Dr. rer. nat. Alexander Rebl
Forschungsinteressen
- Aufklärung von immunologischen und stressphysiologischen Mechanismen, die zur Optimierung von Gesundheitskonzepten in der Aquakultur beitragen
- Erfassung der molekulargenetischen Unterschiede zwischen Individuen und Populationen etablierter und neuer Aquakulturfischarten in Hinblick auf Immunkompetenz und Performance
Lebenslauf
- 2014-heute: Wissenschaftler in der Abteilung Fischgenetik am Forschungsinstitut für Nutztierbiologie (FBN) Dummerstorf
- 2009-2014: Nachwuchsgruppenleiter in der Abteilung Fischgenetik am Leibniz Institut für Nutztierbiologie (FBN)
- 2007-2009: Postdoc in der Abteilung Fischgenetik am Leibniz Institut für Nutztierbiologie (FBN)
- 2007: Promotion in Molekularbiologie
- 2004-2007: Promotionsstudent an der Universität Rostock
- 1999-2004: Diplomand an der Universität Rostock
Publikationen
Köbis, J.; Rebl, H.; Goldammer, T.; Rebl, A. (2017):
Multiple gene and transcript variants encoding trout C-polysaccharide binding proteins are differentially but strongly induced after infection with Aeromonas salmonicida. Fish Shellfish Immun 60: 509-519
https://dx.doi.org/10.1016/j.fsi.2016.11.021
Rebl, A.; Rebl, H.; Köbis, J.; Goldammer, T.; Seyfert, H.-M. (2017):
ST2 from rainbow trout quenches TLR signalling, localises at the nuclear membrane and allows the nuclear translocation of MYD88. Dev Comp Immunol 67: 139-152
https://dx.doi.org/10.1016/j.dci.2016.10.009
Korytar, T.; Nipkow, M.; Altmann, S.; Goldammer, T.; Köllner, B.; Rebl, A. (2016):
Adverse husbandry of Maraena whitefish directs the immune system to increase mobilization of myeloid cells and proinflammatory responses. Front Immunol 7: 631, 1-14
https://dx.doi.org/10.3389/fimmu.2016.00631
Goldammer, T.; Rebl, A.; Köllner, B.; Kühn, C. (2016):
Genetische Biomarker zur Evaluierung einer standortgerechten Aquakultur in M-V – Ergebnisse der EFF-Pilotprojekte Regenbogenforelle Stamm BORN und Ostseeschnäpel. Fischerei und Fischmarkt in Mecklenburg-Vorpommern 16 (3): 32-41
Altmann, S.; Korytar, T.; Kaczmarzyk, D.; Nipkow, M.; Kühn, C.; Goldammer, T.; Rebl, A. (2016):
Toll-like receptors in maraena whitefish: Evolutionary relationship among salmonid fishes and patterns of response to Aeromonas salmonicida. Fish Shellfish Immun 54: 391-401
https://dx.doi.org/10.1016/j.fsi.2016.04.125
Brietzke, A.; Arnemo, M.; Gjøen, T.; Rebl, H.; Korytar, T.; Goldammer, T.; Rebl, A.; Seyfert, H.-M. (2016):
Structurally diverse genes encode TLR2 in rainbow trout: The conserved receptor cannot be stimulated by classical ligands to activate NF-kB in vitro. Dev Comp Immunol 54 (1): 75-88
https://dx.doi.org/10.1016/j.dci.2015.08.012
Altmann, S.; Rebl, A.; Kühn, C.; Goldammer, T. (2015):
Identification and de novo sequencing of housekeeping genes appropriate for gene expression analyses in farmed maraena whitefish (Coregonus maraena) during crowding stress. Fish Physiol Biochem 41 (2): 397-412
https://dx.doi.org/10.1007/s10695-014-9991-y
Verleih, M.; Borchel, A.; Krasnov, A.; Rebl, A.; Korytar, T.; Kühn, C.; Goldammer, T. (2015):
Impact of thermal stress on kidney-specific gene expression in farmed regional and imported rainbow trout. Mar Biotechnol 17 (5): 576-592
https://dx.doi.org/10.1007/s10126-015-9640-1
Rebl, A.; Nipkow, M.; Goldammer, T.; Kühn, C. (2015):
Ostseeschnäpel aus regionaler Aquakultur : Wie kann Haltungsstress aufgedeckt werden?. Forschungsreport 51: 4-7
Brietzke, J.; Korytar, T.; Jaros, J.; Köllner, B.; Goldammer, T.; Seyfert, H.-M.; Rebl, A. (2015):
Aeromonas salmonicida infection only moderately regulates expression of factors contributing to toll-like receptor signaling but massively activates the cellular and humoral branches of innate immunity in rainbow trout (Oncorhynchus mykiss). J Immunol Res 2015: 901015, 1-16
https://dx.doi.org/10.1155/2015/901015
Zante, M.D.; Borchel, A.; Brunner, R. M.; Goldammer, T.; Rebl, A. (2015):
Cloning and characterization of the proximal promoter region of rainbow trout (Oncorhynchus mykiss) interleukin-6 gene. Fish Shellfish Immun 43 (1): 249-256
https://dx.doi.org/10.1016/j.fsi.2014.12.026
Köbis, J.; Rebl, A.; Kühn, C.; Korytar, T.; Köllner, B.; Goldammer, T. (2015):
Comprehensive and comparative transcription analyses of the complement pathway in rainbow trout. Fish Shellfish Immun 42 (1): 98-107
https://dx.doi.org/10.1016/j.fsi.2014.10.032
Rebl, A.; Goldammer, T. (2014):
Burnoutprophylaxe für Forellen. Leibniz Nordost 18: 10-11
Rebl, A.; Brietzke, A.; Goldammer, T.; Seyfert, H.-M. (2014):
GRP94 is encoded by two differentially expressed genes during development of rainbow trout (Oncorhynchus mykiss). Fish Physiol Biochem 40 (6): 1917-1926
https://dx.doi.org/10.1007/s10695-014-9979-7
Borchel, A.; Verleih, M.; Rebl, A.; Goldammer, T. (2014):
Cold shock induced changes in gene expression in rainbow trout (Oncorhynchus mykiss). In: 15th Day of the Doctoral Student : abstracts, 13 May 2014 Dummerstorf (Schriftenreihe / Leibniz-Institut für Nutztierbiologie , 23) (Christa Kühn, Gunther Viereck, Hrsg.): 25-28
Borchel, A.; Verleih, M.; Rebl, A.; Kühn, C.; Goldammer, T. (2014):
Creatine metabolism differs between mammals and rainbow trout (Oncorhynchus mykiss). SpringerPlus 3: 510-519
https://dx.doi.org/10.1186/2193-1801-3-510
Rebl, A.; Rebl, H.; Korytar, T.; Goldammer, T.; Seyfert, H.-M. (2014):
The proximal promoter of a novel interleukin-8-encoding gene in rainbow trout (Oncorhynchus mykiss) is strongly induced by CEBPA, but not NF-κB p65. Dev Comp Immunol 46 (2): 155-164
https://dx.doi.org/10.1016/j.dci.2014.03.024
Brietzke, A.; Goldammer, T.; Rebl, H.; Korytar, T.; Köllner, B.; Yang, W.; Rebl, A.; Seyfert, H.-M. (2014):
Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: the functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells. Fish Shellfish Immun 36 (1): 206-214
https://dx.doi.org/10.1016/j.fsi.2013.11.005
Rebl, A.; Korytar, T.; Köbis, J.; Verleih, M.; Krasnov, A.; Jaros, J.; Kühn, C.; Köllner, B.; Goldammer, T. (2014):
Transcriptome profiling reveals insight into distinct immune responses to Aeromonas salmonicida in gill of two rainbow trout strains. Mar Biotechnol 16 (4): 333-348
https://dx.doi.org/10.1007/s10126-013-9552-x