Prof. Dr. med. vet. Christa Kühn

+49 38208 68-702
Leibniz Institute for Farm Animal Biology (FBN)
Institute of Genome Biology
Genome Physiology Unit
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Research interests

  • Genome analysis
  • Animal breeding and genetics
  • Molecular genetics
  • Disease resistance

Curriculum Vitae

  • 2018-present: Head of Institute of Genome Biology
  • 2014-present: Professor for Genetics of Disease Resistance at the Faculty of Agricultural and Environmental Science at the University Rostock
  • 2013-present: Director of the Genome Physiology Unit, Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf, Institute of Genome Biology
  • 2013: Call for Professor for Genetics of Disease Resistance at the University of Rostock
  • 2012: Vice Chair Research and Development at the Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf
  • 2011: Call for Professor for Animal genetics and pathogenetics at the Justus-Liebig-Universität Gießen
  • 2008: Authorization to provide post-gradual veterinary qualification in „Molecular Biology“
  • 2005: Habilitation at the Faculty for Agricultural and Environmental Sciences of the University of Rostock
  • 2004-2012: Team leader „QTL regions“, Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf, Institute of Molecular Biology
  • 1992-present: Scientist in the Institute of Molecular Biology at the Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf
  • 1991-1992: Veterinary practitioner with focus on farm animals (cattle, pig, sheep, horse) in the veterinary centre M. Schibalski, Quakenbrück, Germany
  • 1990: Post-doc at the Veterinary University Hanover
  • 1989: Promotion to Dr. med. vet. at the Veterinary University Hannover and approbation
  • 1987: Final Veterinary State Examination at the Veterinary University Hanover

Professional Activities

  • 2011-present: Member of the Editorial Board for Animal Genetics
  • 2010-present: Editor for the Journal of Dairy Science
  • 2011-present: Treasurer of the Gesellschaft für Tierzuchtwissenschaften (GfT)
  • 2009-present: Associate Editor for Genetics, Selection, Evolution
  • 2006-2011: Editor for ANIMAL

Teaching

  • since 2004: Teaching at the Faculty of Mathematics and Natural Science at the University Rostock within Diplome and Master courses for Biology and for Diversity and Evolution
  • since 2003: Teaching at the Faculty of Agricultural and Environmental Science at the University Rostock within Bachelor and Master courses in Agricultural Science, Agricultural Ecology and Animal Science

Publications

Heimes, A.; Brodhagen, J.; Weikard, R.; Becker, D.; Meyerholz, M. M.; Petzl, W.; Zerbe, H.; Schuberth, H.-J.; Hoedemaker, M.; Schmicke, M.; Engelmann, S.; Kühn, Ch. (2020):
Cows selected for divergent mastitis susceptibility display a differntial liver transcriptome profile after experimental Staphylococcus aureus mammary gland inoculation. J Dairy Sci (https://doi.org/10.3168/jds.2019-17612)
Heimes, A.; Brodhagen, J.; Weikard, R.; Seyfert, H.-M.; Becker, D.; Meyerholz, M. M.; Petzl, W.; Zerbe, H.; Hoedemaker, M.; Rohmeier, L.; Schubert, H-J; Schmicke, M.; Engelmann, S.; Kühn, Ch. (2020):
Hepatic transcriptome analysis identifies divergent pathogen-specific targeting-strategies to modulate the innate immune system in response to intramammary infection. Front Immunol 11: 715, 1-22
Koch, F.; Thom, U.; Albrecht, E.; Weikard, R.; Nolte, W.; Kuhla, B.; Kühn, Ch. (2019):
Heat stress directly impairs gut integrity and recruits distinct immune cell populations into the bovine intestine. P Natl Acad Sci USA 116 (21): 10333-10338
Liu, Y; Albrecht, E.; Dannenberger, D.; Hammon, H. M.; Kühn, Ch.; Sauerwein, H.; Yang, R; Zhao, Z; Maak, S. (2019):
Retinol binding protein 4 abundance in plasma and tissues is related to body fat deposition in cattle. Sci Rep-UK 9: 8056, 1-13
Heimes, A.; Brodhagen, J.; Weikard, R.; Hammon, H. M.; Meyerholz, M. M.; Petzl, W.; Zerbe, H.; Engelmann, S.; Schmicke, M.; Hoedemaker, M.; Schubert, H-J; Kühn, Ch. (2019):
Characterization of functional traits with focus on udder health in heifers with divergent paternally inherited haplotypes on BTA18. BMC Vet Res 15 (1): 241, 1-11
Robic, A.; Farault, T.; Djebali, S.; Weikard, R.; Feve, K.; Maman, S.; Kühn, Ch. (2019):
Analysis of pig transcriptomes suggests a gloal regulation mechanism enabling temporary bursts of circular RNAs. RNA Biol 16 (9): 1190-1204
Brodhagen, J.; Weikard, R.; Thom, U.; Heimes, A.; Günther, J.; Hadlich, F.; Zerbe, H.; Petzl, W.; Meyerholz, M. M.; Hoedemaker, M.; Schubert, H-J; Engelmann, S.; Kühn, Ch. (2019):
Development and evaluation of a milk protein transcript depletion method for differential transcriptome analysis in mammary gland tissue. BMC Genomics 20 (1): 400, 1-19
Nolte, W.; Thaller, G.; Kühn, Ch. (2019):
Selection signatures in four German warmblood horse breeds: Tracing breeding history in the modern sport horse. Plos One 14 (4): e0215913
Meyerholz, M. M.; Rohmeier, L.; Eickhoff, T.; Hülsebusch, A.; Jander, S.; Linden, M.; Macias, L.; Koy, M; Heimes, A.; Gorriz-Martin, L.; Segelke, D.; Engelmann, S.; Schmicke, M.; Hoedemaker, M.; Petzl, W.; Zerbe, H.; Schuberth, H.-J.; Kühn, Ch. (2019):
Genetic selection for bovine chromosome 18 haplotypes associated with divergent somatic cell score affects post-partum reproductive and metabolic performance. J Dairy Sci 102 (11): 9983-9994
Nolte, W.; Weikard, R.; Brunner, R. M.; Albrecht, E.; Hammon, H. M.; Kühn, Ch. (2019):
Biological network approach for the identification of regulatory long non-coding RNAs associated with metabolic efficiency in cattle. Front Genet 10: 1130, 1-19
Hammon, H. M.; Frieten, D.; Gerbert, C.; Koch, C.; Dusel, G.; Weikard, R.; Kühn, Ch. (2018):
Different milk diets have substantial effects on the jejunal mucosal immune system of pre-weaning calves, as demonstrated by whole transcriptome sequencing. Sci Rep-UK 8: 1693, 1-14
Liu, Y.; Albrecht, E.; Schering, L.; Kühn, Ch.; Yang, R; Zhao, Z; Maak, S. (2018):
Agouti signaling protein and its receptors as potential molecular markers for intramuscular and body fat deposition in cattle. Front Physiol 9: 172, 1-13
Weikard, R.; Hadlich, F.; Hammon, H. M.; Frieten, D.; Gerbert, C.; Koch, C.; Dusel, G.; Kühn, Ch. (2018):
Long noncoding RNAs are associated with metabolic and cellular processes in the jejunum mucosa of pre-weaning calves in response to different diets. Oncotarget 9 (30): 21052-21069
Weikard, R.; Kühn, Ch. (2018):
Different mitochondrial DNA copy number in liver and mammary gland of lactating cows with divergent genetic background for milk production. Mol Biol Rep 45 (5): 1209-1218
Kühn, Ch. (2018):
Neue Phänotypen: Was können sie uns über die Diversität von Prädisposition und Haltungsansprüchen bei Nutztieren sagen?. Schriftenreihe / Leibniz-Institut für Nutztierbiol 26: 25-29
Meyerholz, M. M.; Rohmeier, L.; Eickhoff, T.; Hülsebusch, A.; Jander, S.; Koy, M; Macias, L.; Heimes, A.; Gorriz-Martin, L.; Linden, M.; Schmicke, M.; Engelmann, S.; Hoedemaker, M.; Seyfert, H.-M.; Kühn, Ch.; Petzl, W.; Zerbe, H.; Schuberth, H.-J. (2018):
Genetische Selektion auf Mastitis-Resistenz über paternale Haplotypen - ein erfolgversprechendes Modell?. In: Leitthema: Mastitisbekämpfung in Zeiten eines restriktiven Antibiotikaeinsatzes : Tagung der AG "Sachverständigenausschuss Subklinische Mastitis"
Albrecht, E.; Schering, L.; Liu, Y.; Komolka, K.; Kühn, Ch.; Wimmers, K.; Gotoh, T.; Maak, S. (2017):
Factors influencing bovine intramuscular adipose tissue development and cellularity. J Anim Sci 95 (5): 2244-2254
Weikard, R.; Demasius, W.; Kühn, Ch. (2017):
Mining long noncoding RNA in livestock. Anim Genet 48 (1): 3-18
Usman, T.; Hadlich, F.; Demasius, W.; Weikard, R.; Kühn, Ch. (2017):
Unmapped reads from cattle RNAseq data: a source for missing and misassembled sequences in the reference assemblies and for detection of pathogens in the host. Genomics 109 (1): 36-42
Schering, L.; Albrecht, E.; Komolka, K.; Kühn, Ch.; Maak, S. (2017):
Increased expression of thyroid hormone responsive protein (THRSP) is the result but not the cause of higher intramuscular fat content in cattle. Int J Biol Sci 13 (5): 532-544