PD Dr. rer. nat. Andreas Höflich

+49 38208 68-902
Leibniz-Institut für Nutztierbiologie (FBN)
Institut für Genombiologie
Abteilung Signaltransduktion
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Forschungsinteressen

  • Wachstum und Metabolismus
  • Funktionelle Genomanalyse
  • Biomarkerforschung

Lebenslauf

  • seit 2013: Abteilungsleiter Signaltransduktion am FBN Dummerstorf
  • seit 2009: Vorlesungen an der Universität Rostock
  • 4/2009: Habilitation Mathematisch-Naturwissenschaftlichen Fakultät der Universität Rostock
  • 2006-2012: Arbeitsgruppenleiter Mausgenetik am FBN Dummerstorf
  • 2002-2006: Vorlesungen an der Universität Rostock
  • 6/2002: Habilitation an der Veterinärmedizinischen Fakultät der Universität München
  • 1996-2002: Oberassistent an der Universität München
  • 6/1995: Dissertation am Institut für Organische Chemie und Biologie der Technischen Universität München
  • 1985-2002: Studium der Biologie an der Universität Erlangen-Nürnberg

Lehre

Molekulare Tierzucht: Vorlesungen und Seminare innerhalb des Programms Vielfalt und Evolution (MSc) an der Universität Rostock

Publikationen

Liermann, W.; Schäff, C.; Gruse, J.; Derno, M.; Weitzel, J. M.; Kanitz, E.; Otten, W.; Höflich, A.; Stefaniak, T.; Sauerwein, H.; Bruckmaier, R.; Gross, J.; Hammon, H. M. (2020):
Effects of colostrum instead of formula feeding for the first two days post natum on whole body energy metabolism and its endocrine control in neonatal calves. J Dairy Sci 103 (4): 3577-3598
Wolfien, MW; Galow, A.-M.; Müller, P.; Bartsch, M.; Brunner, R. M.; Goldammer, T.; Wolkenhauer, O.; Höflich, A.; David, R. (2020):
Single-nucleus sequencing of an entire mammalian heart: cell type composition and velocity. Cells-Basel 9 (2): 318,1-6
Wolfien, M.; Galow, A.-M.; Müller, P.; Bartsch, M.; Brunner, R. M.; Goldammer, T.; Wolkenhauer, O.; Höflich, A.; David, R. (2020):
Single nuclei sequencing of entire mammalian hearts: strain-dependent cell type composition and velocity. Cardiovasc Res 116 (7): 1249-1251
Galow, A.-M.; Wolfien, M.; Müller, P.; Bartsch, M.; Brunner, R. M.; Hoeflich, A.; Wolkenhauer, O.; David, R.; Goldammer, T. (2020):
Integrative cluster analysis of whole hearts reveals proliferative cardiomyocytes in adult mice. Cells-Basel 9 (5): 1144,1-16
Ohde, D.; Walz, M.; Walz, C.; Noce, A.; Brenmoehl, J.; Langhammer, M.; Hoeflich, A. (2020):
Sex-specific control of muscle mass: elevated IGFBP proteolysis and reductions of IGF-1 levels are associated with substantial loss of carcass weight in male DU6PxIGFBP-2 transgenic mice. Cells-Basel 9 (10): 2174, 1-17
Hoeflich, A.; Fitzner, B.; Walz, C.; Hecker, M.; Tuchscherer, A; Bastian, M.; Brenmoehl, J.; Schröder, S.; Willenberg, H.S.; Reincke, M. (2020):
Systemic effects by intrathecal administration of triamcinolone acetonide in patients with multiple sclerosis. Front Endocrinol 11: 574, 1-8
Walz, M.; Chau, L.; Sawitzky, M.; Ohde, D.; Brenmoehl, J.; Tuchscherer, A; Langhammer, M.; Metzger, F.; Höflich, C.; Hoeflich, A. (2020):
Overlap of peak growth activity and peak IGF-1 to IGFBP ratio: delayed increase of IGFBPs versus IGF-1 in serum as a mechanism to speed up and down postnatal weight gain in mice. Cells-Basel 9 (6): 1516, 1-12
Braude, S.; Holtze, S.; Begall, S.; Brenmoehl, J.; Burda, H.; Dammann, P.; de Marmol, D.; Gorshkova, E.; Henning, Y.; Hoeflich, A.; Höhn, A.; Jung, T.; Hamo, D.; Sahm, A.; Shebzukhov, Y.; Šumbera, R.; Miwa, S.; Vyssokikh, M.; von Zglinicki, T.; Averina, O.; Hildebrandt, T. B. (2020):
Surprisingly long survival of premature conclusions about naked mole-rat biology. Biol Rev (https://doi.org/10.1111/brv.12660)
Frieten, D.; Gerbert, C.; Koch, C.; Dusel, G.; Eder, K.; Hoeflich, A.; Mielenz, B.; Hammon, H. M. (2018):
Influence of ad libitum milk replacer feeding and butyrate supplementation on the systemic and hepatic insulin-like growth factor I and its binding proteins in Holstein calves. J Dairy Sci 101 (2): 1661-1672
Brenmoehl, J.; Ohde, D.; Wirthgen, E.; Hoeflich, A. (2018):
Cytokines in milk and the role of TGF-beta. Best Pract Res Cl En 32 (1): 47-56
Hoeflich, A.; Kiess, W. (2018):
Preface : Hormones in milk - new directions. Best Pract Res Cl En 32 (1): 1-3
Brenmoehl, J.; Walz, C.; Spitschak, M.; Wirthgen, E.; Walz, M.; Langhammer, M.; Tuchscherer, A; Naumann, R.; Höflich, A. (2018):
Partial phenotype conversion and differential trait response to conditions of husbandry in mice. J Comp Physiol B 188 (3): 527-539
Nipkow, M.; Wirthgen, E.; Luft, P.; Rebl, A.; Hoeflich, A.; Goldammer, T. (2018):
Characterization of igf1 and igf2 genes during maraena whitefish (Coregonus maraena) ontogeny and the effect of temperature on embryogenesis and igf expression. Growth Horm IGF Res 40: 32-43
Hoeflich, A.; Pintar, J.; Forbes, B. (2018):
Editoral: Current perspectives on insulin-like growth factor binding protein (IGFBP) research. Front Endocrinol 9: 667, 1-2
Hinrichs, A.; Kessler, B.; Kurome, M.; Blutke, A.; Kemter, E.; Bernau, M.; Scholz, A. M.; Rathkolb, B.; Renner, S.; Bultmann, S.; Leonhardt, H.; ..., ; Hoeflich, A.; ..., (2018):
Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver. Mol Metab 11: 113-128
Hesse, D.; Trost, J.; Schäfer, N.; Schwerbel, K.; Hoeflich, A.; Schürmann, A.; Brockmann, G. A. (2018):
Effect of adipocyte-derived IGF-I on adipose tissue mass and glucose metabolism in the Berlin Fat Mouse. Growth Factors 36 (1-2): 78-88
Hoeflich, A.; David, R.; Hjortebjerg, R. (2018):
Current IGFBP-related biomarker research in cardiovascular disease - we need more structural and functional information in clinical studies. Front Endocrinol 9: 388, 1-11
Mense, K.; Heidekorn-Dettmer, J.; Wirthgen, E.; Brockelmann, Y.; Bortfeldt, R.; Peter, S.; Jung, M.; Höflich, C.; Hoeflich, A.; Schmicke, M. (2018):
Increased concentrations of insulin-like growth factor binding protein (IGFBP)-2, IGFBP-3, and IGFBP-4 are associated with fetal mortality in pregnant cows. Front Endocrinol 9: 310, 1-10
Spitschak, M.; Hoeflich, A. (2018):
Potential functions of IGFBP-2 for ovarian folliculogenesis and steroidogenesis. Front Endocrinol 9: 119, 1-6
Wirthgen, E.; Goumon, S.; Kunze, M.; Walz, C.; Spitschak, M.; Tuchscherer, A; Brown, J.; Höflich, C.; Faucitano, L.; Hoeflich, A. (2018):
Effects of transport duration and environmental conditions in winter or summer on the concentrations of insulin-like growth factors and insulin-like growth factor-binding proteins in the plasma of market-weight pigs. Front Endocrinol 9: 36, 1-10