Prof. Dr. med. vet. Christa Kühn

+49 38208 68-702
Research Institute for Farm Animal Biology (FBN)
Institute of Genome Biology
Genome Physiology Unit
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Research interests

  • Genome analysis
  • Animal breeding and genetics
  • Molecular genetics
  • Disease resistance

Curriculum Vitae

  • 2018-present: Head of Institute of Genome Biology
  • 2014-present: Professor for Genetics of Disease Resistance at the Faculty of Agricultural and Environmental Science at the University Rostock
  • 2013-present: Director of the Genome Physiology Unit, Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf, Institute of Genome Biology
  • 2013: Call for Professor for Genetics of Disease Resistance at the University of Rostock
  • 2012: Vice Chair Research and Development at the Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf
  • 2011: Call for Professor for Animal genetics and pathogenetics at the Justus-Liebig-Universität Gießen
  • 2008: Authorization to provide post-gradual veterinary qualification in „Molecular Biology“
  • 2005: Habilitation at the Faculty for Agricultural and Environmental Sciences of the University of Rostock
  • 2004-2012: Team leader „QTL regions“, Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf, Institute of Molecular Biology
  • 1992-present: Scientist in the Institute of Molecular Biology at the Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf
  • 1991-1992: Veterinary practitioner with focus on farm animals (cattle, pig, sheep, horse) in the veterinary centre M. Schibalski, Quakenbrück, Germany
  • 1990: Post-doc at the Veterinary University Hanover
  • 1989: Promotion to Dr. med. vet. at the Veterinary University Hannover and approbation
  • 1987: Final Veterinary State Examination at the Veterinary University Hanover

Professional Activities

  • 2011-present: Member of the Editorial Board for Animal Genetics
  • 2010-present: Editor for the Journal of Dairy Science
  • 2011-present: Treasurer of the Gesellschaft für Tierzuchtwissenschaften (GfT)
  • 2009-present: Associate Editor for Genetics, Selection, Evolution
  • 2006-2011: Editor for ANIMAL

Teaching

  • since 2004: Teaching at the Faculty of Mathematics and Natural Science at the University Rostock within Diplome and Master courses for Biology and for Diversity and Evolution
  • since 2003: Teaching at the Faculty of Agricultural and Environmental Science at the University Rostock within Bachelor and Master courses in Agricultural Science, Agricultural Ecology and Animal Science

Publications

Nolte, W.; Weikard, R.; Albrecht, E.; Hammon, H. M.; Kühn, Ch. (2022):
Metabogenomic analysis to functionally annotate the regulatory role of long non-coding RNAs in the liver of cows with different nutrient partitioning phenotype. Genomics 114 (1): 202-214
https://doi.org/10.1016/j.ygeno.2021.12.004
Vosgerau, S.; Krattenmacher, N.; Falker-Gieske, C.; Seidel, A.; Tetens, J.; Stock, K. F.; Nolte, W.; Wobbe, M.; Blaj, I.; Reents, R.; Kühn, Ch.; Prondzinski, M. V.; Kalm, E.; Thaller, G. (2022):
Genetic and genomic characterization followed by single step genomic evaluation of withers height in German Warmblood horses. J Appl Genet 63: 369-378
https://doi.org/10.1007/s13353-021-00681-w
Robic, A.; Cerutti, C.; Demars, J.; Kühn, Ch. (2022):
From the comparative study of a circRNA originating from an mammalian ATXN2L intron to understanding the genesis of intron lariat-derived circRNAs. BBA-Gene Regul Mech 1865 (4): 194815, 1-15
https://doi.org/10.1016/j.bbagrm.2022.194815
Becker, D.; Heimes, A.; Hadlich, F.; Hammon, H. M.; Meyerholz, M. M.; Petzl, W.; Zerbe, H.; Schuberth, H.-J.; Hoedemaker, M.; Schmicke, M.; Engelmann, S.; Kühn, Ch. (2022):
Allele-biased expression of the bovine APOB gene associated with the Cholesterol Deficiency defect suggests cis-regulatory enhancer effects of the LTR retrotransposon insertion. Sci Rep-UK 12: 13469, 1-14
https://doi.org/10.1038/s41598-022-17798-5
Nolte, W.; Alkhoder, H.; Wobbe, M.; Stock, K. F.; Kalm, E.; Vosgerau, S.; Krattenmacher, N.; Thaller, G.; Tetens, J.; Kühn, Ch. (2022):
Replacement of microsatellite markers by imputed medium-density SNP arrays for parentage control in German warmblood horse. J Appl Genet 63: 783-792
https://doi.org/10.1007/s13353-022-00725-9
Stock, K. F.; Wobbe, M.; Häusler, M.; Alkhoder, H.; Nolte, W.; Kühn, Ch.; Vosgerau, S.; Krattenmacher, N.; von depka Prondzinski, M.; Tetens, J.; Thaller, G.; Kalm, E.; Reents, R. (2022):
Infrastruktur zur Etablierung genomisch unterstützter Routineverfahren für die deutsche Pferdezucht Umstellung der Abstammungsüberprüfung beim Reitpferd mit Ausblick auf zukünftige genomische Anwendungen in der Pferdezucht. Zuchtungskunde 94 (5): 321-329
Wobbe, M.; Alkhoder, H.; Liu, Z.; Vosgerau, S.; Krattenmacher, N.; von depka Prondzinski, M.; Kalm, E.; Reents, R.; Nolte, W.; Kühn, Ch.; Tetens, J.; Thaller, G.; Stock, K. F. (2022):
Genomische Zuchtwertschätzung im single-step Verfahren für lineare Exterieur- und Leistungsmerkmale bei Reitpferden. Zuchtungskunde 94 (5): 363-379
Nolte, W.; Alkhoder, H.; Wobbe, M.; Stock, K. F.; Kalm, E.; Vosgerau, S.; Krattenmacher, N.; Thaller, G.; Tetens, J.; Kühn, Ch. (2022):
Umstellung der Abstammungsüberprüfung beim Reitpferd mit Ausblick auf zukünftige genomische Anwendungen in der Pferdezucht. Zuchtungskunde 94 (5): 330-346
Vosgerau, S.; Krattenmacher, N.; Falker-Gieske, C.; Seidel, A.; Tetens, J.; Stock, K. F.; Nolte, W.; Wobbe, M.; Reents, R.; Kühn, Ch.; von depka Prondzinski, M.; Kalm, E.; Thaller, G. (2022):
Analysen zum Einfluss der Struktur der verbandsübergreifenden Lernstichprobe beim deutschen Warmblutpferd anhand verschiedener Kreuzvalidierungsansätze für das Merkmal Stockmaß. Zuchtungskunde 94 (5): 347-362
Kühn, Ch. (2022):
Genomannotation - Funktion genetischer Diversität erkennen. DGfZ-Schriftenreihe 81: 342-347
Becker, D.; Weikard, R.; Hadlich, F.; Kühn, Ch. (2021):
Single-cell RNA sequencing of freshly isolated bovine milk cells and cultured primary mammary epithelial cells. Sci Data 8: 177, 1-9
Robic, A.; Cerutti, C.; Kühn, Ch.; Faraut, T. (2021):
Comparative analysis of the circular transcriptome in muscle, liver and testis in three livestock species. Front Genet 12: 665153, 1-19
https://doi.org/10.3389/fgene.2021.665153
Chitneedi, P.; Weikard, R.; Arranz, J. J.; Martínez-Valladares, M.; Kühn, Ch.; Gutiérrez-Gil, B. (2021):
Identification of Regulatory Functions of LncRNAs Associated With T. circumcincta Infection in Adult Sheep. Front Genet 12: 685341, 1-18
https://doi.org/10.3389/fgene.2021.685341
Chamberlain, A.; Cheng, H.; Giuffra, E.; Kühn, Ch.; Tuggle, C. K.; Zhou, H. (2021):
Editorial: Functional Annotation of Animal Genomes. Front Genet 12: 768626, 1-3
https://doi.org/10.3389/fgene.2021.768626
Heimes, A.; Brodhagen, J.; Weikard, R.; Becker, D.; Meyerholz, M. M.; Petzl, W.; Zerbe, H.; Schuberth, H.-J.; Hoedemaker, M.; Schmicke, M.; Engelmann, S.; Kühn, Ch. (2020):
Cows selected for divergent mastitis susceptibility display a differntial liver transcriptome profile after experimental Staphylococcus aureus mammary gland inoculation. J Dairy Sci 103 (7): 6364-6373
https://doi.org/10.3168/jds.2019-17612
Heimes, A.; Brodhagen, J.; Weikard, R.; Seyfert, H.-M.; Becker, D.; Meyerholz, M. M.; Petzl, W.; Zerbe, H.; Hoedemaker, M.; Rohmeier, L.; Schubert, H-J; Schmicke, M.; Engelmann, S.; Kühn, Ch. (2020):
Hepatic transcriptome analysis identifies divergent pathogen-specific targeting-strategies to modulate the innate immune system in response to intramammary infection. Front Immunol 11: 715, 1-22
https://doi.org/10.3389/fimmu.2020.00715
Mir, B. A.; Reyer, H.; Komolka, K.; Ponsuksili, S.; Kühn, Ch.; Maak, S. (2020):
Differentially expressed miRNA-gene targets related to intramuscular fat in Musculus longissimus dorsi of Charolais x Holstein F2-crossbred bulls. Genes-Basel 11 (6): 700, 1-12
https://doi.org/10.3390/genes11060700
Nolte, W.; Weikard, R.; Brunner, R. M.; Albrecht, E.; Hammon, H. M.; Reverter, A.; Kühn, Ch. (2020):
Identification and annotation of potential function of regulatory antisense long non-coding RNAs related to feed efficiency in Bos taurus bulls. Int J Mol Sci 21 (9): 3292,1-14
https://doi.org/10.3390/ijms21093292
Knaust, J.; Weikard, R.; Albrecht, E.; Brunner, R. M.; Günther, J.; Kühn, Ch. (2020):
Indication of premelanosome protein (PMEL) expression outside of pigmented bovine skin suggests functions beyond eumelanogenesis. Genes-Basel 11 (7): 788,1-13
https://doi.org/10.3390/genes11070788
Rohmeier, L.; Petzl, W.; Koy, M; Eickhoff, T.; Hülsebusch, A.; Jander, S.; Macias, L.; Heimes, A.; Engelmann, S.; Hoedemaker, M.; Seyfert, H.-M.; Kühn, Ch.; Schuberth, H.-J.; Zerbe, H.; Meyerholz, M. M. (2020):
In vivo model to study the impact of genetic variation on clinical outcome of mastitis in dairy heifers. BMC Vet Res 16: 33,1-12
https://doi.org/10.1186/s12917-020-2251-8