PD Dr. rer. nat. habil. Jens Vanselow
Research Institute for Farm Animal Biology (FBN)
Head of Competence area Reproduction and Development
Head of Working group Cell Physiology & Reproduction
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Head of Competence area Reproduction and Development
Head of Working group Cell Physiology & Reproduction
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Research interests
- Reproductive Biology
- Folliculogenesis, Luteinization
- Spermatogenesis
- Gene Regulation
- Epigenetics
Curriculum Vitae
- 2024-present: Head of Competence area Reproduction and Development, Research Institute for Farm Animal Biology (FBN), Dummerstorf, Germany
- 2013-2023: Head of the Institute of Reproductive Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany
- 2002: Habilitation and Lecturer at the Faculty of Mathematics and Natural Sciences and the Faculty of Agricultural and Environmental Sciences at the University of Rostock, Germany
- 1992-2012: Head of the Gene Regulation Group at the Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Research Unit Molecular Biology, Germany
- 1990-1992: Postdoctoral Grant, Boehringer Ingelheim Fonds
- 1990-1992: Harvard Research Fellow at Massachusetts General Hospital, Institute for Developmental Biology, Boston, USA
- 1988-1990: Member of the DFG Graduate College "Neurobiology", Eberhard Karls University Tübingen, Germany
- 1990: Graduation (Dr. rer. nat.) at Eberhard Karls University Tübingen and Max-Planck-Institute for Developmental Biology, Tübingen, Germany
- 1987: Diploma Biology at Eberhard Karls University Tübingen, Germany
- 1983: Prediploma Biology at Johannes Gutenberg University Mainz, Germany
Teaching
- 2023-present: “Molecular Biology of the Cell” (B.Sc.) Biosciences, Faculty of Mathematics and Natural Sciences, University of Rostock, Germany
- 2024-present: “Reproduction and Reproductive Biotechnology” (M.Sc.) Faculty of Agricultural and Environmental Sciences, University of Rostock, Germany
- 2013-present: „Population Genetics, Molecular Animal Breeding and Reproductive Technology“ (MSc), Faculty of Agricultural and Environmental Sciences, University of Rostock, Germany
- 2014-present: “Breeding Programs and Reproduction Management” (B.Sc.), Faculty of Agricultural and Environmental Sciences, University of Rostock, Germany
- 2011-present: „Molecular Animal Breeding“ (MSc), Biosciences, Faculty of Mathematics and Natural Sciences, University of Rostock, Germany
- 1997-2010: „Molecular Mechanisms of Development and Differentiation“ (Dipl-Biol), Faculty of Mathematics and Natural Sciences, University of Rostock, Germany
Publications
Tiemann, U.; Brüssow, K.-P.; Dänicke, S.; Vanselow, J. (2008):
Feeding of pregnant sows with mycotoxin-contaminated diets and their non-effect on foetal and maternal hepatic transcription of genes of the insulin-like growth factor system. Food Addit Contam 25 (11): 1365-1373
https://dx.doi.org/10.1080/02652030802112619
Vanselow, J.; Nürnberg, G.; Koczan, D.; Langhammer, M.; Thiesen, H.-J.; Reinsch, N. (2008):
Expression profiling of a high-fertility mouse line by microarray analysis and qPCR. BMC Genomics 9 (1): 307
https://dx.doi.org/10.1186/1471-2164-9-307
Vanselow, J.; Fürbaß, R.; Tiemann, U. (2008):
Cultured bovine trophoblast cells differentially express genes encoding key steroid synthesis enzymes. Placenta 29 (6): 531-538
https://dx.doi.org/10.1016/j.placenta.2008.03.
Fürbaß, R.; Selimyan, R.; Vanselow, J. (2008):
DNA methylation and chromatin accessibility of the proximal Cyp19 promoter region 1.5/2 correlate with expression levels in sheep placentomes. Mol Reprod Dev 75 (1): 1-7
https://dx.doi.org/10.1002/mrd.20756
Spitschak, M.; Langhammer, M.; Schneider, F.; Renne, U.; Vanselow, J. (2007):
Two high-fertility mouse lines show differences in component fertility traits after long-term selection. Reprod Fert Develop 19 (7): 815-821
https://dx.doi.org/10.1071/RD07009
Tiemann, U.; Schneider, F.; Vanselow, J.; Tomek, W. (2007):
In vitro exposure of porcine granulosa cells to the phytoestrogens genistein and daidzein: Effects on the biosynthesis of reproductive steroid hormones. Reprod Toxicol 24 (3-4): 317-325
https://dx.doi.org/10.1016/j.reprotox.2007.07.008
Nausch, Norman; Manteuffel, G.; Vanselow, J. (2007):
0.2kb promoter sequence of the murine Cyp19 gene target β-galactosidase expression to specific brain areas of transgenic mice. J Steroid Biochem 103 (2): 119-128
https://dx.doi.org/10.1016/j.jsbmb.2006.08.007
Vanselow, J.; Yang, W.; Herrmann, J.; Zerbe, H.; Schuberth, H.-J.; Petzl, W.; Tomek, W.; Seyfert, H.-M. (2006):
DNA-remethylation around a STAT5-binding enhancer in the alpha-S1-casein promoter is associated with abrupt shut-down of alpha-S1-casein synthesis during acute mastitis. J Mol Endocrinol 37 (3): 463-477
https://dx.doi.org/10.1677/jme.1.02131
Vanselow, J.; Viergutz, T.; Fürbaß, R. (2006):
Repression of the aromatase gene (CYP19) during luteinization coincides with DANN methylation of a specific CpG dinucleotide within promoter 2. In: Proc. 8th World Congress on Genetics Applied to Livestock Production (Comm.11-11):
Alm, H.; Brüssow, K.-P.; Torner, H.; Vanselow, J.; Tomek, W.; Dänicke, S.; Tiemann, U. (2006):
Influence of Fusarium-toxin contaminated feed on initial quality and meiotic competence of gilt oocytes. Reprod Toxicol 22 (1): 44-50
https://dx.doi.org/10.1016/j.reprotox.2005.11.008
Pöhland, R.; Lenz, S.; Vanselow, J.; Tomek, W. (2006):
Detection of gene expression and enzyme activity of Cytochrom P450 arom (aromatase) in preantral and early antral bovine follicles depending on culture conditions in vitro. Arch Tierzucht 49 (1): 29-40
Kalbe, C.; Vanselow, J. (2006):
Improved Performance of the LightCycler FastStart DNA MasterPLUS SYBR Green I Kit in Highly Sensitive Transcript Quantification. Biochemica 1: 11-13
Vanselow, J.; Pöhland, R.; Fürbaß, R. (2005):
Promoter-2-derived Cyp19 expression in bovine granulosa cells coincides with gene-specific DNA hypo-methylation. Mol Cell Endocrinol 233 (1-2): 57-64
https://dx.doi.org/10.1016/j.mce.2005.01.007
Hamel, M.; Vanselow, J.; Nicola, E.S.; Price, C.A. (2005):
Androstenedione increases cytochrome P450 aromatase messenger ribonucleic acid transcripts in nonluteinizing bovine granulosa cells . Mol Reprod Dev 70 (2): 175-183
https://dx.doi.org/10.1002/mrd.20194
Walzel, H.; Brock, J.; Pöhland, R.; Vanselow, J.; Tomek, W.; Schneider, F.; Tiemann, U. (2004):
Effects of galectin-1 on regulation of progesterone production in granulosa cells from pig ovaries in vitro. Glycobiology 14 (10): 871-881
https://dx.doi.org/10.1093/glycob/cwh101
Vanselow, J.; Fürbaß, R.; Rehbock, F.; Klautschek, G.; Schwerin, M. (2004):
Cattle and sheep use different promoters to direct the expression of the aromatase cytochrome P450 encoding gene, Cyp19, during pregnancy. DOMEST ANIM ENDOCRIN 27 (2): 99-114
https://dx.doi.org/10.1016/j.domaniend.2004.01.008
Lenz, S.; Pöhland, R.; Becker, D.; Vanselow, J. (2004):
Expression of the bovine aromatase cytochrome P450 gene (Cyp19) is primarily regulated by promoter 2 in bovine follicles and by promoter 1.1 in corpora lutea. Mol Reprod Dev 67 (4): 406-413
https://dx.doi.org/10.1002/mrd.20000
Tiemann, U.; Tomek, W.; Schneider, F.; Vanselow, J. (2003):
Effects of the mycotoxins alpha- and beta-zearalenol on regulation of progesterone synthesis in cultured granulosa cells from porcine ovaries. Reprod Toxicol 17 (6): 675-683
https://dx.doi.org/10.1016/j.reprotox.2003.07.001
Golovine, K.; Schwerin, M.; Vanselow, J. (2003):
Three different promoters control expression of the aromatase cytochrome p450 gene (cyp19) in mouse gonads and brain. Biol Reprod 68 (3): 978-984
https://dx.doi.org/10.1095/biolreprod.102.008037
Zsolnai, A.; Anton, I.; Fésüs, L.; Estonba, A.; Schwerin, M.; Vanselow, J. (2002):
Allele distributions of two novel SNPs within the sheep Cyp19 gene. J Anim Breed Genet 119 (6): 402-405
https://dx.doi.org/10.1046/j.1439-0388.2002.00364.x