Prof. Dr. rer. nat. habil. Klaus Wimmers
Research Institute for Farm Animal Biology (FBN)
Director
Head of Working Group Physiological Genomics
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Germany
Director
Head of Working Group Physiological Genomics
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Germany
Research interests
- inheritance and expression of traits related to productive adaptability and resilience in livestock
- Trait-associated variation at the molecular levels of the genotype-phenotype map
- Transcriptional response to exogenous stimuli and epigenetic basis of genotype-environment interaction
Curriculum Vitae
- since 2016: director of the Research Institute for Farm Animal Biology & Professor "Animal Breeding and Genetics", Faculty of Agricultural and Environmental Science, University Rostock
- 2008-2016: adjunct Professor, University of Bonn
- 2004-2016: head of Institute for Genome Biology of the Research Institute for Farm Animal Biology (FBN)
- 2002: habilitation in Animal Breeding and Genetics, University of Bonn
1996-2003: scientific coworker at the Institute of Animal science, University of Bonn - 1994: doctorate (Dr. rer. nat.)
- 1990-1996: research fellow at the Institute of Animal production, TU Berlin
- 1989: Study of veterinary science, FU Berlin
Teaching
- Lectures and seminars at the Faculty of Agriculture, University of Bonn and at the Faculty of Agricultural and Environmental Sciences, University of Rostock
Publications
Ponsuksili, S.; Du, Y.; Muràni, E.; Schwerin, M.; Wimmers, K. (2012):
Elucidating molecular networks that either affect or respond to plasma cortisol concentration in target tissues of liver and muscle. Genetics 192 (3): 1109-1122
https://dx.doi.org/10.1534/genetics.112.143081
Pareek, C. S.; Pierzchala, M.; Michno, J.; Szymanska, S.; Smoczynski, R.; Jasik, N.; Golebiewski, M.; Tyburski, J.; Urbanski, P.; Goluch, D.; Oprzadek, J.; Zwierzchowski, L.; Ponsuksili, S.; Wimmers, K. (2012):
Gene expression profiling by cDNA-AFLP and identification of differentially expressed transcripts of bovine pituitary gland in growing bulls of dairy breeds. Anim Sci Pap Rep 30 (2): 103-119
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2012):
Transcriptional response of skeletal muscle to a low-protein gestation diet in porcine offspring accumulates in growth- and cell cycle-regulating pathways. Physiol Genomics 44 (16): 811-818
https://dx.doi.org/10.1152/physiolgenomics.00050.2012
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2012):
A low protein diet during pregnancy provokes a lasting shift of hepatic expression of genes related to cell cycle throughout ontogenesis in a porcine model. BMC Genomics 13 (1): 93-107
https://dx.doi.org/10.1186/1471-2164-13-93
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2012):
A gestational high protein diet affects the abundance of muscle transcripts related to cell cycle regulation throughout development in porcine progeny. Plos One 7 (3): 1-9
https://dx.doi.org/10.1371/journal.pone.0034519
Laenoi, W.; Rangkasenee, N.; Uddin, M. J.; Cinar, M. U.; Phatsara, C.; Tesfaye, D.; Scholz, A. M.; Tholen, E.; Looft, C.; Mielenz, M.; Sauerwein, H.; Wimmers, K.; Schellander, K. (2012):
Association and expression study of MMP3, TGFβ1 and COL10A1 as candidate genes for leg weakness-related traits in pigs. Mol Biol Rep 39 (4): 3893-3901
https://dx.doi.org/10.1007/s11033-011-1168-5
Du, Y.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2012):
Flexible and efficient genome tiling design with penalized uniqueness score. BMC Bioinformatics 13: 323-334
https://dx.doi.org/10.1186/1471-2105-13-323
Diesing, A.-K.; Nossol, C.; Ponsuksili, S.; Wimmers, K.; Kluess, J.; Walk, N.; Post, A.; Rothkötter, H.-J.; Kahlert, S. (2012):
Gene regulation of intestinal porcine epithelial cells IPEC-J2 is dependent on the site of deoxynivalenol toxicological action. Plos One 7 (4): 1-10
https://dx.doi.org/10.1371/journal.pone.0034136
Cinar, M. U.; Kayan, A.; Uddin, M. J.; Jonas, E; Tesfaye, D.; Phatsara, C.; Ponsuksili, S.; Wimmers, K.; Tholen, E.; Looft, C.; Jüngst, H.; Schellander, K. (2012):
Association and expression quantitative trait loci (eQTL) analysis of porcine AMBP, GC and PPP1R3B genes with meat quality traits. Mol Biol Rep 39 (4): 4809-4821
https://dx.doi.org/10.1007/s11033-011-1274-4
Chomwisarutkun, K.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2012):
Gene expression analysis of mammary tissue during fetal bud formation and growth in two pig breeds - indications of prenatal initiation of postnatal phenotypic differences. BMC Dev Biol 12: 13-29
https://dx.doi.org/10.1186/1471-213x-12-13
Altmann, S.; Muràni, E.; Schwerin, M.; Metges, C. C.; Wimmers, K.; Ponsuksili, S. (2012):
Maternal dietary protein restriction and excess affects offspring gene expression and methylation of non-SMC subunits of condensin I in liver and skeletal muscle. Epigenetics-US 7 (3): 239-252
https://dx.doi.org/10.4161/epi.7.3.19183
Altmann, S.; Muràni, E.; Schwerin, M.; Metges, C. C.; Wimmers, K.; Ponsuksili, S. (2012):
Somatic cytochrome c (CYCS) gene expression and promoter-specific DNA methylation in a porcine model of prenatal exposure to maternal dietary protein excess and restriction. Brit J Nutr 107 (6): 791-799
https://dx.doi.org/10.1017/S0007114511003667
Altmann, S.; Muràni, E.; Metges, C. C.; Schwerin, M.; Wimmers, K.; Ponsuksili, S. (2012):
Effect of gestational protein deficiency and excess on hepatic expression of genes related to cell cycle and proliferation in offspring from late gestation to finishing phase in pig. Mol Biol Rep 39 (6): 7095-7104
https://dx.doi.org/10.1007/s11033-012-1541-z
Muràni, E.; Reyer, H.; Ponsuksili, S.; Fritschka, S.; Wimmers, K. (2012):
A substitution in the ligand binding domain of the porcine glucocorticoid receptor affects activity of the adrenal gland. Plos One 7 (9): 1-10
https://dx.doi.org/10.1371/journal.pone.0045518
Brunner, R. M.; Srikanchai, T.; Muràni, E.; Wimmers, K.; Ponsuksili, S. (2012):
Genes with expression levels correlating to drip loss prove association of their polymorphism with water holding capacity of pork. Mol Biol Rep 39 (1): 97-107
https://dx.doi.org/10.1007/s11033-011-0714-5
Chomwisarutkun, K.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2012):
Microarray analysis reveals genes and functional networks relevant to the predisposition to inverted teats in pigs. J Anim Sci 90 (1): 1-15
https://dx.doi.org/10.2527/jas.2011-4269
Verleih, M.; Rebl, A.; Köllner, B.; Korytar, T.; Anders, E.; Wimmers, K.; Goldammer, T. (2012):
Comparative molecular characterization of the regucalcin (RGN) gene in rainbow trout (Oncorhynchus mykiss) and maraena whitefish (Coregonus marena). Mol Biol Rep 39 (4): 4291-4300
https://dx.doi.org/10.1007/s11033-011-1216-1
Rebl, A.; Verleih, M.; Korytar, T.; Kühn, C.; Wimmers, K.; Köllner, B.; Goldammer, T. (2012):
Identification of differentially expressed protective genes in liver of two rainbow trout strains. VET IMMUNOL IMMUNOP 145 (1-2): 305-315
https://dx.doi.org/10.1016/j.vetimm.2011.11.023
Wimmers, K.; Do, V. A. K.; Schütze, S.; Muràni, E.; Ponsuksili, S. (2011):
The three-way relationship of polymorphisms of porcine genes encoding terminal complement components, their differential expression, and health-related phenotypes. BMC Proceedings 5 (Suppl.4): S19, 1-4
https://dx.doi.org/10.1186/1753-6561-5-S4-S19
Laenoi, W.; Uddin, M. J.; Cinar, M. U.; Grosse-Brinkhaus, C.; Tesfaye, D.; Jonas, E; Scholz, A. M.; Tholen, E.; Looft, C.; Wimmers, K.; Phatsara, C.; Jüngst, H.; Sauerwein, H.; Mielenz, M.; Schellander, K. (2011):
Quantitative trait loci analysis for leg weakness-related traits in a Duroc x Pietrain crossbred population. Genet Sel Evol 43: 13-20
https://dx.doi.org/10.1186/1297-9686-43-13