Dr. rer. nat. Juliane Günther
Research Institute for Farm Animal Biology (FBN)
working group Glycoimmunology
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
working group Glycoimmunology
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Research interests
- Molecular Biology
- Infection Biology, Cell Biology
- Immunology
- Epigenetics
- Cell Signalling
Curriculum Vitae
- since 2013: Junior Group Leader, Genome Physiology Unit, Leibniz Institute for Farm Animal Biology (FBN)
- 2006-2013: Postdoctoral Research Fellow, Group Gene Analysis, Leibniz Institute for Farm Animal Biology (FBN)
- 2005: Ph.D. (Dr. rer. nat.) at the Friedrich Schiller University of Jena
- 2002-2005: Ph.D. student, Leibniz Institute for Natural Product Research and Infection Biology (Hans-Knöll-Institute), Jena, Germany
- 2001: Diploma (Biology) at the Friedrich Schiller University of Jena
- 1995-2001: Studies in Biological Sciences, Friedrich Schiller University of Jena, Germany
Teaching
- since 2011: „Diversity and Evolution“ (MSc), Faculty of Mathematics and Natural Sciences, University of Rostock, Germany
Publications
Günther, J.; Czabanska, A.; Bauer, I.; Leigh, J.; Holst, Otto; Seyfert, H.-M. (2016):
Streptococcus uberis strains isolated from the bovine mammary gland evade immune recognition by mammary epithelial cells, but not of macrophages. Vet Res 47: 13, 1-14
https://dx.doi.org/10.1186/s13567-015-0287-8
Jaeger, A.; Bardehle, D.; Oster, M.; Günther, J.; Muràni, E.; Ponsuksili, S.; Wimmers, K.; Kemper, N. (2015):
Gene expression profiling of porcine mammary epithelial cells after challenge with Escherichia coli and Staphylococcus aureus in vitro. Vet Res 46: 50, 1-18
https://dx.doi.org/10.1186/s13567-015-0178-z
Bauer, I.; Günther, J.; Wheeler, T.T.; Engelmann, S.; Seyfert, H.-M. (2015):
Extracellular milieu grossly alters pathogen-specific immune response of mammary epithelial cells. BMC Vet Res 11: 172-186
https://dx.doi.org/10.1186/s12917-015-0489-3
Chang, G.; Petzl, W.; Vanselow, J.; Günther, J.; Shen, Z.; Seyfert, H.-M. (2015):
Epigenetic mechanisms contribute to enhanced expression of immune response genes in the liver of cows after experimentally induced Escherichia coli mastitis. Vet J 203 (3): 339-341
https://dx.doi.org/10.1016/j.tvjl.2014.12.023 10.1016/j.tvjl.2014.12.023
Patterson, N.; Günther, J.; Gibson, A.; Offord, V.; Coffey, T. J.; Splitter, G.; Monk, I.; Seyfert, H.-M.; Werling, Dirk (2014):
TwoTIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response. Front microbiol 5: 662-676
https://dx.doi.org/10.3389/fmicb.2014.00662
Jensen, K.; Günther, J.; Talbot, R.; Petzl, W.; Zerbe, H.; Schuberth, H.-J.; Seyfert, H.-M.; Glass, E. (2013):
Escherichia coli- and Staphylococcus aureus-induced mastitis differentially modulate transcriptional response in neighbouring uninfected bovine mammary gland quarters. BMC Genomics 14: 36-55
https://dx.doi.org/10.1186/1471-2164-14-36
Lewandowska-Sabat, A. M.; Günther, J.; Seyfert, H.-M.; Olsaker, I. (2012):
Combining quantitative trait loci and heterogeneous microarray data analyses reveals putative candidate pathways affecting mastitis in cattle. Anim Genet 43 (6): 793-796
https://dx.doi.org/10.1111/j.1365-2025.02342.x.
Günther, J.; Petzl, W.; Zerbe, H.; Schuberth, H.-J.; Koczan, D.; Goetze, L.; Seyfert, H.-M. (2012):
Lipopolysaccharide priming enhances expression of effectors of immune defence while decreasing expression of pro-inflammatory cytokines in mammary epithelia cells from cows. BMC Genomics 13: 17-30
https://dx.doi.org/10.1186/1471-2164-13-17
Petzl, W.; Günther, J.; Pfister, T.; Sauter-Louis, C.; Goetze, L.; von Aulock, S.; Hafner-Marx, A.; Schuberth, H.-J.; Seyfert, H.-M.; Zerbe, H. (2012):
Lipopolysaccharide pretreatment of the udder protects against experimental Escherichia coli mastitis. Innate Immun-London 18 (3): 467-477
https://dx.doi.org/10.1177/1753425911422407
Schukken, Y. H.; Günther, J.; Fitzpatrick, J.; Fontaine, M. C.; Götze, L.; Holst, O.; Leigh, J.; Petzl, W.; Schuberth, H.-J.; Sipka, A.; Smith, D. G. E.; Quesnell, R.; Watts, J.; Yancey, R.; Zerbe, H.; Gurjar, A.; Zadoks, R. N.; Seyfert, H.-M. (2011):
Host response patterns of intramammary infections in dairy cows. VET IMMUNOL IMMUNOP 144 (3-4): 270-289
https://dx.doi.org/10.1016/j.vetimm.2011.08.022
Lui, S.; Shi, X.; Bauer, I.; Günther, J.; Seyfert, H.-M. (2011):
Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-kappaB p65 and C/EBPbeta in mammary epithelial cells. MOL IMMUNOL 48 (6-7): 895-908
https://dx.doi.org/10.1016/j.molimm.2010.12.018
Günther, J.; Esch, K.; Poschadel, N.; Petzl, W.; Zerbe, H.; Mitterhuemer, S.; Blum, H.; Seyfert, H.-M. (2011):
Comparative kinetics of Escherichia coli- and Staphylococcus aureus-specific activation of key immune pathways in mammary epithelial cells demonstrates that S. aureus elicits a delayed response dominated by interleukin-6 (IL-6) but not by IL-1A or tumor necrosis factor alpha. Infect Immun 79 (2): 695-707
https://dx.doi.org/10.1128/IAI.01071-10
Günther, J.; Liu, X.; Esch, K.; Schuberth, H.-J.; Seyfert, H.-M. (2010):
Stimulated expression ofTNF-α and IL-8, but not of lingual antimicrobial peptide reflects the concentration of pathogens contacting bovine mammary epithelial cells. VET IMMUNOL IMMUNOP 135 (1-2): 152-157
https://dx.doi.org/10.1016/j.vetimm.2009.11.004
Günther, J.; Koczan, D.; Yang, W.; Nürnberg, G.; Repsilber, D.; Schuberth, H.-J.; Zaneta, P.; Molenaar, A.; Seyfert, H.-M. (2009):
Assessment of the immune capacity of mammary epithelial cells: Comparison of mammary tissue after challenge with Eschrichia coli. Vet Res 40 (4): 31
https://dx.doi.org/10.1051/vetres/2009014
Petzl, W.; Zerbe, H.; Günther, J.; Yang, W.; Seyfert, H.-M.; Nürnberg, G.; Schuberth, H.-J. (2008):
Escherichia coli, but not Staphylococcus aureus triggers an early increased expression of factors contributing to the innate immune defense in the udder of the cow. Vet Res 39 (2): 18
https://dx.doi.org/10.1051/vetres:2007057
Yang, W.; Holm, Z.; Petzl, W.; Brunner, R. M.; Günther, J.; Draing, C.; von Aulock, S.; Schuberth, H.-J.; Seyfert, H.-M. (2008):
Bovine TLR2 and TLR4 properly transduce signals from S. aureus and E. coli, but S. aureus fails to both activate NF-kappaB in Mammary Epithelial Cells and to quickly induce TNF-alpha and Interleukin-8 (CXCL8) expression in the udder. MOL IMMUNOL 45 (5): 1385-1397
https://dx.doi.org/10.1016/j.molimm.2007.09.004
Yang, W.; Zerbe, H.; Petzl, W.; Brunner, R. M.; Günther, J.; Draing, C.; von Aulock, S.; Schuberth, H.-J.; Seyfert, H.-M. (2008):
Bovine TLR2 and TLR4 properly transduce signals from S. aureus and E. coli, but S. aureus fail to both activate NF-kB in Mammary Epithelial Cells and to quickly induce TNFa and Interleukin-8 (CXCL8) expression in the udder. MOL IMMUNOL 45 (5): 1385-1397
https://dx.doi.org/10.1016/j.molimm.2007.09.004