Dr. rer. nat. habil. Beate Fuchs

+49 38208 68-852
Leibniz-Institut für Nutztierbiologie (FBN)
Servicegruppe Metabolom
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Forschungsinteressen

  • Regulation des Lipidstoffwechsels
  • Lipidomics, Metabolomics
  • Massenspektrometrie & Analytik (GC-MS/MS, MALDI-TOF-MS, TLC, HR-ESI-MS/MS)

Lebenslauf

  • 2017-heute Leiterin der Zentralen Servicegruppe - Metabolomics, Leibniz-Institut für Nutztierbiologie (FBN) Dummerstorf
  • 2016 Habilitation (Dr. rer. nat. habil.) an der Medizinischen Fakultät Leipzig
  • 2016 Forschungsaufenthalt an der University of Pittsburgh, USA
  • 2009-2017 Arbeitsgruppenleiterin am Institut für Medizinische Physik und Biophysik der Medizinischen Fakultät Leipzig
  • 2007-2009 Wissenschaftlerin am Institut für Medizinische Physik und Biophysik der Medizinischen Fakultät Leipzig
  • 2006 Forschungsaufenthalt an der Strathclyde University in Glasgow, UK
  • 2004 Forschungsaufenthalt an der University of Louisville, Kentucky, USA
  • 2002-2006 Postgradualstudium Toxikologie, University Leipzig, Abschluss: Fachchemikerin für Toxikologie und Umweltschutz
  • 2002-2006 Postdoc am Interdisziplinären Zentrum für Klinische Forschung (IZKF) der Medizinischen Fakultät Leipzig ("NMR und MALDI-TOF-MS-Untersuchungen des Knorpelabbaus bei Rheumatischer Arthritis: Strukturaufklärung und klinisches Monitoring")
  • 1998-2001 Doktorandin am Leibniz-Institut für Polymerforschung Dresden (Thema: 19F-NMR-Untersuchungen an strahlenmodifizierten Fluorpolymeren)
  • 1996-1997 Stipendiatin der Carl-Duisberg-Gesellschaft und Praktikantin bei Bayer de México in Mexico-City
  • 1996 Diplomarbeit in der "Analytischen Chemie" an der TU Freiberg (Thema: 31C-NMR-Untersuchungen von strukturellen Änderungen mikrobiell behandelter Braunkohle)

Publikationen

Schober, C.; Fuchs, B.; Schiller, J. (2009):
Differential efficiency of lysophospholipid markers for oxidative stress. Faseb J 23: 1
Bauer, A.; Schumann, A.; Gilbert, M.; Wilhelm, C.; Hengstler, J. G.; Schiller, J.; Fuchs, B. (2009):
Evaluation of carbon tetrachloride-induced stress on rat hepatocytes by P-31 NMR and MALDI-TOF mass spectrometry: lysophosphatidylcholine generation from unsaturated phosphatidylcholines. Chem Phys Lipids 159: 21-29
Schober, C.; Schiller, J.; Pinker, F.; Hengstler, J. G.; Fuchs, B. (2009):
Lysophosphatidylethanolamine is - in contrast to - choline - generated under in vivo conditions exclusively by phospholipase A2 but not by hypochlorous acid. Bioorg Chem 37: 202-210
Fuchs, B.; Schiller, J. (2009):
Lysophospholipids: their generation, physiological role and detection. Are they important disease markers? Mini Rev Med Chem 9: 368-378
Fuchs, B.; Jakop, U.; Goritz, F.; Hermes, R.; Hildebrandt, T.; Schiller, J.; Muller, K. (2009):
MALDI-TOF "fingerprint" phospholipid mass spectra allow the differentiation between ruminantia and feloideae spermatozoa. Theriogenology 71: 568-575"
Fuchs, B.; Suss, R.; Nimptsch, A.; Schiller, J. (2009):
MALDI-TOF-MS Directly Combined with TLC: A Review of the Current State. Chromatographia 69: S95-S105
Jaskolla, T.; Fuchs, B.; Karas, M.; Schiller, J. (2009):
The New Matrix 4-Chloro-alpha-Cyanocinnamic Acid Allows the Detection of Phosphatidylethanolamine Chloramines by MALDI-TOF Mass Spectrometry. J Am Soc Mass Spectr 20: 867-874
Fuchs, B.; Bischoff, A.; Suss, R.; Teuber, K.; Schurenberg, M.; Suckau, D.; Schiller, J. (2009):
Phosphatidylcholines and -ethanolamines can be easily mistaken in phospholipid mixtures: a negative ion MALDI-TOF MS study with 9-aminoacridine as matrix and egg yolk as selected example. Anal Bioanal Chem 395: 2479-2487
Fuchs, B.; Bondzio, A.; Wagner, U.; Schiller, J. (2009):
Phospholipid compositions of sera and synovial fluids from dog, human and horse: a comparison by 31P-NMR and MALDI-TOF MS. J Anim Physiol Anim Nutr (Berl) 93: 410-422
Lessig, J.; Fuchs, B. (2009):
Plasmalogens in biological systems: their role in oxidative processes in biological membranes, their contribution to pathological processes and aging and plasmalogen analysis. Curr Med Chem 16: 2021-2041
Fuchs, B.; Schiller, J. (2009):
Recent Developments of Useful MALDI Matrices for the Mass Spectrometric Characterization of Apolar Compounds. Curr Org Chem 13: 1664-1681
Jakop, U.; Fuchs, B.; Suss, R.; Wibbelt, G.; Braun, B.; Muller, K.; Schiller, J. (2009):
The solubilisation of boar sperm membranes by different detergents - a microscopic, MALDI-TOF MS, P-31 NMR and PAGE study on membrane lysis, extraction efficiency, lipid and protein composition. Lipids Health Dis 8: Artn 49
Fuchs, B.; Nimptsch, A.; Suss, R.; Schiller, J. (2008):
Analysis of Brain Lipids by Directly Coupled Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry and High-Performance Thin-Layer Chromatography. J Aoac Int 91: 1227-1236
Fuchs, B.; Schiller, J.; Suss, R.; Zscharnack, M.; Bader, A.; Muller, P.; Schurenberg, M.; Becker, M.; Suckau, D. (2008):
Analysis of stem cell lipids by offline HPTLC-MALDI-TOF MS. Anal Bioanal Chem 392: 849-860
Richter, G.; Schober, C.; Suss, R.; Fuchs, B.; Birkemeyer, C.; Schiller, J. (2008):
Comparison of the positive and negative ion electrospray ionization and matrix-assisted laser desorption ionization-time-of-flight mass spectra of the reaction products of phosphatidylethanolamines and hypochlorous acid. Anal Biochem 376: 157-159
Jakop, U.; Fuchs, B.; Schiller, J.; Muller, K. (2008):
The influence of different detergents on boar sperm membrane lysis, lipid extraction and analysis. Reprod Domest Anim 43: 16-16
Fuchs, B.; Schiller, J. (2008):
MALDI-TOF MS analysis of lipids from cells, tissues and body fluids. Subcell Biochem 49: 541-565
Richter, G.; Schober, C.; Suss, R.; Fuchs, B.; Muller, M.; Schiller, J. (2008):
The reaction between phosphatidylethanolamines and HOCl investigated by TLC: fading of the dye primuline is induced by dichloramines. J Chromatogr B Analyt Technol Biomed Life Sci 867: 233-237
Fuchs, B.; Schober, C.; Richter, G.; Nimptsch, A.; Suss, R.; Schiller, J. (2008):
The reactions between HOCl and differently saturated phospholipids: Physiological relevance, products and methods of evaluation. Mini-Rev Org Chem 5: 254-261
Fuchs, B.; Schiller, J.; Cross, M. A. (2007):
Apoptosis-associated changes in the glycerophospholipid composition of hematopoietic progenitor cells monitored by P-31 NMR spectroscopy and MALDI-TOF mass spectrometry. Chem Phys Lipids 150: 229-238