PD Dr. rer. nat. habil. Björn Kuhla

Research Institute for Farm Animal Biology (FBN)
Head of working group Nutritional Biochemistry
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Research interests

  • Neuronal and metabolic control of feed intake
  • Links between feed efficiency, diet and methane production
  • Metabolic adaptation to environmental heat

Curriculum Vitae

  • 2013-present: Director of 'Fuel Sensing Unit', Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf, Institute of Nutritional Physiology "Oskar Kellner"
  • 2009-2012: Leader of Junior Research Group „Feed Intake Regulation“, Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf
  • 2006-present: Scientist at the Institute of Nutritional Physiology “Oskar Kellner”, Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf
  • Habilitation and venia legendi in Biochemistry
  • Post Doc at the Agricultural Research Centre of the Bayer AG Monheim, University of Leipzig, and Case Western Reserve University, Cleveland
  • Diploma and Doctoral Degree in Chemistry
  • Secondary education and apprenticeship for animal production

Teaching

  • Anatomic-Physiological Basics and Methods in Animal Nutrition
  • Metabolism and performance physiology
  • Practical Course “Isolation of RNA from plant leaves”

Publications

Kuhla, B.; Laeger, T.; Husi, H.; Mullen, W. (2015):
Cerebrospinal fluid prohormone processing and neuropeptides stimulating feed intake of dairy cows during early lactation. J Proteome Res 14 (2): 823-828
https://dx.doi.org/10.1021/pr500872k
Kuhla, A.; Ludwig, S. C.; Kuhla, B.; Münch, G.; Vollmar, B. (2015):
Advanced glycation end products are mitogenic signals and trigger cell cycle reentry of neurons in Alzheimer's disease brain. Neurobiol Aging 36 (2): 753-761
https://dx.doi.org/10.1016/j.neurobiolaging.2014.09.025
van Knegsel, A. T. M.; Hammon, H. M.; Bernabucci, U.; Bertoni, G.; Bruckmaier, R. M.; Goselink, R. M. A.; Gross, J.; Kuhla, B.; Metges, C. C.; Parmentier, H. K.; Trevisi, E.; Tröscher, A.; van Vuuren, A. (2014):
Metabolic adaptation during early lactation: key to cow health, longevity and a sustainable dairy production chain. CAB Reviews 9 (002): 1-15
https://dx.doi.org/10.1079/PAVSNNR20149002
Laeger, T.; Wirthgen, E.; Piechotta, M.; Metzger, F.; Metges, C. C.; Kuhla, B.; Höflich, A. (2014):
Effects of parturition and feed restriction on concentrations and distribution of the insulin-like growth factor-binding proteins in plasma and cerebrospinal fluid of dairy cows. J Dairy Sci 97 (5): 2876-2885
https://dx.doi.org/10.3168/jds.2013-7671
Metges, C. C.; Hammon, H. M.; Derno, M.; Weber, F. M.; Kuhla, B. (2013):
Beeinflussung des Erhaltungs- und Leistungsbedarfs durch physiologische Faktoren als Grundlage einer effizienten Milchproduktion. Schriftenreihe / Leibniz-Institut für Nutztierbiol 22: 9-16
Schwarm, A.; Schweigel-Röntgen, M.; Ortmann, S.; Kuhla, B.; Meyer, U.; Lohhölter, M.; Derno, M. (2013):
Brown Midrib Mais – ein Futtermittel mit Potential? : Futterwert und Auswirkungen auf Methanemissionen. In: Sind hohe Leistungen „Bio-kompatibel“? Herausforderungen für die Tierernährung (ETH-Schriftenreihe zur Tierernährung , 36) (M. Kreuzer et al., Hrsg.) ETH, Zürich (978-3-906466-36-1) ( 36): 68-71
Mielenz, M.; Kuhla, B.; Hammon, H. M. (2013):
Abundance of adiponectin system and G-protein coupled receptor GPR109A mRNA in adipose tissue and liver of F2 offspring cows of Charolais x German Holstein crosses that differ in body fat accumulation. J Dairy Sci 96 (1): 278-289
https://dx.doi.org/10.3168/jds.2012-5816
Kuhla, B.; Metges, C. C. (2013):
Proteomic tools help understanding the metabolic adaptation to negative energy balance in dairy cows. In: Energy and protein metabolism and nutrition in sustainable animal production (EAAP Publication , 134) (James W. Oltjen et al., Hrsg.) Wageningen Academic Publ., (ISBN 978-90-8686-227-6, eISBN 978-90-8686-781-3): 213-221
Schäff, C. T.; Börner, S.; Hacke, S.; Kautzsch, U.; Sauerwein, H.; Spachmann, S. K.; Schweigel-Röntgen, M.; Hammon, H. M.; Kuhla, B. (2013):
Increased muscle fatty acid oxidation in dairy cows with intensive body fat mobilization during early lactation. J Dairy Sci 96 (10): 6449-6460
https://dx.doi.org/10.3168/jds.2013-6812
Laeger, T.; Sauerwein, H.; Tuchscherer, A.; Bellmann, O.; Metges, C. C.; Kuhla, B. (2013):
Concentrations of hormones and metabolites in cerebrospinal fluid and plasma of dairy cows during the periparturient period. J Dairy Sci 96 (5): 2883-2893
https://dx.doi.org/10.3168/jds.2012-5909
Börner, S.; Albrecht, E.; Schäff, C. T.; Hacke, S.; Kautzsch, U.; Derno, M.; Hammon, H. M.; Röntgen, M.; Sauerwein, H.; Kuhla, B. (2013):
Reduced AgRP activation in the hypothalamus of cows with high extent of fat mobilization after parturition. Gen Comp Endocr 193: 167-177
https://dx.doi.org/10.1016/j.ygcen.2013.08.002
Derno, M.; Nürnberg, G.; Schön, P.-Ch.; Schwarm, A.; Röntgen, M.; Hammon, H. M.; Metges, C. C.; Bruckmaier, R. M.; Kuhla, B. (2013):
Short-term feed intake is regulated by macronutrient oxidation in lactating Holstein cows. J Dairy Sci 96 (2): 971-980
https://dx.doi.org/10.3168/jds.2012-5727
Börner, S.; Derno, M.; Hacke, S.; Kautzsch, U.; Schäff, C. T.; ThanThan, S.; Kuwayama, H.; Hammon, H. M.; Röntgen, M.; Weikard, R.; Kühn, C.; Tuchscherer, A.; Kuhla, B. (2013):
Plasma ghrelin is positively associated with body fat, liver fat and milk fat content, but not with feed intake of dairy cows after parturition. J Endocrinol 216 (2): 217-229
https://dx.doi.org/10.1530/Joe-12-0384
Kuhla, B. (2012):
Die Rolle von Carbonylen bei glycierungsabhängigen neurodegenerativen Prozessen und bei der neuronalen Kontrolle der Nahrungsaufnahme. Habilitationsschrift, Universität Rostock: 1-216
Schäff, C. T.; Albrecht, D.; Hammon, H. M.; Röntgen, M.; Metges, C. C.; Kuhla, B. (2012):
A longitudinal proteomic approach to investigate liver metabolism in periparturient dairy cows with different body fat mobilization. In: Farm Animal Proteomics : proceedings of the 3rd Managing Commitee Meeting and 2nd Meeting of the Working Groups 1,2 & 3 of COST Action FA1002 (Pedro Rodrigues, David Eckersall, Andre de Almeida, Hrsg.) Wageningen Academic Publishers, Wageningen (978-90-8686-195-8, 978-90-8686-751-6 eBook): 145-147
Schäff, C. T.; Boener, S.; Hacke, S.; Kautsch, U.; Albrecht, D.; Hammon, H. M.; Röntgen, M.; Kuhla, B. (2012):
Increased Anaplerosis, TCA Cycling, and Oxidative Phosphorylation in the Liver of Dairy Cows with Intensive Body Fat Mobilization during Early Lactation. J Proteome Res 11 (11): 5503-5514
https://dx.doi.org/10.1021/Pr300732n
Laeger, T.; Pöhland, R.; Metges, C. C.; Kuhla, B. (2012):
The ketone body β-hydroxybutyric acid influences agouti-related peptide expression via AMP-activated protein kinase in hypothalamic GT1-7 cells. J Endocrinol 213 (2): 193-203
https://dx.doi.org/10.1530/Joe-11-0457
Laeger, T.; Hammon, H. M.; Kuhla, B. (2012):
Beta-hydroxybutyric acid/glucose ratio dependent orexigenic signaling in hypothalamic GT1-7 cells. Proc. Soc. Nutr. Physiol. 21: 52-52
Laeger, T.; Görs, S.; Metges, C. C.; Kuhla, B. (2012):
Effect of feed restriction on metabolites in cerebrospinal fluid and plasma of dairy cows. J Dairy Sci 95 (3): 1198-1208
https://dx.doi.org/10.3168/jds.2011-4506
Metges, C. C.; Hammon, H. M.; Kuhla, B.; Röntgen, M.; Souffrant, W.-B. (2011):
International Oskar Kellner Symposium: Metabolic Flexibility in Animal and Human Nutrition, Warnemünde 9.-11.9.2011, Programme with Abstracts (Schriftenreihe / Leibniz-Institut für Nutztierbiologie, 19) : 1-143