PD Dr. rer. nat. habil. Andreas Höflich
Forschungsinstitut für Nutztierbiologie (FBN)
Leiter der Arbeitsgruppe Endokrinologie der Nutztiere
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Leiter der Arbeitsgruppe Endokrinologie der Nutztiere
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Forschungsinteressen
- Wachstum und Metabolismus
- Funktionelle Genomanalyse
- Biomarkerforschung
Lebenslauf
- seit 2013: Abteilungsleiter Signaltransduktion am FBN Dummerstorf
- seit 2009: Vorlesungen an der Universität Rostock
- 4/2009: Habilitation Mathematisch-Naturwissenschaftlichen Fakultät der Universität Rostock
- 2006-2012: Arbeitsgruppenleiter Mausgenetik am FBN Dummerstorf
- 2002-2006: Vorlesungen an der Universität Rostock
- 6/2002: Habilitation an der Veterinärmedizinischen Fakultät der Universität München
- 1996-2002: Oberassistent an der Universität München
- 6/1995: Dissertation am Institut für Organische Chemie und Biologie der Technischen Universität München
- 1985-2002: Studium der Biologie an der Universität Erlangen-Nürnberg
Lehre
Molekulare Tierzucht: Vorlesungen und Seminare innerhalb des Programms Vielfalt und Evolution (MSc) an der Universität Rostock
Publikationen
Reyer, A.; Schindler, N.; Ohde, D.; Walz, C.; Kunze, M.; Tuchscherer, A.; Wirthgen, E.; Brenmoehl, J.; Hoeflich, A. (2015):
The RGD sequence present in IGFBP-2 is required for reduced glucose clearance after oral glucose administration in female transgenic mice. Am J Physiol-Endoc M 309 (4): 409-417
https://dx.doi.org/10.1152/ajpendo.00168.2015
Krieger, F.; Elflein, N.; Saenger, S.; Wirthgen, E.; Rak, K.; Frantz, S.; Höflich, A.; Toyka, K. V.; Metzger, F.; Jablonka, S. (2014):
Polyethylene glycol-coupled IGF1 delays motor function defects in a mouse model of spinal muscular atrophy with respiratory distress type 1. Brain 137 (5): 1374-1393
https://dx.doi.org/10.1093/brain/awu059
Bielohuby, M.; Zarkesh-Esfahani, S.H.; Manolopoulou, J.; Wirthgen, E.; Walpurgis, K.; Toghiany Khorasgani, M.; Aghili, Z. S.; Wilkinson, I. R.; Hoeflich, A.; Thevis, M.; Ross, P.; Bidlingmaier, M. (2014):
Validation of serum IGF-I as a biomarker to monitor the bioactivity of exogenous growth hormone agonists and antagonists in rabbits. Dis Model Mech 7 (11): 1263-1273
https://dx.doi.org/10.1242/dmm.016519. Epub 2014 Sep 19
Hoeflich, A.; Wirthgen, E.; David, R.; Classen, C. F.; Spitschak, M.; Brenmoehl, J. (2014):
Control of IGFBP-2 expression by steroids and peptide hormones in vertebrates. Front Endocrinol 5: 43-52
https://dx.doi.org/10.3389/fendo.2014.00043
Brenmoehl, J.; Albrecht, E.; Komolka, K.; Schering, L.; Langhammer, M.; Hoeflich, A.; Maak, S. (2014):
Irisin is elevated in skeletal muscle and serum of mice immediately after acute exercise. Int J Biol Sci 10 (3): 338-349
https://dx.doi.org/10.7150/ijbs.7972
Laeger, T.; Wirthgen, E.; Piechotta, M.; Metzger, F.; Metges, C. C.; Kuhla, B.; Höflich, A. (2014):
Effects of parturition and feed restriction on concentrations and distribution of the insulin-like growth factor-binding proteins in plasma and cerebrospinal fluid of dairy cows. J Dairy Sci 97 (5): 2876-2885
https://dx.doi.org/10.3168/jds.2013-7671
Komolka, K.; Albrecht, E.; Schering, L.; Brenmoehl, J.; Hoeflich, A.; Maak, S. (2014):
Locus characterization and gene expression of bovine FNDC5: is the myokine irisin relevant in cattle?. Plos One 9 (1): 1-11
https://dx.doi.org/10.1371/journal.pone.0088060
Langhammer, M.; Michaelis, M.; Hoeflich, A.; Sobczak, A.; Schön, J.; Weitzel, J. M. (2014):
High fertility phenotypes: two outbred mouse models exhibit substantially different molecular and physiological strategies warranting improved fertility. Reproduction 147 (4): 427-433
https://dx.doi.org/10.1530/REP-13-0425
Fuellen, G.; Boerries, M.; Busch, H.; de Grey, A.; Hahn, D.; Hiller, T.; Hoeflich, A.; Jansen, L.; Kaleta, C.; Meinema, A.; Schäuble, S.; Simm, A.; Schofield, P.; Smith, B.; Sühnel, J.; Vera, J.; Wagner, Wolfgang; Wönne, E.; Wuttke, D. (2013):
In silico approaches and the role of ontologies in aging research. Rejuv Res 16 (6): 540-546
https://dx.doi.org/10.1089/rej.2013.1517
Renne, U.; Langhammer, M.; Brenmoehl, J.; Walz, C.; Zeissler, A.; Tuchscherer, A.; Piechotta, M.; Wiesner, R. J.; Bielohuby, M.; Hoeflich, A. (2013):
Lifelong obesity in a polygenic mouse model prevents age- and diet-induced glucose intolerance - obesity is no road to late-onset diabetes in mice. Plos One 8 (11): e79788, 1-8
https://dx.doi.org/10.1371/journal.pone.0079788
Pitcher, M. R.; Ward, C. S.; Arvide, E. M.; Chapleau, C. A.; Pozzo-Miller, L.; Hoeflich, A.; Sivaramakrishnan, M.; Saenger, S.; Metzger, F.; Neul, J. L. (2013):
Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function. Hum Mol Genet 22 (13): 2626-2633
https://dx.doi.org/10.1093/Hmg/Ddt111
Michaelis, M.; Langhammer, M.; Hoeflich, A.; Reinsch, N.; Schön, J.; Weitzel, J. M. (2013):
Initial characterization of an outbreed mouse model for male factor (in)fertility. Andrology 1 (5): 772-778
https://dx.doi.org/10.1111/j.2047-2927.2013.00108.x
Piechotta, M.; Kedves, K.; Araujo, M. G.; Hoeflich, A.; Metzger, F.; Heppelmann, M.; Muscher-Banse, A.; Wrenzycki, C.; Pfarrer, C.; Schuberth, H.-J.; Hoedemaker, M.; Bollwein, H.; Kaske, M. (2013):
Hepatic mRNA expression of acid labile subunit and deiodinase 1 differs between cows selected for high versus low concentrations of insulin-like growth factor 1 in late pregnancy. J Dairy Sci 96 (6): 3737-3749
https://dx.doi.org/10.3168/jds.2012-6341
Brenmoehl, J.; Hoeflich, A. (2013):
Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3. Mitochondrion 13 (6): 755-761
https://dx.doi.org/10.1016/j.mito.2013.04.002
Huguet, A.; Medja, F.; Nicole, A.; Vignaud, A.; Guiraud-Dogan, C.; Ferry, A.; Decostre, V.; Hogrel, J.-Y.; Metzger, F.; Hoeflich, A.; Baraibar, M.; Gomes-Pereira, M.; Puymirat, J.; Bassez, G.; Furling, D.; Munnich, A.; Gourdon, G. (2012):
Molecular, physiological, and motor performance defects in DMSXL mice carrying >1000 CTG repeats from the human DM1 locus. PLOS Genet 8 (11): 1-19
https://dx.doi.org/10.1371/journal.pgen.1003043
Fromm-Dornieden, C.; Lytovchenko, O.; von der Heyde, S.; Behnke, N.; Hogl, S.; Berghoff, J.; Köpper, F.; Opitz, L.; Renne, U.; Hoeflich, A.; Beissbarth, T.; Brenig, B.; Baumgartner, B. G. (2012):
Extrinsic and intrinsic regulation of DOR/TP53INP2 expression in mice: effects of dietary fat content, tissue type and sex in adipose and muscle tissues. Nutr Metab 9 (1): 86-97
https://dx.doi.org/10.1186/1743-7075-9-86
Saenger, S.; Holtmmann, B.; Nilges, M.; Schroeder, S.; Hoeflich, A.; Kletzl, H.; Spooren, W.; Ostrowizki, S.; Hanania, T.; Sendtner, M.; Metzger, F. (2012):
Funktional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity. Amyotroph Lateral Sc 13 (5): 418-429
https://dx.doi.org/10.3109/17482968.2012.679944
Fuellen, G.; Dengjel, J.; Hoeflich, A.; Hoeijemakers, J.; Kestler, H. A.; Kowald, A.; Priebe, S.; Rebholz-Schuhmann, D.; Schmeck, B.; Schmitz, U.; Stolzing, A.; Sühnel, J.; Wuttke, D.; Vera, J. (2012):
Systems biology and bioinformatics in aging research: a workshop report. Rejuv Res 15 (6): 631-641
https://dx.doi.org/10.1089/rej.2012.1360
Sawitzky, M.; Zeissler, A.; Langhammer, M.; Bielohuby, M.; Stock, K. F.; Hammon, H. M.; Görs, S.; Metges, C. C.; Stoehr, B. J. M.; Bidlingmaier, M.; Fromm-Dornieden, C.; Baumgartner, B. G.; Christ, B.; Brenig, B.; Binder, G.; Metzger, F.; Renne, U.; Hoeflich, A. (2012):
Phenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female mice. Plos One 7 (6): 1-13
https://dx.doi.org/10.1371/journal.pone.0039711