PD Dr. rer. nat. Andreas Höflich

Forschungsinstitut für Nutztierbiologie (FBN)
Leiter der Arbeitsgruppe Endokrinologie der Nutztiere
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Forschungsinteressen

  • Wachstum und Metabolismus
  • Funktionelle Genomanalyse
  • Biomarkerforschung

Lebenslauf

  • seit 2013: Abteilungsleiter Signaltransduktion am FBN Dummerstorf
  • seit 2009: Vorlesungen an der Universität Rostock
  • 4/2009: Habilitation Mathematisch-Naturwissenschaftlichen Fakultät der Universität Rostock
  • 2006-2012: Arbeitsgruppenleiter Mausgenetik am FBN Dummerstorf
  • 2002-2006: Vorlesungen an der Universität Rostock
  • 6/2002: Habilitation an der Veterinärmedizinischen Fakultät der Universität München
  • 1996-2002: Oberassistent an der Universität München
  • 6/1995: Dissertation am Institut für Organische Chemie und Biologie der Technischen Universität München
  • 1985-2002: Studium der Biologie an der Universität Erlangen-Nürnberg

Lehre

Molekulare Tierzucht: Vorlesungen und Seminare innerhalb des Programms Vielfalt und Evolution (MSc) an der Universität Rostock

Publikationen

Bielohuby, M.; Sawitzky, M.; Johnsen, H.; Wittenburg, D.; Beuschlein, F; Wolf, E.; Hoeflich, A. (2009):
Decreased p44/42 Mitogen-Activated protein Kinase Phoshorylation in Gender- or Hormone-Related But Not during Age-Related Adrenal Gland Growth in Mice. Endocrinology 150 (3): 1269-1277
https://dx.doi.org/10.1210/en.2008-1055
Hoeflich, A.; Bielohuby, M. (2009):
Mechanisms of adrenal gland growth: signal integration by extracellular signal regulated kinases 1/2. J Mol Endocrinol 42 (3): 191-203
https://dx.doi.org/10.1677/JME-08-0160
Diehl, D; Hessel, E.; Oesterle, D; Renner-Müller, Ingrid; Elmlinger, M.W.; Langhammer, M.; Göttlicher, M.; Wolf, M.; Lahm, H; Hoeflich, A. (2008):
IGFBP-2 overexpression reduces the appearance of dysplastic aberrant crypt foci and inhibits growth of adenomas in chemically induced colorectal carcinogenesis. Int J Cancer 124 (9): 2220-2225
https://dx.doi.org/10.1002/ijc.24193
Hoeflich, A.; Bielohuby, M. (2008):
Mechanisms of adrenal gland growth - signal integration by ERK1/2. J Mol Endocrinol 42 (3): 191-203
https://dx.doi.org/10.1677/JME-08-0160
Kiepe, D.; Van der Pas, A.; Ciamatori, S.; Ständker, L.; Schütt, B.; Hoeflich, A.; Hügel, U.; Oh, J; Tönshoff, B. (2008):
Defined Carboxy-Terminal Fragments of Insulin-Like Growth Factor (IGF) Binding Protein-2 Exert Similar Mitogenic Activity on Cultured Rat Growth Plate Chondrocytes as IGF-I. Endocrinology 149 (10): 4901-4911
https://dx.doi.org/10.1210/en.2007-1395
Hoeflich, A. (2008):
Contrasting bone effects of temporary versus permanent IGFBP administration in rodents. Growth Horm IGF Res 18 (3): 181-187
https://dx.doi.org/10.1016/j.ghir.2008.01.003
Reim, N.S.; Breig, B.; Stahr, K.; Eberle, D.; Hoeflich, A.; Wolf, E.; Erben, Reinhold (2008):
Cortical bone loss in androgen-deficient aged male rats is mainly caused by increased endocortical bone remodeling. J Bone Miner Res 23 (5): 694-704
https://dx.doi.org/10.1359/jbmr.080202
Manolopoulou, J.; Bielohuby, M.; Caton, S.J.; Gomez-Sanchez, C.E.; Renner-Müller, Ingrid; Wolf, E.; Lichtenauer, U; Beuschlein, F; Hoeflich, A.; Bidlingmeier, M. (2008):
A highly sensitive immunofluorometric assay for the measurement of aldosterone in small sample volumes: validation in mouse serum. J Endocrinol 196 (2): 215-224
https://dx.doi.org/10.1677/JOE-07-0134
Bielohuby, M.; Herbach, N; Wanke, R; Maser-Gluth, C.; Beuschlein, F; Wolf, E.; Hoeflich, A. (2007):
Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartment. Am J Physiol-Endoc M 293 (1): E139-E146
https://dx.doi.org/10.1152/ajpendo.00705.2006
Hoeflich, A.; Götz, K.W.; Lichanska, A.; Bielohuby, M.; Tönshoff, B.; Kiepe, D. (2007):
Effects of insulin-like growth factor binding proteins in bone - a matter of cell and site. Arch Physiology and Biochemistry 113 (3): 142-153
https://dx.doi.org/10.1080/13813450701531193
Hoeflich, A.; Goetz, W.; Lichanska, A.; Bielohuby, M.; Tönshoff, B.; Kiepe, D. (2007):
Effects of insulin-like growth factor binding proteins in bone - a matter of cell and site. Arch Physiology and Biochemistry 113 (3): 142-153
https://dx.doi.org/10.1080/13813450701531193
Lichtenauer, U; Duchniewicz, M; Kolanczyk, M; Hoeflich, A.; Hahner, S; Else, T; Bicknell, AB; Zemojtel, T; Stallings, NR; Schulte, P.; Schulte, P.; Kamps, P.; Hammer, H.; Scheele, S.; Beuschlein, F (2007):
Pre-B-cell transcription factor 1 and steroidogenic factor 1 synergistically regulate adrenocortical growth and steroidogenesis. Endocrinology 148 (2): 693-704
https://dx.doi.org/10.1210/en.2006-0681
Moerth, Corinna; Schneider, F.; Renner-Müller, Ingrid; Blutke, A.; Elmlinger, M.W.; Erben, Reinhold; Camacho-Hübner, C; Hoeflich, A.; Wolf, M. (2007):
Postnatally elevated levels of insulin-like growth factor (IGF)-II fail to rescue the dwarfism of IGF-I-deficient mice except kidney weight. Endocrinology 148 (1): 441-451
https://dx.doi.org/10.1210/en.2006-0385
Diehl, D; Oesterle, D; Elmlinger, M.W.; Hoeflich, A.; Wolf, M.; Lahm, H (2006):
IGF-II transgenic mice display increased aberrant colon crypt multiplicity and tumor volume after 1,2-dimethylhydrazine treatment. J Carcinogenesis 5: 25
https://dx.doi.org/10.1186/1477-3163-5-24
Hoeflich, A.; Lahm, H; Wolf, M. (2006):
Molekulare Mechanismen der Wachstumswirkung des IGF-Systems. In: Molekularmedizinsche Grundlagen von para- und autokrinen Regulationsstörungen (D. Ganten, K. Ruckpaul, J. Köhrle, Hrsg.) Springer Verlag, (ISBN3-540-20138-6): 109-132
Frommer, KW; Reichenmiller, K; Schütt, BS; Hoeflich, A.; Ranke, MB; Dodt, G; Elmlinger, M.W. (2006):
IGF-independent effects of IGFBP-2 on the human breast cancer cell line Hs578T. J Mol Endocrinol 37 (1): 13-23
https://dx.doi.org/10.1677/jme.1.01955
Christians, JK; Hoeflich, A.; Keightley, P. (2006):
PAPPA2, an enzyme that cleaves an insulin-like growth-factor-binding protein, is a candidate gene for a quantitative trait locus affecting body size in mice. Genetics 173 (3): 1547-1553
https://dx.doi.org/10.1534/genetics.106.057513