PD Dr. rer. nat. habil. Jens Vanselow
Research Institute for Farm Animal Biology (FBN)
Head of Competence area Reproduction and Development
Head of Working group Cell Physiology & Reproduction
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Head of Competence area Reproduction and Development
Head of Working group Cell Physiology & Reproduction
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Research interests
- Reproductive Biology
- Folliculogenesis, Luteinization
- Spermatogenesis
- Gene Regulation
- Epigenetics
Curriculum Vitae
- 2024-present: Head of Competence area Reproduction and Development, Research Institute for Farm Animal Biology (FBN), Dummerstorf, Germany
- 2013-2023: Head of the Institute of Reproductive Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany
- 2002: Habilitation and Lecturer at the Faculty of Mathematics and Natural Sciences and the Faculty of Agricultural and Environmental Sciences at the University of Rostock, Germany
- 1992-2012: Head of the Gene Regulation Group at the Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Research Unit Molecular Biology, Germany
- 1990-1992: Postdoctoral Grant, Boehringer Ingelheim Fonds
- 1990-1992: Harvard Research Fellow at Massachusetts General Hospital, Institute for Developmental Biology, Boston, USA
- 1988-1990: Member of the DFG Graduate College "Neurobiology", Eberhard Karls University Tübingen, Germany
- 1990: Graduation (Dr. rer. nat.) at Eberhard Karls University Tübingen and Max-Planck-Institute for Developmental Biology, Tübingen, Germany
- 1987: Diploma Biology at Eberhard Karls University Tübingen, Germany
- 1983: Prediploma Biology at Johannes Gutenberg University Mainz, Germany
Teaching
- 2023-present: “Molecular Biology of the Cell” (B.Sc.) Biosciences, Faculty of Mathematics and Natural Sciences, University of Rostock, Germany
- 2024-present: “Reproduction and Reproductive Biotechnology” (M.Sc.) Faculty of Agricultural and Environmental Sciences, University of Rostock, Germany
- 2013-present: „Population Genetics, Molecular Animal Breeding and Reproductive Technology“ (MSc), Faculty of Agricultural and Environmental Sciences, University of Rostock, Germany
- 2014-present: “Breeding Programs and Reproduction Management” (B.Sc.), Faculty of Agricultural and Environmental Sciences, University of Rostock, Germany
- 2011-present: „Molecular Animal Breeding“ (MSc), Biosciences, Faculty of Mathematics and Natural Sciences, University of Rostock, Germany
- 1997-2010: „Molecular Mechanisms of Development and Differentiation“ (Dipl-Biol), Faculty of Mathematics and Natural Sciences, University of Rostock, Germany
Publications
Yenuganti, V.; Baddela, V.S.; Baufeld, A.; Singh, D.; Vanselow, J. (2015):
The gene expression pattern induced by high plating density in cultured bovine and buffalo granulosa cells might be regulated by specific miRNA species. J Reprod Develop 61 (2): 154-160
https://dx.doi.org/10.1262/jrd.2014-119
Chang, G.; Petzl, W.; Vanselow, J.; Günther, J.; Shen, Z.; Seyfert, H.-M. (2015):
Epigenetic mechanisms contribute to enhanced expression of immune response genes in the liver of cows after experimentally induced Escherichia coli mastitis. Vet J 203 (3): 339-341
https://dx.doi.org/10.1016/j.tvjl.2014.12.023 10.1016/j.tvjl.2014.12.023
Shrestha, K.; Lukasik, K.; Baufeld, A.; Vanselow, J.; Moallem, U.; Meidan, R. (2015):
Regulation of ovulatory genes in bovine granulosa cells: lessons from siRNA silencing of PTGS2. Reproduction 149 (1): 21-29
https://dx.doi.org/10.1530/REP-14-0337
Baddela, V.; Baufeld, A.; Yenuganti, V.; Vanselow, J.; Singh, D. (2014):
Suitable housekeeping genes for normalization of transcript abundance analysis by real-time RT-PCR in cultured bovine granulosa cells during hypoxia and differential cell plating density. Reprod Biol Endocrin 12: 118-125
https://dx.doi.org/10.1186/1477-7827-12-118
Vanselow, J. (2014):
ISSRF Newsletter: Epigenetic Modulation and Reproduction: A Link Between Environment and Genetics. ISSRF Newsletter (15): 8-11
Vanselow, J. (2014):
Modified maternal protein supply imprints persistent alterations on offspring growth, hepatic gene expression and epigenetic profiles. In: Invited Lectures: Climate Resilient Livestock Feeding Systems for Global Food Security (Samanta,A.K., Bhatta,V., Sejian,V., Kolte,P.K., Malik,P.K., Sirohi,S.K., Prasad,C., Hrsg.) Global Animal Nutrition Conference, April 20-22, 2014, Bengalore, Indien: 88-91
Sahmi, F.; Nicola, E.S.; Zamberlam, G. O.; Goncalves, P. D. B.; Vanselow, J.; Price, C.A. (2014):
Factors regulating the bovine, caprine, rat and human ovarian aromatase promoters in a bovine granulosa cell model. Gen Comp Endocr 200: 10-17
https://dx.doi.org/10.1016/j.ygcen.2014.02.008
Baufeld, A.; Vanselow, J. (2013):
Increasing cell plating density mimics an early post-LH stage in cultured bovine granulosa cells. Cell Tissue Res 354 (3): 869-880
https://dx.doi.org/10.1007/s00441-013-1712-9
Christenson, L. K.; Gunewardena, S.; Hong, X.; Spitschak, M.; Baufeld, A.; Vanselow, J. (2013):
Preovulatory LH surge effects on follicular theca and granulosa transcriptomes. Mol Endocrinol 27 (7): 1153-1171
https://dx.doi.org/10.1210/Me.2013-1093
Spitschak, M.; Vanselow, J. (2012):
Bovine large luteal cells show increasing de novo DNA methylation of the main ovarian CYP19A1 promoter P2. Gen Comp Endocr 178 (1): 37-45
https://dx.doi.org/10.1016/j.ygcen.2012.04.001
Vanselow, J.; Kucia, M.; Langhammer, M.; Koczan, D.; Rehfeldt, C.; Metges, C. C. (2011):
Hepatic expression of the GH/JAK/STAT/IGF pathway, acute-phase response signalling and complement system are affected in mouse offspring by prenatal and early postnatal exposure to maternal high-protein diet. Eur J Nutr 50 (8): 611-623
https://dx.doi.org/10.1007/s00394-011-0168-5
Vanselow, J.; Fürbaß, R. (2011):
The bovine genome contains three differentially methylated paralogous copies of the P450c17 encoding gene (CYP17A1). Gen Comp Endocr 170 (3): 475-479
https://dx.doi.org/10.1016/j.ygcen.2010.11.003
Nimz, M.; Spitschak, M.; Fürbaß, R.; Vanselow, J. (2010):
The preovulatory luteinizing hormone surge is followed by downregulation of CYP19A1, HSD3B1 and CYP17A1 and chromatin condensation of the corresponding promoters in bovine follicles. Mol Reprod Dev 77: 1040-1048
https://dx.doi.org/10.1002/mrd.21257
Vanselow, J.; Fürbaß, R. (2010):
Epigenetic control of folliculogenesis and luteinization. Anim Reprod 7 (3): 134-139
Vanselow, J.; Langhammer, M. (2010):
Biodiversität und Leistung beim landwirtschaftlichen Nutztier. Forschungsreport 1: 20-23
Fürbaß, R.; Tomek, W.; Vanselow, J. (2010):
Upstream Stimulating Factors 1 and 2 Enhance Transcription from the Placenta-Specific Promoter 1.1 of the Bovine Cyp19 Gene. BMC Mol Biol 11: 5
Vanselow, J.; Spitschak, M.; Nimz, M.; Fürbaß, R. (2010):
DNA methylation is not involved in preovulatory down-regulation of CYP11A1, HSD3B1, and CYP19A1 in bovine follicles but may have a role in permanent silencing of CYP19A1 in large granulosa lutein cells. Biol Reprod 82 (2): 289-298
https://dx.doi.org/10.1095/biolreprod.109.079251
Nimz, M.; Spitschak, M.; Schneider, F.; Fürbaß, R.; Vanselow, J. (2009):
Down-regulation of genes encoding steroidogenic enzymes and hormone receptors in late preovulatory follicles of the cow coincides with an accumulation of intrafollicular steroids. DOMEST ANIM ENDOCRIN 37 (1): 45-54
https://dx.doi.org/10.1016/j.domaniend.2009.02.002
Tiemann, U.; Tomek, W.; Schneider, F.; Müller, U.; Pöhland, R.; Vanselow, J. (2009):
The mycotoxins alternariol and alternariol methyl ether negatively affect progesterone synthesis in porcine granulosa cells in vitro. Toxicol lett 186 (2): 139-145
https://dx.doi.org/10.1016/j.toxlet.2009.01.014
Vanselow, J.; Selimyan, R.; Fürbaß, R. (2008):
DNA methylation of placenta-specific Cyp19 promoters of cattle and sheep. Exp Clin Endocr Diab 116 (7): 437-442
https://dx.doi.org/10.1055/s-2008-1058083