PD Dr. rer. nat. Andreas Höflich

+49 38208 68-902
Leibniz Institute for Farm Animal Biology (FBN)
Institute of Genome Biology
Cell Signaling Unit
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Research interests

  • Growth and metabolism
  • Functional genome analysis
  • Biomarker research

Curriculum Vitae

  • since 2013: Director of Cell Signaling Unit, FBN
  • since 2009: Lecturer at the University of Rostock
  • 4/2009: Habilitation at the Faculty of Mathematics and Natural Sciences, University of Rostock
  • 2006-2012: Group Leader, Mouse Genetics, FBN
  • 2002-2006: Lecturer at University of Rostock
  • 6/2002: Habilitation at the Faculty of Veterinary Medicine, University of Munich
  • 1996-2002: Assistant professor University of Munich
  • 6/1995: Dissertation at the Institute of Organic Chemistry and Biology, Technical University of Munich
  • 1985-2002: Studies of Biology, University of Erlangen-Nürnberg,


Molecular Animal Breeding: Lectures, Seminars and practical courses within the program: Diversity and Evolution (MSc)


Hoeflich, A.; Russo, VC (2015):
Physiology and pathophysiology of IGFBP-1 and IGFBP-2-Consensus and dissent on metabolic control and malignant potential. Best Pract Res Cl En 29 (5): 685-700
Meyerholz, M. M.; Mense, K.; Lietzau, M.; Kassens, A.; Linden, M.; Knaak, H.; Wirthgen, E.; Hoeflich, A.; Raliou, M.; Richard, C.; Olivier, S.; Schuberth, H.-J.; Hoedemaker, M.; Schmicke, M. (2015):
Serum IGFBP4 concentration decreased in dairy heifers towards day 18 of pregnancy. J Vet Sci 16 (4): 413-421
Ohde, D.; Brenmoehl, J.; Walz, C.; Höflich, A. (2015):
Identification and characterization of microRNAs relevant for energy metabolism in Dummerstorf "marathon mice" DUhTP. Schriftenreihe / Leibniz-Institut für Nutztierbiol 24: 33-36"
Simon, C. M.; Rauskolb, S.; Gunnersen, J. M.; Holtmann, B.; Drepper, C.; Dombert, B.; Braga, M.; Wiese, S.; Jablonka, S.; Pühringer, D.; Zielasek, J.; Hoeflich, A.; Silani, V.; Wolf, E.; Kneitz, S.; Sommer, C.; Toyka, K. V.; Sendtner, M. (2015):
Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy. Acta Neuropathol 130 (3): 373-387
Piechotta, M.; Mysegades, W.; Ligges, U.; Lilienthal, J.; Hoeflich, A.; Miyamoto, A.; Bollwein, H. (2015):
Antepartal insulin-like growth factor 1 and insulin-like growth factor binding protein 2 concentrations are indicative of ketosis in dairy cows. J Dairy Sci 98 (5): 3100-3109
Wiedmer, P.; Schwarz, F.; Grosse, Birgit; Schindler, N.; Tuchscherer, A; Russo, V. C.; Tschöp, M. H.; Hoeflich, A. (2015):
Gender-specific effects on food intake but no inhibition of age- related fat accretion in transgenic mice overexpressing human IGFBP-2 lacking the Cardin-Weintraub sequence motif. J Cell Commun Signal 9 (2): 143-150
Schindler, N.; Gimsa, U.; Mayer, J.; Kirschstein, T.; Brenmoehl, J.; Ohde, D.; Wirthgen, E.; Höflich, A. (2015):
Functional analysis of the Cardin Weintraub motif present in IGFBP-2 transgenic mice. Schriftenreihe / Leibniz-Institut für Nutztierbiol 24: 29-32
Brenmoehl, J.; Ohde, D.; Walz, C.; Tuchscherer, A; Schultz, J.; Rieder, F.; Hoeflich, A. (2015):
Dynamics of fat mass in DUhTP mice selected for running performance - fat mobilization in a walk. Obesity Facts 8 (6): 373-385
Kunze, M.; Wirthgen, E.; Walz, C.; Spitschak, M.; Brenmoehl, J.; Vanselow, J.; Schwerin, M.; Wimmers, K.; Hoeflich, A. (2015):
Bioanalytical validation for simultaneous quantification of non-aromatic steroids in follicular fluid from cattle via ESI-LC-MS/MS. J Chromatogr B 1007: 132-139
Wirthgen, E.; Hoeflich, A. (2015):
Endotoxin-induced tryptophan degradation along the kynurenine pathway: the role of indolamine 2,3-dioxygenase and aryl hydrocarbon receptor-mediated immunosuppressive effects in endotoxin tolerance and cancer and its implications for immunoparalysis. J Am
Langhammer, M.; Michaelis, M.; Hoeflich, A.; Sobczak, A.; Schön, J.; Weitzel, J. M. (2014):
High fertility phenotypes: two outbred mouse models exhibit substantially different molecular and physiological strategies warranting improved fertility. Reproduction 147 (4): 427-433
Komolka, K.; Albrecht, E.; Schering, L.; Brenmoehl, J.; Hoeflich, A.; Maak, S. (2014):
Locus characterization and gene expression of bovine FNDC5: is the myokine irisin relevant in cattle?. Plos One 9 (1): 1-11
Laeger, T.; Wirthgen, E.; Piechotta, M.; Metzger, F.; Metges, C. C.; Kuhla, B.; Höflich, A. (2014):
Effects of parturition and feed restriction on concentrations and distribution of the insulin-like growth factor-binding proteins in plasma and cerebrospinal fluid of dairy cows. J Dairy Sci 97 (5): 2876-2885
Brenmoehl, J.; Albrecht, E.; Komolka, K.; Schering, L.; Langhammer, M.; Hoeflich, A.; Maak, S. (2014):
Irisin is elevated in skeletal muscle and serum of mice immediately after acute exercise. Int J Biol Sci 10 (3): 338-349
Hoeflich, A.; Wirthgen, E.; David, R.; Classen, C. F.; Spitschak, M.; Brenmoehl, J. (2014):
Control of IGFBP-2 expression by steroids and peptide hormones in vertebrates. Front Endocrinol 5: 43-52
Bielohuby, M.; Zarkesh-Esfahani, S.H.; Manolopoulou, J.; Wirthgen, E.; Walpurgis, K.; Toghiany Khorasgani, M.; Aghili, Z. S.; Wilkinson, I. R.; Hoeflich, A.; Thevis, M.; Ross, R. J.; Bidlingmaier, M. (2014):
Validation of serum IGF-I as a biomarker to monitor the bioactivity of exogenous growth hormone agonists and antagonists in rabbits. Dis Model Mech 7 (11): 1263-1273
Krieger, F.; Elflein, N.; Saenger, S.; Wirthgen, E.; Rak, K.; Frantz, S.; Höflich, A.; Toyka, K. V.; Metzger, F.; Jablonka, S. (2014):
Polyethylene glycol-coupled IGF1 delays motor function defects in a mouse model of spinal muscular atrophy with respiratory distress type 1. Brain 137 (5): 1374-1393
Höflich, A.; Brenmoehl, J. (2014):
Fett weg beim Spaziergang. Leibniz Nordost 19: 4-5
Brenmoehl, J.; Hoeflich, A. (2013):
Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3. Mitochondrion 13 (6): 755-761
Piechotta, M.; Kedves, K.; Araujo, M. G.; Hoeflich, A.; Metzger, F.; Heppelmann, M.; Muscher-Banse, A.; Wrenzycki, C.; Pfarrer, C.; Schuberth, H.-J.; Hoedemaker, M.; Bollwein, H.; Kaske, M. (2013):
Hepatic mRNA expression of acid labile subunit and deiodinase 1 differs between cows selected for high versus low concentrations of insulin-like growth factor 1 in late pregnancy. J Dairy Sci 96 (6): 3737-3749