Project


Characterization of mineral utilisation by functional genomics in two contrasting high-yielding laying hen strains

Contact: Prof. Dr. Klaus Wimmers

Duration: 2022-2025

Funding: Deutsche Forschungsgemeinschaft, DFG WI 1754/16-1

Abstract:
DFG-Research Unit P-FOWL (FOR 2601) Project 3: Characterization of mineral utilisation by functional genomics in two contrasting high-yielding laying hen strains The project investigates endogenous mechanisms of phosphorus (P) and myo-inositol metabolism with the aim of understanding the drivers of variable P utilisation in highly productive laying hens (Lohmann Brown (LB) and Lohmann Selected Leghorn (LSL)) in the complex interplay of diet × microbiome × host through analysis of the host transcriptome and endocrine regulation. Here the focus is on endogenous, post-absorptive mechanisms of P and myo-inositol metabolism in bone and kidney tissue. Thereby, molecular signalling pathways and associated metabolic processes will be identified that are differentially regulated due to phenotypic variability in P efficiency, variable P supply and the development of sexual maturity at the beginning of laying in the two laying hen strains. In parallel, the endocrine response to the experimental conditions will be recorded and the relationship between endocrine and transcriptional shifts will be investigated. The data will be analysed in the context of the multi-layered measurements within the Research Unit and interpreted in terms of the role of the host and microbiota in InsP6 degradation, P utilisation, and the molecular endogenous mechanisms of P and myo-inositol uptake, transformation and distribution.