PD Dr. rer. nat. Andreas Höflich

+49 38208 68-902
Leibniz Institute for Farm Animal Biology (FBN)
Institute of Genome Biology
Cell Signaling Unit
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Research interests

  • Growth and metabolism
  • Functional genome analysis
  • Biomarker research

Curriculum Vitae

  • since 2013: Director of Cell Signaling Unit, FBN
  • since 2009: Lecturer at the University of Rostock
  • 4/2009: Habilitation at the Faculty of Mathematics and Natural Sciences, University of Rostock
  • 2006-2012: Group Leader, Mouse Genetics, FBN
  • 2002-2006: Lecturer at University of Rostock
  • 6/2002: Habilitation at the Faculty of Veterinary Medicine, University of Munich
  • 1996-2002: Assistant professor University of Munich
  • 6/1995: Dissertation at the Institute of Organic Chemistry and Biology, Technical University of Munich
  • 1985-2002: Studies of Biology, University of Erlangen-Nürnberg,


Molecular Animal Breeding: Lectures, Seminars and practical courses within the program: Diversity and Evolution (MSc)


Brenmoehl, J.; Ohde, D.; Albrecht, E.; Walz, C.; Tuchscherer, A; Hoeflich, A. (2017):
Browning of subcutaneous fat and higher surface temperature in response to phenotype selection for advanced endurance exercise performance in male DUhTP mice. J Comp Physiol B 187 (2): 361-373
Wirthgen, E.; Kunze, M.; Goumon, S.; Walz, C.; Höflich, C.; Spitschak, M.; Brenmoehl, J.; Kanitz, E.; Tuchscherer, M.; Otten, W.; Gimsa, U.; Schön, P.- C.; Manteuffel, C.; Tuchscherer, A; Pfuhl, R.; Metges, C. C.; Stabenow, B.; Erdmann, S.; Schluricke, K.; Faucitano, L.; Hoeflich, A. (2017):
Interference of stress with the somatotropic axis in pigs - lights on new biomarkers. Sci Rep-UK 7: 12055, 1-13
Espelund, U. S.; Bjerre, M.; Hjortebjerg, R.; Rasmussen, R.; Lundby, A.; Hoeflich, A.; Folkersen, B. H.; Oxvig, C.; Frystyk, J. (2017):
Insulin-like growth factor bioactivity, stanniocalcin-2, pregnancy-associated plasma protein-A, and IGF-binding protein-4 in pleural fluid and serum from patients with pulmonary disease. J CLIN ENDOCR METAB 102 (9): 3526-3534
Meyer, Z.; Höflich, C.; Wirthgen, E.; Olm, S.; Hammon, H. M.; Hoeflich, A. (2017):
Analysis of the IGF-system in milk from farm animals - occurrence, regulation, and biomarker potential. Growth Horm IGF Res 35: 1-7
Schindler, N.; Mayer, J.; Saenger, S.; Gimsa, U.; Walz, C.; Ohde, D.; Wirthgen, E.; Tuchscherer, A; Russo, V. C.; Frank, M.; Kirschstein, T.; Metzger, F.; Hoeflich, A. (2017):
Phenotype analysis of male transgenic mice overexpressing mutant IGFBP-2 lacking the Cardin-Weintraub sequence motif: reduced expression of synaptic markers and myelin basic protein in the brain and a lower degree of anxiety-like behaviour. Growth Horm IG
Hoeflich, A.; Meyer, Z. (2017):
Functional analysis of the IGF-system in milk. Best Pract Res Cl En 31 (4): 409-418
Hoeflich, A.; Kiess, W. (2017):
Hormones in milk - part 1. Best Pract Res Cl En 31 (4): 363-442
Hoeflich, A.; Kiess, W. (2017):
Preface: Hormones in milk. Best Pract Res Cl En 31 (4): 363-365
Wirthgen, E.; Hoeflich, A.; Rebl, A.; Günther, J. (2017):
Kynurenic acid: The Janus-faced role of an immunomodulatory tryptophan metabolite and its link to pathological conditions. Front Immunol 8: 1957, 1-13
Oster, M.; Nuchchanart, W.; Trakooljul, N.; Muràni, E.; Zeyner, A.; Wirthgen, E.; Hoeflich, A.; Ponsuksili, S.; Wimmers, K. (2016):
Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and IGF signalling and increases foetal weight. Eur J Nutr 55 (4): 1717-1727
Wirthgen, E.; Höflich, C.; Spitschak, M.; Helmer, C.; Brand, B.; Langbein, J.; Metzger, F.; Hoeflich, A. (2016):
Quantitative Western ligand blotting reveals common patterns and differential features of IGFBP-fingerprints in domestic ruminant breeds and species. Growth Horm IGF Res 26: 42-49
Swiderski, K.; Martins, K. J. B.; Chee, A.; Trieu, J.; Naim, T.; Gehrig, S. M.; Baum, D. M.; Brenmoehl, J.; Chau, L.; Koopman, R.; Metzger, F.; Hoeflich, A.; Lynch, G. S. (2016):
Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology. Growth Horm IGF Res 30-31: 1-10
Ohde, D.; Brenmoehl, J.; Walz, C.; Tuchscherer, A; Wirthgen, E.; Hoeflich, A. (2016):
Comparative analysis of hepatic miRNA levels in male marathon mice reveals a link between obesity and endurance exercise capacities. J Comp Physiol B 186 (8): 1067-1078
Kammel, A.; Saussenthaler, S.; Jähnert, M.; Jonas, W.; Stirm, L.; Hoeflich, A.; Staiger, H.; Fritsche, A.; Häring, H.-U.; Joost, H.-G.; Schürmann, A.; Schwenk, R. W. (2016):
Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice. Hum Mol Genet 25 (12): 2588-2599
Hoeflich, A.; Reyer, A.; Ohde, D.; Brenmoehl, J.; Spitschak, M.; Langhammer, M.; Tuchscherer, A; Wirthgen, E.; Renner-Müller, Ingrid; Wanke, R.; Metzger, F.; Bielohuby, M.; Wolf, E. (2016):
Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice. Aging Cell 15 (1): 111-117
Ohde, D.; Moeller, M.; Brenmoehl, J.; Walz, C.; Ponsuksili, S.; Schwerin, M.; Fuellen, G.; Hoeflich, A. (2016):
Advanced running performance by genetic predisposition in male Dummerstorf marathon mice (DUhTP) reveals higher sterol regulatory element-binding protein (SREBP) related mRNA expression in the liver and higher serum levels of progesterone. Plos One 11 (1)
Fischer, J.; Ortel, M.; Hagmann, S.; Hoeflich, A.; Richter, W. (2016):
Role of PTHrP(1-34) pulse frequency versus pulse duration to enhance mesenchymal stromal cell chondrogenesis. J Cell Physiol 231 (12): 2673-2681
Schäff, C.; Gruse, J.; Maciej, J.; Mielenz, M.; Wirthgen, E.; Hoeflich, A.; Schmicke, M.; Pfuhl, R.; Jawor, P.; Stefaniak, T.; Hammon, H. M. (2016):
Effects of feeding milk replacer ad libitum or in restricted amounts for the first five weeks of life on the growth, metabolic adaptation, and immune status of newborn calves. Plos One 11 (12): e0168974, 1-24
López, I. P.; Pineiro-Hermida, S.; Pais, R.; Torrens, R.; Hoeflich, A.; Pichel, J. G. (2016):
Involvement of Igf1r in bronchiolar epithelial regeneration: role during repair kinetics after selective club cell ablation. Plos One 11 (11): e0166388, 1-32
Reyer, A.; Schindler, N.; Ohde, D.; Walz, C.; Kunze, M.; Tuchscherer, A; Wirthgen, E.; Brenmoehl, J.; Hoeflich, A. (2015):
The RGD sequence present in IGFBP-2 is required for reduced glucose clearance after oral glucose administration in female transgenic mice. Am J Physiol-Endoc M 309 (4): 409-417