PD Dr. rer. nat. habil. Andreas Höflich
Forschungsinstitut für Nutztierbiologie (FBN)
Leiter der Arbeitsgruppe Endokrinologie der Nutztiere
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Leiter der Arbeitsgruppe Endokrinologie der Nutztiere
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Forschungsinteressen
- Wachstum und Metabolismus
- Funktionelle Genomanalyse
- Biomarkerforschung
Lebenslauf
- seit 2013: Abteilungsleiter Signaltransduktion am FBN Dummerstorf
- seit 2009: Vorlesungen an der Universität Rostock
- 4/2009: Habilitation Mathematisch-Naturwissenschaftlichen Fakultät der Universität Rostock
- 2006-2012: Arbeitsgruppenleiter Mausgenetik am FBN Dummerstorf
- 2002-2006: Vorlesungen an der Universität Rostock
- 6/2002: Habilitation an der Veterinärmedizinischen Fakultät der Universität München
- 1996-2002: Oberassistent an der Universität München
- 6/1995: Dissertation am Institut für Organische Chemie und Biologie der Technischen Universität München
- 1985-2002: Studium der Biologie an der Universität Erlangen-Nürnberg
Lehre
Molekulare Tierzucht: Vorlesungen und Seminare innerhalb des Programms Vielfalt und Evolution (MSc) an der Universität Rostock
Publikationen
Schäff, C. T.; Gruse, J.; Maciej, J.; Mielenz, M.; Wirthgen, E.; Hoeflich, A.; Schmicke, M.; Pfuhl, R.; Jawor, P.; Stefaniak, T.; Hammon, H. M. (2016):
Effects of feeding milk replacer ad libitum or in restricted amounts for the first five weeks of life on the growth, metabolic adaptation, and immune status of newborn calves. Plos One 11 (12): e0168974, 1-24
https://dx.doi.org/10.1371/journal.pone.0168974
Fischer, J.; Ortel, M.; Hagmann, S.; Hoeflich, A.; Richter, W. (2016):
Role of PTHrP(1-34) pulse frequency versus pulse duration to enhance mesenchymal stromal cell chondrogenesis. J Cell Physiol 231 (12): 2673-2681
https://dx.doi.org/10.1002/jcp.25369
Ohde, D.; Moeller, M.; Brenmoehl, J.; Walz, C.; Ponsuksili, S.; Schwerin, M.; Fuellen, G.; Hoeflich, A. (2016):
Advanced running performance by genetic predisposition in male Dummerstorf marathon mice (DUhTP) reveals higher sterol regulatory element-binding protein (SREBP) related mRNA expression in the liver and higher serum levels of progesterone. Plos One 11 (1): e0146748, 1-16
https://dx.doi.org/10.1371/journal.pone.0146748
Hoeflich, A.; Reyer, A.; Ohde, D.; Brenmoehl, J.; Spitschak, M.; Langhammer, M.; Tuchscherer, A.; Wirthgen, E.; Renner-Müller, Ingrid; Wanke, R.; Metzger, F.; Bielohuby, M.; Wolf, E. (2016):
Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice. Aging Cell 15 (1): 111-117
https://dx.doi.org/10.1111/acel.12413
Kammel, A.; Saussenthaler, S.; Jähnert, M.; Jonas, W.; Stirm, L.; Hoeflich, A.; Staiger, H.; Fritsche, A.; Häring, H.-U.; Joost, H.-G.; Schürmann, A.; Schwenk, R. W. (2016):
Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice. Hum Mol Genet 25 (12): 2588-2599
https://dx.doi.org/10.1093/hmg/ddw121
Ohde, D.; Brenmoehl, J.; Walz, C.; Tuchscherer, A.; Wirthgen, E.; Hoeflich, A. (2016):
Comparative analysis of hepatic miRNA levels in male marathon mice reveals a link between obesity and endurance exercise capacities. J Comp Physiol B 186 (8): 1067-1078
https://dx.doi.org/10.1007/s00360-016-1006-0
Swiderski, K.; Martins, K. J. B.; Chee, A.; Trieu, J.; Naim, T.; Gehrig, S. M.; Baum, D. M.; Brenmoehl, J.; Chau, L.; Koopman, R.; Metzger, F.; Hoeflich, A.; Lynch, G. S. (2016):
Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology. Growth Horm IGF Res 30-31: 1-10
https://dx.doi.org/10.1016/j.ghir.2016.07.002
Wirthgen, E.; Höflich, C.; Spitschak, M.; Helmer, C.; Brand, B.; Langbein, J.; Metzger, F.; Hoeflich, A. (2016):
Quantitative Western ligand blotting reveals common patterns and differential features of IGFBP-fingerprints in domestic ruminant breeds and species. Growth Horm IGF Res 26: 42-49
https://dx.doi.org/10.1016/j.ghir.2015.11.001
Oster, M.; Nuchchanart, W.; Trakooljul, N.; Muràni, E.; Zeyner, A.; Wirthgen, E.; Hoeflich, A.; Ponsuksili, S.; Wimmers, K. (2016):
Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and IGF signalling and increases foetal weight. Eur J Nutr 55 (4): 1717-1727
https://dx.doi.org/10.1007/s00394-015-0990-2
Wirthgen, E.; Hoeflich, A. (2015):
Endotoxin-induced tryptophan degradation along the kynurenine pathway: the role of indolamine 2,3-dioxygenase and aryl hydrocarbon receptor-mediated immunosuppressive effects in endotoxin tolerance and cancer and its implications for immunoparalysis. J Amino Acids 2015: 1-13
https://dx.doi.org/10.1155/2015/973548
Kunze, M.; Wirthgen, E.; Walz, C.; Spitschak, M.; Brenmoehl, J.; Vanselow, J.; Schwerin, M.; Wimmers, K.; Hoeflich, A. (2015):
Bioanalytical validation for simultaneous quantification of non-aromatic steroids in follicular fluid from cattle via ESI-LC-MS/MS. J Chromatogr B 1007: 132-139
https://dx.doi.org/10.1016/j.jchromb.2015.10.010
Brenmoehl, J.; Ohde, D.; Walz, C.; Tuchscherer, A.; Schultz, J.; Rieder, F.; Hoeflich, A. (2015):
Dynamics of fat mass in DUhTP mice selected for running performance - fat mobilization in a walk. Obesity Facts 8 (6): 373-385
https://dx.doi.org/10.1159/000442399
Schindler, N.; Gimsa, U.; Mayer, J.; Kirschstein, T.; Brenmoehl, J.; Ohde, D.; Wirthgen, E.; Höflich, A. (2015):
Functional analysis of the Cardin Weintraub motif present in IGFBP-2 transgenic mice. Schriftenreihe / Leibniz-Institut für Nutztierbiol 24: 29-32
Wiedmer, P.; Schwarz, F.; Grosse, Birgit; Schindler, N.; Tuchscherer, A.; Russo, V. C.; Tschöp, M. H.; Hoeflich, A. (2015):
Gender-specific effects on food intake but no inhibition of age- related fat accretion in transgenic mice overexpressing human IGFBP-2 lacking the Cardin-Weintraub sequence motif. J Cell Commun Signal 9 (2): 143-150
https://dx.doi.org/10.1007/s12079-015-0264-z
Piechotta, M.; Mysegades, W.; Ligges, U.; Lilienthal, J.; Hoeflich, A.; Miyamoto, A.; Bollwein, H. (2015):
Antepartal insulin-like growth factor 1 and insulin-like growth factor binding protein 2 concentrations are indicative of ketosis in dairy cows. J Dairy Sci 98 (5): 3100-3109
https://dx.doi.org/10.3168/jds.2014-8885
Simon, C. M.; Rauskolb, S.; Gunnersen, J. M.; Holtmann, B.; Drepper, C.; Dombert, B.; Braga, M.; Wiese, S.; Jablonka, S.; Pühringer, D.; Zielasek, J.; Hoeflich, A.; Silani, V.; Wolf, E.; Kneitz, S.; Sommer, C.; Toyka, K. V.; Sendtner, M. (2015):
Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy. Acta Neuropathol 130 (3): 373-387
https://dx.doi.org/10.1007/s00401-015-1446-8
Ohde, D.; Brenmoehl, J.; Walz, C.; Höflich, A. (2015):
Identification and characterization of microRNAs relevant for energy metabolism in Dummerstorf "marathon mice" DUhTP. Schriftenreihe / Leibniz-Institut für Nutztierbiol 24: 33-36"
Meyerholz, M. M.; Mense, K.; Lietzau, M.; Kassens, A.; Linden, M.; Knaak, H.; Wirthgen, E.; Hoeflich, A.; Raliou, M.; Richard, C.; Olivier, S.; Schuberth, H.-J.; Hoedemaker, M.; Schmicke, M. (2015):
Serum IGFBP4 concentration decreased in dairy heifers towards day 18 of pregnancy. J Vet Sci 16 (4): 413-421
https://dx.doi.org/10.4142/jvs.2015.16.4.413
Hoeflich, A.; Russo, VC (2015):
Physiology and pathophysiology of IGFBP-1 and IGFBP-2-Consensus and dissent on metabolic control and malignant potential. Best Pract Res Cl En 29 (5): 685-700
https://dx.doi.org/10.1016/j.beem.2015.07.002
Reyer, A.; Schindler, N.; Ohde, D.; Walz, C.; Kunze, M.; Tuchscherer, A.; Wirthgen, E.; Brenmoehl, J.; Hoeflich, A. (2015):
The RGD sequence present in IGFBP-2 is required for reduced glucose clearance after oral glucose administration in female transgenic mice. Am J Physiol-Endoc M 309 (4): 409-417
https://dx.doi.org/10.1152/ajpendo.00168.2015