PD Dr. biol. hom. habil. Sebastian Peter Galuska
Research Institute for Farm Animal Biology (FBN)
Head of working group Glycoimmunology
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Head of working group Glycoimmunology
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Research interests
- Glycobiology
- Reproductive Biology
- Immunology
- Glycoanalytic
Curriculum Vitae
- since 2020: Head of the Glycobiology Unit at the Institute of Reproductive Biology, Research Institute for Farm Animal Biology (FBN), Dummerstorf, Germany
- 2016–2020: Junior Group Leader at the Institute of Reproductive Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany
- 2012–2016: Junior Group leader at the Institute of Biochemistry, Medical Faculty of the Justus-Liebig University, Giessen, Germany
- 2008–2012: Postdoctoral Research Fellow at the Institute of Biochemistry, Medical Faculty of the Justus-Liebig University, Giessen, Germany
- 2008: Dr. in human biology, Dr. biol. hom.
- 2003–2008: PhD student at the Institute of Biochemistry, Medical Faculty of the Justus-Liebig University, Giessen, Germany
- 2003: Dipl. Ing. in Biotechnology
- 1999–2003: Studies in Biotechnology at the University of applied Sciences Giessen/Friedberg (THM), Germany, Germany
Teaching
since 2005: Different practical courses, seminars and lectures in the disciplines of biology and biochemistry in the Medical Faculty as well as in the Faculty of Psychology and Sports Science at the Justus-Liebig University Giessen, Germany
Publications
Venuto, M. T.; Decloquement, M.; Martorell Ribera, J.; Noel, M.; Rebl, A.; Cogez, V.; Petit, D.; Galuska, S. P.; Harduin-Lepers, A. (2020):
Vertebrate Alpha2,8-Sialyltransferases (ST8Sia): A Teleost Perspective
International Journal of Molecular Sciences 21 (2): 513, 1-21
https://doi.org/10.3390/ijms21020513
Kühnle, A.; Galuska, C.E.; Zlatina, K.; Galuska, S. P. (2020):
The bovine antimicrobial peptide lactoferricin interacts with polysialic acid without loss of its antimicrobial activity against Escherichia coli
Animals 10 (1): 1, 1-12
https://doi.org/10.3390/ani10010001
Kudipudi, P.K.; Galuska, S. P.; Dietze, R.; Scheiner-Bobis, G.; Loveland, K.; Konrad, L (2019):
Betaglycan (TβRIII) is a key factor in TGF-β2 sSignaling in prepubertal rat sertoli cells
International Journal of Molecular Sciences 20 (24): 6214, 1-18
https://doi.org/10.3390/ijms20246214
Bornhöfft, K.; Rebl, A.; Gallagher, M.E.; Viergutz, T.; Zlatina, K.; Reid, C.; Galuska, S. P. (2019):
Sialylated cervical mucins inhibit the activation of neutrophils to form neutrophil extracellular traps in bovine in vitro model
Frontiers in Immunology 10: 2478, 1-15
https://doi.org/10.3389/fimmu.2019.02478
Bornhöfft, K.; Galuska, S. P. (2019):
Glycans as modulators for the formation and functional properties of neutrophil extracellular traps: used by the forces of good and evil
Frontiers in Immunology 10: 959, 1-9
https://doi.org/10.3389/fimmu.2019.00959
Kühnle, A.; Lütteke, T.; Bornhöfft, K.; Galuska, S. P. (2019):
Polysialic acid modulates the binding of external lactoferrin in neutrophil extracellular traps
Biology 8 (2): 20, 1-13
https://doi.org/10.3390/biology8020020
Zlatina, K.; Galuska, S. P. (2019):
Polysialic acid modulates only the antimicrobial properties of distinct histones
ACS Omega 4 (1): 1601-1610
https://doi.org/10.1021/acsomega.8b02222
Kühnle, A.; Veelken, R.; Galuska, C.E.; Saftenberger, M.; Verleih, M.; Schuppe, H.C.; Rudloff, S.; Kunz, C.; Galuska, S. P. (2019):
Polysialic acid interacts with lactoferrin and supports its activity to inhibit the release of neutrophil extracellular traps
Carbohydrate Polymers 208: 32-41
https://doi.org/10.1016/j.carbpol.2018.12.033
Kronimus, Y.; Dodel, R.; Galuska, S. P.; Neumann, S. (2019):
IgG Fc N-glycosylation: Alterations in neurologic diseases and potential therapeutic target?
Journal of Autoimmunity 96: 14-23
https://doi.org/10.1016/j.jaut.2018.10.006
Strubl, S.; Schubert, U; Kühnle, A.; Rebl, A.; Ahmadvand, N.; Fischer, S.; Preissner, K.; Galuska, S. P. (2018):
Polysialic acid is released by human umbilical vein endothelial cells (HUVEC) in vitro
Cell & Bioscience 8: 64, 1-9
https://doi.org/10.1186/s13578-018-0262-y
Zlatina, K.; Saftenberger, M.; Kühnle, A.; Galuska, C.E.; Gärtner, U.; Rebl, A.; Oster, M.; Vernunft, A.; Galuska, S. P. (2018):
Polysialic acid in human plasma can compensate the cytotoxicity of histones
Kristina Zlatina,
Christina Galuska,
Alexander Rebl,
Michael Oster,
Andreas Vernunft,
Sebastian Peter Galuska
International Journal of Molecular Sciences 19 (6): 1679, 1-10
https://doi.org/10.3390/ijms19061679
Bornhöfft, K.; Goldammer, T.; Rebl, A.; Galuska, S. P. (2018):
Siglecs: a journey through the evolution of sialic acid-binding immunoglobulin-type lectins
Developmental & Comparative Immunology 86: 219-231
https://doi.org/10.1016/j.dci.2018.05.008
Zlatina, K.; Lütteke, T.; Galuska, S. P. (2017):
Individual impact of distinct polysialic acid chain lengths on the cytotoxicity of histone H1, H2A, H2B, H3 und H4. POLYMERS-BASEL 9 (12): 720, 1-13
https://dx.doi.org/10.3390/polym9120720
Galuska, C.E.; Dambon, J.; Kühnle, A.; Bornhöfft, K.; Prem, G.; Zlatina, K.; Lütteke, T.; Galuska, S. P. (2017):
Artificial polysialic acid chains as sialidase-resistant molecular-anchors to accumulate particles on neutrophil extracellular traps. Front Immunol 8: 1229, 1-10
https://dx.doi.org/10.3389/fimmu.2017.01229
Chan, K.H.; Galuska, S. P.; Kudipudi, P.K.; Riaz, M.A.; Loveland, K.L.; Konrad, L. (2017):
Signaling by TGF-betas in tubule cultures of adult rat testis. Am J Transl Res 9 (3): 1173-1182
Galuska, S. P.; Galuska, C.E.; Tharmalingam, T; Zlatina, K.; Prem, G.; Husejnov, F.C.O.; Rudd, P.M.; Vann, W.F.; Reid, C.; Vionnet, J.; Gallagher, M.E.; Carrington, F.A.; Hassett, S.L.; Carrington, S.D. (2017):
In vitro generation of polysialylated cervical mucins by bacterial polysialyltransferases to counteract cytotoxicity of extracellular histones. FEBS J 284 (11): 1688-1699
https://dx.doi.org/10.1111/febs.14073
Galuska, C.E.; Lütteke, T.; Galuska, S. P. (2017):
Is polysialylated NCAM not only a regulator during brain development but also during the formation of other organs?. BIOLOGY-BASEL 6 (2): 27,1-15
https://dx.doi.org/10.3390/biology6020027
Chen, S.; Palma Vera, S. E.; Langhammer, M.; Galuska, S. P.; Braun, B.C.; Krause, E.; Lucas-Hahn, A.; Schön, J. (2017):
An air-liquid interphase approach for modeling the early embryo-maternal contact zone. Sci Rep-UK 7: 42298, 1-7
https://dx.doi.org/10.1038/srep42298
Zhang, R.; Loers, G.; Schachner, M.; Boelens, R.; Wienk, H.; Siebert, S.; Eckert, T.; Kraan, S.; Rojas-Macias, M.; Lütteke, T.; Galuska, S. P.; Scheidig, A.; Petridis, A.; Liang, S.; Billeter, M.; Schauer, R.; Steinmeyer, J.; Schröder, J.J.; Siebert, H. (2016):
Molecular basis of the receptor interactions of polysialic acid (polySia), polySia mimetics, and sulfated polysaccharides. ChemMedChem 11 (9): 990-1002
https://dx.doi.org/10.1002/cmdc.201500609
Khosravi, F.; Michel, V.; Galuska, C. E.; Bhushan, S.; Christian, P.; Schuppe, H.C.; Pilatz, A.; Galuska, S. P.; Meinhardt, A. (2016):
Desialylation of spermatozoa and epithelial cell glycocalyx is a consequence of bacterial infection of the epididymis. J Biol Chem 291 (34): 17717-17726
https://dx.doi.org/10.1074/jbc.M116.718072