EnErGie/P4 Metabolische Grundlagen von krankheitsbedingter Malnutrition und Sarkopenie

Contact: Prof. Dr. Cornelia C. Metges

Duration: 2018-2022

Funding: Europäischer Sozialfonds (Landesamt für Gesundheit und Soziales Mecklenburg-Vorpommern)

Malnutrition and sarcopenia are consequences of life-threatening gastrointestinal diseases, such as liver cirrhosis, chronic pancreatitis, and short bowel syndrome. In this context we will investigate metabolic interrelationships between malnutrition, sarcopenia and low-grade systemic inflammation. Furthermore, we will explore nutrient metabolism changes and regulatory networks caused by deficiency of dietary nutrients and energy. Together with partners of the University Medicine of Rostock and Greifswald we will perform studies in mouse models of liver cirrhosis, pancreatitis and short-bowel syndrome and will compare the data with patient data of cross-sectional and longitudinal studies. In addition a diagnostic tool set will be developed allowing to monitor disease progress, and identify disease stage indicators. Methods applied include the investigation of the blood plasma metabolome, immune cell funtion, tracer and gene expression studies and the monitoring of longitudinal changes of the intestinal microbiome.