Projekt


Fertility impairment by maternal stress: Regulation of oviduct epithelium physiology and oviduct derived extracellular vesicles by cortisol and its impact on early embryonic development

Kontakt: Dr. Nares Trakooljul

Laufzeit: 2019-2022

Förderung: Deutsche Forschungsgemeinschaft, DFG TR 1656/1-1

Zusammenfassung:
Exposure to maternal stress during the sensitive-window of preimplantation can exert negative impact and consequences on the early embryonic development. Due to the relatively short time span, until now the influence of stress through oviduct has been largely overlooked. Currently the underlying mechanisms of how stress hormone, i.e. cortisol, locally regulates the oviduct physiology and oviduct derived EVs are far from being understood. Therefore, in this project we proposed to utilize the air-liquid interphase (ALI) culture procedure and long-term culture of differentiated porcine and bovine oviduct epithelial cells (ALI-POEC and ALI-BOEC) models to investigate the molecular impact of maternal stress on early embryonic development especially the regulation of oviduct epithelium physiology and oviduct derived extracellular vesicles via cortisol.