Molecular mechanisms of phosphate homeostasis and osteoimmunological processes and their consequences for health and welfare

Contact: Prof. Dr. Klaus Wimmers

Duration: 2020-2023

Funding: Leibniz Association / P-Campus

The project aims at analysing osteoimmunological pathways compromised by P in the microenvironment of the bone marrow in order to combine a thrifty and efficient P-supply with animal health and immunity. Ca and P serum levels are the primary signals activating endocrine responses that in consequence address a number of known and yet to be elucidated sensors and regulators. Results of our previous P-Campus project led to the hypothesis that the P-dependent interplay of osteogenic and hematopoietic cells affects bone metabolism and immunity. In fact, holistic expression analyses showed a P-triggered activation of respective pathways, i.e. Bone Morphogenetic Protein (BMP) and Receptor Activator of NF-ĸB (incl. RANK) signalling. BMP signalling promotes formation and maturation of bone cells but the RANKL/RANK system activates the bone-degrading osteoclasts and also effectively stimulates immune cells (CD4). Functional and regulatory networks of transcripts will reveal a comprehensive picture of all components and their interactions contributing to P-dependent osteoimmunological functions.