PD Dr. rer. nat. habil. Andreas Höflich
Research Institute for Farm Animal Biology (FBN)
Head of working group Endocrinology of Farm Animals
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Head of working group Endocrinology of Farm Animals
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Research interests
- Growth and metabolism
- Functional genome analysis
- Biomarker research
Curriculum Vitae
- since 2013: Director of Cell Signaling Unit, FBN
- since 2009: Lecturer at the University of Rostock
- 4/2009: Habilitation at the Faculty of Mathematics and Natural Sciences, University of Rostock
- 2006-2012: Group Leader, Mouse Genetics, FBN
- 2002-2006: Lecturer at University of Rostock
- 6/2002: Habilitation at the Faculty of Veterinary Medicine, University of Munich
- 1996-2002: Assistant professor University of Munich
- 6/1995: Dissertation at the Institute of Organic Chemistry and Biology, Technical University of Munich
- 1985-2002: Studies of Biology, University of Erlangen-Nürnberg,
Teaching
Molecular Animal Breeding: Lectures, Seminars and practical courses within the program: Diversity and Evolution (MSc)
Publications
Spitschak, M.; Hoeflich, A. (2018):
Potential functions of IGFBP-2 for ovarian folliculogenesis and steroidogenesis
Frontiers in Endocrinology 9: 119, 1-6
https://doi.org/10.3389/fendo.2018.00119
Mense, K.; Heidekorn-Dettmer, J.; Wirthgen, E.; Brockelmann, Y.; Bortfeldt, R.; Peter, S.; Jung, M.; Höflich, C.; Hoeflich, A.; Schmicke, M. (2018):
Increased concentrations of insulin-like growth factor binding protein (IGFBP)-2, IGFBP-3, and IGFBP-4 are associated with fetal mortality in pregnant cows
Frontiers in Endocrinology 9: 310, 1-10
https://doi.org/10.3389/fendo.2018.00310
Hoeflich, A.; David, R.; Hjortebjerg, R. (2018):
Current IGFBP-related biomarker research in cardiovascular disease - we need more structural and functional information in clinical studies
Frontiers in Endocrinology 9: 388, 1-11
https://doi.org/10.3389/fendo.2018.00388
Hesse, D.; Trost, J.; Schäfer, N.; Schwerbel, K.; Hoeflich, A.; Schürmann, A.; Brockmann, G. A. (2018):
Effect of adipocyte-derived IGF-I on adipose tissue mass and glucose metabolism in the Berlin Fat Mouse
Growth Factors 36 (1-2): 78-88
https://doi.org/10.1080/08977194.2018.1497621
Hinrichs, A.; Kessler, B.; Kurome, M.; Blutke, A.; Kemter, E.; Bernau, M.; Scholz, A. M.; Rathkolb, B.; Renner, S.; Bultmann, S.; Leonhardt, H.; Hrabě de Angelis, M.; Nagashima, H.; Hoeflich, A.; Blum, W. F.; Bidlingmaier, M.; Wanke, R.; Dahlhoff, M.; Wolf, E. (2018):
Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver
Molecular Metabolism 11: 113-128
https://doi.org/10.1016/j.molmet.2018.03.006
Hoeflich, A.; Pintar, J.; Forbes, B. (2018):
Editoral: Current perspectives on insulin-like growth factor binding protein (IGFBP) research
Frontiers in Endocrinology 9: 667, 1-2
https://doi.org/10.3389/fendo.2018.00667
Nipkow, M.; Wirthgen, E.; Luft, P.; Rebl, A.; Hoeflich, A.; Goldammer, T. (2018):
Characterization of igf1 and igf2 genes during maraena whitefish (Coregonus maraena) ontogeny and the effect of temperature on embryogenesis and igf expression
Growth Hormone & IGF Research 40: 32-43
https://doi.org/10.1016/j.ghir.2018.04.003
Brenmoehl, J.; Walz, C.; Spitschak, M.; Wirthgen, E.; Walz, M.; Langhammer, M.; Tuchscherer, A.; Naumann, R.; Höflich, A. (2018):
Partial phenotype conversion and differential trait response to conditions of husbandry in mice
Journal of Comparative Physiology B 188: 527-539
https://doi.org/10.1007/s00360-017-1138-x
Hoeflich, A.; Kiess, W. (2018):
Preface: Hormones in milk - new directions
Best Practice & Research Clinical Endocrinology & Metabolism 32 (1): 1-3
https://doi.org/10.1016/j.beem.2018.01.008
Brenmoehl, J.; Ohde, D.; Wirthgen, E.; Hoeflich, A. (2018):
Cytokines in milk and the role of TGF-beta
Best Practice & Research Clinical Endocrinology & Metabolism 32 (1): 47-56
https://doi.org/10.1016/j.beem.2018.01.006
Frieten, D.; Gerbert, C.; Koch, C.; Dusel, G.; Eder, K.; Hoeflich, A.; Mielenz, B.; Hammon, H. M. (2018):
Influence of ad libitum milk replacer feeding and butyrate supplementation on the systemic and hepatic insulin-like growth factor I and its binding proteins in Holstein calves
Journal of Dairy Science 101 (2): 1661-1672
https://doi.org/10.3168/jds.2017-13603
Wirthgen, E.; Hoeflich, A.; Rebl, A.; Günther, J. (2017):
Kynurenic acid: The Janus-faced role of an immunomodulatory tryptophan metabolite and its link to pathological conditions
Frontiers in Immunology 8: 1957, 1-13
https://dx.doi.org/10.3389/fimmu.2017.01957
Hoeflich, A.; Kiess, W. (2017):
Preface: Hormones in milk
Best Practice & Research Clinical Endocrinology & Metabolism 31 (4): 363-365
https://doi.org/10.1016/j.beem.2017.11.003
Hoeflich, A.; Kiess, W. (2017):
Hormones in milk
Best Practice & Research Clinical Endocrinology & Metabolism 31 (4): 363-442
https://doi.org/10.1016/j.beem.2017.11.003
Hoeflich, A.; Meyer, Z. (2017):
Functional analysis of the IGF-system in milk
Best Practice & Research Clinical Endocrinology & Metabolism 31 (4): 409-418
https://dx.doi.org/10.1016/j.beem.2017.10.002
Schindler, N.; Mayer, J.; Saenger, S.; Gimsa, U.; Walz, C.; Ohde, D.; Wirthgen, E.; Tuchscherer, A.; Russo, V. C.; Frank, M.; Kirschstein, T.; Metzger, F.; Hoeflich, A. (2017):
Phenotype analysis of male transgenic mice overexpressing mutant IGFBP-2 lacking the Cardin-Weintraub sequence motif: reduced expression of synaptic markers and myelin basic protein in the brain and a lower degree of anxiety-like
Growth Hormone & IGF Research 33: 1-8
https://dx.doi.org/10.1016/j.ghir.2016.11.003
Meyer, Z.; Höflich, C.; Wirthgen, E.; Olm, S.; Hammon, H. M.; Hoeflich, A. (2017):
Analysis of the IGF-system in milk from farm animals - occurrence, regulation, and biomarker potential
Growth Hormone & IGF Research 35: 1-7
https://dx.doi.org/10.1016/j.ghir.2017.05.004
Espelund, U. S.; Bjerre, M.; Hjortebjerg, R.; Rasmussen, R.; Lundby, A.; Hoeflich, A.; Folkersen, B. H.; Oxvig, C.; Frystyk, J. (2017):
Insulin-like growth factor bioactivity, stanniocalcin-2, pregnancy-associated plasma protein-A, and IGF-binding protein-4 in pleural fluid and serum from patients with pulmonary disease
The Journal of Clinical Endocrinology & Metabolism 102 (9): 3526-3534
https://dx.doi.org/10.1210/jc.2017-00033
Wirthgen, E.; Kunze, M.; Goumon, S.; Walz, C.; Höflich, C.; Spitschak, M.; Brenmoehl, J.; Kanitz, E.; Tuchscherer, M.; Otten, W.; Gimsa, U.; Schön, P.- C.; Manteuffel, C.; Tuchscherer, A.; Pfuhl, R.; Metges, C. C.; Stabenow, B.; Erdmann, S.; Schluricke, K.; Faucitano, L.; Hoeflich, A. (2017):
Interference of stress with the somatotropic axis in pigs - lights on new biomarkers
Scientific Reports 7: 12055, 1-13
https://dx.doi.org/10.1038/s41598-017-11521-5
Brenmoehl, J.; Ohde, D.; Albrecht, E.; Walz, C.; Tuchscherer, A.; Hoeflich, A. (2017):
Browning of subcutaneous fat and higher surface temperature in response to phenotype selection for advanced endurance exercise performance in male DUhTP mice
Journal of Comparative Physiology B 187 (2): 361-373
https://dx.doi.org/10.1007/s00360-016-1036-7