PD Dr. rer. nat. habil. Andreas Höflich
Forschungsinstitut für Nutztierbiologie (FBN)
Leiter der Arbeitsgruppe Endokrinologie der Nutztiere
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Leiter der Arbeitsgruppe Endokrinologie der Nutztiere
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Forschungsinteressen
- Wachstum und Metabolismus
- Funktionelle Genomanalyse
- Biomarkerforschung
Lebenslauf
- seit 2013: Abteilungsleiter Signaltransduktion am FBN Dummerstorf
- seit 2009: Vorlesungen an der Universität Rostock
- 4/2009: Habilitation Mathematisch-Naturwissenschaftlichen Fakultät der Universität Rostock
- 2006-2012: Arbeitsgruppenleiter Mausgenetik am FBN Dummerstorf
- 2002-2006: Vorlesungen an der Universität Rostock
- 6/2002: Habilitation an der Veterinärmedizinischen Fakultät der Universität München
- 1996-2002: Oberassistent an der Universität München
- 6/1995: Dissertation am Institut für Organische Chemie und Biologie der Technischen Universität München
- 1985-2002: Studium der Biologie an der Universität Erlangen-Nürnberg
Lehre
Molekulare Tierzucht: Vorlesungen und Seminare innerhalb des Programms Vielfalt und Evolution (MSc) an der Universität Rostock
Publikationen
Wirthgen, E.; Hoeflich, A.; Rebl, A.; Günther, J. (2017):
Kynurenic acid: The Janus-faced role of an immunomodulatory tryptophan metabolite and its link to pathological conditions. Front Immunol 8: 1957, 1-13
https://dx.doi.org/10.3389/fimmu.2017.01957
Hoeflich, A.; Kiess, W. (2017):
Preface: Hormones in milk. Best Pract Res Cl En 31 (4): 363-365
https://doi.org/10.1016/j.beem.2017.11.003
Hoeflich, A.; Meyer, Z. (2017):
Functional analysis of the IGF-system in milk. Best Pract Res Cl En 31 (4): 409-418
https://dx.doi.org/10.1016/j.beem.2017.10.002
Schindler, N.; Mayer, J.; Saenger, S.; Gimsa, U.; Walz, C.; Ohde, D.; Wirthgen, E.; Tuchscherer, A.; Russo, V. C.; Frank, M.; Kirschstein, T.; Metzger, F.; Hoeflich, A. (2017):
Phenotype analysis of male transgenic mice overexpressing mutant IGFBP-2 lacking the Cardin-Weintraub sequence motif: reduced expression of synaptic markers and myelin basic protein in the brain and a lower degree of anxiety-like behaviour. Growth Horm IGF Res 33: 1-8
https://dx.doi.org/10.1016/j.ghir.2016.11.003
Meyer, Z.; Höflich, C.; Wirthgen, E.; Olm, S.; Hammon, H. M.; Hoeflich, A. (2017):
Analysis of the IGF-system in milk from farm animals - occurrence, regulation, and biomarker potential. Growth Horm IGF Res 35: 1-7
https://dx.doi.org/10.1016/j.ghir.2017.05.004
Espelund, U. S.; Bjerre, M.; Hjortebjerg, R.; Rasmussen, R.; Lundby, A.; Hoeflich, A.; Folkersen, B. H.; Oxvig, C.; Frystyk, J. (2017):
Insulin-like growth factor bioactivity, stanniocalcin-2, pregnancy-associated plasma protein-A, and IGF-binding protein-4 in pleural fluid and serum from patients with pulmonary disease. J CLIN ENDOCR METAB 102 (9): 3526-3534
https://dx.doi.org/10.1210/jc.2017-00033
Wirthgen, E.; Kunze, M.; Goumon, S.; Walz, C.; Höflich, C.; Spitschak, M.; Brenmoehl, J.; Kanitz, E.; Tuchscherer, M.; Otten, W.; Gimsa, U.; Schön, P.- C.; Manteuffel, C.; Tuchscherer, A.; Pfuhl, R.; Metges, C. C.; Stabenow, B.; Erdmann, S.; Schluricke, K.; Faucitano, L.; Hoeflich, A. (2017):
Interference of stress with the somatotropic axis in pigs - lights on new biomarkers. Sci Rep-UK 7: 12055, 1-13
Julia Brenmoehl,
Winfried Otten,
Ulrike Gimsa,
Christian Manteuffel,
Cornelia Christiane Metges,
Andreas Höflich
https://dx.doi.org/10.1038/s41598-017-11521-5
Brenmoehl, J.; Ohde, D.; Albrecht, E.; Walz, C.; Tuchscherer, A.; Hoeflich, A. (2017):
Browning of subcutaneous fat and higher surface temperature in response to phenotype selection for advanced endurance exercise performance in male DUhTP mice. J Comp Physiol B 187 (2): 361-373
https://dx.doi.org/10.1007/s00360-016-1036-7
López, I. P.; Pineiro-Hermida, S.; Pais, R.; Torrens, R.; Hoeflich, A.; Pichel, J. G. (2016):
Involvement of Igf1r in bronchiolar epithelial regeneration: role during repair kinetics after selective club cell ablation. Plos One 11 (11): e0166388, 1-32
https://dx.doi.org/10.1371/journal.pone.0166388
Schäff, C. T.; Gruse, J.; Maciej, J.; Mielenz, M.; Wirthgen, E.; Hoeflich, A.; Schmicke, M.; Pfuhl, R.; Jawor, P.; Stefaniak, T.; Hammon, H. M. (2016):
Effects of feeding milk replacer ad libitum or in restricted amounts for the first five weeks of life on the growth, metabolic adaptation, and immune status of newborn calves. Plos One 11 (12): e0168974, 1-24
https://dx.doi.org/10.1371/journal.pone.0168974
Fischer, J.; Ortel, M.; Hagmann, S.; Hoeflich, A.; Richter, W. (2016):
Role of PTHrP(1-34) pulse frequency versus pulse duration to enhance mesenchymal stromal cell chondrogenesis. J Cell Physiol 231 (12): 2673-2681
https://dx.doi.org/10.1002/jcp.25369
Ohde, D.; Moeller, M.; Brenmoehl, J.; Walz, C.; Ponsuksili, S.; Schwerin, M.; Fuellen, G.; Hoeflich, A. (2016):
Advanced running performance by genetic predisposition in male Dummerstorf marathon mice (DUhTP) reveals higher sterol regulatory element-binding protein (SREBP) related mRNA expression in the liver and higher serum levels of progesterone. Plos One 11 (1): e0146748, 1-16
https://dx.doi.org/10.1371/journal.pone.0146748
Hoeflich, A.; Reyer, A.; Ohde, D.; Brenmoehl, J.; Spitschak, M.; Langhammer, M.; Tuchscherer, A.; Wirthgen, E.; Renner-Müller, Ingrid; Wanke, R.; Metzger, F.; Bielohuby, M.; Wolf, E. (2016):
Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice. Aging Cell 15 (1): 111-117
https://dx.doi.org/10.1111/acel.12413
Kammel, A.; Saussenthaler, S.; Jähnert, M.; Jonas, W.; Stirm, L.; Hoeflich, A.; Staiger, H.; Fritsche, A.; Häring, H.-U.; Joost, H.-G.; Schürmann, A.; Schwenk, R. W. (2016):
Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice. Hum Mol Genet 25 (12): 2588-2599
https://dx.doi.org/10.1093/hmg/ddw121
Ohde, D.; Brenmoehl, J.; Walz, C.; Tuchscherer, A.; Wirthgen, E.; Hoeflich, A. (2016):
Comparative analysis of hepatic miRNA levels in male marathon mice reveals a link between obesity and endurance exercise capacities. J Comp Physiol B 186 (8): 1067-1078
https://dx.doi.org/10.1007/s00360-016-1006-0
Swiderski, K.; Martins, K. J. B.; Chee, A.; Trieu, J.; Naim, T.; Gehrig, S. M.; Baum, D. M.; Brenmoehl, J.; Chau, L.; Koopman, R.; Metzger, F.; Hoeflich, A.; Lynch, G. S. (2016):
Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology. Growth Horm IGF Res 30-31: 1-10
https://dx.doi.org/10.1016/j.ghir.2016.07.002
Wirthgen, E.; Höflich, C.; Spitschak, M.; Helmer, C.; Brand, B.; Langbein, J.; Metzger, F.; Hoeflich, A. (2016):
Quantitative Western ligand blotting reveals common patterns and differential features of IGFBP-fingerprints in domestic ruminant breeds and species. Growth Horm IGF Res 26: 42-49
https://dx.doi.org/10.1016/j.ghir.2015.11.001
Oster, M.; Nuchchanart, W.; Trakooljul, N.; Muràni, E.; Zeyner, A.; Wirthgen, E.; Hoeflich, A.; Ponsuksili, S.; Wimmers, K. (2016):
Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and IGF signalling and increases foetal weight. Eur J Nutr 55 (4): 1717-1727
https://dx.doi.org/10.1007/s00394-015-0990-2
Wirthgen, E.; Hoeflich, A. (2015):
Endotoxin-induced tryptophan degradation along the kynurenine pathway: the role of indolamine 2,3-dioxygenase and aryl hydrocarbon receptor-mediated immunosuppressive effects in endotoxin tolerance and cancer and its implications for immunoparalysis. J Amino Acids 2015: 1-13
https://dx.doi.org/10.1155/2015/973548