PD Dr. rer. nat. habil. Andreas Höflich
Research Institute for Farm Animal Biology (FBN)
Head of working group Endocrinology of Farm Animals
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Head of working group Endocrinology of Farm Animals
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Research interests
- Growth and metabolism
- Functional genome analysis
- Biomarker research
Curriculum Vitae
- since 2013: Director of Cell Signaling Unit, FBN
- since 2009: Lecturer at the University of Rostock
- 4/2009: Habilitation at the Faculty of Mathematics and Natural Sciences, University of Rostock
- 2006-2012: Group Leader, Mouse Genetics, FBN
- 2002-2006: Lecturer at University of Rostock
- 6/2002: Habilitation at the Faculty of Veterinary Medicine, University of Munich
- 1996-2002: Assistant professor University of Munich
- 6/1995: Dissertation at the Institute of Organic Chemistry and Biology, Technical University of Munich
- 1985-2002: Studies of Biology, University of Erlangen-Nürnberg,
Teaching
Molecular Animal Breeding: Lectures, Seminars and practical courses within the program: Diversity and Evolution (MSc)
Publications
Pitcher, M. R.; Ward, C. S.; Arvide, E. M.; Chapleau, C. A.; Pozzo-Miller, L.; Hoeflich, A.; Sivaramakrishnan, M.; Saenger, S.; Metzger, F.; Neul, J. L. (2013):
Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function. Hum Mol Genet 22 (13): 2626-2633
https://dx.doi.org/10.1093/Hmg/Ddt111
Michaelis, M.; Langhammer, M.; Hoeflich, A.; Reinsch, N.; Schön, J.; Weitzel, J. M. (2013):
Initial characterization of an outbreed mouse model for male factor (in)fertility. Andrology 1 (5): 772-778
https://dx.doi.org/10.1111/j.2047-2927.2013.00108.x
Piechotta, M.; Kedves, K.; Araujo, M. G.; Hoeflich, A.; Metzger, F.; Heppelmann, M.; Muscher-Banse, A.; Wrenzycki, C.; Pfarrer, C.; Schuberth, H.-J.; Hoedemaker, M.; Bollwein, H.; Kaske, M. (2013):
Hepatic mRNA expression of acid labile subunit and deiodinase 1 differs between cows selected for high versus low concentrations of insulin-like growth factor 1 in late pregnancy. J Dairy Sci 96 (6): 3737-3749
https://dx.doi.org/10.3168/jds.2012-6341
Brenmoehl, J.; Hoeflich, A. (2013):
Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3. Mitochondrion 13 (6): 755-761
https://dx.doi.org/10.1016/j.mito.2013.04.002
Huguet, A.; Medja, F.; Nicole, A.; Vignaud, A.; Guiraud-Dogan, C.; Ferry, A.; Decostre, V.; Hogrel, J.-Y.; Metzger, F.; Hoeflich, A.; Baraibar, M.; Gomes-Pereira, M.; Puymirat, J.; Bassez, G.; Furling, D.; Munnich, A.; Gourdon, G. (2012):
Molecular, physiological, and motor performance defects in DMSXL mice carrying >1000 CTG repeats from the human DM1 locus. PLOS Genet 8 (11): 1-19
https://dx.doi.org/10.1371/journal.pgen.1003043
Fromm-Dornieden, C.; Lytovchenko, O.; von der Heyde, S.; Behnke, N.; Hogl, S.; Berghoff, J.; Köpper, F.; Opitz, L.; Renne, U.; Hoeflich, A.; Beissbarth, T.; Brenig, B.; Baumgartner, B. G. (2012):
Extrinsic and intrinsic regulation of DOR/TP53INP2 expression in mice: effects of dietary fat content, tissue type and sex in adipose and muscle tissues. Nutr Metab 9 (1): 86-97
https://dx.doi.org/10.1186/1743-7075-9-86
Saenger, S.; Holtmmann, B.; Nilges, M.; Schroeder, S.; Hoeflich, A.; Kletzl, H.; Spooren, W.; Ostrowizki, S.; Hanania, T.; Sendtner, M.; Metzger, F. (2012):
Funktional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity. Amyotroph Lateral Sc 13 (5): 418-429
https://dx.doi.org/10.3109/17482968.2012.679944
Fuellen, G.; Dengjel, J.; Hoeflich, A.; Hoeijemakers, J.; Kestler, H. A.; Kowald, A.; Priebe, S.; Rebholz-Schuhmann, D.; Schmeck, B.; Schmitz, U.; Stolzing, A.; Sühnel, J.; Wuttke, D.; Vera, J. (2012):
Systems biology and bioinformatics in aging research: a workshop report. Rejuv Res 15 (6): 631-641
https://dx.doi.org/10.1089/rej.2012.1360
Sawitzky, M.; Zeissler, A.; Langhammer, M.; Bielohuby, M.; Stock, K. F.; Hammon, H. M.; Görs, S.; Metges, C. C.; Stoehr, B. J. M.; Bidlingmaier, M.; Fromm-Dornieden, C.; Baumgartner, B. G.; Christ, B.; Brenig, B.; Binder, G.; Metzger, F.; Renne, U.; Hoeflich, A. (2012):
Phenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female mice. Plos One 7 (6): 1-13
https://dx.doi.org/10.1371/journal.pone.0039711
Gehrig, S. M.; van der Poel, C.; Hoeflich, A.; Naim, T.; Lynch, G. S.; Metzger, F. (2012):
Therapeutic potential of PEGylated insulin-like growth factor I for skeletal muscle disease evaluated in two murine models of muscular dystrophy. Growth Horm IGF Res 22 (2): 69-75
https://dx.doi.org/10.1016/j.ghir.2012.02.004
Sawitzky, M.; Stock, K. F.; Langhammer, M.; Renne, U.; Hoeflich, A. (2011):
Phosphatase und Tensin Homolog (PTEN) als neuer Biomarkerkandidat für postnatalen Muskelansatz in der Maus. Schriftenreihe / Leibniz-Institut für Nutztierbiol 18: 47-50
Bielohuby, M.; Schaab, M.; Kummann, M.; Sawitzky, M.; Gebhardt, R.; Binder, G.; Frystyk, J.; Bjerre, M.; Hoeflich, A.; Kratzsch, J.; Bidlingmeier, M. (2011):
Serum IGF-I is not a reliable pharmacodynamic marker of exogenous growth hormone activity in mice. Endocrinology 152 (12): 4764-4776
https://dx.doi.org/10.1210/En.2011-1432
Renne, U.; Sawitzky, M.; Brenmoehl, J.; Bidlingmaier, M.; Bielohuby, M.; Langhammer, M.; Hoeflich, A. (2011):
Funktionale Genomanalyse in Inzuchtlinien und Auszuchtpopulationen: Interaktion von Wachstum und Lebensdauer. In: Biometrische Aspekte der Genomanalyse IV (Biometrie und Medizinische Informatik Greifswalder Seminarberichte , 19) (C. Hemmelmann ..., Hrsg.) Shaker Verlag, Aachen (978-3-8440-0155-6): 99-112
Metzger, F.; Sajid, W.; Saenger, S.; Staudenmaier, C.; van der Poel, C.; Sobottka, B.; Schuler, A.; Sawitzky, M.; Poirier, R.; Tuerck, D.; Schick, E.; Schaubmar, A.; Hesse, F; Amrein, K.; Loetscher, H.; Lynch, G. S.; Hoeflich, A.; de Meyts, P.; Schoenfeld, H.-J. (2011):
Separation of fast from slow anabolism by site-specific PEGylation of insulin-like growth factor I. J Biol Chem 286 (22): 19501-19510
https://dx.doi.org/10.1074/jbc.M110.172189
Bielohuby, M.; Sawitzky, M.; Stoehr, B. J. M.; Stock, K. F.; Menhofer, D.; Ebensing, S.; Bjerre, M.; Frystyk, J.; Binder, G.; Strasburger, C.; Wu, Z.; Christ, B.; Hoeflich, A.; Bidlingmeier, M. (2011):
Lack of dietary carbohydrates induces hepatic growth hormone (GH) resistance in rats. Endocrinology 152 (5): 1948-1960
https://dx.doi.org/10.1210/en.2010-1423
Nagel, Jutta M.; Staffa, J.; Renner-Müller, Ingrid; Horst, David; Vogeser, M.; Langkamp, M.; Hoeflich, A.; Göke, B.; Kolligs, F.; Mantzoros, C. (2010):
Insulin glargine and NPH insulin increase to a similar degree epithelial cell proliferation and aberrant crypt foci formation in colons of diabetic mice. Horm Cancer 1 (6): 320-330
https://dx.doi.org/10.1007/s12672-010-0020-z
Sun, H.; Manolopoulou, J.; Spyroglou, A.; Beuschlein, F; Hantel, C.; Wu, Z.; Bielohuby, M.; Hoeflich, A.; Liu, C; Bidlingmaier, M. (2010):
A microsphere-based duplex competitive immunoassay for the simultaneous measurements of aldosterone and testosterone in small sample volumes: validation in human and mouse plasma. Steroids 75 (13-14): 1089-1096
https://dx.doi.org/10.1016/j.steroids.2010.07.005
Rehfeldt, C.; Renne, U.; Sawitzky, M.; Binder, G.; Hoeflich, A. (2010):
Increased fat mass, decreased myofiber size, and a shift to glycolytic muscle metabolism in adolescent male transgenic mice overexpressing IGFBP-2 . Am J Physiol-Endoc M 299 (2): E287-E298
https://dx.doi.org/10.1152/ajpendo.00492.2009
Bielohuby, M.; Matsuura, M.; Herbach, N; Kienzle, E.; Slawik, M.; Hoeflich, A.; Bindlingmaier, M. (2010):
Short term exposure to low-carbohydrate / high fat diets induces low bone mineral density and reduces bone formation in rats. J Bone Miner Res 25 (2): 275-284
https://dx.doi.org/10.1359/jbmr.090813
Bielohuby, M.; Roemmler, J.; Manolopoulou, J.; Johnsen, I.; Sawitzky, M.; Reincke, M.; Wolf, E.; Hoeflich, A.; Bindlingmaier, M. (2009):
Chronic growth Hormone Excess Is Associated with Increased Aldosterone: A Study in Patients with Acromegaly and in Growth Hormone Transgenic mice. Exp Biol Med 234 (8): 1002-1009
https://dx.doi.org/10.3181/0901-RM-34