PD Dr. rer. nat. habil. Andreas Höflich

Forschungsinstitut für Nutztierbiologie (FBN)
Leiter der Arbeitsgruppe Endokrinologie der Nutztiere
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

ResearchGate

Forschungsinteressen

Wachstum und Metabolismus
Funktionelle Genomanalyse
Biomarkerforschung

Lebenslauf

seit 2013: Abteilungsleiter Signaltransduktion am FBN Dummerstorf
seit 2009: Vorlesungen an der Universität Rostock
4/2009: Habilitation Mathematisch-Naturwissenschaftlichen Fakultät der Universität Rostock
2006-2012: Arbeitsgruppenleiter Mausgenetik am FBN Dummerstorf
2002-2006: Vorlesungen an der Universität Rostock
6/2002: Habilitation an der Veterinärmedizinischen Fakultät der Universität München
1996-2002: Oberassistent an der Universität München
6/1995: Dissertation am Institut für Organische Chemie und Biologie der Technischen Universität München
1985-2002: Studium der Biologie an der Universität Erlangen-Nürnberg

Lehre

Molekulare Tierzucht: Vorlesungen und Seminare innerhalb des Programms Vielfalt und Evolution (MSc) an der Universität Rostock

Publikationen

Galow, A.-M.; Kussauer, S.K; Wolfien, M.; Brunner, R. M.; Goldammer, T.; Hoeflich, A.; David, R. (2021):

Quality control in scRNA-Seq can discriminate pacemaker cells: the mtRNA bias

Anne-Marie Galow, Tom Goldammer, Andreas Höflich

Cellular and Molecular Life Sciences 78: 6585-6592

https://doi.org/10.1007/s00018-021-03916-5

Uken, K. L.; Vogel, L.; Gnott, M.; Görs, S.; Schäff, C. T.; Tuchscherer, A.; Hoeflich, A.; Weitzel, J. M.; Kanitz, E.; Tröscher, A.; Sauerwein, H.; Zitnan, R.; Bruckmaier, R. M.; Gross, J.; Liermann, W.; Hammon, H. M. (2021):

Effect of maternal supplementation with essential fatty acids and conjugated linoleic acid on metabolic and endocrine development of neonatal calves

Solvig Görs, Andreas Höflich, Joachim Weitzel, Wendy Liermann, Harald Michael Hammon

Journal of Dairy Science 104 (6): 7295-7314

https://doi.org/10.3168/jds.2020-20039

Walz, M.; Höflich, C.; Walz, C.; Ohde, D.; Brenmoehl, J.; Sawitzky, M.; Vernunft, A.; Zettl, U. K.; Holtze, S.; Hildebrandt, T. B.; Wolf, E.; Hoeflich, A. (2021):

Development of a Sensitive Bioassay for the Analysis of IGF-Related Activation of AKT/mTOR Signaling in Biological Matrices

Andreas Höflich, Julia Brenmoehl, Andreas Vernunft

Cells 10 (3): 482, 1-19

https://doi.org/10.3390/cells10030482

Walz, C.; Brenmoehl, J.; Trakooljul, N.; Noce, A.; Caffier, C.; Ohde, D.; Langhammer, M.; Wimmers, K.; Ponsuksili, S.; Hoeflich, A. (2021):

Control of Protein and Energy Metabolism in the Pituitary Gland in Response to Three-Week Running Training in Adult Male Mice

Julia Brenmoehl, Klaus Wimmers, Siriluck Wimmers, Andreas Höflich

Cells 10 (4): 736, 1-20

https://doi.org/10.3390/cells10040736

Noce, A.; Qanbari, S.; Gonzalez-Prendes, R.; Brenmoehl, J.; Luigi-Sierra, M. G.; Theerkorn, M.; Fiege, M.-A.; Pilz, H.; Bota, A.; Vidu, L.; Horwath, C.; Haraszthy, L.; Penchev, P.; Ilieva, Y.; Peeva, T.; Lüpcke, W.; Krawczynski, R.; Wimmers, K.; Thiele, M.; Hoeflich, A. (2021):

Genetic Diversity of Bubalus bubalis in Germany and Global Relations of Its Genetic Background

Julia Brenmoehl, Klaus Wimmers, Andreas Höflich

Frontiers in Genetics 11: 610353, 1-16

https://doi.org/10.3389/fgene.2020.610353

Vogel, L.; Gnott, M.; Kröger-Koch, C.; Görs, S.; Weitzel, J. M.; Kanitz, E.; Hoeflich, A.; Tuchscherer, A.; Tröscher, A.; Gross, J.; Bruckmaier, R. M.; Starke, S.; Bachmann, L.; Hammon, H. M. (2021):

Glucose metabolism and the somatotropic axis in dairy cows after abomasal infusion of essential fatty acids together with conjugated linoleic acid during late gestation and early lactation

Solvig Görs, Joachim Weitzel, Andreas Höflich, Lisa Bachmann, Harald Michael Hammon

Journal of Dairy Science 104: 3646-3664

https://doi.org//10.3168/jds.2020-19321

Hoeflich, A.; Fitzner, B.; Walz, C.; Hecker, M.; Tuchscherer, A.; Brenmoehl, J.; Zettl, U. K. (2021):

Reduced Fragmentation of IGFBP-2 and IGFBP-3 as a Potential Mechanism for Decreased Ratio of IGF-II to IGFBPs in Cerebrospinal Fluid in Response to Repeated Intrathecal Administration of Triamcinolone Acetonide in Patients With Multiple Sclerosis

Andreas Höflich, Julia Brenmoehl

Frontiers in Endocrinology 11: 565557, 1-10

https://doi.org/10.3389/fendo.2020.565557

Braude, S.; Holtze, S.; Begall, S.; Brenmoehl, J.; Burda, H.; Dammann, P.; de Marmol, D.; Gorshkova, E.; Henning, Y.; Hoeflich, A.; Höhn, A.; Jung, T.; Hamo, D.; Sahm, A.; Shebzukhov, Y.; Šumbera, R.; Miwa, S.; Vyssokikh, M.; von Zglinicki, T.; Averina, O.; Hildebrandt, T. B. (2021):

Surprisingly long survival of premature conclusions about naked mole-rat biology

Julia Brenmoehl, Andreas Höflich

Biology Reviews 96 (2): 376-393

https://doi.org/10.1111/brv.12660

Galow, A.-M.; Goldammer, T.; Hoeflich, A. (2020):

Xenogeneic and stem cell-based therapy for cardiovascular diseases: genetic engineering of porcine cells and their applications in heart regeneration. Int J Mol Sci 21 (24): 9686, 1-22

Anne-Marie Galow, Tom Goldammer, Andreas Höflich

https://doi.org/10.3390/ijms21249686

Brenmoehl, J.; Ohde, D.; Walz, C.; Langhammer, M.; Schultz, J.; Hoeflich, A. (2020):

Analysis of activity-dependent energy metabolism in mice reveals regulation of mitochondrial fission and fusion mRNA by voluntary physical exercise in subcutaneous fat from male marathon mice (DUhTP)

Julia Brenmoehl, Andreas Höflich

Cells 9 (12): 2697, 1-20

https://doi.org/10.3390/cells9122697

Haubold, S. S.; Kröger-Koch, C.; Tuchscherer, A.; Kanitz, E.; Weitzel, J. M.; Hoeflich, A.; Starke, S.; Tröscher, A.; Sauerwein, H.; Hammon, H. M. (2020):

Effects of a combined essential fatty acid and conjugated linoleic acid abomasal infusion on metabolic and endocrine traits, including the somatotropic axis, in dairy cows

Joachim Weitzel, Andreas Höflich, Harald Michael Hammon

Journal of Dairy Science 103 (12): 12069-12082

https://doi.org/10.3168/jds.2020-18569

Walz, M.; Chau, L.; Sawitzky, M.; Ohde, D.; Brenmoehl, J.; Tuchscherer, A.; Langhammer, M.; Metzger, F.; Höflich, C.; Hoeflich, A. (2020):

Overlap of peak growth activity and peak IGF-1 to IGFBP ratio: delayed increase of IGFBPs versus IGF-1 in serum as a mechanism to speed up and down postnatal weight gain in mice. Cells-Basel 9 (6): 1516, 1-12

Julia Brenmoehl, Andreas Höflich

https://doi.org/10.3390/cells9061516

Hoeflich, A.; Fitzner, B.; Walz, C.; Hecker, M.; Tuchscherer, A.; Bastian, M.; Brenmoehl, J.; Schröder, S.; Willenberg, H.S.; Reincke, M. (2020):

Systemic effects by intrathecal administration of triamcinolone acetonide in patients with multiple sclerosis. Front Endocrinol 11: 574, 1-8

Andreas Höflich, Julia Brenmoehl

https://doi.org/10.3389/fendo.2020.00574

Ohde, D.; Walz, M.; Walz, C.; Noce, A.; Brenmoehl, J.; Langhammer, M.; Hoeflich, A. (2020):

Sex-specific control of muscle mass: elevated IGFBP proteolysis and reductions of IGF-1 levels are associated with substantial loss of carcass weight in male DU6PxIGFBP-2 transgenic mice. Cells-Basel 9 (10): 2174, 1-17

Julia Brenmoehl, Andreas Höflich

https://doi.org/10.3390/cells9102174

Galow, A.-M.; Wolfien, M.; Müller, J.; Bartsch, M.; Brunner, R. M.; Hoeflich, A.; Wolkenhauer, O.; David, R.; Goldammer, T. (2020):

Integrative cluster analysis of whole hearts reveals proliferative cardiomyocytes in adult mice

Anne-Marie Galow, Andreas Höflich, Tom Goldammer

Cells 9 (5): 1144, 1-16

https://doi.org/10.3390/cells9051144

Wolfien, M.; Galow, A.-M.; Müller, J.; Bartsch, M.; Brunner, R. M.; Goldammer, T.; Wolkenhauer, O.; Höflich, A.; David, R. (2020):

Single nuclei sequencing of entire mammalian hearts: strain-dependent cell type composition and velocity. Cardiovasc Res 116 (7): 1249-1251

Anne-Marie Galow, Tom Goldammer, Andreas Höflich

https://doi.org/10.1093/cvr/cvaa054

Wolfien, MW; Galow, A.-M.; Müller, P.; Bartsch, M.; Brunner, R. M.; Goldammer, T.; Wolkenhauer, O.; Höflich, A.; David, R. (2020):

Single-nucleus sequencing of an entire mammalian heart: cell type composition and velocity. Cells-Basel 9 (2): 318,1-6

Anne-Marie Galow, Tom Goldammer, Andreas Höflich

https://doi.org/10.3390/cells9020318

Liermann, W.; Schäff, C. T.; Gruse, J.; Derno, M.; Weitzel, J. M.; Kanitz, E.; Otten, W.; Höflich, A.; Stefaniak, T.; Sauerwein, H.; Bruckmaier, R. M.; Gross, J.; Hammon, H. M. (2020):

Effects of colostrum instead of formula feeding for the first two days post natum on whole body energy metabolism and its endocrine control in neonatal calves

Wendy Liermann, Joachim Weitzel, Andreas Höflich, Harald Michael Hammon

Journal of Dairy Science 103 (4): 3577-3598

https://doi.org/10.3168/jds.2019-17708

Wirthgen, E.; Goumon, S.; Kunze, M.; Walz, C.; Spitschak, M.; Tuchscherer, A.; Brown, J.; Höflich, C.; Faucitano, L.; Hoeflich, A. (2018):

Effects of transport duration and environmental conditions in winter or summer on the concentrations of insulin-like growth factors and insulin-like growth factor-binding proteins in the plasma of market-weight pigs. Front Endocrinol 9: 36, 1-10

Andreas Höflich

https://doi.org/10.3389/fendo.2018.00036

Spitschak, M.; Hoeflich, A. (2018):

Potential functions of IGFBP-2 for ovarian folliculogenesis and steroidogenesis. Front Endocrinol 9: 119, 1-6

Andreas Höflich

https://doi.org/10.3389/fendo.2018.00119