PD Dr. rer. nat. Andreas Höflich

+49 38208 68-902
Research Institute for Farm Animal Biology (FBN)
Institute of Genome Biology
Cell Signaling Unit
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Research interests

  • Growth and metabolism
  • Functional genome analysis
  • Biomarker research

Curriculum Vitae

  • since 2013: Director of Cell Signaling Unit, FBN
  • since 2009: Lecturer at the University of Rostock
  • 4/2009: Habilitation at the Faculty of Mathematics and Natural Sciences, University of Rostock
  • 2006-2012: Group Leader, Mouse Genetics, FBN
  • 2002-2006: Lecturer at University of Rostock
  • 6/2002: Habilitation at the Faculty of Veterinary Medicine, University of Munich
  • 1996-2002: Assistant professor University of Munich
  • 6/1995: Dissertation at the Institute of Organic Chemistry and Biology, Technical University of Munich
  • 1985-2002: Studies of Biology, University of Erlangen-Nürnberg,

Teaching

Molecular Animal Breeding: Lectures, Seminars and practical courses within the program: Diversity and Evolution (MSc)

Publications

Müller-Eigner, A.; Sanz-moreno, A.; de Diego, I.; Venkateswaran Venkatasubramani, A.; Langhammer, M.; Gerlini, R.; Rathkolb, B.; Aguilar-Pimentel, A.; Klein-Rodewald, T.; Calzada-Wack, J.; Becker, L.; Palma Vera, S.; Gille, B.; Forne, I.; Imhof, A.; Meng, C.; Ludwig, A.; Koch, F.; Heiker, J.; Kuhla, A.; Caton, V.; Brenmoehl, J.; Reyer, H.; Schön, J.; Fuchs, B.; Gailus-Durner, V.; Hoeflich, A.; Hrabe de Angelis, M.; Peleg, S. (2022):
Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse. COMMUN BIOL 5: 408, 1-17
https://doi.org/10.1038/s42003-022-03339-3
Braude, S.; Holtze, S.; Begall, S.; Brenmoehl, J.; Burda, H.; Dammann, P.; de Marmol, D.; Gorshkova, E.; Henning, Y.; Hoeflich, A.; Höhn, A.; Jung, T.; Hamo, D.; Sahm, A.; Shebzukhov, Y.; Šumbera, R.; Miwa, S.; Vyssokikh, M.; von Zglinicki, T.; Averina, O.; Hildebrandt, T. B. (2021):
Surprisingly long survival of premature conclusions about naked mole-rat biology. Biol Rev 96 (2): 376-393
https://doi.org/10.1111/brv.12660
Hoeflich, A.; Fitzner, B.; Walz, C.; Hecker, M.; Tuchscherer, A.; Brenmoehl, J.; Zettl, U. K. (2021):
Reduced Fragmentation of IGFBP-2 and IGFBP-3 as a Potential Mechanism for Decreased Ratio of IGF-II to IGFBPs in Cerebrospinal Fluid in Response to Repeated Intrathecal Administration of Triamcinolone Acetonide in Patients With Multiple Sclerosis. Front Endocrinol 11: 565557, 1-10
https://doi.org/10.3389/fendo.2020.565557
Vogel, L.; Gnott, M.; Kröger-Koch, C.; Görs, S.; Weitzel, J. M.; Kanitz, E.; Hoeflich, A.; Tuchscherer, A.; Tröscher, A.; Gross, J.; Bruckmaier, R. M.; Starke, S.; Bachmann, L.; Hammon, H. M. (2021):
Glucose metabolism and the somatotropic axis in dairy cows after abomasal infusion of essential fatty acids together with conjugated linoleic acid during late gestation and early lactation. J Dairy Sci 104: 3646-3664
https://doi.org//10.3168/jds.2020-19321
Noce, A.; Qanbari, S.; Gonzalez-Prendes, R.; Brenmoehl, J.; Luigi-Sierra, M. G.; Theerkorn, M.; Fiege, M.-A.; Pilz, H.; Bota, A.; Vidu, L.; Horwath, C.; Haraszthy, L.; Penchev, P.; Ilieva, Y.; Peeva, T.; Lüpcke, W.; Krawczynski, R.; Wimmers, K.; Thiele, M.; Hoeflich, A. (2021):
Genetic Diversity of Bubalus bubalis in Germany and Global Relations of Its Genetic Background. Front Genet 11: 610353, 1-16
https://doi.org/10.3389/fgene.2020.610353
Walz, C.; Brenmoehl, J.; Trakooljul, N.; Noce, A.; Caffier, C.; Ohde, D.; Langhammer, M.; Wimmers, K.; Ponsuksili, S.; Hoeflich, A. (2021):
Control of Protein and Energy Metabolism in the Pituitary Gland in Response to Three-Week Running Training in Adult Male Mice . Cells-Basel 10 (4): 736, 1-20
https://doi.org/10.3390/cells10040736
Walz, M.; Höflich, C.; Walz, C.; Ohde, D.; Brenmoehl, J.; Sawitzky, M.; Vernunft, A.; Zettl, U. K.; Holtze, S.; Hildebrandt, T. B.; Wolf, E.; Hoeflich, A. (2021):
Development of a Sensitive Bioassay for the Analysis of IGF-Related Activation of AKT/mTOR Signaling in Biological Matrices. Cells-Basel 10 (3): 482, 1-19
https://doi.org/10.3390/cells10030482
Uken, K. L.; Vogel, L.; Gnott, M.; Görs, S.; Schäff, C. T.; Tuchscherer, A.; Hoeflich, A.; Weitzel, J. M.; Kanitz, E.; Tröscher, A.; Sauerwein, H.; Zitnan, R.; Bruckmaier, R. M.; Gross, J.; Liermann, W.; Hammon, H. M. (2021):
Effect of maternal supplementation with essential fatty acids and conjugated linoleic acid on metabolic and endocrine development of neonatal calves. J Dairy Sci 104 (6): 7295-7314
https://doi.org/10.3168/jds.2020-20039
Galow, A.-M.; Kussauer, S.K; Wolfien, M.; Brunner, R. M.; Goldammer, T.; Hoeflich, A.; David, R. (2021):
Quality control in scRNA-Seq can discriminate pacemaker cells: the mtRNA bias. Cell Mol Life Sci 78: 6585-6592
https://doi.org/10.1007/s00018-021-03916-5
Brenmoehl, J.; Walz, C.; Caffier, C.; Brosig, E.; Walz, C.; Ohde, D.; Trakooljul, N.; Langhammer, M.; Ponsuksili, S.; Wimmers, K.; Zettl, U. K.; Höflich, A. (2021):
Central Suppression of the GH/IGF Axis and Abrogation of Exercise-Related mTORC1/2 Activation in the Muscle of Phenotype-Selected Male Marathon Mice (DUhTP). Cells-Basel 10 (12): 3418, 1-19
https://doi.org/10.3390/cells10123418
Holtze, S.; Gorshkova, E.; Braude, S.; Cellerino, A.; Dammann, P.; Hildebrandt, T.; Höflich, A.; Hoffman, S.; Koch, P.; Terzibasi Tozzini, E.; Skulachev, M.; Skulachev, W. P.; Sahm, A. (2021):
Alternative Animal Models of Aging Research. FRONT MOL BIOSCI 8: 660959, 1-27
https://doi.org/10.3389/fmolb.2021.660959
Liermann, W.; Schäff, C. T.; Gruse, J.; Derno, M.; Weitzel, J. M.; Kanitz, E.; Otten, W.; Höflich, A.; Stefaniak, T.; Sauerwein, H.; Bruckmaier, R. M.; Gross, J.; Hammon, H. M. (2020):
Effects of colostrum instead of formula feeding for the first two days post natum on whole body energy metabolism and its endocrine control in neonatal calves. J Dairy Sci 103 (4): 3577-3598
https://doi.org/10.3168/jds.2019-17708
Wolfien, MW; Galow, A.-M.; Müller, P.; Bartsch, M.; Brunner, R. M.; Goldammer, T.; Wolkenhauer, O.; Höflich, A.; David, R. (2020):
Single-nucleus sequencing of an entire mammalian heart: cell type composition and velocity. Cells-Basel 9 (2): 318,1-6
https://doi.org/10.3390/cells9020318
Wolfien, M.; Galow, A.-M.; Müller, J.; Bartsch, M.; Brunner, R. M.; Goldammer, T.; Wolkenhauer, O.; Höflich, A.; David, R. (2020):
Single nuclei sequencing of entire mammalian hearts: strain-dependent cell type composition and velocity. Cardiovasc Res 116 (7): 1249-1251
https://doi.org/10.1093/cvr/cvaa054
Galow, A.-M.; Wolfien, M.; Müller, J.; Bartsch, M.; Brunner, R. M.; Hoeflich, A.; Wolkenhauer, O.; David, R.; Goldammer, T. (2020):
Integrative cluster analysis of whole hearts reveals proliferative cardiomyocytes in adult mice. Cells-Basel 9 (5): 1144,1-16
https://doi.org/10.3390/cells9051144
Ohde, D.; Walz, M.; Walz, C.; Noce, A.; Brenmoehl, J.; Langhammer, M.; Hoeflich, A. (2020):
Sex-specific control of muscle mass: elevated IGFBP proteolysis and reductions of IGF-1 levels are associated with substantial loss of carcass weight in male DU6PxIGFBP-2 transgenic mice. Cells-Basel 9 (10): 2174, 1-17
https://doi.org/10.3390/cells9102174
Hoeflich, A.; Fitzner, B.; Walz, C.; Hecker, M.; Tuchscherer, A.; Bastian, M.; Brenmoehl, J.; Schröder, S.; Willenberg, H.S.; Reincke, M. (2020):
Systemic effects by intrathecal administration of triamcinolone acetonide in patients with multiple sclerosis. Front Endocrinol 11: 574, 1-8
https://doi.org/10.3389/fendo.2020.00574
Walz, M.; Chau, L.; Sawitzky, M.; Ohde, D.; Brenmoehl, J.; Tuchscherer, A.; Langhammer, M.; Metzger, F.; Höflich, C.; Hoeflich, A. (2020):
Overlap of peak growth activity and peak IGF-1 to IGFBP ratio: delayed increase of IGFBPs versus IGF-1 in serum as a mechanism to speed up and down postnatal weight gain in mice. Cells-Basel 9 (6): 1516, 1-12
https://doi.org/10.3390/cells9061516
Haubold, S. S.; Kröger-Koch, C.; Tuchscherer, A.; Kanitz, E.; Weitzel, J. M.; Hoeflich, A.; Starke, S.; Tröscher, A.; Sauerwein, H.; Hammon, H. M. (2020):
Effects of a combined essential fatty acid and conjugated linoleic acid abomasal infusion on metabolic and endocrine traits, including the somatotropic axis, in dairy cows. J Dairy Sci 103 (12): 12069-12082
https://doi.org/10.3168/jds.2020-18569
Brenmoehl, J.; Ohde, D.; Walz, C.; Langhammer, M.; Schultz, J.; Hoeflich, A. (2020):
Analysis of activity-dependent energy metabolism in mice reveals regulation of mitochondrial fission and fusion mRNA by voluntary physical exercise in subcutaneous fat from male marathon mice (DUhTP). Cells-Basel 9: 2697, 1-20
https://doi.org/10.3390/cells9122697