PD Dr. rer. nat. Andreas Höflich

Research Institute for Farm Animal Biology (FBN)
Head of working group Endocrinology of Farm Animals
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Research interests

  • Growth and metabolism
  • Functional genome analysis
  • Biomarker research

Curriculum Vitae

  • since 2013: Director of Cell Signaling Unit, FBN
  • since 2009: Lecturer at the University of Rostock
  • 4/2009: Habilitation at the Faculty of Mathematics and Natural Sciences, University of Rostock
  • 2006-2012: Group Leader, Mouse Genetics, FBN
  • 2002-2006: Lecturer at University of Rostock
  • 6/2002: Habilitation at the Faculty of Veterinary Medicine, University of Munich
  • 1996-2002: Assistant professor University of Munich
  • 6/1995: Dissertation at the Institute of Organic Chemistry and Biology, Technical University of Munich
  • 1985-2002: Studies of Biology, University of Erlangen-Nürnberg,

Teaching

Molecular Animal Breeding: Lectures, Seminars and practical courses within the program: Diversity and Evolution (MSc)

Publications

Brenmoehl, J.; Ohde, D.; Walz, C.; Tuchscherer, A.; Schultz, J.; Rieder, F.; Hoeflich, A. (2015):
Dynamics of fat mass in DUhTP mice selected for running performance - fat mobilization in a walk. Obesity Facts 8 (6): 373-385
https://dx.doi.org/10.1159/000442399
Schindler, N.; Gimsa, U.; Mayer, J.; Kirschstein, T.; Brenmoehl, J.; Ohde, D.; Wirthgen, E.; Höflich, A. (2015):
Functional analysis of the Cardin Weintraub motif present in IGFBP-2 transgenic mice. Schriftenreihe / Leibniz-Institut für Nutztierbiol 24: 29-32
Wiedmer, P.; Schwarz, F.; Grosse, Birgit; Schindler, N.; Tuchscherer, A.; Russo, V. C.; Tschöp, M. H.; Hoeflich, A. (2015):
Gender-specific effects on food intake but no inhibition of age- related fat accretion in transgenic mice overexpressing human IGFBP-2 lacking the Cardin-Weintraub sequence motif. J Cell Commun Signal 9 (2): 143-150
https://dx.doi.org/10.1007/s12079-015-0264-z
Piechotta, M.; Mysegades, W.; Ligges, U.; Lilienthal, J.; Hoeflich, A.; Miyamoto, A.; Bollwein, H. (2015):
Antepartal insulin-like growth factor 1 and insulin-like growth factor binding protein 2 concentrations are indicative of ketosis in dairy cows. J Dairy Sci 98 (5): 3100-3109
https://dx.doi.org/10.3168/jds.2014-8885
Simon, C. M.; Rauskolb, S.; Gunnersen, J. M.; Holtmann, B.; Drepper, C.; Dombert, B.; Braga, M.; Wiese, S.; Jablonka, S.; Pühringer, D.; Zielasek, J.; Hoeflich, A.; Silani, V.; Wolf, E.; Kneitz, S.; Sommer, C.; Toyka, K. V.; Sendtner, M. (2015):
Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy. Acta Neuropathol 130 (3): 373-387
https://dx.doi.org/10.1007/s00401-015-1446-8
Ohde, D.; Brenmoehl, J.; Walz, C.; Höflich, A. (2015):
Identification and characterization of microRNAs relevant for energy metabolism in Dummerstorf "marathon mice" DUhTP. Schriftenreihe / Leibniz-Institut für Nutztierbiol 24: 33-36"
Meyerholz, M. M.; Mense, K.; Lietzau, M.; Kassens, A.; Linden, M.; Knaak, H.; Wirthgen, E.; Hoeflich, A.; Raliou, M.; Richard, C.; Olivier, S.; Schuberth, H.-J.; Hoedemaker, M.; Schmicke, M. (2015):
Serum IGFBP4 concentration decreased in dairy heifers towards day 18 of pregnancy. J Vet Sci 16 (4): 413-421
https://dx.doi.org/10.4142/jvs.2015.16.4.413
Hoeflich, A.; Russo, VC (2015):
Physiology and pathophysiology of IGFBP-1 and IGFBP-2-Consensus and dissent on metabolic control and malignant potential. Best Pract Res Cl En 29 (5): 685-700
https://dx.doi.org/10.1016/j.beem.2015.07.002
Reyer, A.; Schindler, N.; Ohde, D.; Walz, C.; Kunze, M.; Tuchscherer, A.; Wirthgen, E.; Brenmoehl, J.; Hoeflich, A. (2015):
The RGD sequence present in IGFBP-2 is required for reduced glucose clearance after oral glucose administration in female transgenic mice. Am J Physiol-Endoc M 309 (4): 409-417
https://dx.doi.org/10.1152/ajpendo.00168.2015
Höflich, A.; Brenmoehl, J. (2014):
Fett weg beim Spaziergang. Leibniz Nordost 19: 4-5
Krieger, F.; Elflein, N.; Saenger, S.; Wirthgen, E.; Rak, K.; Frantz, S.; Höflich, A.; Toyka, K. V.; Metzger, F.; Jablonka, S. (2014):
Polyethylene glycol-coupled IGF1 delays motor function defects in a mouse model of spinal muscular atrophy with respiratory distress type 1. Brain 137 (5): 1374-1393
https://dx.doi.org/10.1093/brain/awu059
Bielohuby, M.; Zarkesh-Esfahani, S.H.; Manolopoulou, J.; Wirthgen, E.; Walpurgis, K.; Toghiany Khorasgani, M.; Aghili, Z. S.; Wilkinson, I. R.; Hoeflich, A.; Thevis, M.; Ross, P.; Bidlingmaier, M. (2014):
Validation of serum IGF-I as a biomarker to monitor the bioactivity of exogenous growth hormone agonists and antagonists in rabbits. Dis Model Mech 7 (11): 1263-1273
https://dx.doi.org/10.1242/dmm.016519. Epub 2014 Sep 19
Hoeflich, A.; Wirthgen, E.; David, R.; Classen, C. F.; Spitschak, M.; Brenmoehl, J. (2014):
Control of IGFBP-2 expression by steroids and peptide hormones in vertebrates. Front Endocrinol 5: 43-52
https://dx.doi.org/10.3389/fendo.2014.00043
Brenmoehl, J.; Albrecht, E.; Komolka, K.; Schering, L.; Langhammer, M.; Hoeflich, A.; Maak, S. (2014):
Irisin is elevated in skeletal muscle and serum of mice immediately after acute exercise. Int J Biol Sci 10 (3): 338-349
https://dx.doi.org/10.7150/ijbs.7972
Laeger, T.; Wirthgen, E.; Piechotta, M.; Metzger, F.; Metges, C. C.; Kuhla, B.; Höflich, A. (2014):
Effects of parturition and feed restriction on concentrations and distribution of the insulin-like growth factor-binding proteins in plasma and cerebrospinal fluid of dairy cows. J Dairy Sci 97 (5): 2876-2885
https://dx.doi.org/10.3168/jds.2013-7671
Komolka, K.; Albrecht, E.; Schering, L.; Brenmoehl, J.; Hoeflich, A.; Maak, S. (2014):
Locus characterization and gene expression of bovine FNDC5: is the myokine irisin relevant in cattle?. Plos One 9 (1): 1-11
https://dx.doi.org/10.1371/journal.pone.0088060
Langhammer, M.; Michaelis, M.; Hoeflich, A.; Sobczak, A.; Schön, J.; Weitzel, J. M. (2014):
High fertility phenotypes: two outbred mouse models exhibit substantially different molecular and physiological strategies warranting improved fertility. Reproduction 147 (4): 427-433
https://dx.doi.org/10.1530/REP-13-0425
Fuellen, G.; Boerries, M.; Busch, H.; de Grey, A.; Hahn, D.; Hiller, T.; Hoeflich, A.; Jansen, L.; Kaleta, C.; Meinema, A.; Schäuble, S.; Simm, A.; Schofield, P.; Smith, B.; Sühnel, J.; Vera, J.; Wagner, Wolfgang; Wönne, E.; Wuttke, D. (2013):
In silico approaches and the role of ontologies in aging research. Rejuv Res 16 (6): 540-546
https://dx.doi.org/10.1089/rej.2013.1517
Renne, U.; Langhammer, M.; Brenmoehl, J.; Walz, C.; Zeissler, A.; Tuchscherer, A.; Piechotta, M.; Wiesner, R. J.; Bielohuby, M.; Hoeflich, A. (2013):
Lifelong obesity in a polygenic mouse model prevents age- and diet-induced glucose intolerance - obesity is no road to late-onset diabetes in mice. Plos One 8 (11): e79788, 1-8
https://dx.doi.org/10.1371/journal.pone.0079788
Pitcher, M. R.; Ward, C. S.; Arvide, E. M.; Chapleau, C. A.; Pozzo-Miller, L.; Hoeflich, A.; Sivaramakrishnan, M.; Saenger, S.; Metzger, F.; Neul, J. L. (2013):
Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function. Hum Mol Genet 22 (13): 2626-2633
https://dx.doi.org/10.1093/Hmg/Ddt111