PD Dr. rer. nat. Andreas Höflich

+49 38208 68-902
Leibniz Institute for Farm Animal Biology (FBN)
Institute of Genome Biology
Cell Signaling Unit
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Research interests

  • Growth and metabolism
  • Functional genome analysis
  • Biomarker research

Curriculum Vitae

  • since 2013: Director of Cell Signaling Unit, FBN
  • since 2009: Lecturer at the University of Rostock
  • 4/2009: Habilitation at the Faculty of Mathematics and Natural Sciences, University of Rostock
  • 2006-2012: Group Leader, Mouse Genetics, FBN
  • 2002-2006: Lecturer at University of Rostock
  • 6/2002: Habilitation at the Faculty of Veterinary Medicine, University of Munich
  • 1996-2002: Assistant professor University of Munich
  • 6/1995: Dissertation at the Institute of Organic Chemistry and Biology, Technical University of Munich
  • 1985-2002: Studies of Biology, University of Erlangen-Nürnberg,


Molecular Animal Breeding: Lectures, Seminars and practical courses within the program: Diversity and Evolution (MSc)


Renne, U.; Sawitzky, M.; Brenmoehl, J.; Bidlingmaier, M.; Bielohuby, M.; Langhammer, M.; Hoeflich, A. (2011):
Funktionale Genomanalyse in Inzuchtlinien und Auszuchtpopulationen: Interaktion von Wachstum und Lebensdauer. In: Biometrische Aspekte der Genomanalyse IV (Biometrie und Medizinische Informatik Greifswalder Seminarberichte , 19) (C. Hemmelmann ..., Hrsg.) Shaker Verlag, Aachen (978-3-8440-0155-6): 99-112
Bielohuby, M.; Schaab, M.; Kummann, M.; Sawitzky, M.; Gebhardt, R.; Binder, G.; Frystyk, J.; Bjerre, M.; Hoeflich, A.; Kratzsch, J.; Bidlingmeier, M. (2011):
Serum IGF-I is not a reliable pharmacodynamic marker of exogenous growth hormone activity in mice. Endocrinology 152 (12): 4764-4776
Sawitzky, M.; Stock, K. F.; Langhammer, M.; Renne, U.; Hoeflich, A. (2011):
Phosphatase und Tensin Homolog (PTEN) als neuer Biomarkerkandidat für postnatalen Muskelansatz in der Maus. Schriftenreihe / Leibniz-Institut für Nutztierbiol 18: 47-50
Bielohuby, M.; Matsuura, M.; Herbach, N; Kienzle, E.; Slawik, M.; Hoeflich, A.; Bindlingmaier, M. (2010):
Short term exposure to low-carbohydrate / high fat diets induces low bone mineral density and reduces bone formation in rats. J Bone Miner Res 25 (2): 275-284
Rehfeldt, C.; Renne, U.; Sawitzky, M.; Binder, G.; Hoeflich, A. (2010):
Increased fat mass, decreased myofiber size, and a shift to glycolytic muscle metabolism in adolescent male transgenic mice overexpressing IGFBP-2 . Am J Physiol-Endoc M 299 (2): E287-E298
Sun, H.; Manolopoulou, J.; Spyroglou, A.; Beuschlein, F; Hantel, C.; Wu, Z.; Bielohuby, M.; Hoeflich, A.; Liu, C; Bidlingmaier, M. (2010):
A microsphere-based duplex competitive immunoassay for the simultaneous measurements of aldosterone and testosterone in small sample volumes: validation in human and mouse plasma. Steroids 75 (13-14): 1089-1096
Nagel, Jutta M.; Staffa, J.; Renner-Müller, Ingrid; Horst, David; Vogeser, M.; Langkamp, M.; Hoeflich, A.; Göke, B.; Kolligs, F.; Mantzoros, C. (2010):
Insulin glargine and NPH insulin increase to a similar degree epithelial cell proliferation and aberrant crypt foci formation in colons of diabetic mice. Horm Cancer 1 (6): 320-330
Hoeflich, A.; Bielohuby, M. (2009):
Mechanisms of adrenal gland growth: signal integration by extracellular signal regulated kinases 1/2. J Mol Endocrinol 42 (3): 191-203
Bielohuby, M.; Sawitzky, M.; Johnsen, I.; Wittenburg, D.; Beuschlein, F; Wolf, E.; Hoeflich, A. (2009):
Decreased p44/42 Mitogen-Activated protein Kinase Phoshorylation in Gender- or Hormone-Related But Not during Age-Related Adrenal Gland Growth in Mice. Endocrinology 150 (3): 1269-1277
Diehl, D; Hessel, E.; Oesterle, D; Renner-Müller, Ingrid; Elmlinger, Martin; Langhammer, M.; Göttlicher, M.; Wolf, E.; Lahm, H; Hoeflich, A. (2009):
IGFBP-2 overexpression reduces the appearance of dysplastic aberrant crypt foci and inhibits growth of adenomas in chemically induced colorectal carcinogenesis. Int J Cancer 124 (9): 2220-2225
Bielohuby, M.; Roemmler, J.; Manolopoulou, J.; Johnsen, I.; Sawitzky, M.; Reincke, M.; Wolf, E.; Hoeflich, A.; Bindlingmaier, M. (2009):
Chronic growth Hormone Excess Is Associated with Increased Aldosterone: A Study in Patients with Acromegaly and in Growth Hormone Transgenic mice. Exp Biol Med 234 (8): 1002-1009
Manolopoulou, J.; Bielohuby, M.; Caton, S.J.; Gomez-Sanchez, C.E.; Renner-Müller, Ingrid; Wolf, E.; Lichtenauer, U; Beuschlein, F; Hoeflich, A.; Bidlingmeier, M. (2008):
A highly sensitive immunofluorometric assay for the measurement of aldosterone in small sample volumes: validation in mouse serum. J Endocrinol 196 (2): 215-224
Reim, N.S.; Breig, B.; Stahr, K.; Eberle, D.; Hoeflich, A.; Wolf, E.; Erben, Reinhold (2008):
Cortical bone loss in androgen-deficient aged male rats is mainly caused by increased endocortical bone remodeling. J Bone Miner Res 23 (5): 694-704
Hoeflich, A. (2008):
Contrasting bone effects of temporary versus permanent IGFBP administration in rodents. Growth Horm IGF Res 18 (3): 181-187
Kiepe, D.; Van der Pas, A.; Ciamatori, S.; Ständker, L.; Schütt, B.; Hoeflich, A.; Hügel, U.; Oh, J; Tönshoff, B. (2008):
Defined Carboxy-Terminal Fragments of Insulin-Like Growth Factor (IGF) Binding Protein-2 Exert Similar Mitogenic Activity on Cultured Rat Growth Plate Chondrocytes as IGF-I. Endocrinology 149 (10): 4901-4911
Hoeflich, A.; Bielohuby, M. (2008):
Mechanisms of adrenal gland growth - signal integration by ERK1/2. J Mol Endocrinol 42 (3): 191-203
Diehl, D; Hessel, E.; Oesterle, D; Renner-Müller, Ingrid; Elmlinger, M.W.; Langhammer, M.; Göttlicher, M.; Wolf, M.; Lahm, H; Hoeflich, A. (2008):
IGFBP-2 overexpression reduces the appearance of dysplastic aberrant crypt foci and inhibits growth of adenomas in chemically induced colorectal carcinogenesis. Int J Cancer 124 (9): 2220-2225
Moerth, Corinna; Schneider, F.; Renner-Müller, Ingrid; Blutke, A.; Elmlinger, M.W.; Erben, Reinhold; Camacho-Hübner, C; Hoeflich, A.; Wolf, M. (2007):
Postnatally elevated levels of insulin-like growth factor (IGF)-II fail to rescue the dwarfism of IGF-I-deficient mice except kidney weight. Endocrinology 148 (1): 441-451
Lichtenauer, U; Duchniewicz, M; Kolanczyk, M; Hoeflich, A.; Hahner, S; Else, T; Bicknell, AB; Zemojtel, T; Stallings, NR; Schulte, P.; Schulte, P.; Kamps, P.; Hammer, H.; Scheele, S.; Beuschlein, F (2007):
Pre-B-cell transcription factor 1 and steroidogenic factor 1 synergistically regulate adrenocortical growth and steroidogenesis. Endocrinology 148 (2): 693-704
Hoeflich, A.; Goetz, W.; Lichanska, A.; Bielohuby, M.; Tönshoff, B.; Kiepe, D. (2007):
Effects of insulin-like growth factor binding proteins in bone - a matter of cell and site. Arch Physiology and Biochemistry 113 (3): 142-153