Prof. Dr. rer. nat. habil. Klaus Wimmers
Research Institute for Farm Animal Biology (FBN)
Director
Head of Working Group Physiological Genomics
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Germany
Director
Head of Working Group Physiological Genomics
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Germany
Research interests
- inheritance and expression of traits related to productive adaptability and resilience in livestock
- Trait-associated variation at the molecular levels of the genotype-phenotype map
- Transcriptional response to exogenous stimuli and epigenetic basis of genotype-environment interaction
Curriculum Vitae
- since 2016: director of the Research Institute for Farm Animal Biology & Professor "Animal Breeding and Genetics", Faculty of Agricultural and Environmental Science, University Rostock
- 2008-2016: adjunct Professor, University of Bonn
- 2004-2016: head of Institute for Genome Biology of the Research Institute for Farm Animal Biology (FBN)
- 2002: habilitation in Animal Breeding and Genetics, University of Bonn
1996-2003: scientific coworker at the Institute of Animal science, University of Bonn - 1994: doctorate (Dr. rer. nat.)
- 1990-1996: research fellow at the Institute of Animal production, TU Berlin
- 1989: Study of veterinary science, FU Berlin
Teaching
- Lectures and seminars at the Faculty of Agriculture, University of Bonn and at the Faculty of Agricultural and Environmental Sciences, University of Rostock
Publications
Reyer, H.; Ponsuksili, S.; Wimmers, K.; Muràni, E. (2013):
Transcript variants of the porcine glucocorticoid receptor gene (NR3C1). Gen Comp Endocr 189: 127-133
https://dx.doi.org/10.1016/j.ygcen.2013.04.038
Altmann, S.; Muràni, E.; Schwerin, M.; Metges, C. C.; Wimmers, K.; Ponsuksili, S. (2013):
Dietary protein restriction and excess of pregnant German Landrace sows induce changes in hepatic gene expression and promoter methylation of key metabolic genes in the offspring. J Nutr Biochem 24 (2): 484-495
https://dx.doi.org/10.1016/j.jnutbio.2012.01.011
Yang, X.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2013):
Association of TLR5 sequence variants and mRNA level with cytokine transcription in pigs. Immunogenetics 65 (2): 125-132
https://dx.doi.org/10.1007/s00251-012-0662-9
Rangkasenee, N.; Muràni, E.; Brunner, R. M.; Schellander, K.; Cinar, M. U.; Scholz, A. M.; Luther, H.; Hofer, A.; Ponsuksili, S.; Wimmers, K. (2013):
KRT8, FAF1 and PTH1R gene polymorphisms are associated with leg weakness traits in pigs. Mol Biol Rep 39 (4): 2859-2866
https://dx.doi.org/10.1007/s11033-012-2301-9
Chomwisarutkun, K.; Muràni, E.; Brunner, R. M.; Ponsuksili, S.; Wimmers, K. (2013):
QTL region-specific microarrays reveal differential expression of positional candidate genes of signaling pathways associated with the liability for the inverted teat defect. Anim Genet 44 (2): 139-148
https://dx.doi.org/10.1111/j.1365-2052.2012.02378.x
Yang, X.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2012):
Association of TLR4 polymorphism with cytokine expression level and pulmonary lesion score in pigs. Mol Biol Rep 39 (6): 7003-7009
https://dx.doi.org/10.1007/s11033-012-1530-2
Do, V. A. K.; Ponsuksili, S.; Muràni, E.; Huynh, L. T. P.; Brunner, R. M.; Wimmers, K. (2012):
Detection of a polymorphic site of the porcine C8G gene and evaluation of association with haemolytic complement activity. Arch Tierzucht 55 (3): 255-262
Ponsuksili, S.; Muràni, E.; Schwerin, M.; Schellander, K.; Tesfaye, D.; Wimmers, K. (2012):
Gene expression and DNA-methylation of bovine pretransfer endometrium depending on its receptivity after in vitro-produced embryo transfer. Plos One 7 (8): 1-13
https://dx.doi.org/10.1371/journal.pone.0042402
Ponsuksili, S.; Du, Y.; Muràni, E.; Schwerin, M.; Wimmers, K. (2012):
Elucidating molecular networks that either affect or respond to plasma cortisol concentration in target tissues of liver and muscle. Genetics 192 (3): 1109-1122
https://dx.doi.org/10.1534/genetics.112.143081
Pareek, C. S.; Pierzchala, M.; Michno, J.; Szymanska, S.; Smoczynski, R.; Jasik, N.; Golebiewski, M.; Tyburski, J.; Urbanski, P.; Goluch, D.; Oprzadek, J.; Zwierzchowski, L.; Ponsuksili, S.; Wimmers, K. (2012):
Gene expression profiling by cDNA-AFLP and identification of differentially expressed transcripts of bovine pituitary gland in growing bulls of dairy breeds. Anim Sci Pap Rep 30 (2): 103-119
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2012):
Transcriptional response of skeletal muscle to a low-protein gestation diet in porcine offspring accumulates in growth- and cell cycle-regulating pathways. Physiol Genomics 44 (16): 811-818
https://dx.doi.org/10.1152/physiolgenomics.00050.2012
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2012):
A low protein diet during pregnancy provokes a lasting shift of hepatic expression of genes related to cell cycle throughout ontogenesis in a porcine model. BMC Genomics 13 (1): 93-107
https://dx.doi.org/10.1186/1471-2164-13-93
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2012):
A gestational high protein diet affects the abundance of muscle transcripts related to cell cycle regulation throughout development in porcine progeny. Plos One 7 (3): 1-9
https://dx.doi.org/10.1371/journal.pone.0034519
Laenoi, W.; Rangkasenee, N.; Uddin, M. J.; Cinar, M. U.; Phatsara, C.; Tesfaye, D.; Scholz, A. M.; Tholen, E.; Looft, C.; Mielenz, M.; Sauerwein, H.; Wimmers, K.; Schellander, K. (2012):
Association and expression study of MMP3, TGFβ1 and COL10A1 as candidate genes for leg weakness-related traits in pigs. Mol Biol Rep 39 (4): 3893-3901
https://dx.doi.org/10.1007/s11033-011-1168-5
Du, Y.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2012):
Flexible and efficient genome tiling design with penalized uniqueness score. BMC Bioinformatics 13: 323-334
https://dx.doi.org/10.1186/1471-2105-13-323
Diesing, A.-K.; Nossol, C.; Ponsuksili, S.; Wimmers, K.; Kluess, J.; Walk, N.; Post, A.; Rothkötter, H.-J.; Kahlert, S. (2012):
Gene regulation of intestinal porcine epithelial cells IPEC-J2 is dependent on the site of deoxynivalenol toxicological action. Plos One 7 (4): 1-10
https://dx.doi.org/10.1371/journal.pone.0034136
Cinar, M. U.; Kayan, A.; Uddin, M. J.; Jonas, E; Tesfaye, D.; Phatsara, C.; Ponsuksili, S.; Wimmers, K.; Tholen, E.; Looft, C.; Jüngst, H.; Schellander, K. (2012):
Association and expression quantitative trait loci (eQTL) analysis of porcine AMBP, GC and PPP1R3B genes with meat quality traits. Mol Biol Rep 39 (4): 4809-4821
https://dx.doi.org/10.1007/s11033-011-1274-4
Chomwisarutkun, K.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2012):
Gene expression analysis of mammary tissue during fetal bud formation and growth in two pig breeds - indications of prenatal initiation of postnatal phenotypic differences. BMC Dev Biol 12: 13-29
https://dx.doi.org/10.1186/1471-213x-12-13
Altmann, S.; Muràni, E.; Schwerin, M.; Metges, C. C.; Wimmers, K.; Ponsuksili, S. (2012):
Maternal dietary protein restriction and excess affects offspring gene expression and methylation of non-SMC subunits of condensin I in liver and skeletal muscle. Epigenetics-US 7 (3): 239-252
https://dx.doi.org/10.4161/epi.7.3.19183
Altmann, S.; Muràni, E.; Schwerin, M.; Metges, C. C.; Wimmers, K.; Ponsuksili, S. (2012):
Somatic cytochrome c (CYCS) gene expression and promoter-specific DNA methylation in a porcine model of prenatal exposure to maternal dietary protein excess and restriction. Brit J Nutr 107 (6): 791-799
https://dx.doi.org/10.1017/S0007114511003667