Prof. Dr. rer. nat. habil. Cornelia Christiane Metges
Research Institute for Farm Animal Biology (FBN)
Head of working group Nutritional Physiology
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Head of working group Nutritional Physiology
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Research interests
- Effect of pre- and early postnatal nutrition on growth and development in farm animals
- Amino acid and energy metabolism
- Nutrient and energy efficiency and emissions in farm animals
Curriculum Vitae
- 2017: Professorship Biochemistry in Nutrition, University of Rostock
- 2001-present: Director of Institute of Nutritional Physiology 'Oskar Kellner', Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf
- 2002-present: Lecturer in Animal Nutrition and Feed Science, University of Rostock
- 2001: Habilitation in Nutritional Physiology (Dr. rer. nat. habil.), University of Potsdam
- 1995-1997: Visiting Scientist, Massachusetts Institute of Technology, Clinical Research Center and Laboratory of Human Nutrition, Cambridge, USA
- 1994-2001: Head, Working group 'Protein Metabolism', Dpt. Biochemistry and Physiology of Nutrition, German Institute of Human Nutrition (DIfE), Potsdam-Nuthetal
- 1987-1994: Research Scientist, Chair of Nutrition Science, TU München
- 1983-1987: Doctoral studies, TU München, Chair of General Chemistry and Biochemistry (1988; Doctorate in Agricultural Sciences; Dr. agr.), TU München
- 1977-1983: Studies of Agricultural Sciences (Dipl.-Ing. agr.), TU München
Teaching
- Since 2012: „Stoffwechsel-, Leistungs- und Pathophysiologie, Experimentelle Methoden in der Ernährungsphysiologie“, Master course Animal Science, University of Rostock
- Since 2012: „Anatomisch-physiologische Grundlagen und experimentelle Methoden der Tierernährung“, Master course Animal Science, University of Rostock
- Since 2010: „Zell- u. Molekularbiologie in der Ernährungs-forschung“ (Energy and Macronutrient metabolism), Master course Ökotrophologie, Christian-Albrechts-Universität zu Kiel
- Since 2003: „Biochemie des Intermediärstoffwechsels“, Bachelor course in Agricultural Sciences, University of Rostock
- 1994-2001: „Biochemie und Physiologie der Ernährung“, Master course in Nutrition Science, University of Potsdam
- 1989-1993: „Various Aspects of Human Nutrition“ in Nutrition Science, Chair of Nutrition Science, TU München
Publications
Oster, M.; Muràni, E.; Metges, C. C.; Ponsuksili, S.; Wimmers, K. (2012):
A gestational high protein diet affects the abundance of muscle transcripts related to cell cycle regulation throughout development in porcine progeny. Plos One 7 (3): 1-9
https://dx.doi.org/10.1371/journal.pone.0034519
Altmann, S.; Muràni, E.; Schwerin, M.; Metges, C. C.; Wimmers, K.; Ponsuksili, S. (2012):
Maternal dietary protein restriction and excess affects offspring gene expression and methylation of non-SMC subunits of condensin I in liver and skeletal muscle. Epigenetics-US 7 (3): 239-252
https://dx.doi.org/10.4161/epi.7.3.19183
Altmann, S.; Muràni, E.; Schwerin, M.; Metges, C. C.; Wimmers, K.; Ponsuksili, S. (2012):
Somatic cytochrome c (CYCS) gene expression and promoter-specific DNA methylation in a porcine model of prenatal exposure to maternal dietary protein excess and restriction. Brit J Nutr 107 (6): 791-799
https://dx.doi.org/10.1017/S0007114511003667
Altmann, S.; Muràni, E.; Metges, C. C.; Schwerin, M.; Wimmers, K.; Ponsuksili, S. (2012):
Effect of gestational protein deficiency and excess on hepatic expression of genes related to cell cycle and proliferation in offspring from late gestation to finishing phase in pig. Mol Biol Rep 39 (6): 7095-7104
https://dx.doi.org/10.1007/s11033-012-1541-z
Michalski, J. P.; Kowalczyk, B.; Voigt, J.; Hammon, H. M.; Czauderna, M.; Metges, C. C. (2012):
Efficiency of endogenous urea 15N nitrogen incorporation into bacterial and milk protein of goats fed diets with three different protein levels. J Anim Feed Sci 21 (4): 599-612
https://dx.doi.org/10.22358/jafs/65918/2013
Derno, M.; Langhammer, M.; Renne, U.; Hennig, U.; Kuhla, S.; Nürnberg, G.; Klaus, S.; Brockmann, G. A.; Metges, C. C. (2012):
Mice long-term selected for high body mass are more susceptible to body fat deposition in response to a high fat diet due to insufficient increase in heat production. Arch Tierzucht 55 (6): 633-646
Mickiewicz, M.; Zabielski, R.; Grenier, B.; Le Normand, L.; Savary, G.; Holst, J. J.; Oswald, I. P.; Metges, C. C.; Guilloteau, P. (2012):
Structural and functional development of small intestine in intrauterine growth retarded porcine offspring born to gilts fed diets with differing protein ratios throughout pregnancy. J Physiol Pharmacol 63 (3): 225-239
Berger, L. M.; Wein, S.; Blank, R.; Metges, C. C.; Wolffram, S. (2012):
Bioavailability of the flavonol quercetin in cows after intraruminal application of quercetin aglycone and rutin. J Dairy Sci 95 (9): 5047-5055
https://dx.doi.org/10.3168/jds.2012-5439
Petzke, K.-J.; Metges, C. C. (2012):
Practical recommendations for the reduction of memory effects in compound-specific 15N/14N-ratio analysis of enriched amino acids by gas chromatography/combustion/isotope ratio mass spectrometry. Rapid Commun Mass Sp 26 (2): 195-204
https://dx.doi.org/10.1002/Rcm.5319
Hammon, H. M.; Steinhoff-Wagner, J.; Schönhusen, U.; Metges, C. C.; Blum, J. W. (2012):
Energy metabolism in the newborn farm animal with emphasis on the calf: Endocrine changes and responses to milk-born and systemic hormones. DOMEST ANIM ENDOCRIN 43 (2): 171-185
https://dx.doi.org/10.1016/j.domaniend.2012.02.005
Schäff, C. T.; Albrecht, D.; Hammon, H. M.; Röntgen, M.; Metges, C. C.; Kuhla, B. (2012):
A longitudinal proteomic approach to investigate liver metabolism in periparturient dairy cows with different body fat mobilization. In: Farm Animal Proteomics : proceedings of the 3rd Managing Commitee Meeting and 2nd Meeting of the Working Groups 1,2 & 3 of COST Action FA1002 (Pedro Rodrigues, David Eckersall, Andre de Almeida, Hrsg.) Wageningen Academic Publishers, Wageningen (978-90-8686-195-8, 978-90-8686-751-6 eBook): 145-147
Tuchscherer, M.; Otten, W.; Kanitz, E.; Gräbner, M.; Tuchscherer, A.; Bellmann, O.; Rehfeldt, C.; Metges, C. C. (2012):
Effects of inadequate maternal dietary protein:carbohydrate ratios during pregnancy on offspring immunity in pigs. BMC Vet Res 8: 232-243
https://dx.doi.org/10.1186/1746-6148-8-232
Sawitzky, M.; Zeissler, A.; Langhammer, M.; Bielohuby, M.; Stock, K. F.; Hammon, H. M.; Görs, S.; Metges, C. C.; Stoehr, B. J. M.; Bidlingmaier, M.; Fromm-Dornieden, C.; Baumgartner, B. G.; Christ, B.; Brenig, B.; Binder, G.; Metzger, F.; Renne, U.; Hoeflich, A. (2012):
Phenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female mice. Plos One 7 (6): 1-13
https://dx.doi.org/10.1371/journal.pone.0039711
Shi, X.; Metges, C. C.; Seyfert, H.-M. (2012):
Interaction of C/EBP-beta and NF-Y factors constrains activity levels of the nutritionally controlled promoter IA expressing the acetyl-CoA carboxylase-alpha gene in cattle. BMC Mol Biol 13: 13-21
https://dx.doi.org/10.1186/1471-2199-13-21
Laeger, T.; Pöhland, R.; Metges, C. C.; Kuhla, B. (2012):
The ketone body β-hydroxybutyric acid influences agouti-related peptide expression via AMP-activated protein kinase in hypothalamic GT1-7 cells. J Endocrinol 213 (2): 193-203
https://dx.doi.org/10.1530/Joe-11-0457
Metzler-Zebeli, B. U.; Lang, I. S.; Görs, S.; Brüssow, K.-P.; Hennig, U.; Nürnberg, G.; Rehfeldt, C.; Otten, W.; Metges, C. C. (2012):
High-protein-low-carbohydrate diet during pregnancy alters maternal plasma amino acid concentration and placental amino acid extraction but not fetal plasma amino acids in pigs. Brit J Nutr 108 (12): 2176-2189
https://dx.doi.org/10.1017/S0007114512000414
Laeger, T.; Görs, S.; Metges, C. C.; Kuhla, B. (2012):
Effect of feed restriction on metabolites in cerebrospinal fluid and plasma of dairy cows. J Dairy Sci 95 (3): 1198-1208
https://dx.doi.org/10.3168/jds.2011-4506
Metges, C. C.; Lang, I. S.; Hennig, U.; Brüssow, K.-P.; Kanitz, E.; Tuchscherer, M.; Schneider, F.; Weitzel, J. M.; Steinhoff-Ooster, A.; Sauerwein, H.; Bellmann, O.; Nürnberg, G.; Rehfeldt, C.; Otten, W. (2012):
Intrauterine growth retarded progeny of pregnant sows fed high protein:low carbohydrate diet is related to metabolic energy deficit. Plos One 7 (2): 1-10
https://dx.doi.org/10.1371/journal.pone.0031390
Rehfeldt, C.; Stabenow, B.; Pfuhl, R.; Block, J.; Nürnberg, G.; Otten, W.; Metges, C. C.; Kalbe, C. (2012):
Effects of limited and excess protein intake of pregnant gilts on carcass quality and cellular properties of skeletal muscle and subcutaneous adipose tissue in fattening pigs. J Anim Sci 90 (1): 184-196
https://dx.doi.org/10.2527/jas.2011-4234
Rehfeldt, C.; Lefaucheur, L.; Block, J.; Stabenow, B.; Pfuhl, R.; Otten, W.; Metges, C. C.; Kalbe, C. (2012):
Limited and excess protein intake of pregnant gilts differently affects body composition and cellularity of skeletal muscle and subcutaneous adipose tissue of newborn and weanling piglets. Eur J Nutr 51 (2): 151-165
https://dx.doi.org/10.1007/s00394-011-0201-8