Dr. rer. nat. habil. Beate Fuchs

Research Institute for Farm Animal Biology (FBN)
Haed of Service group Metabolomics & Lipidomics
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Research interests

  • Regulation of lipid metabolism
  • Lipidomics, Metabolomics
  • Mass spectrometry & Analytics (GC-MS/MS, MALDI-TOF MS, TLC, HR-ESI-MS/MS)

Curriculum Vitae

  • 2017-present Head of Core Facility - Metabolomics, Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf
  • 2016 Habilitation (Dr. rer. nat. habil.) at the Medical Faculty, University Leipzig
  • 2016 Research stay at the University of Pittsburgh, USA
  • 2009-2017 Independent Research Group Leader, DFG-funded research-project: HOCl-induced lysophospholipid generation from diacyl- and alkenyl-acyl phospholipids
  • 2007-2009 Scientific Co-worker at the Institute of Medical Physics and Bio¬physics at the Medi¬cal Faculty of the University of Leipzig
  • 2006 Research stay at the Strathclyde University in Glasgow, UK
  • 2004 Research stay at the University of Louisville, Kentucky, USA
  • 2002-2006 Postgraduate studies in Toxicology, University of Leipzig
  • 2002-2006 Postdoctoral fellowship of the Interdisciplinary Centre of Clinical Research of the Medical Faculty in Leipzig ("NMR and MALDI-TOF MS studies of cartilage degradation in rheumatoid arthritis: structure elucidation and clinical monitoring")
  • 1998-2001 PhD student at the Institute of Polymer Research in Dresden
  • Thesis: 19F NMR studies of irradiation-modified fluoropolymers
  • 1996-1997 Stipendiary of the Carl Duisberg foundation and trainee at Bayer de México in Mexico
  • 1996 Diploma Thesis at the Chair of Analytical Chemistry at the Univer¬sity of Freiberg (Topic: 31C NMR studies of structural changes of microbial treated brown coal)

Publications

Lessig, J.; Fuchs, B. (2010):
HOCl-mediated glycerophosphocholine and glycerophosphoethanolamine generation from plasmalogens in phospholipid mixtures. Lipids 45: 37-51
Galle, J.; Bader, A.; Hepp, P.; Grill, W.; Fuchs, B.; Kas, J. A.; Krinner, A.; Marquass, B.; Muller, K.; Schiller, J.; Schulz, R. M.; von Buttlar, M.; von der Burg, E.; Zscharnack, M.; Loffler, M. (2010):
Mesenchymal stem cells in cartilage repair: state of the art and methods to monitor cell growth, differentiation and cartilage regeneration. Curr. Med. Chem. 17: 2274-2291
Fuchs, B.; Suss, R.; Schiller, J. (2010):
An update of MALDI-TOF mass spectrometry in lipid research. Prog Lipid Res 49: 450-475
Dannenberger, D.; Suss, R.; Teuber, K.; Fuchs, B.; Nuernberg, K.; Schiller, J. (2010):
The intact muscle lipid composition of bulls: an investigation by MALDI-TOF MS and P-31 NMR. Chemistry and Physics of Lipids 163: 157-164
Schober, C.; Schiller, J.; Pinker, F.; Hengstler, J. G.; Fuchs, B. (2009):
Lysophosphatidylethanolamine is - in contrast to - choline - generated under in vivo conditions exclusively by phospholipase A2 but not by hypochlorous acid. Bioorg. Chem. 37: 202-210
Schober, C.; Fuchs, B.; Schiller, J. (2009):
Differential efficiency of lysophospholipid markers for oxidative stress. FASEB J. 23: 1
Nimptsch, A.; Schibur, S.; Schnabelrauch, M.; Fuchs, B.; Huster, D.; Schiller, J. (2009):
Characterization of the quantitative relationship between signal-to-noise (S/N) ratio and sample amount on-target by MALDI-TOF MS: Determination of chondroitin sulfate subsequent to enzymatic digestion. Anal. Chim. Acta 635: 175-182
Lessig, J.; Fuchs, B. (2009):
Plasmalogens in biological systems: their role in oxidative processes in biological membranes, their contribution to pathological processes and aging and plasmalogen analysis. Curr. Med. Chem. 16: 2021-2041
Jaskolla, T.; Fuchs, B.; Karas, M.; Schiller, J. (2009):
The New Matrix 4-Chloro-alpha-Cyanocinnamic Acid Allows the Detection of Phosphatidylethanolamine Chloramines by MALDI-TOF Mass Spectrometry. J. Am. Soc. Mass Spectrom. 20: 867-874
Jakop, U.; Fuchs, B.; Suss, R.; Wibbelt, G.; Braun, B.; Muller, K.; Schiller, J. (2009):
The solubilisation of boar sperm membranes by different detergents - a microscopic, MALDI-TOF MS, P-31 NMR and PAGE study on membrane lysis, extraction efficiency, lipid and protein composition. Lipids in Health and Disease 8: Artn 49
Fuchs, B.; Suss, R.; Nimptsch, A.; Schiller, J. (2009):
MALDI-TOF-MS Directly Combined with TLC: A Review of the Current State. Chromatographia 69: S95-S105
Fuchs, B.; Schiller, J.; Suss, R.; Nimptsch, A.; Schurenberg, M.; Suckau, D. (2009):
Capabilities and Disadvantages of Combined Matrix-Assisted Laser-Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) and High-Performance Thin-Layer Chromatography (HPTLC): Analysis of Egg Yolk Lipids. Jpc-Journal of Planar Chromatography-Modern Tlc 22: 35-42
Fuchs, B.; Schiller, J. (2009):
Recent Developments of Useful MALDI Matrices for the Mass Spectrometric Characterization of Apolar Compounds. Current Organic Chemistry 13: 1664-1681
Fuchs, B.; Schiller, J. (2009):
Application of MALDI-TOF mass spectrometry in lipidomics. European Journal of Lipid Science and Technology 111: 83-98
Fuchs, B.; Schiller, J. (2009):
Lysophospholipids: their generation, physiological role and detection. Are they important disease markers? Mini Rev Med Chem 9: 368-378
Fuchs, B.; Nimptsch, A.; Suss, R.; Schiller, J. (2009):
Capabilities and drawbacks of phospholipid analysis by MALDI-TOF mass spectrometry. Methods Mol Biol 579: 103-125
Fuchs, B.; Jakop, U.; Goritz, F.; Hermes, R.; Hildebrandt, T.; Schiller, J.; Muller, K. (2009):
MALDI-TOF "fingerprint" phospholipid mass spectra allow the differentiation between ruminantia and feloideae spermatozoa. Theriogenology 71: 568-575"
Fuchs, B.; Bondzio, A.; Wagner, U.; Schiller, J. (2009):
Phospholipid compositions of sera and synovial fluids from dog, human and horse: a comparison by 31P-NMR and MALDI-TOF MS. J Anim Physiol Anim Nutr (Berl) 93: 410-422
Fuchs, B.; Bischoff, A.; Suss, R.; Teuber, K.; Schurenberg, M.; Suckau, D.; Schiller, J. (2009):
Phosphatidylcholines and -ethanolamines can be easily mistaken in phospholipid mixtures: a negative ion MALDI-TOF MS study with 9-aminoacridine as matrix and egg yolk as selected example. Anal. Bioanal. Chem. 395: 2479-2487
Bauer, A.; Schumann, A.; Gilbert, M.; Wilhelm, C.; Hengstler, J. G.; Schiller, J.; Fuchs, B. (2009):
Evaluation of carbon tetrachloride-induced stress on rat hepatocytes by P-31 NMR and MALDI-TOF mass spectrometry: lysophosphatidylcholine generation from unsaturated phosphatidylcholines. Chemistry and Physics of Lipids 159: 21-29