The Editor-in-Chief of the Journal of Comparative Physiology B, Prof. Dr. Gerhard Heldmaier, has chosen an article on genetic linkage of running performance, fat accretion, and metabolic health in the Dummerstorf marathon mouse model DUhTP as „Highlight article of issue 2 (2017)“
FBN scientists Julia Brenmoehl, Daniela Ohde, Elke Albrecht, Christina Walz, Armin Tuchscherer and Andreas Hoeflich report in their recent publication (“Browning of subcutaneous fat and higher surface temperature in response to phenotype selection for advanced endurance exercise performance in male DUhTP mice”), that superior running performance in Dummerstorf marathon mice (DUhTP) is accompanied by efficient fat metabolization even during moderate voluntary running wheel activity. In marathon mice, expression of PPARa and UCP1 in subcutaneous fat correlates with elevated surface temperature. In addition, DUhTP mice are more sensitive to oral glucose application if compared to unselected controls. All phenotypes can be observed in sedentary mice in the absence of running wheels suggesting the genetic linkage of running performance and metabolic health in the marathon mouse model.
You can find the open access article here:
http://doi.org/10.1007/s00360-016-1036-7
