PD Dr. rer. nat. habil. Manfred Mielenz
Research Institute for Farm Animal Biology (FBN)
working group Nutritional Physiology
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
working group Nutritional Physiology
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Research interests
- insects as farm animals for the utilization of residuals and by-products
- nutrient sensing
- energy efficiency
- metabolism
- adipokines
- fatty acids
- metabolic signalling pathways
- bioactive food ingredients
Curriculum Vitae
- 2013–present: Senior Scientist, Research Institute for Farm Animal Biology (FBN) Dummerstorf, Institute of Nutritional Physiology 'Oskar Kellner'
- 2013–present: Private Lecturer at the University of Bonn
- 2013: Habilitation (Physiology) at the University of Bonn
- 2002–2012: Senior Scientist at the University of Bonn, Institute of Animal Science, Physiology and Hygiene Unit
- Doctorate at the University of Hannover; Thesis at the Friedrich-Loeffler Institute, Federal Research Institute of Animal Health, Institute of Farm Animal Genetics, Department of Functional Genomics and Bioregulation, formerly Federal Agricultural Research Center (FAL) in Mariensee
- Studies in Biology at the University of Hannover; Diploma thesis at the Federal Agricultural Research Center (FAL) in Mariensee
Teaching
- Physiology and anatomy
Publications
Schäff, C. T.; Gruse, J.; Maciej, J.; Mielenz, M.; Wirthgen, E.; Hoeflich, A.; Schmicke, M.; Pfuhl, R.; Jawor, P.; Stefaniak, T.; Hammon, H. M. (2016):
Effects of feeding milk replacer ad libitum or in restricted amounts for the first five weeks of life on the growth, metabolic adaptation, and immune status of newborn calves. Plos One 11 (12): e0168974, 1-24
https://dx.doi.org/10.1371/journal.pone.0168974
van den Borne, J.J.G.C.; Labussière, E.; Mielenz, M.; Sauerwein, H.; Gerrits, W. J. J. (2016):
Exchanging fat for lactose in milk replacer stimulates de novo lipogenesis in calves. In: Energy and protein metabolism and nutrition : 5th EAAP International Symposium, Krakow, Poland, 12-15 September 2016 (EAAP Publication , 137) (Jacek Skomial, Hélène Lapierre, Hrsg.) Wageninen Academic Publishers, Wageningen (978-90-8686-286-3): 145-146
Stoldt, A.-K.; Mielenz, M.; Nürnberg, G.; Sauerwein, H.; Esatbeyoglu, T.; Wagner, A. E.; Rimbach, G.; Starke, S.; Wolffram, S.; Metges, C. C. (2016):
Effects of a six-week intraduodenal supplementation with quercetin on liver lipid metabolism and oxidative stress in peripartal dairy cows. J Anim Sci 94 (5): 1913-1923
https://dx.doi.org/10.2527/jas.2016-0338
Friedrichs, P.; Sauerwein, H.; Huber, K.; Locher, L. F.; Rehage, J.; Meyer, U.; Dänicke, S.; Kuhla, B.; Mielenz, M. (2016):
Expression of metabolic sensing receptors in adipose tissues of periparturient dairy cows with differing extent of negative energy balance. Animal 10 (4): 623-632
https://dx.doi.org/10.1017/s175173111500227x
Weber, M.; Locher, L.; Rehage, J.; Tienken, R.; Meyer, U.; Dänicke, S.; Webb, L.; Sauerwein, H.; Mielenz, M. (2016):
Longitudinal changes in adipose tissue of dairy cows from late pregnancy to lactation, Part 2: The SIRT-PPARGC1A axis and its relationship with the adiponectin system. J Dairy Sci 99 (2): 1560-1570
https://dx.doi.org/10.3168/jds.2015-10132
Weber, M.; Locher, L.; Huber, K.; Kenéz, Á.; Rehage, J.; Tienken, R.; Meyer, U.; Dänicke, S.; Sauerwein, H.; Mielenz, M. (2016):
Longitudinal changes in adipose tissue of dairy cows from late pregnancy to lactation, Part 1: The adipokines apelin and resistin and their relationship to receptors linked with lipolysis. J Dairy Sci 99 (2): 1549-1559
https://dx.doi.org/10.3168/jds.2015-10131
Pfundt, B.; Mielenz, B.; Sanver, F.; Pfeffer, E.; Sauerwein, H.; Mielenz, M. (2016):
Effects of largely different feeding intensities on serum insulin-like growth factor-1 concentrations, quantified by enzyme immunoassay, leptin and growth hormone receptor 1 mRNA in rainbow trout (Oncorhynchus mykiss). Aquacult Nutr 22 (3): 586-596
https://dx.doi.org/10.1111/anu.12282
Tienken, R.; Kersten, S.; Frahm, J.; Meyer, U.; Locher, L.; Rehage, J.; Huber, K.; Kenéz, Á.; Sauerwein, H.; Mielenz, M.; Dänicke, S. (2015):
Effects of an energy-dense diet and nicotinic acid supplementation on production and metabolic variables of primiparous or multiparous cows in periparturient period. Arch Anim Nutr 69 (5): 319-339
https://dx.doi.org/10.1080/1745039x.2015.1073002
Rahman, M.M.; Lecchi, C.; Sauerwein, H.; Mielenz, M.; Häussler, S.; Restelli, L.; Giudice, C.; Ceciliani, F. (2015):
Expression of α1-acid glycoprotein and lipopolysaccharide binding protein in visceral and subcutaneous adipose tissue of dairy cattle. Vet J 203 (2): 223-227
https://dx.doi.org/10.1016/j.tvjl.2014.12.001
Lamp, O.; Derno, M.; Otten, W.; Mielenz, M.; Nürnberg, G.; Kuhla, B. (2015):
Metabolic heat stress adaption in transition cows: differences in macronutrient oxidation between late-gestating and early-lactating German Holstein dairy cows. Plos One 10 (5): e0125264, 1-24
https://dx.doi.org/10.1371/journal.pone.0125264
Kuhla, B.; Mielenz, M.; Metges, C. C. (2015):
Die Kuh produziert kein Methan. Leibniz Nordost 20: 6-7
Kopp, C.; Hosseini, A.; Singh, S. P.; Regenhard, P.; Khalilvandi-Behroozyar, H.; Sauerwein, H.; Mielenz, M. (2014):
Nicotinic acid increases adiponectin secretion from differentiated bovine preadipocytes through G-protein coupled receptor signaling. Int J Mol Sci 15: 21401-21418
https://dx.doi.org/10.3390/ijms151121401
Singh, S. P.; Häussler, S.; Heinz, J. F. L.; Akter, H.S.; Saremi, B.; Müller, U.; Rehage, J.; Dänicke, S.; Mielenz, M.; Sauerwein, H. (2014):
Lactation driven dynamics of adiponectin supply from different fat depots to circulation in cows. DOMEST ANIM ENDOCRIN 47: 35-46
https://dx.doi.org/10.1016/j.domaniend.2013.12.001
Singh, S. P.; Häussler, S.; Heinz, J. F. L.; Saremi, B.; Mielenz, B.; Rehage, J.; Dänicke, S.; Mielenz, M.; Sauerwein, H. (2014):
Supplementation with conjugated linoleic acids extends the adiponectin deficit during early lactation in dairy cows. Gen Comp Endocr 198: 13-21
https://dx.doi.org/10.1016/j.ygcen.2013.12.008
Friedrichs, P.; Saremi, B.; Winand, S.; Rehage, J.; Dänicke, S.; Sauerwein, H.; Mielenz, M. (2014):
Energy and metabolic sensing G protein-coupled receptors during lactation-induced changes in energy balance. DOMEST ANIM ENDOCRIN 48: 33-41
https://dx.doi.org/10.1016/j.domaniend.2014.01.005
Kopp, C.; Singh, S. P.; Regenhard, P.; Müller, U.; Sauerwein, H.; Mielenz, M. (2014):
Trans-cinnamic acid increases adiponectin and the phosphorylation of AMP-activated protein kinase through G-protein-coupled receptor signaling in 3T3-L1 adipocytes. Int J Mol Sci 15 (2): 2906-2915
https://dx.doi.org/10.3390/ijms15022906
Saremi, B.; Winand, S.; Friedrichs, P.; Kinoshita, A.; Rehage, J.; Dänicke, S.; Häussler, S.; Breves, G.; Mielenz, M.; Sauerwein, H. (2014):
Longitudinal profiling of the tissue-specific expression of genes related with insulin sensitivity in dairy cows during lactation focusing on different fat depots. Plos One 9 (1): 1-15
https://dx.doi.org/10.1371/journal.pone.0086211
Mielenz, M. (2013):
Role of adipose tissue in metabolic regulation of farmed animals. Habilitationsschrift, Rheinische Friedrich-Wilhelms-Universität Bonn: 1-161
Saremi, B.; Mielenz, M.; Rahmann, M. M.; Hosseini, A.; Kopp, C.; Dänicke, S.; Ceciliani, F.; Sauerwein, H. (2013):
Hepatic and extrahepatic expression of serum amyloid A3 during lactation in dairy cows. J Dairy Sci 96 (11): 6944-6954
https://dx.doi.org/10.3168/jds.2012-6495
Sauerwein, H.; Saremi, B.; Pappritz, J.; von Soosten, D.; Meyer, U.; Dänicke, S.; Mielenz, M. (2013):
Aquaporin-7 mRNA in adipose depots of primiparous and pluriparous dairy cows: long-term physiological and conjugated linoleic acid-induced changes. J Dairy Sci 96 (7): 4508-4513
https://dx.doi.org/10.3168/jds.2012-6363