PD Dr. rer. nat. habil. Manfred Mielenz

Research Institute for Farm Animal Biology (FBN)
working group Nutritional Physiology
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Research interests

  • insects as farm animals for the utilization of residuals and by-products
  • nutrient sensing
  • energy efficiency
  • metabolism
  • adipokines
  • fatty acids
  • metabolic signalling pathways
  • bioactive food ingredients

Curriculum Vitae

  • 2013–present: Senior Scientist, Research Institute for Farm Animal Biology (FBN) Dummerstorf, Institute of Nutritional Physiology 'Oskar Kellner'
  • 2013–present: Private Lecturer at the University of Bonn
  • 2013: Habilitation (Physiology) at the University of Bonn
  • 2002–2012: Senior Scientist at the University of Bonn, Institute of Animal Science, Physiology and Hygiene Unit
  • Doctorate at the University of Hannover; Thesis at the Friedrich-Loeffler Institute, Federal Research Institute of Animal Health, Institute of Farm Animal Genetics, Department of Functional Genomics and Bioregulation, formerly Federal Agricultural Research Center (FAL) in Mariensee
  • Studies in Biology at the University of Hannover; Diploma thesis at the Federal Agricultural Research Center (FAL) in Mariensee


  • Physiology and anatomy


Weber, M.; Locher, L.; Rehage, J.; Tienken, R.; Meyer, U.; Dänicke, S.; Webb, L.; Sauerwein, H.; Mielenz, M. (2016):
Longitudinal changes in adipose tissue of dairy cows from late pregnancy to lactation, Part 2: The SIRT-PPARGC1A axis and its relationship with the adiponectin system. J Dairy Sci 99 (2): 1560-1570
Weber, M.; Locher, L.; Huber, K.; Kenéz, Á.; Rehage, J.; Tienken, R.; Meyer, U.; Dänicke, S.; Sauerwein, H.; Mielenz, M. (2016):
Longitudinal changes in adipose tissue of dairy cows from late pregnancy to lactation, Part 1: The adipokines apelin and resistin and their relationship to receptors linked with lipolysis. J Dairy Sci 99 (2): 1549-1559
Pfundt, B.; Mielenz, B.; Sanver, F.; Pfeffer, E.; Sauerwein, H.; Mielenz, M. (2016):
Effects of largely different feeding intensities on serum insulin-like growth factor-1 concentrations, quantified by enzyme immunoassay, leptin and growth hormone receptor 1 mRNA in rainbow trout (Oncorhynchus mykiss). Aquacult Nutr 22 (3): 586-596
Tienken, R.; Kersten, S.; Frahm, J.; Meyer, U.; Locher, L.; Rehage, J.; Huber, K.; Kenéz, Á.; Sauerwein, H.; Mielenz, M.; Dänicke, S. (2015):
Effects of an energy-dense diet and nicotinic acid supplementation on production and metabolic variables of primiparous or multiparous cows in periparturient period. Arch Anim Nutr 69 (5): 319-339
Rahman, M.M.; Lecchi, C.; Sauerwein, H.; Mielenz, M.; Häussler, S.; Restelli, L.; Giudice, C.; Ceciliani, F. (2015):
Expression of α1-acid glycoprotein and lipopolysaccharide binding protein in visceral and subcutaneous adipose tissue of dairy cattle. Vet J 203 (2): 223-227
Lamp, O.; Derno, M.; Otten, W.; Mielenz, M.; Nürnberg, G.; Kuhla, B. (2015):
Metabolic heat stress adaption in transition cows: differences in macronutrient oxidation between late-gestating and early-lactating German Holstein dairy cows. Plos One 10 (5): e0125264, 1-24
Kuhla, B.; Mielenz, M.; Metges, C. C. (2015):
Die Kuh produziert kein Methan. Leibniz Nordost 20: 6-7
Kopp, C.; Hosseini, A.; Singh, S. P.; Regenhard, P.; Khalilvandi-Behroozyar, H.; Sauerwein, H.; Mielenz, M. (2014):
Nicotinic acid increases adiponectin secretion from differentiated bovine preadipocytes through G-protein coupled receptor signaling. Int J Mol Sci 15: 21401-21418
Singh, S. P.; Häussler, S.; Heinz, J. F. L.; Akter, H.S.; Saremi, B.; Müller, U.; Rehage, J.; Dänicke, S.; Mielenz, M.; Sauerwein, H. (2014):
Lactation driven dynamics of adiponectin supply from different fat depots to circulation in cows. DOMEST ANIM ENDOCRIN 47: 35-46
Singh, S. P.; Häussler, S.; Heinz, J. F. L.; Saremi, B.; Mielenz, B.; Rehage, J.; Dänicke, S.; Mielenz, M.; Sauerwein, H. (2014):
Supplementation with conjugated linoleic acids extends the adiponectin deficit during early lactation in dairy cows. Gen Comp Endocr 198: 13-21
Friedrichs, P.; Saremi, B.; Winand, S.; Rehage, J.; Dänicke, S.; Sauerwein, H.; Mielenz, M. (2014):
Energy and metabolic sensing G protein-coupled receptors during lactation-induced changes in energy balance. DOMEST ANIM ENDOCRIN 48: 33-41
Kopp, C.; Singh, S. P.; Regenhard, P.; Müller, U.; Sauerwein, H.; Mielenz, M. (2014):
Trans-cinnamic acid increases adiponectin and the phosphorylation of AMP-activated protein kinase through G-protein-coupled receptor signaling in 3T3-L1 adipocytes. Int J Mol Sci 15 (2): 2906-2915
Saremi, B.; Winand, S.; Friedrichs, P.; Kinoshita, A.; Rehage, J.; Dänicke, S.; Häussler, S.; Breves, G.; Mielenz, M.; Sauerwein, H. (2014):
Longitudinal profiling of the tissue-specific expression of genes related with insulin sensitivity in dairy cows during lactation focusing on different fat depots. Plos One 9 (1): 1-15
Mielenz, M. (2013):
Role of adipose tissue in metabolic regulation of farmed animals. Habilitationsschrift, Rheinische Friedrich-Wilhelms-Universität Bonn: 1-161
Saremi, B.; Mielenz, M.; Rahmann, M. M.; Hosseini, A.; Kopp, C.; Dänicke, S.; Ceciliani, F.; Sauerwein, H. (2013):
Hepatic and extrahepatic expression of serum amyloid A3 during lactation in dairy cows. J Dairy Sci 96 (11): 6944-6954
Sauerwein, H.; Saremi, B.; Pappritz, J.; von Soosten, D.; Meyer, U.; Dänicke, S.; Mielenz, M. (2013):
Aquaporin-7 mRNA in adipose depots of primiparous and pluriparous dairy cows: long-term physiological and conjugated linoleic acid-induced changes. J Dairy Sci 96 (7): 4508-4513
Mielenz, M.; Mielenz, B.; Singh, S. P.; Kopp, C.; Heinz, J.; Häussler, S.; Sauerwein, H. (2013):
Development, validation, and pilot application of a semiquantitative Western blot analysis and an ELISA for bovine adiponectin. DOMEST ANIM ENDOCRIN 44 (3): 121-130
Mielenz, M.; Kuhla, B.; Hammon, H. M. (2013):
Abundance of adiponectin system and G-protein coupled receptor GPR109A mRNA in adipose tissue and liver of F2 offspring cows of Charolais x German Holstein crosses that differ in body fat accumulation. J Dairy Sci 96 (1): 278-289