PD Dr. rer. nat. Andreas Höflich

+49 38208 68-902
Leibniz Institute for Farm Animal Biology (FBN)
Institute of Genome Biology
Cell Signaling Unit
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Research interests

  • Growth and metabolism
  • Functional genome analysis
  • Biomarker research

Curriculum Vitae

  • since 2013: Director of Cell Signaling Unit, FBN
  • since 2009: Lecturer at the University of Rostock
  • 4/2009: Habilitation at the Faculty of Mathematics and Natural Sciences, University of Rostock
  • 2006-2012: Group Leader, Mouse Genetics, FBN
  • 2002-2006: Lecturer at University of Rostock
  • 6/2002: Habilitation at the Faculty of Veterinary Medicine, University of Munich
  • 1996-2002: Assistant professor University of Munich
  • 6/1995: Dissertation at the Institute of Organic Chemistry and Biology, Technical University of Munich
  • 1985-2002: Studies of Biology, University of Erlangen-Nürnberg,


Molecular Animal Breeding: Lectures, Seminars and practical courses within the program: Diversity and Evolution (MSc)


Laeger, T.; Wirthgen, E.; Piechotta, M.; Metzger, F.; Metges, C. C.; Kuhla, B.; Höflich, A. (2014):
Effects of parturition and feed restriction on concentrations and distribution of the insulin-like growth factor-binding proteins in plasma and cerebrospinal fluid of dairy cows. J Dairy Sci 97 (5): 2876-2885
Brenmoehl, J.; Albrecht, E.; Komolka, K.; Schering, L.; Langhammer, M.; Hoeflich, A.; Maak, S. (2014):
Irisin is elevated in skeletal muscle and serum of mice immediately after acute exercise. Int J Biol Sci 10 (3): 338-349
Hoeflich, A.; Wirthgen, E.; David, R.; Classen, C. F.; Spitschak, M.; Brenmoehl, J. (2014):
Control of IGFBP-2 expression by steroids and peptide hormones in vertebrates. Front Endocrinol 5: 43-52
Bielohuby, M.; Zarkesh-Esfahani, S.H.; Manolopoulou, J.; Wirthgen, E.; Walpurgis, K.; Toghiany Khorasgani, M.; Aghili, Z. S.; Wilkinson, I. R.; Hoeflich, A.; Thevis, M.; Ross, R. J.; Bidlingmaier, M. (2014):
Validation of serum IGF-I as a biomarker to monitor the bioactivity of exogenous growth hormone agonists and antagonists in rabbits. Dis Model Mech 7 (11): 1263-1273
Krieger, F.; Elflein, N.; Saenger, S.; Wirthgen, E.; Rak, K.; Frantz, S.; Höflich, A.; Toyka, K. V.; Metzger, F.; Jablonka, S. (2014):
Polyethylene glycol-coupled IGF1 delays motor function defects in a mouse model of spinal muscular atrophy with respiratory distress type 1. Brain 137 (5): 1374-1393
Höflich, A.; Brenmoehl, J. (2014):
Fett weg beim Spaziergang. Leibniz Nordost 19: 4-5
Brenmoehl, J.; Hoeflich, A. (2013):
Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3. Mitochondrion 13 (6): 755-761
Piechotta, M.; Kedves, K.; Araujo, M. G.; Hoeflich, A.; Metzger, F.; Heppelmann, M.; Muscher-Banse, A.; Wrenzycki, C.; Pfarrer, C.; Schuberth, H.-J.; Hoedemaker, M.; Bollwein, H.; Kaske, M. (2013):
Hepatic mRNA expression of acid labile subunit and deiodinase 1 differs between cows selected for high versus low concentrations of insulin-like growth factor 1 in late pregnancy. J Dairy Sci 96 (6): 3737-3749
Michaelis, M.; Langhammer, M.; Hoeflich, A.; Reinsch, N.; Schön, J.; Weitzel, J. M. (2013):
Initial characterization of an outbreed mouse model for male factor (in)fertility. Andrology 1 (5): 772-778
Pitcher, M. R.; Ward, C. S.; Arvide, E. M.; Chapleau, C. A.; Pozzo-Miller, L.; Hoeflich, A.; Sivaramakrishnan, M.; Saenger, S.; Metzger, F.; Neul, J. L. (2013):
Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function. Hum Mol Genet 22 (13): 2626-2633
Renne, U.; Langhammer, M.; Brenmoehl, J.; Walz, C.; Zeissler, A.; Tuchscherer, A; Piechotta, M.; Wiesner, R. J.; Bielohuby, M.; Hoeflich, A. (2013):
Lifelong obesity in a polygenic mouse model prevents age- and diet-induced glucose intolerance - obesity is no road to late-onset diabetes in mice. Plos One 8 (11): 1-8
Fuellen, G.; Boerries, M.; Busch, H.; de Grey, A.; Hahn, D.; Hiller, T.; Hoeflich, A.; Jansen, L.; Kaleta, C.; Meinema, A.; Schäuble, S.; Simm, A.; Schofield, P.; Smith, B.; Sühnel, J.; Vera, J.; Wagner, Wolfgang; Wönne, E.; Wuttke, D. (2013):
In silico approaches and the role of ontologies in aging research. Rejuv Res 16 (6): 540-546
Gehrig, S. M.; van der Poel, C.; Hoeflich, A.; Naim, T.; Lynch, G. S.; Metzger, F. (2012):
Therapeutic potential of PEGylated insulin-like growth factor I for skeletal muscle disease evaluated in two murine models of muscular dystrophy. Growth Horm IGF Res 22 (2): 69-75
Sawitzky, M.; Zeissler, A.; Langhammer, M.; Bielohuby, M.; Stock, K. F.; Hammon, H. M.; Görs, S.; Metges, C. C.; Stoehr, B. J. M.; Bidlingmaier, M.; Fromm-Dornieden, C.; Baumgartner, B. G.; Christ, B.; Brenig, B.; Binder, G.; Metzger, F.; Renne, U.; Hoeflich, A. (2012):
Phenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female mice. Plos One 7 (6): 1-13
Fuellen, G.; Dengjel, J.; Hoeflich, A.; Hoeijemakers, J.; Kestler, H. A.; Kowald, A.; Priebe, S.; Rebholz-Schuhmann, D.; Schmeck, B.; Schmitz, U.; Stolzing, A.; Sühnel, J.; Wuttke, D.; Vera, J. (2012):
Systems biology and bioinformatics in aging research: a workshop report. Rejuv Res 15 (6): 631-641
Saenger, S.; Holtmmann, B.; Nilges, M.; Schroeder, S.; Hoeflich, A.; Kletzl, H.; Spooren, W.; Ostrowizki, S.; Hanania, T.; Sendtner, M.; Metzger, F. (2012):
Funktional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity. Amyotroph Lateral Sc 13 (5): 418-429
Fromm-Dornieden, C.; Lytovchenko, O.; von der Heyde, S.; Behnke, N.; Hogl, S.; Berghoff, J.; Köpper, F.; Opitz, L.; Renne, U.; Hoeflich, A.; Beissbarth, T.; Brenig, B.; Baumgartner, B. G. (2012):
Extrinsic and intrinsic regulation of DOR/TP53INP2 expression in mice: effects of dietary fat content, tissue type and sex in adipose and muscle tissues. Nutr Metab 9 (1): 86-97
Huguet, A.; Medja, F.; Nicole, A.; Vignaud, A.; Guiraud-Dogan, C.; Ferry, A.; Decostre, V.; Hogrel, J.-Y.; Metzger, F.; Hoeflich, A.; Baraibar, M.; Gomes-Pereira, M.; Puymirat, J.; Bassez, G.; Furling, D.; Munnich, A.; Gourdon, G. (2012):
Molecular, physiological, and motor performance defects in DMSXL mice carrying >1000 CTG repeats from the human DM1 locus. PLOS Genet 8 (11): 1-19
Bielohuby, M.; Sawitzky, M.; Stoehr, B. J. M.; Stock, K. F.; Menhofer, D.; Ebensing, S.; Bjerre, M.; Frystyk, J.; Binder, G.; Strasburger, C.; Wu, Z.; Christ, B.; Hoeflich, A.; Bidlingmeier, M. (2011):
Lack of dietary carbohydrates induces hepatic growth hormone (GH) resistance in rats. Endocrinology 152 (5): 1948-1960
Metzger, F.; Sajid, W.; Saenger, S.; Staudenmaier, C.; van der Poel, C.; Sobottka, B.; Schuler, A.; Sawitzky, M.; Poirier, R.; Tuerck, D.; Schick, E.; Schaubmar, A.; Hesse, F; Amrein, K.; Loetscher, H.; Lynch, G. S.; Hoeflich, A.; de Meyts, P.; Schoenfeld, H.-J. (2011):
Separation of fast from slow anabolism by site-specific PEGylation of insulin-like growth factor I. J Biol Chem 286 (22): 19501-19510