "Populationsgenetik, molekulare Tierzucht und Reproduktionstechniken" (MSc) an der Agrar- und Umweltwissenschaftlichen Fakultät der Universität Rostock
2014-heute: "Zuchtprogramme und Reproduktionsmanagement" (B.Sc.) an der Agrar- und Umweltwissenschaftlichen Fakultät der Universität Rostock
2011-heute: "Molekulare Tierzucht" (MSc) an der Mathematisch-naturwissenschaftliche Fakultät der Universität Rostock
1997-2010: "Molekulare Mechanismen der Entwicklung und and Differenzierung" (Dipl.-Biol.), Mathematisch-naturwissenschaftliche Fakultät der Universität Rostock

Publikationen

Tao, X.; Rahimi, M.; Michaelis, M.; Görs, S.; Brenmoehl, J.; Vanselow, J.; Baddela, V. S. (2024):

Saturated fatty acids inhibit unsaturated fatty acid induced glucose uptake involving GLUT10 and aerobic glycolysis in bovine granulosa cells

Marten Michaelis, Solvig Görs, Julia Brenmoehl, Jens Vanselow, Vijay Simha Baddela

Scientific reports 14: 9888, 1-15

https://doi.org/10.1038/s41598-024-59883-x

Vanselow, J.; Wesenauer, C.; Eggert, A.; Sharma, A.; Becker, F. (2024):

Summer heat during spermatogenesis reduces in vitro blastocyst rates and affects sperm quality of next generation bulls

Jens Vanselow, Anja Eggert, Frank Becker

Andrology

https://doi.org/10.1111/andr.13627

Röttgen, V.; Tümmler, L.-M.; Koczan, D.; Rebl, A.; Kuhla, B.; Vanselow, J.; Baufeld, A. (2023):

Early milk-feeding regimes in calves exert long-term effects on the development of ovarian granulosa cells. BMC Genomics 24: 485, 1-13

Volker Röttgen, Alexander Rebl, Björn Kuhla, Jens Vanselow, Anja Baufeld

Baddela, V. S.; Michaelis, M.; Tao, X.; Koczan, D.; Vanselow, J. (2023):

ERK1/2-SOX9/FOXL2 axis regulates ovarian steroidogenesis and favors the follicular-luteal transition. LIFE SCI ALLIANCE 6 (10): e202302100, 1-13

Vijay Simha Baddela, Marten Michaelis, Jens Vanselow

Pöhland, R.; Vanselow, J.; Melo-Sterza, F.D. (2023):

Translocation of Oocytic HES1 into Surrounding Cumulus Cells in Bovine: Mechanism of Cellular Interaction during IVM? [epublished ahead of print]. Int J Mol Sci 24 (15): 11932, 1-10

Ralf Pöhland, Jens Vanselow

Baddela, V. S.; Michaelis, M.; Sharma, A.; Plinski, C.; Viergutz, T.; Vanselow, J. (2022):

Estradiol production of granulosa cells is unaffected by the physiological mix of non-esterified fatty acids in follicular fluid. J Biol Chem 298 (10): 102477, 1-11

Vijay Simha Baddela, Marten Michaelis, Jens Vanselow

Baddela, V. S.; Sharma, A.; Plinski, C.; Vanselow, J. (2022):

Palmitic acid protects granulosa cells from oleic acid induced steatosis and rescues progesterone production via cAMP dependent mechanism. BBA-MOL CELL BIOL L 1867 (8): 159159, 1-11

Vijay Simha Baddela, Jens Vanselow

https://doi.org/10.1016/j.bbalip.2022.159159

Baufeld, A.; Vanselow, J. (2022):

Lactate-induced effects on bovine granulosa cells are mediated via PKA signaling. Cell Tissue Res 388 (2): 471-477

Anja Baufeld, Jens Vanselow

https://doi.org/10.1007/s00441-021-03569-7

Berger, T; Vanselow, J.; Conley, A. J.; Almand, T. J.; Nitta-Oda, B. S. (2022):

Multifaceted epigenetic regulation of porcine testicular aromatase. Mol Cell Endocrinol 541: 111526, 1-8

Jens Vanselow

https://doi.org/10.1016/j.mce.2021.111526

Vanselow, J.; Conley, A. J.; Berger, T (2021):

Aromatase and the three little paralogs. Biol Reprod 105 (1): 5-6

Jens Vanselow

https://doi.org/10.1093/biolre/ioab112

Yenuganti, V.; Koczan, D.; Vanselow, J. (2021):

Genome wide effects of oleic acid on cultured bovine granulosa cells: evidence for the activation of pathways favoring folliculo-luteal transition. BMC Genomics 22: 486, 1-10

Jens Vanselow

https://doi.org/10.1186/s12864-021-07817-6

Vanselow, J.; Conley, A. J.; Corbin, C. J.; Berger, T (2021):

Genomic Structure of the Porcine CYP19 Locus and Expression of the CYP19A3 Paralog . Genes-Basel 12 (4): 533, 1-12

Jens Vanselow

https://doi.org/10.3390/genes12040533

Pöhland, R.; Souza Cáceres, M. B.; Datta, T. K.; Vanselow, J.; Martins, M.I.M.; Silva, W.A.L.; Cardoso, C. T.; Melo Sterza, F. A. (2020):

Influence of long-term thermal stress on the in vitro maturation on embryo development and Heat Shock Protein abundance in zebu cattle. Anim Reprod 17 (3): e20190085, 1-10

Ralf Pöhland, Jens Vanselow

https://doi.org/10.1590/1984-3143-AR2019-0085

Baddela, V. S.; Sharma, A.; Vanselow, J. (2020):

Non-esterified fatty acids in the ovary: friends or foes?. Reprod Biol Endocrin 18: 60, 1-14

Vijay Simha Baddela, Jens Vanselow

https://doi.org/10.1186/s12958-020-00617-9

Baddela, V. S.; Sharma, A.; Michaelis, M.; Vanselow, J. (2020):

HIF1 driven transcriptional activity regulates steroidogenesis and proliferation of bovine granulosa cells. Sci Rep-UK 10: 3906

Vijay Simha Baddela, Marten Michaelis, Jens Vanselow

https://doi.org/10.1038/s41598-020-60935-1

Sharma, A.; Baddela, V. S.; Roettgen, V.; Vernunft, A.; Viergutz, T.; Dannenberger, D.; Hammon, H. M.; Schoen, J.; Vanselow, J. (2020):

Effects of dietary fatty acids on bovine oocyte competence and granulosa cells. Front Endocrinol 11: 87, 1-12

Vijay Simha Baddela, Volker Röttgen, Andreas Vernunft, Dirk Dannenberger, Harald Michael Hammon, Jens Vanselow

https://doi.org/10.3389/fendo.2020.00087

Vanselow, J.; Christenson, L. K.; Pate, J. L. (2020):

Editorial: Regulation of dynamic changes and remodeling events during the formation, rescue and regression of the corpus luteum. Front Endocrinol 11: 244, 1-2

Jens Vanselow

https://doi.org/10.3389/fendo.2020.00244

Sharma, A.; Baddela, V. S.; Becker, D.; Dannenberger, D.; Viergutz, T.; Vanselow, J. (2019):

Elevated free fatty acids affect bovine granulosa cell function: a molecular cue for compromised reproduction during negative energy balance. Endocr Connect 8 (5): 493-505

Vijay Simha Baddela, Frank Becker, Dirk Dannenberger, Jens Vanselow

https://doi.org/10.1530/EC-19-0011

Baufeld, A.; Koczan, D.; Vanselow, J. (2019):

L-lactate induces specific genome wide alterations of gene expression in cultured bovine granulosa cells. BMC Genomics 20: 273, 1-11

Anja Baufeld, Jens Vanselow

https://doi.org/10.1186/s12864-019-5657-6

Baufeld, A.; Vanselow, J. (2018):

A tissue culture model of estrogen-producing primary bovine granulosa cells. 139: e58208

Anja Baufeld, Jens Vanselow

https://doi.org/doi:10.3791/58208