Dr. rer. nat. habil. Beate Fuchs
Research interests
- Regulation of lipid metabolism
- Lipidomics, Metabolomics
- Mass spectrometry & Analytics (GC-MS/MS, MALDI-TOF MS, TLC, HR-ESI-MS/MS)
Curriculum Vitae
- 2017-present Head of Core Facility - Metabolomics, Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf
- 2016 Habilitation (Dr. rer. nat. habil.) at the Medical Faculty, University Leipzig
- 2016 Research stay at the University of Pittsburgh, USA
- 2009-2017 Independent Research Group Leader, DFG-funded research-project: HOCl-induced lysophospholipid generation from diacyl- and alkenyl-acyl phospholipids
- 2007-2009 Scientific Co-worker at the Institute of Medical Physics and Bio¬physics at the Medi¬cal Faculty of the University of Leipzig
- 2006 Research stay at the Strathclyde University in Glasgow, UK
- 2004 Research stay at the University of Louisville, Kentucky, USA
- 2002-2006 Postgraduate studies in Toxicology, University of Leipzig
- 2002-2006 Postdoctoral fellowship of the Interdisciplinary Centre of Clinical Research of the Medical Faculty in Leipzig ("NMR and MALDI-TOF MS studies of cartilage degradation in rheumatoid arthritis: structure elucidation and clinical monitoring")
- 1998-2001 PhD student at the Institute of Polymer Research in Dresden
- Thesis: 19F NMR studies of irradiation-modified fluoropolymers
- 1996-1997 Stipendiary of the Carl Duisberg foundation and trainee at Bayer de México in Mexico
- 1996 Diploma Thesis at the Chair of Analytical Chemistry at the Univer¬sity of Freiberg (Topic: 31C NMR studies of structural changes of microbial treated brown coal)
Publications
Richter, G.; Schober, C.; Suss, R.; Fuchs, B.; Birkemeyer, C.; Schiller, J. (2008):
Comparison of the positive and negative ion electrospray ionization and matrix-assisted laser desorption ionization-time-of-flight mass spectra of the reaction products of phosphatidylethanolamines and hypochlorous acid. Anal. Biochem. 376: 157-159
Jakop, U.; Fuchs, B.; Schiller, J.; Muller, K. (2008):
The influence of different detergents on boar sperm membrane lysis, lipid extraction and analysis. Reproduction in Domestic Animals 43: 16-16
Fuchs, B.; Schober, C.; Richter, G.; Nimptsch, A.; Suss, R.; Schiller, J. (2008):
The reactions between HOCl and differently saturated phospholipids: Physiological relevance, products and methods of evaluation. Mini-Reviews in Organic Chemistry 5: 254-261
Fuchs, B.; Schiller, J.; Suss, R.; Zscharnack, M.; Bader, A.; Muller, P.; Schurenberg, M.; Becker, M.; Suckau, D. (2008):
Analysis of stem cell lipids by offline HPTLC-MALDI-TOF MS. Anal. Bioanal. Chem. 392: 849-860
Fuchs, B.; Schiller, J. (2008):
MALDI-TOF MS analysis of lipids from cells, tissues and body fluids. Subcell Biochem 49: 541-565
Fuchs, B.; Nimptsch, A.; Suss, R.; Schiller, J. (2008):
Analysis of Brain Lipids by Directly Coupled Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry and High-Performance Thin-Layer Chromatography. J. AOAC Int. 91: 1227-1236
Schiller, J.; Suss, R.; Fuchs, B.; Muller, M.; Zschornig, O.; Arnold, K. (2007):
Recent applications of MALDI-TOF mass spectrometry and P-31 NMR spectroscopy in phospholipid research. Future Lipidology 1: 115-125
Schiller, J.; Suss, R.; Fuchs, B.; Muller, M.; Zschornig, O.; Arnold, K. (2007):
MALDI-TOF MS in lipidomics. Frontiers in Bioscience-Landmark 12: 2568-2579
Schiller, J.; Suss, R.; Fuchs, B.; Muller, M.; Petkovic, M.; Zschornig, O.; Waschipky, H. (2007):
The suitability of different DHB isomers as matrices for the MALDI-TOF MS analysis of phospholipids: which isomer for what purpose? European Biophysics Journal with Biophysics Letters 36: 517-527
Schiller, J.; Muller, M.; Fuchs, B.; Arnold, K.; Huster, D. (2007):
P-31 NMR Spectroscopy of phospholipids: from micelles to membranes. Current Analytical Chemistry 3: 283-301
Lessig, J.; Schiller, J.; Arnhold, J.; Fuchs, B. (2007):
Hypochlorous acid-mediated generation of glycerophosphocholine from unsaturated plasmalogen glycerophosphocholine lipids. J. Lipid Res. 48: 1316-1324
Fuchs, B.; Schober, C.; Richter, G.; Suss, R.; Schiller, J. (2007):
MALDI-TOF MS of phosphatidylethanolamines: Different adducts cause different post source decay (PSD) fragment ion spectra. J. Biochem. Biophys. Methods 70: 689-692
Fuchs, B.; Schiller, J.; Suss, R.; Schurenberg, M.; Suckau, D. (2007):
A direct and simple method of coupling matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) to thin-layer chromatography (TLC) for the analysis of phospholipids from egg yolk. Anal. Bioanal. Chem. 389: 827-834
Fuchs, B.; Schiller, J.; Cross, M. A. (2007):
Apoptosis-associated changes in the glycerophospholipid composition of hematopoietic progenitor cells monitored by P-31 NMR spectroscopy and MALDI-TOF mass spectrometry. Chemistry and Physics of Lipids 150: 229-238
Fuchs, B.; Muller, K.; Goritz, F.; Blottner, S.; Schiller, J. (2007):
Characteristic oxidation products of choline plasmalogens are detectable in cattle and roe deer spermatozoa by MALDI-TOF mass spectrometry. Lipids 42: 991-998
Schiller, J.; Fuchs, B.; Arnold, K. (2006):
The molecular organization of polymers of cartilage in health and disease. Current Organic Chemistry 10: 1771-1789
Fuchs, B.; Schiller, J.; Wagner, U.; Hantzschel, H.; Arnold, K. (2005):
The phosphatidylcholine/lysophosphatidylcholine ratio in human plasma is an indicator of the severity of rheumatoid arthritis: investigations by 31P NMR and MALDI-TOF MS. Clin. Biochem. 38: 925-933
Schiller, J.; Suss, R.; Arnhold, J.; Fuchs, B.; Lessig, J.; Muller, M.; Petkovic, M.; Spalteholz, H.; Zschornig, O.; Arnold, K. (2004):
Matrix-assisted laser desorption and ionization time-of-flight (MALDI-TOF) mass spectrometry in lipid and phospholipid research. Prog Lipid Res 43: 449-488
Schiller, J.; Huster, D.; Fuchs, B.; Naji, L.; Kaufmann, J.; Arnold, K. (2004):
Evaluation of cartilage composition and degradation by high-resolution magic-angle spinning nuclear magnetic resonance. Methods Mol Med 101: 267-285
Fuchs, B.; Scheler, U. (2004):
F-19 spin-lattice relaxation and stable radicals in radiation-modified fluoropolymers. Applied Magnetic Resonance 27: 435-442