PD Dr. rer. nat. Andreas Höflich

+49 38208 68-902
Leibniz-Institut für Nutztierbiologie (FBN)
Institut für Genombiologie
Abteilung Signaltransduktion
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Forschungsinteressen

  • Wachstum und Metabolismus
  • Funktionelle Genomanalyse
  • Biomarkerforschung

Lebenslauf

  • seit 2013: Abteilungsleiter Signaltransduktion am FBN Dummerstorf
  • seit 2009: Vorlesungen an der Universität Rostock
  • 4/2009: Habilitation Mathematisch-Naturwissenschaftlichen Fakultät der Universität Rostock
  • 2006-2012: Arbeitsgruppenleiter Mausgenetik am FBN Dummerstorf
  • 2002-2006: Vorlesungen an der Universität Rostock
  • 6/2002: Habilitation an der Veterinärmedizinischen Fakultät der Universität München
  • 1996-2002: Oberassistent an der Universität München
  • 6/1995: Dissertation am Institut für Organische Chemie und Biologie der Technischen Universität München
  • 1985-2002: Studium der Biologie an der Universität Erlangen-Nürnberg

Lehre

Molekulare Tierzucht: Vorlesungen und Seminare innerhalb des Programms Vielfalt und Evolution (MSc) an der Universität Rostock

Publikationen

Hoeflich, A.; Fitzner, B.; Walz, C.; Hecker, M.; Tuchscherer, A; Brenmoehl, J.; Zettl, U. K. (2021):
Reduced fragmentation of IGFBP-2 and IGFBP-3 as a potential mechanism for decreased ratios of IGF-II to IGFBPs in cerebrospinal fluid in response to repeated intrathecal administration of triamcinolone acetonide in patients with multiple sclerosis. Front Endocrinol 11: 565557, 1-10
Noce, A.; Qanbari, S.; Gonzalez-Prendes, R.; Brenmoehl, J.; Luigi-Sierra, M. G.; Theerkorn, M.; Fiege, M.-A.; Pilz, H.; Bota, A.; Vidu, L.; Horwath, C.; Haraszthy, L.; Penchev, P.; Ilieva, Y.; Peeva, T.; Lüpcke, W.; Krawczynski, R.; Wimmers, K.; Thiele, M.; Hoeflich, A. (2021):
Genetic diversity of Bubalus bubalis in Germany and global relations of its genetic background. Front Genet
Walz, C.; Brenmoehl, J.; Trakooljul, N.; Noce, A.; Caffier, C.; Ohde, D.; Langhammer, M.; Wimmers, K.; Ponsuksili, S.; Hoeflich, A. (2021):
Control of protein and energy metabolism in the pituitary gland in response to three-week running training in adult male mice. Cells-Basel 10: 736, 1-20
Walz, M.; Höflich, C.; Walz, C.; Ohde, D.; Sawitzky, M.; Vernunft, A.; Zettl, U. K.; Holtze, S.; Hildebrandt, T. B.; Wolf, E.; Hoeflich, A. (2021):
Development of a sensitive bioassay for the analysis of IGF-related activation of AKT/mTOR signaling in biological matrices. Cells-Basel 10 (3): 482, 1-19
Liermann, W.; Schäff, C.; Gruse, J.; Derno, M.; Weitzel, J. M.; Kanitz, E.; Otten, W.; Höflich, A.; Stefaniak, T.; Sauerwein, H.; Bruckmaier, R.; Gross, J.; Hammon, H. M. (2020):
Effects of colostrum instead of formula feeding for the first two days post natum on whole body energy metabolism and its endocrine control in neonatal calves. J Dairy Sci 103 (4): 3577-3598
Wolfien, MW; Galow, A.-M.; Müller, P.; Bartsch, M.; Brunner, R. M.; Goldammer, T.; Wolkenhauer, O.; Höflich, A.; David, R. (2020):
Single-nucleus sequencing of an entire mammalian heart: cell type composition and velocity. Cells-Basel 9 (2): 318,1-6
Wolfien, M.; Galow, A.-M.; Müller, P.; Bartsch, M.; Brunner, R. M.; Goldammer, T.; Wolkenhauer, O.; Höflich, A.; David, R. (2020):
Single nuclei sequencing of entire mammalian hearts: strain-dependent cell type composition and velocity. Cardiovasc Res 116 (7): 1249-1251
Galow, A.-M.; Wolfien, M.; Müller, P.; Bartsch, M.; Brunner, R. M.; Hoeflich, A.; Wolkenhauer, O.; David, R.; Goldammer, T. (2020):
Integrative cluster analysis of whole hearts reveals proliferative cardiomyocytes in adult mice. Cells-Basel 9 (5): 1144,1-16
Ohde, D.; Walz, M.; Walz, C.; Noce, A.; Brenmoehl, J.; Langhammer, M.; Hoeflich, A. (2020):
Sex-specific control of muscle mass: elevated IGFBP proteolysis and reductions of IGF-1 levels are associated with substantial loss of carcass weight in male DU6PxIGFBP-2 transgenic mice. Cells-Basel 9 (10): 2174, 1-17
Hoeflich, A.; Fitzner, B.; Walz, C.; Hecker, M.; Tuchscherer, A; Bastian, M.; Brenmoehl, J.; Schröder, S.; Willenberg, H.S.; Reincke, M. (2020):
Systemic effects by intrathecal administration of triamcinolone acetonide in patients with multiple sclerosis. Front Endocrinol 11: 574, 1-8
Walz, M.; Chau, L.; Sawitzky, M.; Ohde, D.; Brenmoehl, J.; Tuchscherer, A; Langhammer, M.; Metzger, F.; Höflich, C.; Hoeflich, A. (2020):
Overlap of peak growth activity and peak IGF-1 to IGFBP ratio: delayed increase of IGFBPs versus IGF-1 in serum as a mechanism to speed up and down postnatal weight gain in mice. Cells-Basel 9 (6): 1516, 1-12
Braude, S.; Holtze, S.; Begall, S.; Brenmoehl, J.; Burda, H.; Dammann, P.; de Marmol, D.; Gorshkova, E.; Henning, Y.; Hoeflich, A.; Höhn, A.; Jung, T.; Hamo, D.; Sahm, A.; Shebzukhov, Y.; Šumbera, R.; Miwa, S.; Vyssokikh, M.; von Zglinicki, T.; Averina, O.; Hildebrandt, T. B. (2020):
Surprisingly long survival of premature conclusions about naked mole-rat biology. Biol Rev
Haubold, S.S; Kröger-Koch, C.; Tuchscherer, A; Kanitz, E.; Weitzel, J. M.; Hoeflich, A.; Starke, A.; Tröscher, A.; Sauerwein, H.; Hammon, H. M. (2020):
Effects of a combined essential fatty acid and conjugated linoleic acid abomasal infusion on metabolic and endocrine traits, including the somatotropic axis, in dairy cows. J Dairy Sci 103 (12): 12069-12082
Brenmoehl, J.; Ohde, D.; Walz, C.; Langhammer, M.; Schultz, J.; Hoeflich, A. (2020):
Analysis of activity-dependent energy metabolism in mice reveals regulation of mitochondrial fission and fusion mRNA by voluntary physical exercise in subcutaneous fat from male marathon mice (DUhTP). Cells-Basel 9: 2697, 1-20
Galow, A.-M.; Goldammer, T.; Hoeflich, A. (2020):
Xenogeneic and stem cell-based therapy for cardiovascular diseases: genetic engineering of porcine cells and their applications in heart regeneration. Int J Mol Sci 21 (24): 9686, 1-22
Vogel, L.; Gnott, M.; Kröger-Koch, C.; Görs, S.; Weitzel, J. M.; Kanitz, E.; Hoeflich, A.; Tuchscherer, A; Tröscher, A.; Gross, J.; Bruckmaier, R.; Starke, A.; Bachmann, L.; Hammon, H. M. (2020):
Glucose metabolism and the somatotropic axis in dairy cows after abomasal infusion of essential fatty acids together with conjugated linoleic acid during late gestation and early lactation. J Dairy Sci
Frieten, D.; Gerbert, C.; Koch, C.; Dusel, G.; Eder, K.; Hoeflich, A.; Mielenz, B.; Hammon, H. M. (2018):
Influence of ad libitum milk replacer feeding and butyrate supplementation on the systemic and hepatic insulin-like growth factor I and its binding proteins in Holstein calves. J Dairy Sci 101 (2): 1661-1672
Brenmoehl, J.; Ohde, D.; Wirthgen, E.; Hoeflich, A. (2018):
Cytokines in milk and the role of TGF-beta. Best Pract Res Cl En 32 (1): 47-56
Hoeflich, A.; Kiess, W. (2018):
Preface : Hormones in milk - new directions. Best Pract Res Cl En 32 (1): 1-3
Brenmoehl, J.; Walz, C.; Spitschak, M.; Wirthgen, E.; Walz, M.; Langhammer, M.; Tuchscherer, A; Naumann, R.; Höflich, A. (2018):
Partial phenotype conversion and differential trait response to conditions of husbandry in mice. J Comp Physiol B 188 (3): 527-539