PD Dr. rer. nat. Andreas Höflich

+49 38208 68-902
Leibniz Institute for Farm Animal Biology (FBN)
Institute of Genome Biology
Cell Signaling Unit
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Research interests

  • Growth and metabolism
  • Functional genome analysis
  • Biomarker research

Curriculum Vitae

  • since 2013: Director of Cell Signaling Unit, FBN
  • since 2009: Lecturer at the University of Rostock
  • 4/2009: Habilitation at the Faculty of Mathematics and Natural Sciences, University of Rostock
  • 2006-2012: Group Leader, Mouse Genetics, FBN
  • 2002-2006: Lecturer at University of Rostock
  • 6/2002: Habilitation at the Faculty of Veterinary Medicine, University of Munich
  • 1996-2002: Assistant professor University of Munich
  • 6/1995: Dissertation at the Institute of Organic Chemistry and Biology, Technical University of Munich
  • 1985-2002: Studies of Biology, University of Erlangen-Nürnberg,


Molecular Animal Breeding: Lectures, Seminars and practical courses within the program: Diversity and Evolution (MSc)


Nipkow, M.; Wirthgen, E.; Luft, P.; Rebl, A.; Hoeflich, A.; Goldammer, T. (2018):
Characterization of igf1 and igf2 genes during maraena whitefish (Coregonus maraena) ontogeny and the effect of temperature on embryogenesis and igf expression. Growth Horm IGF Res 40: 32-43
Hoeflich, A.; Pintar, J.; Forbes, B. (2018):
Editoral: Current perspectives on insulin-like growth factor binding protein (IGFBP) research. Front Endocrinol 9: 667, 1-2
Hinrichs, A.; Kessler, B.; Kurome, M.; Blutke, A.; Kemter, E.; Bernau, M.; Scholz, A. M.; Rathkolb, B.; Renner, S.; Bultmann, S.; Leonhardt, H.; ..., ; Hoeflich, A.; ..., (2018):
Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver. Mol Metab 11: 113-128
Hesse, D.; Trost, J.; Schäfer, N.; Schwerbel, K.; Hoeflich, A.; Schürmann, A.; Brockmann, G. A. (2018):
Effect of adipocyte-derived IGF-I on adipose tissue mass and glucose metabolism in the Berlin Fat Mouse. Growth Factors 36 (1-2): 78-88
Hoeflich, A.; David, R.; Hjortebjerg, R. (2018):
Current IGFBP-related biomarker research in cardiovascular disease - we need more structural and functional information in clinical studies. Front Endocrinol 9: 388, 1-11
Mense, K.; Heidekorn-Dettmer, J.; Wirthgen, E.; Brockelmann, Y.; Bortfeldt, R.; Peter, S.; Jung, M.; Höflich, C.; Hoeflich, A.; Schmicke, M. (2018):
Increased concentrations of insulin-like growth factor binding protein (IGFBP)-2, IGFBP-3, and IGFBP-4 are associated with fetal mortality in pregnant cows. Front Endocrinol 9: 310, 1-10
Spitschak, M.; Hoeflich, A. (2018):
Potential functions of IGFBP-2 for ovarian folliculogenesis and steroidogenesis. Front Endocrinol 9: 119, 1-6
Wirthgen, E.; Goumon, S.; Kunze, M.; Walz, C.; Spitschak, M.; Tuchscherer, A; Brown, J.; Höflich, C.; Faucitano, L.; Hoeflich, A. (2018):
Effects of transport duration and environmental conditions in winter or summer on the concentrations of insulin-like growth factors and insulin-like growth factor-binding proteins in the plasma of market-weight pigs. Front Endocrinol 9: 36, 1-10
Brenmoehl, J.; Ohde, D.; Albrecht, E.; Walz, C.; Tuchscherer, A; Hoeflich, A. (2017):
Browning of subcutaneous fat and higher surface temperature in response to phenotype selection for advanced endurance exercise performance in male DUhTP mice. J Comp Physiol B 187 (2): 361-373
Wirthgen, E.; Kunze, M.; Goumon, S.; Walz, C.; Höflich, C.; Spitschak, M.; Brenmoehl, J.; Kanitz, E.; Tuchscherer, M.; Otten, W.; Gimsa, U.; Schön, P.- C.; Manteuffel, C.; Tuchscherer, A; Pfuhl, R.; Metges, C. C.; Stabenow, B.; Erdmann, S.; Schluricke, K.; Faucitano, L.; Hoeflich, A. (2017):
Interference of stress with the somatotropic axis in pigs - lights on new biomarkers. Sci Rep-UK 7: 12055, 1-13
Espelund, U. S.; Bjerre, M.; Hjortebjerg, R.; Rasmussen, R.; Lundby, A.; Hoeflich, A.; Folkersen, B. H.; Oxvig, C.; Frystyk, J. (2017):
Insulin-like growth factor bioactivity, stanniocalcin-2, pregnancy-associated plasma protein-A, and IGF-binding protein-4 in pleural fluid and serum from patients with pulmonary disease. J CLIN ENDOCR METAB 102 (9): 3526-3534
Meyer, Z.; Höflich, C.; Wirthgen, E.; Olm, S.; Hammon, H. M.; Hoeflich, A. (2017):
Analysis of the IGF-system in milk from farm animals - occurrence, regulation, and biomarker potential. Growth Horm IGF Res 35: 1-7
Schindler, N.; Mayer, J.; Saenger, S.; Gimsa, U.; Walz, C.; Ohde, D.; Wirthgen, E.; Tuchscherer, A; Russo, V. C.; Frank, M.; Kirschstein, T.; Metzger, F.; Hoeflich, A. (2017):
Phenotype analysis of male transgenic mice overexpressing mutant IGFBP-2 lacking the Cardin-Weintraub sequence motif: reduced expression of synaptic markers and myelin basic protein in the brain and a lower degree of anxiety-like behaviour. Growth Horm IGF Res 33: 1-8
Hoeflich, A.; Meyer, Z. (2017):
Functional analysis of the IGF-system in milk. Best Pract Res Cl En 31 (4): 409-418
Hoeflich, A.; Kiess, W. (2017):
Hormones in milk - part 1. Best Pract Res Cl En 31 (4): 363-442
Hoeflich, A.; Kiess, W. (2017):
Preface: Hormones in milk. Best Pract Res Cl En 31 (4): 363-365
Wirthgen, E.; Hoeflich, A.; Rebl, A.; Günther, J. (2017):
Kynurenic acid: The Janus-faced role of an immunomodulatory tryptophan metabolite and its link to pathological conditions. Front Immunol 8: 1957, 1-13
Oster, M.; Nuchchanart, W.; Trakooljul, N.; Muràni, E.; Zeyner, A.; Wirthgen, E.; Hoeflich, A.; Ponsuksili, S.; Wimmers, K. (2016):
Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and IGF signalling and increases foetal weight. Eur J Nutr 55 (4): 1717-1727
Wirthgen, E.; Höflich, C.; Spitschak, M.; Helmer, C.; Brand, B.; Langbein, J.; Metzger, F.; Hoeflich, A. (2016):
Quantitative Western ligand blotting reveals common patterns and differential features of IGFBP-fingerprints in domestic ruminant breeds and species. Growth Horm IGF Res 26: 42-49
Swiderski, K.; Martins, K. J. B.; Chee, A.; Trieu, J.; Naim, T.; Gehrig, S. M.; Baum, D. M.; Brenmoehl, J.; Chau, L.; Koopman, R.; Metzger, F.; Hoeflich, A.; Lynch, G. S. (2016):
Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology. Growth Horm IGF Res 30-31: 1-10