Dr. rer. nat. Juliane Günther

Institute of Genome Biology

+49 38208 68-702
Leibniz Institute for Farm Animal Biology (FBN)
Institute of Genome Biology
Genome Physiology Unit
Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Research interests

  • Molecular Biology
  • Infection Biology, Cell Biology
  • Immunology
  • Epigenetics
  • Cell Signalling

Curriculum Vitae

  • since 2013: Junior Group Leader, Genome Physiology Unit, Leibniz Institute for Farm Animal Biology (FBN)
  • 2006-2013: Postdoctoral Research Fellow, Group Gene Analysis, Leibniz Institute for Farm Animal Biology (FBN)
  • 2005: Ph.D. (Dr. rer. nat.) at the Friedrich Schiller University of Jena
  • 2002-2005: Ph.D. student, Leibniz Institute for Natural Product Research and Infection Biology (Hans-Knöll-Institute), Jena, Germany
  • 2001: Diploma (Biology) at the Friedrich Schiller University of Jena
  • 1995-2001: Studies in Biological Sciences, Friedrich Schiller University of Jena, Germany

Teaching

  • since 2011: „Diversity and Evolution“ (MSc), Faculty of Mathematics and Natural Sciences, University of Rostock, Germany

Publications

Brodhagen, J.; Weikard, R.; Thom, U.; Heimes, A.; Günther, J.; Hadlich, F.; Zerbe, H.; Petzl, W.; Meyerholz, M. M.; Hoedemaker, M.; Schubert, H-J; Engelmann, S.; Kühn, Ch. (2019):
Development and evaluation of a milk protein transcript depletion method for differential transcriptome analysis in mammary gland tissue. BMC Genomics 20 (1): 400, 1-19
Günther, J.; Däbritz, J.; Wirthgen, Elisa (2019):
Limitations and off-target effects of tryptophan-related IDO inhibitors in cancer treatment. Front Immunol 10: 1801, 1-8
Petzl, W.; Zerbe, H.; Günther, J.; Seyfert, H.-M.; Hussen, J.; Schuberth, H.-J. (2018):
Pathogen-specific responses in the bovine udder: Models and immunoprophylactic concepts. Res Vet Sci 116: 55-61
Wirthgen, E.; Otten, W.; Tuchscherer, M.; Tuchscherer, A.; Domanska, G.; Brenmoehl, J.; Günther, J.; Ohde, D.; Weitschies, W.; Seidlitz, A.; Scheuch, W.; Kanitz, E. (2018):
Effects of 1-Methyltryptophan on immune responses and the kynurenine pathway after lipopolysaccharide challenge in pigs. Int J Mol Sci 19 (10): 3009, 1-23
Günther, J.; Seyfert, H.M. (2018):
The first line of defence: insights into mechanisms and relevance of phagocytosis in epithelial cells. Semin Immunopathol 40 (6): 555-565
Günther, J.; Petzl, W.; Zerbe, H.; Schuberth, H.-J.; Seyfert, H.-M. (2017):
TLR ligands, but not modulators of histone modifiers, can induce the complex immune response pattern of endotoxin tolerance in mammary epithelial cells. Innate Immun-London 23 (2): 155-164
Günther, J.; Petzl, W.; Bauer, I.; Ponsuksili, S.; Zerbe, H.; Schuberth, H.-J.; Brunner, R. M.; Seyfert, H.-M. (2017):
Differentiating Staphylococcus aureus from Escherichia coli mastitis: S. aureus triggers unbalanced immune-dampening and host cell invasion immediately after udder infection. Sci Rep-UK 7: 4811,1-14
Wirthgen, E.; Hoeflich, A.; Rebl, A.; Günther, J. (2017):
Kynurenic acid: The Janus-faced role of an immunomodulatory tryptophan metabolite and its link to pathological conditions. Front Immunol 8: 1957, 1-13
Günther, J.; Czabanska, A.; Bauer, I.; Leigh, J.; Holst, Otto; Seyfert, H.-M. (2016):
Streptococcus uberis strains isolated from the bovine mammary gland evade immune recognition by mammary epithelial cells, but not of macrophages. Vet Res 47: 13, 1-14
Günther, J.; Koy, M.; Berthold, A.; Schuberth, H.-J.; Seyfert, H.-M. (2016):
Comparison of the pathogen species-specific immune response in udder derived cell types and their models. Vet Res 47: 22, 1-11
Petzl, W.; Günther, J.; Mühlbauer, I.C.; Seyfert, H.-M.; Schuberth, H.-J.; Hussen, J.; Sauter-Louis, C.; Hafner-Marx, A.; Zerbe, H. (2016):
Early transcriptional events in the udder and teat after intramammary Escherichia coli and Staphylococcus aureus challenge. Innate Immun-London 22 (4): 294-304
Chang, G.; Petzl, W.; Vanselow, J.; Günther, J.; Shen, Z.; Seyfert, H.-M. (2015):
Epigenetic mechanisms contribute to enhanced expression of immune response genes in the liver of cows after experimentally induced Escherichia coli mastitis. Vet J 203 (3): 339-341
Bauer, I.; Günther, J.; Wheeler, T.T.; Engelmann, S.; Seyfert, H.-M. (2015):
Extracellular milieu grossly alters pathogen-specific immune response of mammary epithelial cells. BMC Vet Res 11: 172-186
Jaeger, A.; Bardehle, D.; Oster, M.; Günther, J.; Muràni, E.; Ponsuksili, S.; Wimmers, K.; Kemper, N. (2015):
Gene expression profiling of porcine mammary epithelial cells after challenge with Escherichia coli and Staphylococcus aureus in vitro. Vet Res 46: 1-18
Patterson, N.; Günther, J.; Gibson, A.; Offord, V.; Coffey, T. J.; Splitter, G.; Monk, I.; Seyfert, H.-M.; Werling, Dirk (2014):
TwoTIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response. Front microbiol 5: 662-676
Jensen, K.; Günther, J.; Talbot, R.; Petzl, W.; Zerbe, H.; Schuberth, H.-J.; Seyfert, H.-M.; Glass, E. (2013):
Escherichia coli- and Staphylococcus aureus-induced mastitis differentially modulate transcriptional response in neighbouring uninfected bovine mammary gland quarters. BMC Genomics 14: 36-55
Petzl, W.; Günther, J.; Pfister, T.; Sauter-Louis, C.; Goetze, L.; von Aulock, S.; Hafner-Marx, A.; Schuberth, H.-J.; Seyfert, H.-M.; Zerbe, H. (2012):
Lipopolysaccharide pretreatment of the udder protects against experimental Escherichia coli mastitis. Innate Immun-London 18 (3): 467-477
Günther, J.; Petzl, W.; Zerbe, H.; Schuberth, H.-J.; Koczan, D.; Goetze, L.; Seyfert, H.-M. (2012):
Lipopolysaccharide priming enhances expression of effectors of immune defence while decreasing expression of pro-inflammatory cytokines in mammary epithelia cells from cows. BMC Genomics 13: 17-30
Lewandowska-Sabat, A. M.; Günther, J.; Seyfert, H.-M.; Olsaker, I. (2012):
Combining quantitative trait loci and heterogeneous microarray data analyses reveals putative candidate pathways affecting mastitis in cattle. Anim Genet 43 (6): 793-796
Günther, J.; Esch, K.; Poschadel, N.; Petzl, W.; Zerbe, H.; Mitterhuemer, S.; Blum, H.; Seyfert, H.-M. (2011):
Comparative kinetics of Escherichia coli- and Staphylococcus aureus-specific activation of key immune pathways in mammary epithelial cells demonstrates that S. aureus elicits a delayed response dominated by interleukin-6 (IL-6) but not by IL-1A or tumor n