PD Dr. rer. nat. habil. Andreas Höflich
Forschungsinstitut für Nutztierbiologie (FBN)
Leiter der Arbeitsgruppe Endokrinologie der Nutztiere
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Leiter der Arbeitsgruppe Endokrinologie der Nutztiere
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Forschungsinteressen
- Wachstum und Metabolismus
- Funktionelle Genomanalyse
- Biomarkerforschung
Lebenslauf
- seit 2013: Abteilungsleiter Signaltransduktion am FBN Dummerstorf
- seit 2009: Vorlesungen an der Universität Rostock
- 4/2009: Habilitation Mathematisch-Naturwissenschaftlichen Fakultät der Universität Rostock
- 2006-2012: Arbeitsgruppenleiter Mausgenetik am FBN Dummerstorf
- 2002-2006: Vorlesungen an der Universität Rostock
- 6/2002: Habilitation an der Veterinärmedizinischen Fakultät der Universität München
- 1996-2002: Oberassistent an der Universität München
- 6/1995: Dissertation am Institut für Organische Chemie und Biologie der Technischen Universität München
- 1985-2002: Studium der Biologie an der Universität Erlangen-Nürnberg
Lehre
Molekulare Tierzucht: Vorlesungen und Seminare innerhalb des Programms Vielfalt und Evolution (MSc) an der Universität Rostock
Publikationen
Haubold, S. S.; Kröger-Koch, C.; Tuchscherer, A.; Kanitz, E.; Weitzel, J. M.; Hoeflich, A.; Starke, S.; Tröscher, A.; Sauerwein, H.; Hammon, H. M. (2020):
Effects of a combined essential fatty acid and conjugated linoleic acid abomasal infusion on metabolic and endocrine traits, including the somatotropic axis, in dairy cows. J Dairy Sci 103 (12): 12069-12082
https://doi.org/10.3168/jds.2020-18569
Walz, M.; Chau, L.; Sawitzky, M.; Ohde, D.; Brenmoehl, J.; Tuchscherer, A.; Langhammer, M.; Metzger, F.; Höflich, C.; Hoeflich, A. (2020):
Overlap of peak growth activity and peak IGF-1 to IGFBP ratio: delayed increase of IGFBPs versus IGF-1 in serum as a mechanism to speed up and down postnatal weight gain in mice. Cells-Basel 9 (6): 1516, 1-12
https://doi.org/10.3390/cells9061516
Hoeflich, A.; Fitzner, B.; Walz, C.; Hecker, M.; Tuchscherer, A.; Bastian, M.; Brenmoehl, J.; Schröder, S.; Willenberg, H.S.; Reincke, M. (2020):
Systemic effects by intrathecal administration of triamcinolone acetonide in patients with multiple sclerosis. Front Endocrinol 11: 574, 1-8
https://doi.org/10.3389/fendo.2020.00574
Ohde, D.; Walz, M.; Walz, C.; Noce, A.; Brenmoehl, J.; Langhammer, M.; Hoeflich, A. (2020):
Sex-specific control of muscle mass: elevated IGFBP proteolysis and reductions of IGF-1 levels are associated with substantial loss of carcass weight in male DU6PxIGFBP-2 transgenic mice. Cells-Basel 9 (10): 2174, 1-17
https://doi.org/10.3390/cells9102174
Galow, A.-M.; Wolfien, M.; Müller, J.; Bartsch, M.; Brunner, R. M.; Hoeflich, A.; Wolkenhauer, O.; David, R.; Goldammer, T. (2020):
Integrative cluster analysis of whole hearts reveals proliferative cardiomyocytes in adult mice. Cells-Basel 9 (5): 1144,1-16
https://doi.org/10.3390/cells9051144
Wolfien, M.; Galow, A.-M.; Müller, J.; Bartsch, M.; Brunner, R. M.; Goldammer, T.; Wolkenhauer, O.; Höflich, A.; David, R. (2020):
Single nuclei sequencing of entire mammalian hearts: strain-dependent cell type composition and velocity. Cardiovasc Res 116 (7): 1249-1251
https://doi.org/10.1093/cvr/cvaa054
Wolfien, MW; Galow, A.-M.; Müller, P.; Bartsch, M.; Brunner, R. M.; Goldammer, T.; Wolkenhauer, O.; Höflich, A.; David, R. (2020):
Single-nucleus sequencing of an entire mammalian heart: cell type composition and velocity. Cells-Basel 9 (2): 318,1-6
https://doi.org/10.3390/cells9020318
Liermann, W.; Schäff, C. T.; Gruse, J.; Derno, M.; Weitzel, J. M.; Kanitz, E.; Otten, W.; Höflich, A.; Stefaniak, T.; Sauerwein, H.; Bruckmaier, R. M.; Gross, J.; Hammon, H. M. (2020):
Effects of colostrum instead of formula feeding for the first two days post natum on whole body energy metabolism and its endocrine control in neonatal calves. J Dairy Sci 103 (4): 3577-3598
https://doi.org/10.3168/jds.2019-17708
Wirthgen, E.; Goumon, S.; Kunze, M.; Walz, C.; Spitschak, M.; Tuchscherer, A.; Brown, J.; Höflich, C.; Faucitano, L.; Hoeflich, A. (2018):
Effects of transport duration and environmental conditions in winter or summer on the concentrations of insulin-like growth factors and insulin-like growth factor-binding proteins in the plasma of market-weight pigs. Front Endocrinol 9: 36, 1-10
https://doi.org/10.3389/fendo.2018.00036
Spitschak, M.; Hoeflich, A. (2018):
Potential functions of IGFBP-2 for ovarian folliculogenesis and steroidogenesis. Front Endocrinol 9: 119, 1-6
https://doi.org/10.3389/fendo.2018.00119
Mense, K.; Heidekorn-Dettmer, J.; Wirthgen, E.; Brockelmann, Y.; Bortfeldt, R.; Peter, S.; Jung, M.; Höflich, C.; Hoeflich, A.; Schmicke, M. (2018):
Increased concentrations of insulin-like growth factor binding protein (IGFBP)-2, IGFBP-3, and IGFBP-4 are associated with fetal mortality in pregnant cows. Front Endocrinol 9: 310, 1-10
https://doi.org/10.3389/fendo.2018.00310
Hoeflich, A.; David, R.; Hjortebjerg, R. (2018):
Current IGFBP-related biomarker research in cardiovascular disease - we need more structural and functional information in clinical studies. Front Endocrinol 9: 388, 1-11
https://doi.org/10.3389/fendo.2018.00388
Hesse, D.; Trost, J.; Schäfer, N.; Schwerbel, K.; Hoeflich, A.; Schürmann, A.; Brockmann, G. A. (2018):
Effect of adipocyte-derived IGF-I on adipose tissue mass and glucose metabolism in the Berlin Fat Mouse. Growth Factors 36 (1-2): 78-88
https://doi.org/10.1080/08977194.2018.1497621
Hinrichs, A.; Kessler, B.; Kurome, M.; Blutke, A.; Kemter, E.; Bernau, M.; Scholz, A. M.; Rathkolb, B.; Renner, S.; Bultmann, S.; Leonhardt, H.; ..., ; Hoeflich, A.; ..., (2018):
Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver. Mol Metab 11: 113-128
https://doi.org/10.1016/j.molmet.2018.03.006
Hoeflich, A.; Pintar, J.; Forbes, B. (2018):
Editoral: Current perspectives on insulin-like growth factor binding protein (IGFBP) research. Front Endocrinol 9: 667, 1-2
https://doi.org/10.3389/fendo.2018.00667
Nipkow, M.; Wirthgen, E.; Luft, P.; Rebl, A.; Hoeflich, A.; Goldammer, T. (2018):
Characterization of igf1 and igf2 genes during maraena whitefish (Coregonus maraena) ontogeny and the effect of temperature on embryogenesis and igf expression. Growth Horm IGF Res 40: 32-43
https://doi.org/10.1016/j.ghir.2018.04.003
Brenmoehl, J.; Walz, C.; Spitschak, M.; Wirthgen, E.; Walz, M.; Langhammer, M.; Tuchscherer, A.; Naumann, R.; Höflich, A. (2018):
Partial phenotype conversion and differential trait response to conditions of husbandry in mice. J Comp Physiol B 188 (3): 527-539
https://doi.org/10.1007/s00360-017-1138-x
Hoeflich, A.; Kiess, W. (2018):
Preface : Hormones in milk - new directions. Best Pract Res Cl En 32 (1): 1-3
https://doi.org/10.1016/j.beem.2018.01.008
Brenmoehl, J.; Ohde, D.; Wirthgen, E.; Hoeflich, A. (2018):
Cytokines in milk and the role of TGF-beta. Best Pract Res Cl En 32 (1): 47-56
https://doi.org/10.1016/j.beem.2018.01.006
Frieten, D.; Gerbert, C.; Koch, C.; Dusel, G.; Eder, K.; Hoeflich, A.; Mielenz, B.; Hammon, H. M. (2018):
Influence of ad libitum milk replacer feeding and butyrate supplementation on the systemic and hepatic insulin-like growth factor I and its binding proteins in Holstein calves. J Dairy Sci 101 (2): 1661-1672
https://doi.org/10.3168/jds.2017-13603