PD Dr. rer. nat. Andreas Höflich

+49 38208 68-902
Leibniz Institute for Farm Animal Biology (FBN)
Institute of Genome Biology
Cell Signaling Unit
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Research interests

  • Growth and metabolism
  • Functional genome analysis
  • Biomarker research

Curriculum Vitae

  • since 2013: Director of Cell Signaling Unit, FBN
  • since 2009: Lecturer at the University of Rostock
  • 4/2009: Habilitation at the Faculty of Mathematics and Natural Sciences, University of Rostock
  • 2006-2012: Group Leader, Mouse Genetics, FBN
  • 2002-2006: Lecturer at University of Rostock
  • 6/2002: Habilitation at the Faculty of Veterinary Medicine, University of Munich
  • 1996-2002: Assistant professor University of Munich
  • 6/1995: Dissertation at the Institute of Organic Chemistry and Biology, Technical University of Munich
  • 1985-2002: Studies of Biology, University of Erlangen-Nürnberg,


Molecular Animal Breeding: Lectures, Seminars and practical courses within the program: Diversity and Evolution (MSc)


Ohde, D.; Brenmoehl, J.; Walz, C.; Tuchscherer, A; Wirthgen, E.; Hoeflich, A. (2016):
Comparative analysis of hepatic miRNA levels in male marathon mice reveals a link between obesity and endurance exercise capacities. J Comp Physiol B 186 (8): 1067-1078
Kammel, A.; Saussenthaler, S.; Jähnert, M.; Jonas, W.; Stirm, L.; Hoeflich, A.; Staiger, H.; Fritsche, A.; Häring, H.-U.; Joost, H.-G.; Schürmann, A.; Schwenk, R. W. (2016):
Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice. Hum Mol Genet 25 (12): 2588-2599
Hoeflich, A.; Reyer, A.; Ohde, D.; Brenmoehl, J.; Spitschak, M.; Langhammer, M.; Tuchscherer, A; Wirthgen, E.; Renner-Müller, Ingrid; Wanke, R.; Metzger, F.; Bielohuby, M.; Wolf, E. (2016):
Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice. Aging Cell 15 (1): 111-117
Ohde, D.; Moeller, M.; Brenmoehl, J.; Walz, C.; Ponsuksili, S.; Schwerin, M.; Fuellen, G.; Hoeflich, A. (2016):
Advanced running performance by genetic predisposition in male Dummerstorf marathon mice (DUhTP) reveals higher sterol regulatory element-binding protein (SREBP) related mRNA expression in the liver and higher serum levels of progesterone. Plos One 11 (1): e0146748, 1-16
Fischer, J.; Ortel, M.; Hagmann, S.; Hoeflich, A.; Richter, W. (2016):
Role of PTHrP(1-34) pulse frequency versus pulse duration to enhance mesenchymal stromal cell chondrogenesis. J Cell Physiol 231 (12): 2673-2681
Schäff, C.; Gruse, J.; Maciej, J.; Mielenz, M.; Wirthgen, E.; Hoeflich, A.; Schmicke, M.; Pfuhl, R.; Jawor, P.; Stefaniak, T.; Hammon, H. M. (2016):
Effects of feeding milk replacer ad libitum or in restricted amounts for the first five weeks of life on the growth, metabolic adaptation, and immune status of newborn calves. Plos One 11 (12): e0168974, 1-24
López, I. P.; Pineiro-Hermida, S.; Pais, R.; Torrens, R.; Hoeflich, A.; Pichel, J. G. (2016):
Involvement of Igf1r in bronchiolar epithelial regeneration: role during repair kinetics after selective club cell ablation. Plos One 11 (11): e0166388, 1-32
Reyer, A.; Schindler, N.; Ohde, D.; Walz, C.; Kunze, M.; Tuchscherer, A; Wirthgen, E.; Brenmoehl, J.; Hoeflich, A. (2015):
The RGD sequence present in IGFBP-2 is required for reduced glucose clearance after oral glucose administration in female transgenic mice. Am J Physiol-Endoc M 309 (4): 409-417
Hoeflich, A.; Russo, VC (2015):
Physiology and pathophysiology of IGFBP-1 and IGFBP-2-Consensus and dissent on metabolic control and malignant potential. Best Pract Res Cl En 29 (5): 685-700
Meyerholz, M. M.; Mense, K.; Lietzau, M.; Kassens, A.; Linden, M.; Knaak, H.; Wirthgen, E.; Hoeflich, A.; Raliou, M.; Richard, C.; Olivier, S.; Schuberth, H.-J.; Hoedemaker, M.; Schmicke, M. (2015):
Serum IGFBP4 concentration decreased in dairy heifers towards day 18 of pregnancy. J Vet Sci 16 (4): 413-421
Ohde, D.; Brenmoehl, J.; Walz, C.; Höflich, A. (2015):
Identification and characterization of microRNAs relevant for energy metabolism in Dummerstorf "marathon mice" DUhTP. Schriftenreihe / Leibniz-Institut für Nutztierbiol 24: 33-36"
Simon, C. M.; Rauskolb, S.; Gunnersen, J. M.; Holtmann, B.; Drepper, C.; Dombert, B.; Braga, M.; Wiese, S.; Jablonka, S.; Pühringer, D.; Zielasek, J.; Hoeflich, A.; Silani, V.; Wolf, E.; Kneitz, S.; Sommer, C.; Toyka, K. V.; Sendtner, M. (2015):
Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy. Acta Neuropathol 130 (3): 373-387
Piechotta, M.; Mysegades, W.; Ligges, U.; Lilienthal, J.; Hoeflich, A.; Miyamoto, A.; Bollwein, H. (2015):
Antepartal insulin-like growth factor 1 and insulin-like growth factor binding protein 2 concentrations are indicative of ketosis in dairy cows. J Dairy Sci 98 (5): 3100-3109
Wiedmer, P.; Schwarz, F.; Grosse, Birgit; Schindler, N.; Tuchscherer, A; Russo, V. C.; Tschöp, M. H.; Hoeflich, A. (2015):
Gender-specific effects on food intake but no inhibition of age- related fat accretion in transgenic mice overexpressing human IGFBP-2 lacking the Cardin-Weintraub sequence motif. J Cell Commun Signal 9 (2): 143-150
Schindler, N.; Gimsa, U.; Mayer, J.; Kirschstein, T.; Brenmoehl, J.; Ohde, D.; Wirthgen, E.; Höflich, A. (2015):
Functional analysis of the Cardin Weintraub motif present in IGFBP-2 transgenic mice. Schriftenreihe / Leibniz-Institut für Nutztierbiol 24: 29-32
Brenmoehl, J.; Ohde, D.; Walz, C.; Tuchscherer, A; Schultz, J.; Rieder, F.; Hoeflich, A. (2015):
Dynamics of fat mass in DUhTP mice selected for running performance - fat mobilization in a walk. Obesity Facts 8 (6): 373-385
Kunze, M.; Wirthgen, E.; Walz, C.; Spitschak, M.; Brenmoehl, J.; Vanselow, J.; Schwerin, M.; Wimmers, K.; Hoeflich, A. (2015):
Bioanalytical validation for simultaneous quantification of non-aromatic steroids in follicular fluid from cattle via ESI-LC-MS/MS. J Chromatogr B 1007: 132-139
Wirthgen, E.; Hoeflich, A. (2015):
Endotoxin-induced tryptophan degradation along the kynurenine pathway: the role of indolamine 2,3-dioxygenase and aryl hydrocarbon receptor-mediated immunosuppressive effects in endotoxin tolerance and cancer and its implications for immunoparalysis. J Amino Acids 2015: 1-13
Langhammer, M.; Michaelis, M.; Hoeflich, A.; Sobczak, A.; Schön, J.; Weitzel, J. M. (2014):
High fertility phenotypes: two outbred mouse models exhibit substantially different molecular and physiological strategies warranting improved fertility. Reproduction 147 (4): 427-433
Komolka, K.; Albrecht, E.; Schering, L.; Brenmoehl, J.; Hoeflich, A.; Maak, S. (2014):
Locus characterization and gene expression of bovine FNDC5: is the myokine irisin relevant in cattle?. Plos One 9 (1): 1-11