PD Dr. rer. nat. Andreas Höflich
+49 38208 68-902
Research Institute for Farm Animal Biology (FBN)
Institute of Genome Biology
Cell Signaling Unit
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Institute of Genome Biology
Cell Signaling Unit
Wilhelm-Stahl-Allee 2
18196 Dummerstorf
Research interests
- Growth and metabolism
- Functional genome analysis
- Biomarker research
Curriculum Vitae
- since 2013: Director of Cell Signaling Unit, FBN
- since 2009: Lecturer at the University of Rostock
- 4/2009: Habilitation at the Faculty of Mathematics and Natural Sciences, University of Rostock
- 2006-2012: Group Leader, Mouse Genetics, FBN
- 2002-2006: Lecturer at University of Rostock
- 6/2002: Habilitation at the Faculty of Veterinary Medicine, University of Munich
- 1996-2002: Assistant professor University of Munich
- 6/1995: Dissertation at the Institute of Organic Chemistry and Biology, Technical University of Munich
- 1985-2002: Studies of Biology, University of Erlangen-Nürnberg,
Teaching
Molecular Animal Breeding: Lectures, Seminars and practical courses within the program: Diversity and Evolution (MSc)Publications
Galow, A.-M.; Wolfien, M.; Müller, J.; Bartsch, M.; Brunner, R. M.; Hoeflich, A.; Wolkenhauer, O.; David, R.; Goldammer, T. (2020):
Integrative cluster analysis of whole hearts reveals proliferative cardiomyocytes in adult mice. Cells-Basel 9 (5): 1144,1-16
https://doi.org/10.3390/cells9051144
Wolfien, M.; Galow, A.-M.; Müller, J.; Bartsch, M.; Brunner, R. M.; Goldammer, T.; Wolkenhauer, O.; Höflich, A.; David, R. (2020):
Single nuclei sequencing of entire mammalian hearts: strain-dependent cell type composition and velocity. Cardiovasc Res 116 (7): 1249-1251
https://doi.org/10.1093/cvr/cvaa054
Wolfien, MW; Galow, A.-M.; Müller, P.; Bartsch, M.; Brunner, R. M.; Goldammer, T.; Wolkenhauer, O.; Höflich, A.; David, R. (2020):
Single-nucleus sequencing of an entire mammalian heart: cell type composition and velocity. Cells-Basel 9 (2): 318,1-6
https://doi.org/10.3390/cells9020318
Liermann, W.; Schäff, C. T.; Gruse, J.; Derno, M.; Weitzel, J. M.; Kanitz, E.; Otten, W.; Höflich, A.; Stefaniak, T.; Sauerwein, H.; Bruckmaier, R. M.; Gross, J.; Hammon, H. M. (2020):
Effects of colostrum instead of formula feeding for the first two days post natum on whole body energy metabolism and its endocrine control in neonatal calves. J Dairy Sci 103 (4): 3577-3598
https://doi.org/10.3168/jds.2019-17708
Wirthgen, E.; Goumon, S.; Kunze, M.; Walz, C.; Spitschak, M.; Tuchscherer, A.; Brown, J.; Höflich, C.; Faucitano, L.; Hoeflich, A. (2018):
Effects of transport duration and environmental conditions in winter or summer on the concentrations of insulin-like growth factors and insulin-like growth factor-binding proteins in the plasma of market-weight pigs. Front Endocrinol 9: 36, 1-10
https://doi.org/10.3389/fendo.2018.00036
Spitschak, M.; Hoeflich, A. (2018):
Potential functions of IGFBP-2 for ovarian folliculogenesis and steroidogenesis. Front Endocrinol 9: 119, 1-6
https://doi.org/10.3389/fendo.2018.00119
Mense, K.; Heidekorn-Dettmer, J.; Wirthgen, E.; Brockelmann, Y.; Bortfeldt, R.; Peter, S.; Jung, M.; Höflich, C.; Hoeflich, A.; Schmicke, M. (2018):
Increased concentrations of insulin-like growth factor binding protein (IGFBP)-2, IGFBP-3, and IGFBP-4 are associated with fetal mortality in pregnant cows. Front Endocrinol 9: 310, 1-10
https://doi.org/10.3389/fendo.2018.00310
Hoeflich, A.; David, R.; Hjortebjerg, R. (2018):
Current IGFBP-related biomarker research in cardiovascular disease - we need more structural and functional information in clinical studies. Front Endocrinol 9: 388, 1-11
https://doi.org/10.3389/fendo.2018.00388
Hesse, D.; Trost, J.; Schäfer, N.; Schwerbel, K.; Hoeflich, A.; Schürmann, A.; Brockmann, G. A. (2018):
Effect of adipocyte-derived IGF-I on adipose tissue mass and glucose metabolism in the Berlin Fat Mouse. Growth Factors 36 (1-2): 78-88
https://doi.org/10.1080/08977194.2018.1497621
Hinrichs, A.; Kessler, B.; Kurome, M.; Blutke, A.; Kemter, E.; Bernau, M.; Scholz, A. M.; Rathkolb, B.; Renner, S.; Bultmann, S.; Leonhardt, H.; ..., ; Hoeflich, A.; ..., (2018):
Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver. Mol Metab 11: 113-128
https://doi.org/10.1016/j.molmet.2018.03.006
Hoeflich, A.; Pintar, J.; Forbes, B. (2018):
Editoral: Current perspectives on insulin-like growth factor binding protein (IGFBP) research. Front Endocrinol 9: 667, 1-2
https://doi.org/10.3389/fendo.2018.00667
Nipkow, M.; Wirthgen, E.; Luft, P.; Rebl, A.; Hoeflich, A.; Goldammer, T. (2018):
Characterization of igf1 and igf2 genes during maraena whitefish (Coregonus maraena) ontogeny and the effect of temperature on embryogenesis and igf expression. Growth Horm IGF Res 40: 32-43
https://doi.org/10.1016/j.ghir.2018.04.003
Brenmoehl, J.; Walz, C.; Spitschak, M.; Wirthgen, E.; Walz, M.; Langhammer, M.; Tuchscherer, A.; Naumann, R.; Höflich, A. (2018):
Partial phenotype conversion and differential trait response to conditions of husbandry in mice. J Comp Physiol B 188 (3): 527-539
https://doi.org/10.1007/s00360-017-1138-x
Hoeflich, A.; Kiess, W. (2018):
Preface : Hormones in milk - new directions. Best Pract Res Cl En 32 (1): 1-3
https://doi.org/10.1016/j.beem.2018.01.008
Brenmoehl, J.; Ohde, D.; Wirthgen, E.; Hoeflich, A. (2018):
Cytokines in milk and the role of TGF-beta. Best Pract Res Cl En 32 (1): 47-56
https://doi.org/10.1016/j.beem.2018.01.006
Frieten, D.; Gerbert, C.; Koch, C.; Dusel, G.; Eder, K.; Hoeflich, A.; Mielenz, B.; Hammon, H. M. (2018):
Influence of ad libitum milk replacer feeding and butyrate supplementation on the systemic and hepatic insulin-like growth factor I and its binding proteins in Holstein calves. J Dairy Sci 101 (2): 1661-1672
https://doi.org/10.3168/jds.2017-13603
Wirthgen, E.; Hoeflich, A.; Rebl, A.; Günther, J. (2017):
Kynurenic acid: The Janus-faced role of an immunomodulatory tryptophan metabolite and its link to pathological conditions. Front Immunol 8: 1957, 1-13
https://dx.doi.org/10.3389/fimmu.2017.01957
Hoeflich, A.; Kiess, W. (2017):
Preface: Hormones in milk. Best Pract Res Cl En 31 (4): 363-365
https://doi.org/10.1016/j.beem.2017.11.003
Hoeflich, A.; Meyer, Z. (2017):
Functional analysis of the IGF-system in milk. Best Pract Res Cl En 31 (4): 409-418
https://dx.doi.org/10.1016/j.beem.2017.10.002