Dr. rer. tech. Pål Westermark

+49 38208 68-902
Leibniz Institute for Farm Animal Biology (FBN)
Institute of Genetics and Biometry
Biomathematics and Bioinformatics Unit
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Research interests

  • Circadian rhythms in animals
  • Regulation of gene expression, metabolic and signal transduction pathways
  • Mechanisms governing tissue homeostasis
  • Senescence and aging
  • Time series analysis
  • Control theory
  • Biostatistics
  • more on:  orcid.org/0000-0002-6637-2566

Curriculum Vitae

  • 2016 – present: Head of Unit, Biomathematics and Bioinformatics, FBN Dummerstorf
  • 2011 – 2016: Group leader, Institute for Theoretical Biology, Charité – Universitätsmedizin Berlin
  • 2005 – 2011: Postdoctoral researcher, Hanspeter Herzel lab, Institute for Theoretical Biology, Charité – Universitätsmedizin Berlin
  • 2005: PhD Thesis "Models of the Metabolism of the Pancreatic β-Cell", Royal Inst. of Technology Stockholm, Sweden
  • 1999: MSc Molecular Biotechnology, Uppsala University, Sweden

Publications

Klosa, J.; Simon, N.; Westermark, P. O.; Liebscher, V.; Wittenburg, D. (2020):
Seagull: lasso, group lasso and sparse-group lasso regularisation for linear regression models via proximal gradient descent . BMC Bioinformatics 21: 407, 1-8
Pett, J. P.; Westermark, P. O.; Herzel, H. (2020):
Simple kinetic models in molecular chronobiology. In: Circadian clocks : methods and protocols (Methods in molecular biology , 2130) (Steven A. Brown, Hrsg.) Humana Press, New York (978-1-07-160380-2): 87-100
Daş, G.; Westermark, P. O.; Gauly, M. (2019):
Diurnal variation in egg excretion by Heterakis gallinarum. Parasitology 146 (2): 206-212
Wang, J.; Symul, L.; Yeung, J.; Gobet, C.; Sobel, J.; Lück, S.; Westermark, P. O.; Molina, N.; Naef, F. (2018):
Circadian clock-dependent and -independent posttranscriptional regulation underlies temporal mRNA accumulation in mouse liver. P Natl Acad Sci USA 115 (8): E1916-E1925
van der Linden, N.; Cornelis, T.; Kimenai, D. M.; Klinkenberg, L. J. J.; Hilderink, J. M.; Lück, S.; Litjens, E. J. R.; Peeters, F. E. C. M.; Streng, A. S.; Breidthardt, T.; van Loon, L. J. C.; Bekers, O.; Kooman, J. P.; Westermark, P.; Mueller, C.; Meex, S. J. R. (2017):
Origin of cardiac troponin T elevations in chronic kidney disease. Circulation 136 (11): 1073-1075
Hughes, M.; Abruzzi, K.; Allada, A.; Anafi, R.; Arpat, A. B.; Asher, G.; Baldi, P.; de Bekker, C.; Bell-Pedersen, D.; Blau, J.; Brown, S.; Ceriani, F.; ..., ; Westermark, P. O.; et al., . (2017):
Guidelines for genome-scale analysis of biological rhythms. J Biol Rhythm 32 (5): 380-393
Thurley, K.; Herbst, C.; Wesener, F.; Koller, B.; Wallach, T.; Maier, B.; Kramer, A.; Westermark, P. O. (2017):
Principles for circadian orchestration of metabolic pathways. Proceedings of the National Academy of Sciences 114: 1572-1577
Lück, S.; Westermark, P. O. (2016):
Circadian mRNA expression: insights from modeling and transcriptomics. Cell. Mol. Life Sci. 73: 497-521
Thaben, P. F.; Westermark, P. O. (2016):
Differential rhythmicity: detecting altered rhythmicity in biological data. Bioinformatics 32: 2800-2808
Westermark, P. O. (2016):
Linking core promoter classes to circadian transcription. PLoS Genet. 12: e1006231
Thaben, P. F.; Westermark, P. O. (2014):
Detecting rhythms in time series with RAIN. J. Biol. Rhythms 29: 391-400
Lück, S.; Thurley, K.; Thaben, Paul F.; Westermark, Pål O. (2014):
Rhythmic degradation explains and unifies circadian transcriptome and proteome data. Cell Reports 9: 741-751
Westermark, Pål O.; Herzel, H. (2013):
Mechanism for 12 hr rhythm generation by the circadian clock. Cell Reports 3: 1228-1238
Relógio, A.; Westermark, P. O.; Wallach, T.; Schellenberg, K.; Kramer, A.; Herzel, H. (2011):
Tuning the mammalian circadian clock: robust synergy of two loops. PLoS Comp. Biol. 7: e1002309
Arner, E.; Westermark, P. O.; Spalding, K. L.; Britton, T.; Rydén, M.; Frisén, J.; Bernard, S.; Arner, P. (2010):
Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 59: 105-109
Abraham, U.; Granada, A. E.; Westermark, P. O.; Heine, M.; Kramer, A.; Herzel, H. (2010):
Coupling governs entrainment range of circadian clocks. Mol. Syst. Biol. 6: 438
Westermark, P. O.; Welsh, D. K.; Okamura, H.; Herzel, H. (2009):
Quantification of circadian rhythms in single cells. PLoS Comp. Biol. 5: e1000580
Spalding, K. L.; Arner, E.; Westermark, P. O.; Bernard, S.; Buchholz, B. A.; Bergmann, O.; Blomqvist, L.; Hoffstedt, J.; Naslund, E.; Britton, T.; Concha, H.; Hassan, M.; Ryden, M.; Frisen, J.; Arner, P. (2008):
Dynamics of fat cell turnover in humans. Nature 453: 783-787
Locke, J.; Westermark, P.; Kramer, A.; Herzel, H. (2008):
Global parameter search reveals design principles of the mammalian circadian clock. BMC Systems Biology 2: 22
Chauhan, A.; Legewie, S.; Westermark, P. O.; Lorenzen, S.; Herzel, H. (2008):
A mesoscale model of G1/S phase transition in liver regeneration. J. Theor. Biol. 252: 465-473