Prof. Dr. rer. nat. habil. Klaus Wimmers

Research Institute for Farm Animal Biology (FBN)
Director
Head of Working Group Physiological Genomics
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Germany

Research interests

  • inheritance and expression of traits related to productive adaptability and resilience in livestock
  • Trait-associated variation at the molecular levels of the genotype-phenotype map
  • Transcriptional response to exogenous stimuli and epigenetic basis of genotype-environment interaction

Curriculum Vitae

  • since 2016: director of the Research Institute for Farm Animal Biology & Professor "Animal Breeding and Genetics", Faculty of Agricultural and Environmental Science, University Rostock
  • 2008-2016: adjunct Professor, University of Bonn
  • 2004-2016: head of Institute for Genome Biology of the Research Institute for Farm Animal Biology (FBN)
  • 2002: habilitation in Animal Breeding and Genetics, University of Bonn
    1996-2003: scientific coworker at the Institute of Animal science, University of Bonn
  • 1994: doctorate (Dr. rer. nat.)
  • 1990-1996: research fellow at the Institute of Animal production, TU Berlin
  • 1989: Study of veterinary science, FU Berlin

Teaching

  • Lectures and seminars at the Faculty of Agriculture, University of Bonn and at the Faculty of Agricultural and Environmental Sciences, University of Rostock

Publications

Heidt, H.; Cinar, M. U.; Uddin, M. J.; Looft, C.; Jüngst, H.; Tesfaye, D.; Becker, A.; Zimmer, A.; Ponsuksili, S.; Wimmers, K.; Tholen, E.; Schellander, K.; Grosse-Brinkhaus, C. (2013):
A genetical genomics approach reveals new candidates and confirms known candidate genes for drip loss in a porcine resource population. Mamm Genome 24 (9-10): 416-426
https://dx.doi.org/10.1007/s00335-013-9473-z
Adler, M.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2013):
PBMC transcription profiles of pigs with divergent humoral immune responses and lean growth performance. Int J Biol Sci 9 (9): 907-916
https://dx.doi.org/10.1371/journal.pone.0076705
Huynh, L. T. P.; Muràni, E.; Maak, S.; Ponsuksili, S.; Wimmers, K. (2013):
UBE3B and ZRANB1 polymorphisms and transcript abundance are associated with water holding capacity of porcine M. longissimus dorsi. Meat Sci 95 (2): 166-172
https://dx.doi.org/10.1016/j.meatsci.2013.04.033
Rebl, A.; Verleih, M.; Köbis, J.; Kühn, C.; Wimmers, K.; Köllner, B.; Goldammer, T. (2013):
Transcriptome profiling of gill tissue in regionally bred and globally farmed rainbow trout strains reveals different strategies for coping with thermal stress. Mar Biotechnol 15 (4): 445-460
https://dx.doi.org/10.1007/s10126-013-9501-8
Muràni, E.; Ponsuksili, S.; Reyer, H.; Wittenburg, D.; Wimmers, K. (2013):
Expression variation of the porcine ADRB2 has a complex genetic background. Mol Genet genomics 288 (11): 615-625
https://dx.doi.org/10.1007/s00438-013-0776-2
Verleih, M.; Rebl, A.; Köllner, B.; Korytar, T.; Köbis, J.; Kühn, C.; Wimmers, K.; Goldammer, T. (2013):
Iron-sulfur cluster scaffold (ISCU) gene is duplicated in salmonid fish and tissue and temperature dependent expressed in rainbow trout. Gene 512 (2): 251-258
https://dx.doi.org/10.1016/j.gene.2012.10.037
Reyer, H.; Ponsuksili, S.; Wimmers, K.; Muràni, E. (2013):
Transcript variants of the porcine glucocorticoid receptor gene (NR3C1). Gen Comp Endocr 189: 127-133
https://dx.doi.org/10.1016/j.ygcen.2013.04.038
Altmann, S.; Muràni, E.; Schwerin, M.; Metges, C. C.; Wimmers, K.; Ponsuksili, S. (2013):
Dietary protein restriction and excess of pregnant German Landrace sows induce changes in hepatic gene expression and promoter methylation of key metabolic genes in the offspring. J Nutr Biochem 24 (2): 484-495
https://dx.doi.org/10.1016/j.jnutbio.2012.01.011
Yang, X.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2013):
Association of TLR5 sequence variants and mRNA level with cytokine transcription in pigs. Immunogenetics 65 (2): 125-132
https://dx.doi.org/10.1007/s00251-012-0662-9
Rangkasenee, N.; Muràni, E.; Brunner, R. M.; Schellander, K.; Cinar, M. U.; Scholz, A. M.; Luther, H.; Hofer, A.; Ponsuksili, S.; Wimmers, K. (2013):
KRT8, FAF1 and PTH1R gene polymorphisms are associated with leg weakness traits in pigs. Mol Biol Rep 39 (4): 2859-2866
https://dx.doi.org/10.1007/s11033-012-2301-9
Chomwisarutkun, K.; Muràni, E.; Brunner, R. M.; Ponsuksili, S.; Wimmers, K. (2013):
QTL region-specific microarrays reveal differential expression of positional candidate genes of signaling pathways associated with the liability for the inverted teat defect. Anim Genet 44 (2): 139-148
https://dx.doi.org/10.1111/j.1365-2052.2012.02378.x
Yang, X.; Muràni, E.; Ponsuksili, S.; Wimmers, K. (2012):
Association of TLR4 polymorphism with cytokine expression level and pulmonary lesion score in pigs. Mol Biol Rep 39 (6): 7003-7009
https://dx.doi.org/10.1007/s11033-012-1530-2
Do, V. A. K.; Ponsuksili, S.; Muràni, E.; Huynh, L. T. P.; Brunner, R. M.; Wimmers, K. (2012):
Detection of a polymorphic site of the porcine C8G gene and evaluation of association with haemolytic complement activity. Arch Tierzucht 55 (3): 255-262
Ponsuksili, S.; Muràni, E.; Schwerin, M.; Schellander, K.; Tesfaye, D.; Wimmers, K. (2012):
Gene expression and DNA-methylation of bovine pretransfer endometrium depending on its receptivity after in vitro-produced embryo transfer. Plos One 7 (8): 1-13
https://dx.doi.org/10.1371/journal.pone.0042402
Ponsuksili, S.; Du, Y.; Muràni, E.; Schwerin, M.; Wimmers, K. (2012):
Elucidating molecular networks that either affect or respond to plasma cortisol concentration in target tissues of liver and muscle. Genetics 192 (3): 1109-1122
https://dx.doi.org/10.1534/genetics.112.143081
Pareek, C. S.; Pierzchala, M.; Michno, J.; Szymanska, S.; Smoczynski, R.; Jasik, N.; Golebiewski, M.; Tyburski, J.; Urbanski, P.; Goluch, D.; Oprzadek, J.; Zwierzchowski, L.; Ponsuksili, S.; Wimmers, K. (2012):
Gene expression profiling by cDNA-AFLP and identification of differentially expressed transcripts of bovine pituitary gland in growing bulls of dairy breeds. Anim Sci Pap Rep 30 (2): 103-119
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2012):
Transcriptional response of skeletal muscle to a low-protein gestation diet in porcine offspring accumulates in growth- and cell cycle-regulating pathways. Physiol Genomics 44 (16): 811-818
https://dx.doi.org/10.1152/physiolgenomics.00050.2012
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2012):
A low protein diet during pregnancy provokes a lasting shift of hepatic expression of genes related to cell cycle throughout ontogenesis in a porcine model. BMC Genomics 13 (1): 93-107
https://dx.doi.org/10.1186/1471-2164-13-93
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2012):
A gestational high protein diet affects the abundance of muscle transcripts related to cell cycle regulation throughout development in porcine progeny. Plos One 7 (3): 1-9
https://dx.doi.org/10.1371/journal.pone.0034519
Laenoi, W.; Rangkasenee, N.; Uddin, M. J.; Cinar, M. U.; Phatsara, C.; Tesfaye, D.; Scholz, A. M.; Tholen, E.; Looft, C.; Mielenz, M.; Sauerwein, H.; Wimmers, K.; Schellander, K. (2012):
Association and expression study of MMP3, TGFβ1 and COL10A1 as candidate genes for leg weakness-related traits in pigs. Mol Biol Rep 39 (4): 3893-3901
https://dx.doi.org/10.1007/s11033-011-1168-5