PD Dr. rer. nat. habil. Andreas Höflich
Research Institute for Farm Animal Biology (FBN)
Head of working group Endocrinology of Farm Animals
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Head of working group Endocrinology of Farm Animals
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Research interests
- Growth and metabolism
- Functional genome analysis
- Biomarker research
Curriculum Vitae
- since 2013: Director of Cell Signaling Unit, FBN
- since 2009: Lecturer at the University of Rostock
- 4/2009: Habilitation at the Faculty of Mathematics and Natural Sciences, University of Rostock
- 2006-2012: Group Leader, Mouse Genetics, FBN
- 2002-2006: Lecturer at University of Rostock
- 6/2002: Habilitation at the Faculty of Veterinary Medicine, University of Munich
- 1996-2002: Assistant professor University of Munich
- 6/1995: Dissertation at the Institute of Organic Chemistry and Biology, Technical University of Munich
- 1985-2002: Studies of Biology, University of Erlangen-Nürnberg,
Teaching
Molecular Animal Breeding: Lectures, Seminars and practical courses within the program: Diversity and Evolution (MSc)
Publications
Hoeflich, A.; Reyer, A.; Ohde, D.; Brenmoehl, J.; Spitschak, M.; Langhammer, M.; Tuchscherer, A.; Wirthgen, E.; Renner-Müller, Ingrid; Wanke, R.; Metzger, F.; Bielohuby, M.; Wolf, E. (2016):
Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice. Aging Cell 15 (1): 111-117
https://dx.doi.org/10.1111/acel.12413
Kammel, A.; Saussenthaler, S.; Jähnert, M.; Jonas, W.; Stirm, L.; Hoeflich, A.; Staiger, H.; Fritsche, A.; Häring, H.-U.; Joost, H.-G.; Schürmann, A.; Schwenk, R. W. (2016):
Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice. Hum Mol Genet 25 (12): 2588-2599
https://dx.doi.org/10.1093/hmg/ddw121
Ohde, D.; Brenmoehl, J.; Walz, C.; Tuchscherer, A.; Wirthgen, E.; Hoeflich, A. (2016):
Comparative analysis of hepatic miRNA levels in male marathon mice reveals a link between obesity and endurance exercise capacities. J Comp Physiol B 186 (8): 1067-1078
https://dx.doi.org/10.1007/s00360-016-1006-0
Swiderski, K.; Martins, K. J. B.; Chee, A.; Trieu, J.; Naim, T.; Gehrig, S. M.; Baum, D. M.; Brenmoehl, J.; Chau, L.; Koopman, R.; Metzger, F.; Hoeflich, A.; Lynch, G. S. (2016):
Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology. Growth Horm IGF Res 30-31: 1-10
https://dx.doi.org/10.1016/j.ghir.2016.07.002
Wirthgen, E.; Höflich, C.; Spitschak, M.; Helmer, C.; Brand, B.; Langbein, J.; Metzger, F.; Hoeflich, A. (2016):
Quantitative Western ligand blotting reveals common patterns and differential features of IGFBP-fingerprints in domestic ruminant breeds and species. Growth Horm IGF Res 26: 42-49
https://dx.doi.org/10.1016/j.ghir.2015.11.001
Oster, M.; Nuchchanart, W.; Trakooljul, N.; Muràni, E.; Zeyner, A.; Wirthgen, E.; Hoeflich, A.; Ponsuksili, S.; Wimmers, K. (2016):
Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and IGF signalling and increases foetal weight. Eur J Nutr 55 (4): 1717-1727
https://dx.doi.org/10.1007/s00394-015-0990-2
Wirthgen, E.; Hoeflich, A. (2015):
Endotoxin-induced tryptophan degradation along the kynurenine pathway: the role of indolamine 2,3-dioxygenase and aryl hydrocarbon receptor-mediated immunosuppressive effects in endotoxin tolerance and cancer and its implications for immunoparalysis. J Amino Acids 2015: 1-13
https://dx.doi.org/10.1155/2015/973548
Kunze, M.; Wirthgen, E.; Walz, C.; Spitschak, M.; Brenmoehl, J.; Vanselow, J.; Schwerin, M.; Wimmers, K.; Hoeflich, A. (2015):
Bioanalytical validation for simultaneous quantification of non-aromatic steroids in follicular fluid from cattle via ESI-LC-MS/MS. J Chromatogr B 1007: 132-139
https://dx.doi.org/10.1016/j.jchromb.2015.10.010
Brenmoehl, J.; Ohde, D.; Walz, C.; Tuchscherer, A.; Schultz, J.; Rieder, F.; Hoeflich, A. (2015):
Dynamics of fat mass in DUhTP mice selected for running performance - fat mobilization in a walk. Obesity Facts 8 (6): 373-385
https://dx.doi.org/10.1159/000442399
Schindler, N.; Gimsa, U.; Mayer, J.; Kirschstein, T.; Brenmoehl, J.; Ohde, D.; Wirthgen, E.; Höflich, A. (2015):
Functional analysis of the Cardin Weintraub motif present in IGFBP-2 transgenic mice. Schriftenreihe / Leibniz-Institut für Nutztierbiol 24: 29-32
Wiedmer, P.; Schwarz, F.; Grosse, Birgit; Schindler, N.; Tuchscherer, A.; Russo, V. C.; Tschöp, M. H.; Hoeflich, A. (2015):
Gender-specific effects on food intake but no inhibition of age- related fat accretion in transgenic mice overexpressing human IGFBP-2 lacking the Cardin-Weintraub sequence motif. J Cell Commun Signal 9 (2): 143-150
https://dx.doi.org/10.1007/s12079-015-0264-z
Piechotta, M.; Mysegades, W.; Ligges, U.; Lilienthal, J.; Hoeflich, A.; Miyamoto, A.; Bollwein, H. (2015):
Antepartal insulin-like growth factor 1 and insulin-like growth factor binding protein 2 concentrations are indicative of ketosis in dairy cows. J Dairy Sci 98 (5): 3100-3109
https://dx.doi.org/10.3168/jds.2014-8885
Simon, C. M.; Rauskolb, S.; Gunnersen, J. M.; Holtmann, B.; Drepper, C.; Dombert, B.; Braga, M.; Wiese, S.; Jablonka, S.; Pühringer, D.; Zielasek, J.; Hoeflich, A.; Silani, V.; Wolf, E.; Kneitz, S.; Sommer, C.; Toyka, K. V.; Sendtner, M. (2015):
Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy. Acta Neuropathol 130 (3): 373-387
https://dx.doi.org/10.1007/s00401-015-1446-8
Ohde, D.; Brenmoehl, J.; Walz, C.; Höflich, A. (2015):
Identification and characterization of microRNAs relevant for energy metabolism in Dummerstorf "marathon mice" DUhTP. Schriftenreihe / Leibniz-Institut für Nutztierbiol 24: 33-36"
Meyerholz, M. M.; Mense, K.; Lietzau, M.; Kassens, A.; Linden, M.; Knaak, H.; Wirthgen, E.; Hoeflich, A.; Raliou, M.; Richard, C.; Olivier, S.; Schuberth, H.-J.; Hoedemaker, M.; Schmicke, M. (2015):
Serum IGFBP4 concentration decreased in dairy heifers towards day 18 of pregnancy. J Vet Sci 16 (4): 413-421
https://dx.doi.org/10.4142/jvs.2015.16.4.413
Hoeflich, A.; Russo, VC (2015):
Physiology and pathophysiology of IGFBP-1 and IGFBP-2-Consensus and dissent on metabolic control and malignant potential. Best Pract Res Cl En 29 (5): 685-700
https://dx.doi.org/10.1016/j.beem.2015.07.002
Reyer, A.; Schindler, N.; Ohde, D.; Walz, C.; Kunze, M.; Tuchscherer, A.; Wirthgen, E.; Brenmoehl, J.; Hoeflich, A. (2015):
The RGD sequence present in IGFBP-2 is required for reduced glucose clearance after oral glucose administration in female transgenic mice. Am J Physiol-Endoc M 309 (4): 409-417
https://dx.doi.org/10.1152/ajpendo.00168.2015
Krieger, F.; Elflein, N.; Saenger, S.; Wirthgen, E.; Rak, K.; Frantz, S.; Höflich, A.; Toyka, K. V.; Metzger, F.; Jablonka, S. (2014):
Polyethylene glycol-coupled IGF1 delays motor function defects in a mouse model of spinal muscular atrophy with respiratory distress type 1. Brain 137 (5): 1374-1393
https://dx.doi.org/10.1093/brain/awu059
Bielohuby, M.; Zarkesh-Esfahani, S.H.; Manolopoulou, J.; Wirthgen, E.; Walpurgis, K.; Toghiany Khorasgani, M.; Aghili, Z. S.; Wilkinson, I. R.; Hoeflich, A.; Thevis, M.; Ross, P.; Bidlingmaier, M. (2014):
Validation of serum IGF-I as a biomarker to monitor the bioactivity of exogenous growth hormone agonists and antagonists in rabbits. Dis Model Mech 7 (11): 1263-1273
https://dx.doi.org/10.1242/dmm.016519. Epub 2014 Sep 19