PD Dr. rer. nat. habil. Jens Vanselow
Research interests
- Reproductive Biology
- Folliculogenesis, Luteinization
- Gene Regulation
- Epigenetics
Curriculum Vitae
- 2013-present: Head of the Institute of Reproductive Biology, Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf
- 2002: Habilitation and Lecturer at the Faculty of Mathematics and Natural Sciences and the Faculty of Agricultural and Environmental Sciences at the University of Rostock
- 1992-2012: Head of the Gene Regulation Group at the Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf, Research Unit Molecular Biology
- 1990-1992: Postdoctoral Grant, Boehringer Ingelheim Fonds
- 1990-1992: Harvard Research Fellow at Massachusetts General Hospital, Institute for Developmental Biology, Boston, USA
- 1988-1990: Member of the DFG Graduate College "Neurobiology", Eberhard Karls University Tübingen, Germany
- 1990: Graduation (Dr. rer. nat.) at Eberhard Karls University Tübingen and Max-Planck-Institute for Developmental Biology, Tübingen, Germany
- 1987: Diploma Biology at Eberhard Karls University Tübingen, Germany
- 1983: Prediploma Biology at Johannes Gutenberg University Mainz, Germany
Teaching
- 2013-present: "Population Genetics, Molecular Animal Breeding and Reproductive Technology" (MSc), Faculty of Agricultural and Environmental Sciences, University of Rostock, Germany
- 2014-present: "Breeding Programs and Reproduction Management" (B.Sc.), Faculty of Agricultural and Environmental Sciences, University of Rostock, Germany
- 2011-present: "Molecular Animal Breeding" (MSc), Faculty of Mathematics and Natural Sciences, University of Rostock, Germany
- 1997-2010: "Molecular Mechanisms of Development and Differentiation" (Dipl-Biol), Faculty of Mathematics and Natural Sciences, University of Rostock, Germany
Publications
Christenson, L. K.; Gunewardena, S.; Hong, X.; Spitschak, M.; Baufeld, A.; Vanselow, J. (2013):
Preovulatory LH surge effects on follicular theca and granulosa transcriptomes. Mol Endocrinol 27 (7): 1153-1171
https://dx.doi.org/10.1210/Me.2013-1093
Vanselow, J.; Kucia, M.; Langhammer, M.; Koczan, D.; Rehfeldt, C.; Metges, C. C. (2011):
Hepatic expression of the GH/JAK/STAT/IGF pathway, acute-phase response signalling and complement system are affected in mouse offspring by prenatal and early postnatal exposure to maternal high-protein diet. Eur J Nutr 50 (8): 611-623
https://dx.doi.org/10.1007/s00394-011-0168-5
Nimz, M.; Spitschak, M.; Fürbaß, R.; Vanselow, J. (2010):
The preovulatory luteinizing hormone surge is followed by downregulation of CYP19A1, HSD3B1 and CYP17A1 and chromatin condensation of the corresponding promoters in bovine follicles. Mol Reprod Dev 77: 1040-1048
https://dx.doi.org/10.1002/mrd.21257
Vanselow, J.; Fürbaß, R. (2010):
Epigenetic control of folliculogenesis and luteinization. Anim Reprod 7 (3): 134-139
Vanselow, J.; Langhammer, M. (2010):
Biodiversität und Leistung beim landwirtschaftlichen Nutztier. Forschungsreport 1: 20-23
Fürbaß, R.; Tomek, W.; Vanselow, J. (2010):
Upstream Stimulating Factors 1 and 2 Enhance Transcription from the Placenta-Specific Promoter 1.1 of the Bovine Cyp19 Gene. BMC Mol Biol 11: 5
Vanselow, J.; Spitschak, M.; Nimz, M.; Fürbaß, R. (2010):
DNA methylation is not involved in preovulatory down-regulation of CYP11A1, HSD3B1, and CYP19A1 in bovine follicles but may have a role in permanent silencing of CYP19A1 in large granulosa lutein cells. Biol Reprod 82 (2): 289-298
https://dx.doi.org/10.1095/biolreprod.109.079251
Nimz, M.; Spitschak, M.; Schneider, F.; Fürbaß, R.; Vanselow, J. (2009):
Down-regulation of genes encoding steroidogenic enzymes and hormone receptors in late preovulatory follicles of the cow coincides with an accumulation of intrafollicular steroids. DOMEST ANIM ENDOCRIN 37 (1): 45-54
https://dx.doi.org/10.1016/j.domaniend.2009.02.002
Tiemann, U.; Tomek, W.; Schneider, F.; Müller, U.; Pöhland, R.; Vanselow, J. (2009):
The mycotoxins alternariol and alternariol methyl ether negatively affect progesterone synthesis in porcine granulosa cells in vitro. Toxicol lett 186 (2): 139-145
https://dx.doi.org/10.1016/j.toxlet.2009.01.014
Tiemann, U.; Brüssow, K.-P.; Dänicke, S.; Vanselow, J. (2008):
Feeding of pregnant sows with mycotoxin-contaminated diets and their non-effect on foetal and maternal hepatic transcription of genes of the insulin-like growth factor system. Food Addit Contam 25 (11): 1365-1373
https://dx.doi.org/10.1080/02652030802112619
Vanselow, J.; Nürnberg, G.; Koczan, D.; Langhammer, M.; Thiesen, H.-J.; Reinsch, N. (2008):
Expression profiling of a high-fertility mouse line by microarray analysis and qPCR. BMC Genomics 9 (1): 307
https://dx.doi.org/10.1186/1471-2164-9-307
Fürbaß, R.; Selimyan, R.; Vanselow, J. (2008):
DNA methylation and chromatin accessibility of the proximal Cyp19 promoter region 1.5/2 correlate with expression levels in sheep placentomes. Mol Reprod Dev 75 (1): 1-7
https://dx.doi.org/10.1002/mrd.20756
Spitschak, M.; Langhammer, M.; Schneider, F.; Renne, U.; Vanselow, J. (2007):
Two high-fertility mouse lines show differences in component fertility traits after long-term selection. Reprod Fert Develop 19 (7): 815-821
https://dx.doi.org/10.1071/RD07009
Tiemann, U.; Schneider, F.; Vanselow, J.; Tomek, W. (2007):
In vitro exposure of porcine granulosa cells to the phytoestrogens genistein and daidzein: Effects on the biosynthesis of reproductive steroid hormones. Reprod Toxicol 24 (3-4): 317-325
https://dx.doi.org/10.1016/j.reprotox.2007.07.008
Nausch, Norman; Manteuffel, G.; Vanselow, J. (2007):
0.2kb promoter sequence of the murine Cyp19 gene target β-galactosidase expression to specific brain areas of transgenic mice. J Steroid Biochem 103 (2): 119-128
https://dx.doi.org/10.1016/j.jsbmb.2006.08.007